1.A Case of Humoral Hypercalcemia of Malignancy Associated with Hepatoma: A Case in which both PTHrP and 1,25 (OH) 2D were elevated.
Seol Young YOON ; Chang Ryol LEE ; Jun Ho LEE ; So Jin CHOI ; Seung Pyo SON
Journal of Korean Society of Endocrinology 1999;14(1):197-202
Hypercalcemia is one of the most common paraneoplastic syndromes and believed to occur through two general mechanisms, one humoral and the other local. The former mechanism has been termed humoral hypercalcemia of malignancy (HHM) and has been associated with the secretion of various cytokines, including parathyroid hormone-related protein (PTHrP). PTHrP beats sttuctural and functional similarities to PTH and seems to play a key role in the pathogenesis of HHM. We experienced the case of HHM associated with hepatoma, a rare cause of HHM, in 48 year-old male. We found no evidence of bone metastasis. In this case, contrary to our general acknowledgment, serum 1,25 (OH)D concentration was elevated. We report this case with a brief review of related literatures.
Carcinoma, Hepatocellular*
;
Cytokines
;
Humans
;
Hypercalcemia*
;
Male
;
Middle Aged
;
Neoplasm Metastasis
;
Paraneoplastic Syndromes
;
Parathyroid Hormone-Related Protein*
2.A Case of Multiple Endocrine Neoplasia Neoplasia Type IIa Complicated by Acute Myocardial Infarction.
Eung Ho KARL ; Mi Duck LEE ; Young Uck KIM ; Young Goo SHIN ; Jung Han YOON ; Seong Joon KANG ; Choon Hee CHUNG
Journal of Korean Society of Endocrinology 1999;14(1):189-196
MEN IIa is the rare disorder consisted of thyroid medullary carcinoma, pheochromocytoma, and hyperparathyroidism. We experienced the case in which 42 year-old male patient with thyroid medullary carcinoma and pheochromocytoma complicated by acute myocardial infarction. During the process of conventional treatment of acute myocardial infarction, paroxysmal hypertension occurred for several times. We sought for the cause of paroxysmal hypertension, and found pheochromocytoma by the radiologic imaging study and the biochemical study and we found the 4X4 cm sized neck mass by palpation. After stabilizing his blood pressure by the use of phenoxybenzamine, we removed the pheochromocytoma in right adrenal gland and the medullary thyroid cancer, by right adrenalectomy and total thyroidectomy respectively. Thereafter, his subjective symptoms and objective signs were improved. We report the case with review of literatures.
Adrenal Glands
;
Adrenalectomy
;
Adult
;
Blood Pressure
;
Carcinoma, Medullary
;
Humans
;
Hyperparathyroidism
;
Hypertension
;
Male
;
Multiple Endocrine Neoplasia Type 2a
;
Multiple Endocrine Neoplasia*
;
Myocardial Infarction*
;
Neck
;
Palpation
;
Phenoxybenzamine
;
Pheochromocytoma
;
Thyroid Gland
;
Thyroid Neoplasms
;
Thyroidectomy
3.A Case of Ventricular Tachycardia Induced by Amitriptyline in a Patient with Painful Diabetic Neuropathy.
Hyun Jung BOK ; Young Ok KIM ; Hui Kyung JEON ; Mi Jung SHIN ; Eun Jung JUN ; Tae Seo SHON ; Sun Ae YOON ; Ki Ho SONG ; Hyun Shik SON ; Jang Seong CHAE
Journal of Korean Society of Endocrinology 1999;14(1):183-188
Diabetic neuropathy is one of the most common complications of diabetic mellitus and has myriad clinical presentations. Amitriptyline is an effective drug for painful diabetic neuropathy, but has a wide variety of cardiovascular effects. We report a case of amitriptyline-induced ventricular tachycardia in a patient with painful diabetic neuropathy. A 48-year-old man with no history of heart disease was treated with amitriptyline for the past 2 months. The dosage of this drug was gradually increased and the maximal dose was 170 mg per day. Prior to administration of this drug, his chest X-ray and electrocardiogram were normal. On admission he complained of chest discomfort and palpitation for 3 days, but his vital sign was stable. The electrocardiogram showed a wide QRS complex with a rate of 170 beats per minute. The ventricular tachycardia was successfully treated with electrical cardioversion.
Amitriptyline*
;
Diabetic Neuropathies*
;
Electric Countershock
;
Electrocardiography
;
Heart Diseases
;
Humans
;
Middle Aged
;
Tachycardia, Ventricular*
;
Thorax
;
Vital Signs
4.Unolateral Aldosterone-producing Adenoma with a Contralateral Black Adenoma.
Eun Young OH ; Myung Shik LEE ; Young Hee LIM ; Soo Jung KANG ; Jung Hak CHUN ; Byoung Joon KIM ; Jae Hoon CHUNG ; Yong Ki MIN ; Moon Kyu LEE ; Kwang Won KIM ; Jung Hyun YANG
Journal of Korean Society of Endocrinology 1999;14(1):177-182
Primary aldosteronism due to unilateral adenoma is a rare cause of surgically curable hypertension. Bilateral adrenal mass has occasionally been reported in this syndrome, and bilateral aldosterone-producing adenoma (APA), or bilateral adrenal nodular hyperplasia have been demonstrated in some cases. However, another possibility is the coexistence of a unilateral APA with a contralateral benign or metastatic nonfunctioning mass, because adrenal tumors are frequently found at autopsy or incidentally detected during abdominal morphological evaluation in patients without adrenal dysfunction. A 39 year-old woman presented with hyperaldosteronism, suppressed renin levels, and bilateral adrenal mass on adrenal CT scanning. Selective adrenal venous sampling was unsuccessful in demonstrating concentration gradient of aldosterone. Postoperative measurement of hormone content in the tumor extract revealed unilateral aldosteron-producing adenoma with contralateral nonfunctioning black adenoma, Determination of hormone content in the tumor extract could be useful for the discrimination of functioning and nonfunctioning endocrine tumors, particularly in case of multiple tumors.
Adenoma*
;
Adult
;
Aldosterone
;
Autopsy
;
Discrimination (Psychology)
;
Female
;
Humans
;
Hyperaldosteronism
;
Hyperplasia
;
Hypertension
;
Renin
;
Tomography, X-Ray Computed
5.A Case of Parathyroid Carcinoma Invading Thyroid Gland as Solitary Nodular Form.
Young Keun CHOI ; Jae Seung LEE ; Hyung Wook KIM ; Young Min KIM ; Seok Man SON ; In Joo KIM ; Yong Ki KIM ; Hyo Jung CHAE
Journal of Korean Society of Endocrinology 1999;14(1):171-176
Parathyroid carcinoma is a rare cause of primary hyperparathyroidism and commonly metastasize to lymph node, lung, liver, and bone. In Korea, there has been no report of distant metastasis in parathyroid carcinoma except for one case of pulmonary metastasis. A 58-year-old man presenting with weakness, nausea, and a palpable thyroid nodule visited our hospital. Elevated serum calcium and parathyroid hormone (PTH) concentration allowed the diagnosis of hyperparathyroidism. Two discrete masses were identified by neck ultrasound scan, computed tomography (CI') and Tc-Sestamibi scan in the left lobe of thyroid gland and ipsilateral parathyroid gland. So multiple endocrine neoplasia (MEN) type 2A" was suspected initially, but postoperative histological diagnosis was left parathyroid carcinoma with solitary nodular lesion invading left thyroid gland. He was successfully treated with left parathyroidectomy and left thyroid lobectomy.
Calcium
;
Diagnosis
;
Humans
;
Hyperparathyroidism
;
Hyperparathyroidism, Primary
;
Korea
;
Liver
;
Lung
;
Lymph Nodes
;
Middle Aged
;
Multiple Endocrine Neoplasia
;
Multiple Endocrine Neoplasia Type 2a
;
Nausea
;
Neck
;
Neoplasm Metastasis
;
Parathyroid Glands
;
Parathyroid Hormone
;
Parathyroid Neoplasms*
;
Parathyroidectomy
;
Thyroid Gland*
;
Thyroid Nodule
;
Ultrasonography
6.Relationship between the Expression of Growth Hormone-Releasing Hormone Receptor Gene and Endocrinologic Profiles in GH-Secreting Pituitary Adenomas.
Sung Woon KIM ; Jin Woo KIM ; Young Seol KIM ; Young Kil CHOI ; Seung Joon PARK ; In Myoung YANG ; Jung Taek WOO ; Mi Sook RYU ; Chul Young PARK ; Sun Woo KIM
Journal of Korean Society of Endocrinology 1999;14(2):241-254
BACKGROUND: Growth hormone-releasing hormone (GHRH) plays a key role in the regulation of the proliferation and differentiation of somatomammotroph cells as well as secretion of GH. The actions of GHRH are mediated through the GHRH receptor (GHRH-R) that is a G protein coupled receptor with seven transmembrane domains. It has been demonstrated that alternative splicing occurs in the third cytoplasmic domain of rat and human GHRH-R mRNA, However, the clinical significance of the altemative splicing remains to be unsolved. To find an insight into the clinical significance, we investigate the correlation between the GHRH-R gene expression and a variety of clinical clinical and endocrinological findings in 11 acromegalic patients. METHODS: Eleven acromegalic patients (3 males and 8 females, mean age 43.5 years) were included in this study. Six endocrine tests were carried out to evaluate the GH seeretory function of tumors. Invasiveness of tumors were evaluated by preoperative MRI findings on the basis of Hardys classification. Sequence the gsp oncogene and estimate the GHRH-R gene expression by RT-PCR and in vitro transcription. RESULTS: Three different sized cDNA fragments, 250 bp, 700 bp and 810 bp, were found after RT-PCR. The amount of 250 bp fragment was higher than those of the other two fragments. The clinical findings (age, size, GH level, frequency of paradoxical response to TRH or GnRH, octreotide response, hypothalamic somatostatinergic activity) of the group with high expression of the 250 bp fragment did not significantly differ from those of the group with low expression. The GHRH-R gene expression of tumors with gsp oncogene did not significantly differ from that of tumors without gsp oncogene. CONCLUSION: These results suggest that the expression of GHRH-R gene may not be an important determinant for tumor growth, and the lower GH response to GHRH of tumors with gsp oncogene may not be attributed to the lower expression of GHRH-R gene. The expression of GHRH-R is likely to be regulated by a certain property of tumors for GH secretion and growth.
Acromegaly
;
Alternative Splicing
;
Animals
;
Classification
;
Cytoplasm
;
DNA, Complementary
;
Female
;
Gene Expression
;
Gonadotropin-Releasing Hormone
;
Growth Hormone-Releasing Hormone*
;
Growth Hormone-Secreting Pituitary Adenoma*
;
GTP-Binding Proteins
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Octreotide
;
Oncogenes
;
Rats
;
RNA, Messenger
7.A case of lingual thyroid with euthyroidism.
Sin Hyung LEE ; Yong Hyun KIM ; Eun Jong LEE ; Sang Jin KIM ; Jae Myung YU ; Sei Hyun BAIK ; Dong Seop CHOI
Journal of Korean Society of Endocrinology 1992;7(3):300-304
No abstract available.
Lingual Thyroid*
8.Two cases of hypothyroidism presenting with dyspnea.
Shin Ho BANG ; Kyoung Sook WON ; Young Suk OH ; Won PARK ; Hong Soon LEE
Journal of Korean Society of Endocrinology 1992;7(3):295-299
No abstract available.
Dyspnea*
;
Hypothyroidism*
9.A case of primary thyroid lymphoma presenting with obstructive manifestations.
You Hern AHN ; Kwoung Won KAHNG ; Jeong Ho KIM ; In Soon KIM ; Woong Hwan CHOI ; Taek Wha KIM ; Mok Hyun KIM ; Young Yeh KO
Journal of Korean Society of Endocrinology 1992;7(3):288-294
No abstract available.
Lymphoma*
;
Thyroid Gland*
10.A screening method for neuroblastoma and organic acidemias by gas chromatography-mass spectrometry.
Hyun Gyung JANG ; Soo Kyung PARK ; Bong Chul CHUN ; Jongsei PARK
Journal of Korean Society of Endocrinology 1992;7(3):280-287
No abstract available.
Gas Chromatography-Mass Spectrometry*
;
Mass Screening*
;
Neuroblastoma*