Holistic integrative medicine,abbreviated as HIM,has been officially proposed since 2012.Its theoretical system has been continuously improved,and its practical methods have become increasingly diverse,becoming an inevitable choice and path for the medical development in the new era.This article demonstrates ten major propositions for HIM,elaborating on the connotation and extension of HIM from the perspectives of epistemology and methodology,in order to achieve the transformation and adaptive evolution of modern medicine.

To summarize the syndrome differentiation and treatment of hemorrhoids bleeding of doctor Ding Zeming by ana-lyzing the composing principle of traditional Chinese medicines(Hemorrhoid Bleeding Mixture for oral administration,Yuhuai Zanglian pill,Buqi Shexue decoction and Fanhuang Xiaozhi liquid for external use and inj ection,etc),which are developed by doctor Ding and are used to treat bleeding from hemorrhoids.The pathogenesis of bleeding form hemorrhoids are the oppres-sion from wind,heat(fire) and dryness to the large intestine,the obstruction of the collaterals,the blood overflowing the veins and are mostly excess syndrome.The treating methods are cooling the blood,clearing away the heat,treating both symptoms and root causes,using charcoal drug,treating the internal and external symptoms,combining diseases and syndromes to find the common causes.

Based on the relation between liver and kidney,this paper discussed Professor Zhou Zhongying's theory of kidney deficiency and liver hyperactivity and its bases of disease and the clinical manifestations.Cases were shown to prove that the new terminology regarding to the pathogenesis as kidney deficiency and liver hyperactivity summarized the clinical manifesta-tions of the relation about the diseases between liver and kidney and was of great significance to the clinical practices.

This paper analyzed the cases regarding to dysphagia and regurgitation and discussed the treating methods in Wang Xugao's Cases.Doctor Wang combined Zhang Zhongjing's method of resolving the phlegm to tranquilize the reverse and Ye Tianshi's method of nourishing Yin and the stomach and meanwhile took the treating of three energizers and the treating of the mind and body into consideration.Dysphagia,regurgitation and gastroesophageal reflux disease have lots in common. While the syndrome differentiation and treatment of dysphagia and regurgitation were reviewed,it's of great significance for the differentiation and treatment of gastroesphageal reflux disease.

OBJECTIVE To investigate the effect of Shuzheng granules on diabetic foot pain,ulcer healing and lower limb blood supply of the patients with diabetic foot after taking interventional treatment.METHODS Patients with diabetic foot who had taken interventional therapy successfully were randomly divided into Shuzheng granules treatment group(n=22)and basic treatment group(n=21).The two groups were given the same regular basic treatment while Shuzheng granules was add-ed to the first group.Then the results including pain symptoms integral,ulcer healing extent,ankle-brachial index(ABI),ar-terial flow velocity and the artery diameter before and after the treatment of the two groups were compared.RESULTS The improvement in pain symptoms integral depth of ulcer,ulcer area,ankle-brachial index,arterial blood flow velocity,arterial diameter and hemarheology were better in the treatment group(P<0.05).CONCLUSION ShuZheng granules combined with basic therapy has advantages in ulcer healing,pain relieving and lower limb blood flow increasing for patients with diabetic foot after intervention.

OBJECTIVE To study the clinical effect of Salpingocatheterism combined with Chinese medicine liquid irrigation under endoscope for chronic secretory otitis media(CSOM).METHODS From September 2012 to March 2014,80 patients with CSOM(120 ears) in the clinic were randomly divided into two groups.The experimental group:40 cases(61ears) were treated with Salpingocatheterism combined with Chinese medicine liquid irrigation and the liquid named Qingqiao tang(empirical recipe)was injected for 4 to 7days with 2ml each time.The control group:40 cases(59ears)were treated by myingotomy with grommet insertion.The ventilation tube was generally pulled out after 6 to 8 weeks or dropped out by itself .All patients were followed up for 6 months and the effects were to be evaluated.RESULTS In the experimental group,among 61ears,50 ears were cured,6 showed effectual results,2 were positive to the treatment and 3 showed ineffective results.The cure rate was 81. 97% and the total effective rate was 95.08% .In the control group,among 59 ears,38 ears were recovered,6 showed effectual results,5 were positive to the treatment,10 showed ineffective results.The cure rate was 64.61% and the total effective rate was 83.05% .The therapeutic effect of experimental group was better than that of the control group.The complication rate of the experimental group was 9.84%,while the control group was 28.81%.The complication rate of the experimental group was significantly lower than that of the control group.The recurrence rate of the experimental group was 6 .5 6% while the control group was 20.34%,the recurrence rate in the control group was significantly higher than that of the experimental group.The differences both had statistical significance(P<0.05).CONCLUSION The treatment of CSOM with salingocatheterism com-bined with Qingqiao tang irrigation under endoscope is effective and causes little inj ury.With a low recurring rate and less ad-verse reaction,this treating method is worth of being applied widely.

OBJECTIVE To observe the clinical effects of needling method of purging liver and tonifying lungs in treating people of Taiyin constitution with depression and explore its endocrine and immune mechanism.METHODS Ninety cases with depression were randomly divided into 3 groups (treatment group,control group and medicine group),with 30 cases in each group.The treatment group were treated by needling method of purging liver and nourishing lungs which originated from Ko-rean medicine,and control group were treated by acupuncture of traditional Chinese medicine around Baihui (GV 20) and Neiguan(PC 6);the medicine control group were given Proza.And the treatment last 8 weeks.Then Hamilton Depression Scale(HAMD),levels of CORT,ACTH,IL-6 and CRP in peripheral blood were compared in three groups both before and af-ter the treatment.RESULTS After treatment,level of HAMD decreased in three groups (P<0.01),with treatment group being the best(P<0.05~0.01);and levels of CORT and ACTH decreased dramatically in all groups (P<0.01),with the treatment group being the most obvious(P<0.05~0.01);levels of IL-6 and CRP in peripheral blood reduced in all groups(P<0.01),but there was no difference between them.CONCLUSION Compared to acupuncture of traditional Chinese medicine and Proza,needling method of purging liver and tonifying lungs can greatly improve depression and is effective in reducing lev-els of CORT,ACTH,IL-6 and CRP in peripheral blood of Tayin people with depression.

OBJECTIVE To explore the clinical effects of neuromuscular electrical stimulation combined with swallowing training for relieving dysphagia in patients with craniocerebral inj ury,providing reference basis for further study.METHODS 90 patients with craniocerebral injury suffered from dysphagia were selected and divided into A,B,C groups.Patients in group A received conventional treatment and rehabilitation exercise.Patients in group B were also given neuromuscular electrical stimulation and combined all the treatment in group A.Neuromuscular electrical stimulation and moxibustion therapy were added for patients in group C.The swallowing function,dysphagia degree and the quality of daily life were compared before and after the treatment.RESULTS The total effective rate in the three groups was 93.3%,73.3% and 53.3% respectively with statistically significant differences(P<0.05).The VFG scores after treatment were higher than those before treatment in all the groups,showing statistically significant differences(P<0.05).The WST scores after treatment were lower than those before treatment in the three groups with statistically significant differences(P<0.05).The VFG score of group C were high-er than that of group A and group B after treatment,which showed statistically significant differences(P<0.05).The WST score of group C were lower than that of group A and group B after treatment,indicating statistically significant differences(P<0.05).The SWAL-QOL scores after treatment were lower than those before treatment in all the groups with statistically significant differences(P<0.05).The SWAL-QOL score in group C were lower than that of both group A and B after treat-ment,which showed statistically significant differences (P<0.05).CONCLUSION Neuromuscular electrical stimulation combined with acupuncture and rehabilitation exercise can significantly improve patients'swallowing function and quality of life.

OBJECTIVE This paper is to discuss possible targets in the treatment of heart failure with reduced left ventricu-lar ejection fraction(HFREF) with QiangXinKang by observing the effect of QiangXinKang on the brain natriuretic peptide (BNP)and red blood cell volume distribution width(RDW)of patients with HFREF.METHODS 198 patients meeting the selecting criteria of HFREF were randomly divided into the experimental group with 102 cases and the control group with 96 cases.Both groups received routine treatments conforming to Guideline for the Diagnosis and Treatment for Heart Failure (2007 Edition) and the experimental group took QiangXinKang additionally.After 4-week treatment,changes of BNP,RDW level and LVEF were compared between the two groups before and after treatment.RESULTS As LVEF was improved after treatment,BNP concentration and RDW level of patients in both groups were significantly reduced,while those of the experi-mental group decreased more significantly,which showed a significant difference between the two groups (P<0.05).CON-CLUSION QiangXinKang may significantly reduce the BNP and RDW level and improve the heart function of patients with HFREF.

OBJECTIVE To investigate the clinical efficacy of Danlou tablet in Non-revascularization Patients with acute cor-onary syndrome(ACS)and phlegm and blood stasis syndrome type(PBSST).METHODS 70 ACS patients with PBSST for various reasons failed revascularization therapy were randomly assigned to the control group and the treatment group.The con-trol group was given a standardized western medicine treatment and the treatment group was given Danlou tablets (every time 1.5g,3 times a day)based on standardized western medicine treatment for a month.Angina episodes(intensity,frequency, duration),nitroglycerin use (consumption,angina relief time after taking nitroglycerin ) and the score of angina,traditional Chinese Medicine(TCM)clinical syndrome (including:chest pain or tightness and its frequency and duration,palpitations, shortness of breath,fatigue and total syndrome score),lipids including total cholesterol(TC),low-density lipoprotein choles-terol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglycerides(TG)and hypersensitive C-reactive protein(hs-CRP) were observed in the two groups of patients before and after treatment.The clinical efficacy of angina,the score of TCM clinical syndrome and blood biochemical changes were recorded and compared between the two groups.RESULT The total ef-fective rate of angina(85.29%)was significantly better than that of the control group(48.48%)(P<0.01).Compared with the same group before treatment,the frequency and duration of angina,the angina relief time after taking nitroglycerin,the a-mount of nitroglycerin,the score of angina and TCM clinical syndromes and the total score of syndrome,all these were signifi-cantly lower(P<0.01)in the two groups of patients after treatment.Compared with the control group,the frequency and du-ration of angina,the angina relief time after taking nitroglycerin,the amount of nitroglycerin,the total score of TCM clinical syndrome(P<0.05)and the score of angina(P<0.01)were significantly lower in the treatment group after treatment.The improvement of TCM clinical syndromes in the treatment group(the total efficiency of syndrome score was 79.41%)was sig-nificantly better than the control group (the total efficiency of syndrome score was 45.45%)(P<0.01).TC,LDL-C(P<0.01)and hs-CRP(P<0.05) levels after treatment were significantly lower than before.After treatment,hs-CRP in the treatment group was significantly lower compared with the control group(P<0.05).CONCLUSION Danlou tablet can pro-mote a significant improvement to angina and TCM clinical syndromes in Non-revascularization Patients with ACS and PBSST, inhibit the inflammation,and show plaque stabilizing effects.