This case was diagnosed as multiple cementoosseous dysplasia on the basis of clinical & radiological features but was diagnosed as ossifying fibroma on the basis of histopathological feature. The histopathologic features of the multiple cementoosseous dysplasia and cementoossifying fibroma have common features of cementum, fibrous network and bone. Multiple cementoosseous dysplasia is reactive lesion and shows restricted lesion size, occurred on anterior and posterior tooth of the mandible and needs no treatment except periodic follow up. But Cementoossifying fibroma is the true neoplasm and grows continuously and needs surgical removal. The final diagnosis of the multiple cementoosseous dysplasia requires good correlation of the clinical histopathological, and radiological features.
Dental Cementum ; Diagnosis ; Fibroma ; Fibroma, Ossifying ; Follow-Up Studies ; Mandible ; Tooth

This report details a case of 8-year-old girl showing failure of odontogenesis after chemo-radiation therapy for rhabdomysarcoma at the age of 4. The observed results were as follows ; 1. Past history revealed that she had received for a total radiation dose od 4430cGy, 29 fractions in 6 weeks and chemotherapy with vincristine, actinomycin D and cytoxan, followed as maintenance phase for 2 years. 2. The patient was symptom-free and appointed for the treatment of multiple dental caries. 3. Oral examination showed hypoplastic enamel on whole erupted permanent teeth and showed retarded eruption. 4. Conventional radiograms showed failure of root development including abrupt cessation of root formation and root agenesis, and microdobtia, missing teeth, irregular enamel, dislocation of the impacted teeth. Additional finding showed good healing bone pattern on the left mandibular ramus and angle area. 5. Cehalometric analysis revealed failure of bite raising due to incomplete eruption of all the first molars and made it possible to suspect entrapped mandibular growth and then Class II tendency growth. 6. There was correlation between the time of chemo-radiation therapy and the damage of the teeth.
Child ; Cyclophosphamide ; Dactinomycin ; Dental Caries ; Dental Enamel ; Dental Enamel Hypoplasia ; Diagnosis, Oral ; Dislocations ; Drug Therapy ; Female ; Humans ; Molar ; Odontogenesis* ; Rhabdomyosarcoma* ; Tooth ; Tooth, Impacted ; Vincristine

The purpose of this study was to aid in the prediction of tumor cell tolerance to radiotherapy and/or chemotherapy. For this study, cell surviving curves were obtained for human squamous cell carcinoma KB cell line after radiation exposure and/or administration of antitumor drugs. 2, 4, 6, 8 10Gy were irradiated at a dose rate of 210Gy/min using 60Co Irradiator ALDORADO 8. After irradiation, KB cell lines(3*104cells/ml) were exposed to 2 /ml of bleomycin ir cisplatin for 1 hour. The viable cells were determined by MTT assay for each radiation dose and/or each drug at the 4th day. And they were compared to control values. The obtained results were as follows ; 1. The slope of the surviving curve after irradiation of 2, 4, 6, 8, 10Gy on KB cell line was relatively steep. 2. There was no significant difference between ths cytotoxicity of bleomycin compared to control group. But, there was significant difference between the cytotoxicity of cisplatin compared to control group. And the cytotoxicity of cisplatin was greater than that of bleomycin on KB cell line. 3. There were dignificant differences of surviving fractions after irradiation of 2Gy and 10Gy with 2 /ml of bleomycin compared with the groups of irradiation only on KB cell line. 4. There were significant differences of surviving fractions after irradiation of 2, 4, 6, 8, 10Gy with 2 /ml of cisplantin compared with the groups of irradiation only on KB cell line. 5, There was significant difference of surviving fraction between groups after irradiation of 10Gy with 2 /ml of bleomycin and cisplatin.
Antineoplastic Agents ; Bleomycin ; Carcinoma, Squamous Cell ; Cisplatin ; Drug Therapy ; Humans ; KB Cells* ; Radiation Tolerance* ; Radiotherapy

With the CT findings as gold standard, the sensitivity, the specificity, and the diagnostic accuracy of WatersO radiography and WatersO radiography with panoramic radiography were compared in the diognosis of antral mucosal thickening of 16 patients. Three oral radiologists and three non-oral radiologists interpreted the WatersO radiographs and after 4 weeks, interpreted the WatersO radiographs and panoramic radiographs simutaneously. The interpretation was the existence or the non-existence of the mucosal thickening on the medial, the posterolateral, the floor, and the roof of maxillary sinus. The obtained results were as followed ; 1. In oral radiologist group, the sensitivity, specificity and diagnostic accuracy of WatersO film were 0.7250, 0.8489 and 0.7578 respectively. 2. The sensitivity and the diagnostic accuracy in oral radiologist group were higher than those of non-oral radiologist group (P<0.05), but there was no significant difference between two groups in the specificity>0.05). 3. There was no significant difference of the diagnostic abilities except the specificity in oral radiologist group between WatersO radiography and WatersO radiography with panoramic radiography (p>0.05). 4. The sensitivity and the diagnostic accuracy were the highest in the case of medial wall interpretation, the specificity was the highest in the posterioateral wall. 5. In the posterolateral wall and the floor, the sensiticity and the diagnostic accuracy of oral radiologist group were higher than those of non-oral radiologist group (P<0.05).
Diagnosis* ; Humans ; Maxillary Sinus ; Radiography* ; Radiography, Panoramic* ; Sensitivity and Specificity

Cellular transforming genes have been identified in a number of different tumor cell lines and tumor types. A significant number of these oncogenes belong to the ras gene family. The ras gene family consists of three closely related genes:H-ras, K-ras and N-ras which code for a related 21 kDa protein. Mutations in codon 12, 13 and 61 of one of the three ras genes convert these genes into acute oncogenes. The presence of H-ras gene mutaions has important prognostic implication in various tumors. Each genomic DNA was isolated from tumors induced by implantation with DMBA, or by treatment with DMBA-implantation/irradiation. When genome DNA was transfected into NIH 3T3 cells and investigated by two-step PCR-RFLP, the following results were concluded : 1. Transformation foci developed in two groups when the genome DNA of two experimental groups were transfected into NIH 3T3 cells. 2. Transformation efficiency was 0.01-0.02 foci/ DNA in the experimental group with the DMBA-implantation, 0.01-0.03 foci/ DNA in the experimental group with the DMBA-implantation/irradiation according to results of trasfection assay. 3. When the point mutation of H-ras gene was investigated by a two-step PCR-RFLP, there was 13.9%(5/36) in the experimental group with the DMBA implantation, 15.4%(6/39) in the experimental group with the DMBA-implantation/irradiation. 4. The point mutation in codon 12 and 61 of H-ras was 5.6%(2/36) and 8.3%(3/36) in the experimental group with the DMBA implantation. 5. The point mutation in codon 12 and 61 of H-ras gene was 7.7%(3/39) in the experimental group with the DMBA-implantation/irradiation.
9,10-Dimethyl-1,2-benzanthracene* ; Animals ; Cell Line, Tumor ; Codon ; DNA ; Genes, ras* ; Genome ; Humans ; NIH 3T3 Cells ; Oncogenes ; Point Mutation ; Rats* ; Salivary Glands*

Cementifying fibroma is an odontogenic tumor of periodontal ligament origin, consistingof a proliferation of fibrous tissue that forms cementum. Cemento-ossifying fibroma, cemenrifying fibroma and ossifying firoma are difficult to distinguish on clinical and radiographic examination, and on histoapathology. However, when the calcified products is represented by ovoid or curvilinear deposites, the lesion is often referred to as cementifying fibroma. Cementifying fibroma of the jaws are well-circumscribed, generally slow-growing lesions. Although most lesions appear to be limited to the tooth-bearing areas, a few have extended into the angle-ramus area or encroached on the maxillary sinus. Radiographically, the cementifying fibroma could present as a radiolucent, radiopaque or mixed density lesion, depending on the degree of maturity. We have oberved two cases f cementifyingfibroma occurred in the left maxillary premolar-molar area of 38-year-old woman and 35-year old man. We obtained that two cases were shown the followed results ; 1. Clinically, main clinical sympton was facial swelling and pain at palpation. 2. Radiographically, well-circumscribed radiolucent lesion and radiolucent lesion with radiopaque foci were seen on the left maxillary premolar-molar areas. Loss of lamina dura and root resorption or divergency were also seen. 3. Histopathologically, many cementum-like calcifications were observed in the hypercellular connective tissue.
Adult ; Connective Tissue ; Dental Cementum ; Female ; Fibroma* ; Humans ; Jaw ; Maxillary Sinus ; Odontogenic Tumors ; Palpation ; Periodontal Ligament ; Root Resorption

We used five adult dog mandibles embedded in resin block and six different cross-sectional planes for each mandible were choosen. According to the angle of mandibular occlusal plane to vertical plane(mandibular angle) and gantry angle of CT machine, we classfied 4 experimental groups and 1 control group. The control group images were taken at the mandivylar angle 0 degrees (group 1) ;30 degrees and 0 degrees (group 2);15 degrees and 15 degrees (group 3);30 degrees and 30 degrees(group 4), respectively. Using the reformatted cross-sectional images, the distance from the mandibular canal to the alveolar crest and the distance from the mandibular canal to the buccal cortex and to the lingual cortex was measured and compared. The obtained results were as follows ; 1. The distance from the mandibular canal to the alveolar crest of group 1 and 2 was larger than control group, but the distance of group 3 and 4 was smaller. The distance from the mandibular canal to the buccal cortex and to the lingual cortex of all experimental groups was smaller than control group. 2. The distance from the mandibular canal to the alveolar crest showed the largest difference from control group in all experimental groups, especially in group 2 and 4(P<0.05). 3. In the distance from the mandibular canal to the alveolar crest, the number of deviation value under 1mm was 20 in group 3 and was 11 in group 2 and 4, respectively. 4. The deviation value of the distance from the mandibular canal to the buccal cortex and to the lingual cortex was under 1mm in most cases.
Adult ; Animals ; Dental Occlusion ; Dogs ; Humans ; Mandible*

The purpose of this study was to evaluate the Waters' views, panoramic and periapical radiograms as well as clinic al symptoms in the diagnosis of maxillary sinusitis. The author analyzed the types of mucosal thickenings, the types of bony wall changes, the pathologic changes of antra l floors and total amount of agreement on radiograms in 495 patients with 505 maxillary sinuses which demonstrated radio graphic changes. The results were obtained as follows : 1. 125 cases (24.8%) showed the mucosal thickening of antral floor and lateral wall(Type II), 106 cases (20.9%) showed the mucosal thickening around the whole antral wall(Type IV) and 75 cases (14.8%) showed increased radiopacity of whole antrum. 2. Among 505 cases of mucosal thickening, 319 cases(63.2%) showed the bony wall changes: 114 cases (35.9%) showed the thining of lateral walls, 105 cases(32.8%) showed the thickening of lateral walls and 47 cases(14.7%) showed indistinct antral walls. 3. Among 6 types of mucosal thickenings, the incidence of bony wall changes was high in type VI(73.3%) and in type IV(7 1.6%). 4. 139 cases(25.1%) showed no pathologic change of antral floor, 127 cases(22.9%) showed the indistinct antral floor an d 022 cases (22.1%) showed the halo appearance of antral floor on panoramic and periapical radiograms. 5. 449 cases(88.9%) showed apparent increased radiopacity and 47 cases(9.3%) showed suspicious increased radiopacity on Waters' views. 280 cases(71.6%) showed apparent increased radiopacity and 88 cased (22.5%) showed suspicious increased radiopacity on panoramic radiograms. And 141 cases(31.6%) showed apparent increased radiopacity and 133 cases(33.4%) showed suspicious increased radiopacity on periapical radiograms.
Diagnosis ; Humans ; Incidence ; Maxillary Sinus* ; Maxillary Sinusitis*

Patient with compalints of swelling, pain in the maxillary region and discomfort visited Seoul National University Dental Hospital in August last year. Clinical examination and diagnostic imagings implied he was suffered from fungal h yphal infection but no causative fungus was found by the histopathologic and microbiologic investigation. Therefore he w as diagnosed with nonspecific inflammation. But as yet, we do think this case is very similar to some kinds of mucomycos is. So we presented this case for more thorough discussion. Following are founded in the examination. 1. Patient had sufferd from Diabetes mellitus and complained of stuffness, headache, swelling in buccal cheeks and pare sthesia. And we found more maxillary bony destruction and ulcer with elevated margin in the palate by clinical examinati on. 2. In the first visit, Plain films revealed general bony destruction of the maxilla, radiopaqueness in the sinonasal ca vities. CT and MRI showed soft tissue mass filled in the paranasal sinus except frontal sinus and bony destruction in in volved bones. 3. No causative bacteria and fungus was found in the biopsy and microbiologic cultures. 4. Caldwell-Luc operation and curettage were carried and antibiotics were taken for 4 months. But now he was worse than in the past. 5. In the second visit, involvement of orbit, parapharyngeal sinus, clivus, cavernous sinus and middle cranial fossa we re seen clearly in the CT and MRI.
Anti-Bacterial Agents ; Bacteria ; Biopsy ; Cavernous Sinus ; Cheek ; Cranial Fossa, Middle ; Cranial Fossa, Posterior ; Curettage ; Diabetes Mellitus ; Frontal Sinus ; Fungi ; Headache ; Humans ; Inflammation* ; Magnetic Resonance Imaging ; Maxilla ; Orbit ; Palate ; Seoul ; Ulcer

The authors diagnosed a 54-year-old male as central mucoepidermoid carcinoma after undegoing clinical, radiologica l and histopathological examinations. The charateristics were as followed : 1. Clinically, the patient complained of the painless unilateral swelling of the left mandibular molar region and had a pus discharge through the fistula. Painful nodule was palpated on the scalp of the left frontal area and it was regarde d as a metastatic lesion. 2. Plain radiographs showed the ill-defined permeative radiolucent lesion. The osteolytic lesions were also detected in the cranial bone, number 9 and 11 ribs, scapula, and vertebral bodies. 3. The mandibular CT and PNS MRI showed the swelling of the left mandible and the enlargement of the several lymph node s of 1.5 cm in size. 4. Histopathologically, many solid epidermoid type cells were mixed with mucus-secreting cells and they were arranged i n duct-like structure. Most of them were epidermoid type, which indicates a high grade tumor. Mucins could be found in mucicarmine staining.
Carcinoma, Mucoepidermoid* ; Fistula ; Humans ; Lymph Nodes ; Magnetic Resonance Imaging ; Male ; Mandible* ; Middle Aged ; Molar ; Mucins ; Neoplasm Metastasis* ; Ribs ; Scalp ; Scapula ; Suppuration