1.Liquid Levodopa/Carbidopa: Old Solution, Forgotten Complication.
Nirosen VIJIARATNAM ; Shuli CHENG ; Kelly Lucinda BERTRAM ; David Richard WILLIAMS
Journal of Movement Disorders 2017;10(3):164-165
No abstract available.
Carbidopa
;
Levodopa
;
Memory Disorders
;
Chromatography, High Pressure Liquid
2.Presynaptic Dopaminergic Degeneration in a Patient with Beta-Propeller Protein-Associated Neurodegeneration Documented by Dopamine Transporter Positron Emission Tomography Images: A Case Report.
Min Ki KIM ; Nan Young KIM ; Sangkyoon HONG ; Hyeo Il MA ; Yun Joong KIM
Journal of Movement Disorders 2017;10(3):161-163
No abstract available.
Dopamine Plasma Membrane Transport Proteins*
;
Dopamine*
;
Electrons*
;
Humans
;
Positron-Emission Tomography*
3.Spinal Myoclonus Responding to Continuous Intrathecal Morphine Pump.
Jung Eun AHN ; Dallah YOO ; Ki Young JUNG ; Jong Min KIM ; Beomseok JEON ; Myung Chong LEE
Journal of Movement Disorders 2017;10(3):158-160
Spinal myoclonus is a sudden, brief, and involuntary movement of segmental or propriospinal muscle groups. Spinal myoclonus has occasionally been reported in patients undergoing opioid therapy, but the pathophysiology of opioid-induced myoclonus has not been elucidated yet. Here, we present two patients with spinal segmental myoclonus secondary to ischemic and radiation myelopathy. Conventional medications did not help treat persistent myoclonus in both legs. Continuous intrathecal morphine infusion was implanted for pain control in one patient, which relieved spinal myoclonus entirely. This experience led to the application of this method with a second patient, leading to the same gratifying result. Spinal myoclonus reemerged as soon as the morphine pumps were off, which confirmed the therapeutic role of opioids. In contrast to the opioid-induced myoclonus, these cases show a benefit of opioids on spinal myoclonus, which could be explained by synaptic reorganization after pathologic insults in the spinal cord.
Analgesics, Opioid
;
Dyskinesias
;
Humans
;
Leg
;
Methods
;
Morphine*
;
Myoclonus*
;
Spinal Cord
;
Spinal Cord Diseases
4.Holmes' Tremor with Shoulder Pain Treated by Deep Brain Stimulation of Unilateral Ventral Intermediate Thalamic Nucleus and Globus Pallidus Internus.
Sabri AYDIN ; Huseyin CANAZ ; Ezgi Tuna ERDOGAN ; Nazlı DURMAZ ; Barıs TOPCULAR
Journal of Movement Disorders 2017;10(2):92-95
A 21-year-old male was admitted with severe right arm and hand tremors after a thalamic hemorrhage caused by a traffic accident. He was also suffering from agonizing pain in his right shoulder that manifested after the tremor. Neurologic examination revealed a disabling, severe, and irregular kinetic and postural tremor in the right arm during target-directed movements. There was also an irregular ipsilateral rest tremor and dystonic movements in the distal part of the right arm. The amplitude was moderate at rest and extremely high during kinetic and intentional movements. The patient underwent left globus pallidum internus and ventral intermediate thalamic nucleus deep brain stimulation. The patient improved by more than 80% as rated by the Fahn-Tolosa-Marin Tremor Rating Scale and Visual Analog Scale six months after surgery.
Accidents, Traffic
;
Arm
;
Deep Brain Stimulation*
;
Felodipine
;
Globus Pallidus*
;
Hand
;
Hemorrhage
;
Humans
;
Male
;
Neurologic Examination
;
Shoulder Pain*
;
Shoulder*
;
Tremor*
;
Visual Analog Scale
;
Young Adult
5.Progressive Supranuclear Gaze Palsy with Predominant Cerebellar Ataxia: A Case Series with Videos.
Zheyu XU ; Tchoyoson C C LIM ; Wing Lok AU ; Louis C S TAN
Journal of Movement Disorders 2017;10(2):87-91
Progressive supranuclear palsy (PSP) with predominant cerebellar ataxia (PSP-C) is a rare phenotype of PSP. The clinical and radiological features of this disorder remain poorly characterized. Through a retrospective case series, we aim to characterize the clinical and radiological features of PSP-C. Four patients with PSP-C were identified: patients who presented with prominent cerebellar dysfunction that disappeared with the progression of the disease. Supranuclear gaze palsy occurred at a mean of 2.0 ± 2.3 years after the onset of ataxia. Mild cerebellar volume loss and midbrain atrophy were detected on brain imaging, which are supportive of a diagnosis of PSP. Videos are presented illustrating the co-existence of cerebellar signs and supranuclear gaze palsy and the disappearance of cerebellar signs with disease progression. Better recognition and the development of validated diagnostic criteria would aid in the antemortem recognition of this rare condition.
Ataxia
;
Atrophy
;
Cerebellar Ataxia*
;
Cerebellar Diseases
;
Diagnosis
;
Disease Progression
;
Humans
;
Mesencephalon
;
Neuroimaging
;
Paralysis*
;
Phenotype
;
Retrospective Studies
;
Supranuclear Palsy, Progressive
6.Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson's Disease: Therapeutic and Adverse Effects.
Ho Sung RYU ; Mi Sun KIM ; Sooyeoun YOU ; Mi Jung KIM ; Young Jin KIM ; Juyeon KIM ; Kiju KIM ; Sun Ju CHUNG
Journal of Movement Disorders 2017;10(2):80-86
OBJECTIVE: To compare the therapeutic and adverse effects of globus pallidus interna (GPi) and subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of advanced Parkinson's disease (PD). METHODS: We retrospectively analyzed the clinical data of patients with PD who underwent GPi (n = 14) or STN (n = 28) DBS surgery between April 2002 and May 2014. The subjects were matched for age at surgery and disease duration. The Unified Parkinson's Disease Rating Scale (UPDRS) scores and levodopa equivalent dose (LED) at baseline and 12 months after surgery were used to assess the therapeutic effects of DBS. Adverse effects were also compared between the two groups. RESULTS: At 12 months, the mean changes in the UPDRS total and part I–IV scores did not differ significantly between the two groups. However, the subscores for gait disturbance/postural instability and dyskinesia were significantly more improved after GPi DBS than those after STN DBS (p = 0.024 and 0.016, respectively). The LED was significantly more reduced in patients after STN DBS than that after GPi DBS (p = 0.004). Serious adverse effects did not differ between the two groups (p = 0.697). CONCLUSION: The patients with PD showed greater improvement in gait disturbance/postural instability and dyskinesia after GPi DBS compared with those after STN DBS, although the patients had a greater reduction in LED after STN DBS. These results may provide useful information for optimal target selection for DBS in PD.
Deep Brain Stimulation*
;
Dyskinesias
;
Gait
;
Globus Pallidus
;
Humans
;
Levodopa
;
Parkinson Disease*
;
Retrospective Studies
;
Subthalamic Nucleus
;
Therapeutic Uses
7.Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson's Disease.
Xiaoli SI ; Jiali PU ; Baorong ZHANG
Journal of Movement Disorders 2017;10(2):69-79
Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy.
alpha-Synuclein
;
Alzheimer Disease
;
Dopaminergic Neurons
;
Lewy Bodies
;
Neurodegenerative Diseases
;
Parkinson Disease*
8.Dropped Head Syndrome after Minor Trauma in a Patient with Levosulpiride-Aggravated Vascular Parkinsonism.
Soo Hyun CHO ; Dokyung LEE ; Tae Beom AHN
Journal of Movement Disorders 2016;9(2):126-128
No abstract available.
Head*
;
Humans
;
Parkinsonian Disorders*
9.Tremor in a Bassoonist: Tremor in Dystonia or Essential Tremor?.
Jung E PARK ; Vesper Fe Marie L RAMOS ; Mark HALLETT
Journal of Movement Disorders 2016;9(2):124-125
No abstract available.
Dystonia*
;
Essential Tremor*
;
Tremor*
10.Woodhouse-Sakati Syndrome: Report of the First Tunisian Family with the C2orf37 Gene Mutation.
Olfa HDIJI ; Emna TURKI ; Nouha BOUZIDI ; Imen BOUCHHIMA ; Mariem DAMAK ; Saeed BOHLEGA ; Chokri MHIRI
Journal of Movement Disorders 2016;9(2):120-123
Woodhouse-Sakati syndrome (WSS) is an infrequent autosomal recessive condition characterized by progressive extrapyramidal signs, mental retardation, hypogonadism, alopecia, and diabetes mellitus. This syndrome belongs to a heterogeneous group of inherited neurodegenerative disorders characterized iron accumulation in the brain, and it is caused by mutations of the C2orf37 gene. We report the first Tunisian family with two affected sisters presenting with a phenotype suggestive of WSS. We examined the index patient presenting with movement disorders and mental retardation and then searched for similar cases in her family, which identified a sister with similar signs. We performed a genetic study that confirmed the diagnosis and revealed a c.436delC mutation of the C2orf37 gene. Therefore, WSS is an important consideration in patients presenting with movement disorders and intellectual disability. A high consanguinity contributes to the clustering of such rare autosomal recessive syndromes.
Alopecia
;
Brain
;
Consanguinity
;
Diabetes Mellitus
;
Diagnosis
;
Dystonia
;
Humans
;
Hypogonadism
;
Intellectual Disability
;
Iron
;
Movement Disorders
;
Neurodegenerative Diseases
;
Phenotype
;
Siblings