Kabuki (Niikawa-Kuroki) syndrome was first reported by Niikawa et al(1981). The faces of the patients are similar to the make-up of traditional Japanese Kabuki actors: long palpebral fissures, an ectropium of the lateral third of the eyelids,and arching eyebrows with sparse lateral halves. Craniofacial findings include a depressed nasal tip, short nasal septum, large and prominent ears, and micrognathia. Other main features area mild to moderate mental deficiency, short stature, skeletal and dermatoglyphic abnormalities, including prominent finger tip pads. Oral anomalies are common in KS(over 60percent) and include abnormal dentition, widely spaced teeth, cleft palate or lip, high vault of palate, hypodontia, conical incisors, screw driver-shaped incisors and ectopic upper 6-year molars. The increased occurrence of cleft lip and palate or the development of a high vault of palate has been described by a number of authors. This condition is believed to be common in Japan, but has been reported from other parts of the world. The objective of this presentation is to report a case of this syndrome in six-year-old girl, with characteristic findings.
Anodontia ; Asian Continental Ancestry Group ; Cleft Lip ; Cleft Palate ; Dentition ; Dermatoglyphics ; Ear ; Eyebrows ; Female ; Fingers ; Humans ; Incisor ; Intellectual Disability ; Japan ; Lip ; Molar ; Nasal Septum ; Palate ; Tooth

Basaloid squamous cell carcinoma (BSCC) is uncommon and distinct variant of squamous cell carcinoma that arises mostly in the upper aerodigestive tract and aggressive, high grade tumor with an increased tendency to be deeply invasive, multifocal, and metastatic even at the initial presentation. The typical microscopic features of carcinoma with a basaloid pattern in intimate association with a squamous component helps in diagnosis of this tumour. Since Wain's report in 1986, BSCC of oral cavity, the palate, floor of the mouth, nasopharynx, oropharynx and mastoid region have been reported. However, BSCC in the nasal cavity or in the paranasal sinuses is rare and there are few reports in the Korean literature. We had experienced a case of basaloid squamous cell carcinoma that occurred in the left maxillary sinus of 72-year-old woman and reported with review of the clinical and pathologic features from the literature.
Aged ; Carcinoma, Squamous Cell* ; Diagnosis ; Female ; Humans ; Mastoid ; Maxillary Sinus* ; Mouth ; Nasal Cavity ; Nasopharynx ; Oropharynx ; Palate ; Paranasal Sinuses

Orbital infection or inflammation is a rare but serious complication of an odontogenic infection. Odontogenic infection can spread to the orbit by one or more of several paths. Such extension is potentially dangerous and can lead to loss of vision or worse. 5-cases of orbital infection and inflammation secondary to infection from upper or lower molar teeth, which extended to the subperiosteal or the retrobulbar region of the orbit, are presented in this report. The infections spreaded to the infratemporal and temporal fossa or the ethmoidal labyrinth, and then to the orbit via the inferior orbital fissure or the lamina papyracea. The clinical presentation, differential diagnosis, route of spread, value of serial CT scanning, treatment and possible complications are reviewed.
Abscess ; Cellulitis ; Diagnosis, Differential ; Ear, Inner ; Inflammation ; Molar ; Orbit* ; Tomography, X-Ray Computed ; Tooth

We investigated 248 patients who were diagnosed as malignant tumor in the department of Oral and maxillofacial Surgery of Kyungpook National University from 1999 to 2006, and following results were obtained. 1. Among 248 patients who have malignant tumor, 164 were men and 84 were women, which made the ratio of male to female 1.95 : 1. 2. The average age of oral cancer patients was 58.3. 3. As of the primary origin site, lower alveolus and gingiva were the greatest with 70 cases(28.2percent), followed by tongue(16.9percent), upper alveolus and gingiva(14.9percent), palate(13.7percent), mouth floor(9.7percent), buccal mucosa(4.8percent), retromolar trigone(4.4percent), Mx. and Mn. bone(3.2percent) and lip(2.8percent). 4. As of histologic distribution, squamous cell carcinoma was the greatest with 170 cases(68.6percent), followed by sarcoma with 17 cases(6.9percent), adenoid cystic carcinoma with 17 cases(6.9percent), malignant lymphoma with 15 cases(6.0percent), mucoepidermoid carcinoma with 13 cases(5.2percent), metastatic carcinoma with 6 cases(2.4percent) and malignant melanoma with 4 cases(1.6percent). 5. Period between recognition of the symptom and the first visit to hospital was less than 3 months for 58.9percent of the patients, and more than 3 months for 41percent of the patients. 6. Investigation of whether the patients drink or smoke revealed that the number of non-smoking and non-drinking patients was 63 among 170 patients (37.0percent) that were able to investigate. The number of patients who smoke only was 29(17.1percent) and both drinking and smoking patients were 78(45.9percent). 7. In clinical stage order, Stage IV(61.7percent) was found th be the largest, followed by stage I(17.2percent), stage II(13percent) and stage III(7.8percent). 8. The 5-year survival rate of the entire oral cancer patients appeared to be 57.7percent. The survival rate was higher in younger group and women had higher survival rate but there was no statistical significance to this. In the aspect of stage, the survival rate was Stage I, Stage II, Stage IV and Stage III in decreasing order. The order according to T classification was the same. In N classification, patients with N0 had the highest survival rate and the survival rate decreased in the order of N1 and N2. Survival rate was especially low in patients with N2.
Carcinoma, Adenoid Cystic ; Carcinoma, Mucoepidermoid ; Carcinoma, Squamous Cell ; Classification ; Drinking ; Female ; Gingiva ; Gyeongsangbuk-do ; Humans ; Lymphoma ; Male ; Melanoma ; Mouth ; Mouth Neoplasms* ; Sarcoma ; Smoke ; Smoking ; Surgery, Oral ; Survival Rate

We performed sinus bone graft using some amount of autogenous bone and BioOss(R) and covered the sinus window with Ossix(R) membrane in these case series. After 4 to 6 months after operation, histopathologic examinations of trephine core biopsy showed following results. 1. There were bone density of 39.2 percent to 41.2 percent four months after operation, and we could observe the favorable early new bone formation. 2. Active bony remodeling of woven and lamellar bone was observed during 4 to 6 months healing period. 3. There were no significant differences between two groups. And also there were no significant differences between 4 months and 6 months.
Biopsy ; Bone Density ; Membranes ; Osteogenesis ; Transplants*

This case study investigated the clinical effect of guided bone regeneration (GBR) using Regenaform(R) and Ossix(R) membrane and the histology of the new bone that formed just under the membranes. Regenaform(R) transplantation and covering with Ossix(R) membrane were performed to repair bone defects around implants after implantation in three patients. After 3-4 months, the membranes were removed in a second operation, and a biopsy was taken under the membrane. The biopsies showed a bone density of 23-42percent, and subsequent prosthetic treatments were successful in all cases.
Biopsy ; Bone Density ; Bone Regeneration* ; Humans ; Membranes*

PURPOSE: The purpose of study was to investigate the correlationship between lip canting change and occlusal canting change after bimaxillary orthognathic surgery, and the ratio of lip canting change and occlusal canting change after the surgery. PATIENTS AND METHODS: The subjects for this study was obtained from a group of 25 patients who took bimaxillary orthognathic surgery for occlusal canting correction at the Department of the Oral and Maxillofacial Surgery, Samsung Medical Center in Seoul, Korea between January 2000 and December 2005 and a patient's chart had to contain a resting frontal facial photograph in natural head position and a corresponding PA cephalogram in occlusion on the same day before the surgery and post-op 6 months later. The lip canting change was assessed with the angle each labial commissure and the bipupilary reference line. And, the occlusal caning change in the frontal plane was assessed with the angle between the each maxillary first molar occulasal surface and the bi-frontozygomatic suture reference line. RESULTS: In angular measurement, average occlusal canting change was 3.09degrees and standard deviation was 1.05degrees, average lip canting change was 1.56degrees and standard deviation was 1.05degrees. In linear measurement, average occlusal canting change was 2.41mm and standard deviation was 2.75mm, average lip canting change was 1.18mm and standard deviation was 0.43mm. Lip canting correction ration to occlusal canting correction was 51.5(+/-8.4)percent in angular measurement and 48.8 (+/-9.1)percent in linear measurement. Under Pearson's correlation analysis, Pearson's correlation coefficient was 0.869 in angular measurement and 0.887 in linear measurement (p-value < 0.01). High correlationship was shown between occlusal canting change and lip canting change. CONCLUSION: First, Bimaxillary orthognathic surgery can correct lip canting as well as occlusal canting. Second, The average amount of lip canting correction is 51.5+/-8.4percent, 48.8+/-9.1percent of occlusal canting correction in the study.
Canes ; Facial Asymmetry ; Head ; Humans ; Korea ; Lip* ; Molar ; Orthognathic Surgery* ; Seoul ; Surgery, Oral ; Sutures

BACKGROUND: CpG DNA plays an important role in immune cell function. This study examined whether the temporal control of toll-like receptor (TLR)9 by CpG DNA can regulate the expression of matrix metalloproteinase-9 (MMP-9). MeETHODS AND MATERIALS: Macrophages were cultured in the presence of 10percent FBS. For the various MMP genes analysis, RT-PCR and real-time PCR were performed. In addition, zymography assay performed for the MMP activity. The phosphorylation assay did for the ERK1/2 and NFkappaB activation, and luciferase promoter assay was for the NFkappaB activity. RESULTS: CpG DNA induced the mRNA expression of MMP-2, MMP-9, and MMP-13, but not of MMP-7, MMP-8, and MMP-12, in a time-dependent manner. Especially, the mRNA expression of MMP-9 was strongly induced by CpG DNA using real-time RT-PCR. The TLR9 inhibitor, chloroquine, suppressed CpG DNA-induced MMP-9 expression and its activity. Moreover, CpG DNA induced the phosphorylation of ERK and the inhibition of ERK by U0126 suppressed CpG DNA-induced MMP-9 expression and its activity. CpG DNA stimulated IkappaB-alpha degradation and luciferase activity. In addition, pretreatment of SN-50, the inhibitor of NFkappaB, strongly blocked the CpG DNA-induced MMP-9 expression and activity. CONCLUSION: These observations suggest that CpG DNA may play important roles in the activation of macrophages by regulating the production of MMP-9 via the sequential TLR9-ERK-NFkappaB signaling pathway.
Chloroquine ; DNA ; Luciferases ; Macrophages ; Matrix Metalloproteinase 9* ; Phosphorylation ; Real-Time Polymerase Chain Reaction ; RNA, Messenger ; Toll-Like Receptors*

PURPOSE: The classic technique for open reduction of subcondylar fractures is the submandibular approach. The aim of this study was to evaluate clinical result of retromandibular approach to displaced subcondylar fractures. MATERIAL AND METHODS: During a period of 24months we perfomed a prospective study with a retromandibular approach in 23 paients with displaced subcondylar fractures. In this article we describe clinical result in 23 patients with follow ups for 3 months after surgery. Preoperatively all patients had malocclusion and radiology demonstrated displacement. RESULT: The retromandibularl approach for ORIF was good in all case. Mouth opening(M/O) was 49mm. Occlusion was good too. Permanent facial nerve palsy was not detected. CONCLUSION: Our findings indicate that the retromandibular approach is a safe technique for subcondylar fractures.
Facial Nerve ; Follow-Up Studies ; Humans ; Malocclusion ; Mouth ; Paralysis ; Prospective Studies

Fractures of the mandibular condyle are account for between 26 percent and 57 percent of all mandibular fractures. Clinicians should decide how to treat the fractured condyle with many factors considered. Many surgical methods have been developed to reduction of fractured condyle and it's internal fixation. In open reduction of fractured condylar neck and subcondyle, retromandibular approach offers a safe and effective approach for direct fixation due to easy access and low surgical morbidity.
Mandibular Condyle ; Mandibular Fractures ; Neck*