Objective To make clear of the mechanism of metastasis and recurrence of primary liver cancer, and to make sure of the preventive value of transeatheter arterial immun- ehemoembolization (ICE) in treatment of liver cancer. Methods The study is a double-blinded, controlled, prospective, randomized trial. 146 patients were randomly divided into 3 groups. Group A: regular surgery of primary liver cancer;group B: TACE 1month after surgery, treatment proposal was: ADM + DDP + 5-Fu + LP; group C:transeatheter arterial immun-chemoembolization 1 month after surgery, treatment proposal : ADM + DDP +5-Fu+LP+Octreotide+IFN. Results CD3+, CD4+, CD4+/CD8+ increased 1 month after surgery in group A; In group B: CD3+, CD4+, CD4+/CD8+ decreased but CD8+ increased 1 week after TACE; CD3+, CD4+, CD4+ /CD8+ increased but CD8+ decreased 4 weeks after TACE(P<0.05); In group C: CD3+ , CD4+, CD4+/CD8+ increased slightly 1 week after TACE, but increased significantly 4 weeks later(P<0.05). In group A, the level of VEGF was high before surgery but decreased 1 month after surgery; In group B, the level of VEGF decreased 1 week after TACE, decreased more significantly 4 weeks after TACE than that in group B(P <0.05). 1 year survival rate, 2 year survival rate and 3 year survival rate in group C ware higher than those in group A; 1 year survival rate was higher in group B than that in group A, however, 2 year survival had and 3 year survival rate had no differ-ences between group B and group A. Conclusion Transcatheter arterial ICE can prevent metastasis and recurrence after surgery of primary liver cancer increase the 1,2,3 year survival rate. It not only has the role of TACE,but can increase the immunefunction,and inhibit tumor angiogenesis, then increase the therapeutic effect.

Objective To investigate the reversal effect of the monomer of traditional Chinese medicine on muhidrug resistance(MDR) and its possible mechanism in K562/ADM cell line in vitro. Methods With different concentrations of baicalin, geniposide administered to K562/ADM cells, the proliferation of K562/ ADM cells was detected by the MTY assay. Expression of mdr-1 mRNA, Topo Ⅱ mRNA was measured by semi-quantitive RT-PCR. Results Thatbaicalin and geniposide could increase the sensitivity of K562/ADM cells to adriamycin, multiples of reversion were 1.95 times and 1.46 times. The proliferation of K562/ADM cells was in-hibited obviously by baicalin and geniposide, the level of mdr-1 mRNA expression was down-regulated and the Topo Ⅱ mRNA was up-regulated(P<0.01 ). Conclusion Baicalin and geniposide may reverse the multi-drag-resistance of K562/ADM cells, which was related to the down-regulation of mdr-1 expression and up-reg-ulation of Topo Ⅱ beta expression.

Apigenin is a plant flavonoid which has various biological activities and pharmacological effects including anti-tumor, antioxidant, anti-inflammatory, sedative and so on, particularly in the anti-tumor areas. It can inhibit proliferation, invasion, metastasis and angiogenesis of tumor cells. In addition, it can also induce apoptosis and enhance chemotherapy sensitivity.

Platelets can interact with circulating tumor cells to form platelet-tumor cell thrombus, which can facilitate the immune evasion of tumor cells. Activated platelets can also release a variety of bioactive factors, promoting tumor growth, invasion and angiogenesis. Research exploring the relationship between platelet and tumor metastasis can help elucidate the mechanisms of tumor metastasis and find new therapies for treatment of tumor metastasis.

The incident of colorectal cancer are closely related to factors such as genetics, life styles, dietary patterns, external environment, enteral environment, and exercise. Epidemiological studies of geographic regions with different eating habits have shown that the incidence of CRC varies as diets change. Further studies are needed to investigate the underlying mechanisms

NK/T-cell lymphoma(NTCL)can be classified into upper aerodigestive tract(UAT)NTCL and non-UAT NTCL. The Ann Arbor staging system is unsatisfactory for this lymphoma. A new staging system for NTCL is proposed:limited disease(stage Ⅰ/Ⅱ UAT-NTCL without local invasion)and extensive disease(stage Ⅰ/Ⅱ with local invasion or stage Ⅲ/Ⅳ disease of UAT NTCL, non-UAT NTCL). There is an ongoing debate regarding the use of the Ann Arbor staging and the International Prognostic Index for prognostic purposes in NK/T-cell lymphoma. Other factors, including tumor's local infiltration, Epstein-Barr virus, tumor biology and microenvironment, have also been found to affect the prognosis.

Autophagy is a catabolic process involving the degradation of a cell's own proteins and organelles and the subsequent recycle of cellular products. Despite the fact that autophagy helps maintain survival, excessive autophagy can lead to autophagic cell death. Recent researches showed that autophagy played an important role in the development, progression and treatment of colorectal cancer;however, the exact mechanisms of autophagy and its effect on chemotherapy and radiotherapy are still under debate.

Strontium-89(89Sr)therapy has been recognized as an effective method for treating bone metastases. It functions as a calcium analog that binds with collagen matrix produced by the MC3T3-E1 cells during collagen mineralization. 89Sr emits pure β rays which palliate bone pains and reduce the number of new metastasis sites. Response to 89Sr is affected by factors such as the location, size and histological type of lung cancer, the type of metastasis and the duration of treatment, and can be predicted by relief of bone pain, elimination of metastasis, CD4 +/CD8 +, ALP, and others. 89Sr therapy is safe and effective. Repeat administration or combined used with other treatments can improve the therapeutic effect of 89Sr.

For breast cancer among youth, overtreatment should be avoided to reduce toxic effects on reproductive function while maintaining acceptable therapeutic effect on cancer. Research has indicated that breast cancer can have a relatively small treatment-related threat to fertility among youth patients if the timing of pregnancy after breast cancer is optimized. Pregnancy and childbirth have not been associated with recurrence and survival among early stage breast cancer.

Metastasis is the main cause of the high mortality of lung cancer. Research is currently underway to understand metastasis at molecular level. Many molecular markers have been shown to participate in metastasis, including thymidylate synthase, angiogenesis lymphangiogenesis-related factors, cell adhesion molecules, extracellular matrix metalloproteinases, cytokines, and metastasis-associated genes. Elucidating the molecular mechanism of metastasis will help improve the early diagnosis and treatment of lung cancer.