No abstract available.

No abstract available.
Hematuria*

No abstract available.

No abstract available.
Heart Murmurs*

No abstract available.
Mortality*

Neuropathic pain has recently been defined as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system". Neuropathic pain is a debilitating chronic condition that remains very difficult to treat and challenging to manage. Tricyclic antidepressants (amitryptiline, nortriptyline, imipramine), selective serotonin and norepinephrine reuptake inhibitors (duloxetine, venlafaxine), anticonvulsants (gabapentin, pregabalin), and 5% lidocaine patches have demonstrated efficacy in neuropathic pain and are recommended as first-line medications. In patients who fail to respond to these first-line medications alone and/or in combination, opioid analgesics or tramadol can be used as a second-line treatment alone or in combination with one of the first-line medications. Opioid analgesics and tramadol can also be considered for first-line use in selected clinical circumstances. Other pharmacological therapeutic options include selective serotonin reuptake inhibitors, antiepileptic drugs (levetiracetam, lacosamide, lamotrigine, valproic acid), cannabinoids, high concentration capsaicin patch, and botulinum toxin A. Medication selection should be individualized, with side effects taken into consideration as well as potential beneficial or deleterious effects on comorbidities, and whether or not prompt onset of pain relief is necessary.
Acetamides ; Analgesics, Opioid ; Anticonvulsants ; Antidepressive Agents, Tricyclic ; Botulinum Toxins ; Cannabinoids ; Capsaicin ; Comorbidity ; Humans ; Lidocaine ; Neuralgia ; Norepinephrine ; Nortriptyline ; Serotonin ; Serotonin Uptake Inhibitors ; Tramadol ; Triazines

Most textbooks for biostatistics only explain each individual statistical test with its mathematical formula. However, it is crucial to understand the relationships among the statistical methods and to properly integrate the individual methods to effectively apply them to real clinical research settings. The choice for valid statistical tests greatly depends on the dependency of the sample and the number of independent variables in the analyses as well as the measurement scale of dependent variables and independent variables. In this report, many statistical tests such as the two sample t-test, ANOVA, non-parametric tests, chi-square test, log-rank test, multiple linear regression, logistic regression, mixed model, and Cox regression model are addressed through hypothetical examples. The key for a successful analysis of a clinical experiment is to adopt suitable statistical tests. This study presents a guideline to clinical researchers for selecting valid and powerful statistical tests in their study design. The choice of suitable statistical tests increases the reliability of analytical results and therefore the possibility of accepting a researcher's clinical hypothesis. The proposed flowchart of appropriate tests of statistical inference will be of help to many clinical researchers to their study.
Biostatistics ; Dependency (Psychology) ; Linear Models ; Logistic Models ; Software Design ; Statistics, Nonparametric

Chronic low back pain has become a major public health problem in Korea. The lifetime prevalence of low back pain has been reported to be as high as 90%. The prevalences of discogenic pain, facet joint pain, and sacroiliac joint pain are 42%, 30%, and 18%, respectively. Increasing age is associated with a decreasing probability of discogenic pain but increasing probabilities of facet joint pain and sacroiliac joint pain as the source of low back pain. Physical examination of low back pain is limited and imaging may lack objective clues. Diagnostic interventions allow us to determine the etiology of back pain. Techniques include lumbar disc stimulation, facet joint block, medial branch block, and sacroilliac joint block. Initial therapy includes modification of activity, pharmacological analgesic therapy, and education of patients. In patients with chronic low back pain, a multimodal and interdisciplinary treatment approach is necessary. Use of interventional treatments for chronic low back pain are increasing but their utilization remains uncertain or controversial. Therefore, management of patients with chronic and disabling low back pain remains a clinical challenge.
Back Pain ; Humans ; Intervertebral Disc ; Joints ; Korea ; Low Back Pain ; Pain Management ; Patient Education as Topic ; Physical Examination ; Prevalence ; Public Health ; Sacroiliac Joint ; Zygapophyseal Joint

Diarrheal disorders in childhood are the second most common cause of child deaths worldwide. Nutritional rehabilitation is the most important factor among treatments when diarrheal disorders develop and has a general beneficial effect on the patient's condition, intestinal function, and immune response. Breast milk is the most nutritious food for treating acute and chronic diarrhea in infants. Until now, many infant formulas have been developed, and particularly, special formulas for treating acute or chronic diarrhea are commonly used. Lactose-free formulas, soy based formulas, and hydrolyzed and amino acid-based formula are typical formulas. In general, replacement with specialized lactose-free formulations is unnecessary in children with persistent diarrhea, and it has been reported that infants that are not severely compromised have food allergy and intestinal failure. However, a general knowledge does not always applied to all populations because the genetic, economic or environmental factors are different. Physicians should know about the components and characteristics of special formulas in order to coach parents to use these formulas properly.
Child ; Diarrhea ; Food Hypersensitivity ; Humans ; Infant ; Infant Formula ; Milk, Human ; Parents

Chronic nonspecific diarrhea (CNSD) or toddler's diarrhea is the most frequent cause of chronic diarrhea in young children of developed countries. The pathogenesis of CNSD remains unclear. It has been associated with drinking large amounts of fluids and fruit juices that contain large amounts of fructose and sorbitol. Reduction in the intake of fat and fiber can also be the cause of CNSD. Children with CNSD do not show signs of malnutrition or growth retardation. They experience watery stools four to more than ten times daily. Stools are foul smelling, occasionally with undigested food remnants because of the short transit time. The patients do not normally suffer from their ailment; however, diarrhea may cause parents to be extremely worried. Pediatricians and primary physicians have to diagnose CNSD with clinical symptoms and exclusion of specific illness. Proper dietary manipulation improves the condition of most patients.
Child ; Developed Countries ; Diarrhea ; Drinking ; Fructose ; Fruit ; Humans ; Malnutrition ; Parents ; Smell ; Sorbitol