Objective:To assess the efficacy and safety of Zyrtec drops which is a patent product of UCBpharma in treatment of allergy rhinitis in children. Method :A total of 47 children of both sexes aged between 2 to6 years with allergy rhinitis (AR) were included in this study,who were randomly selected to be treated withZyrtec (Cetirizine 2 HCL) drops 5 mg daily for 3 weeks. Investigators made a global evaluation with symptomscores before treatment and once a week for 3 weeks after treatment. Result:An improvement was shown in eachweek after treatment with statistical significance (P＜0.01). Zyrtec drops provided an excellent improvement atthe end of the study. Tolerance was good. Conclusion :For acting fast ,potent ,good tolerance and convenience inuse,Zyrtec drops is a better treatment in AR in kids.

Objective:To observe the cross-links between stereocilia on guinea pig utricle hair cells. Method:Twenty-four utricles from pigmented guinea pigs were examined using high resolution scanning (SEM)andtransmission electron microscopy(TEM). Result:an extensive network of cross-links occurs between stereociliaof utricle hair cells. These links fall into three categories. Upward-pointing links:from the tips of shorterstereocilia to the side of the adjacent taller stereocilia;Side-to-side links:between stereocilia of the same row;Row-to-row links :between adjacent rows. Conclusion :The existence of the stereociliary cross-links binds the hairbundles together and may be associated with the transduction process.

Objective: To discuss how to improve the level of diagnosis and treatment about the firstbranchial fistula. Method:16 cases with the first branchial fistula were analyzed retrospectively. Result :Of all thepatients underwent surgery, 14 cases were free from disease postoperatively within 0.5 years follow-up, 2patients underwent re-operation because of recurrence. Conclusion:Knowing about the disease fully, selectingproper surgical incision and possessing skilled surgical technique is important to improve the level of diagnosisand treatment about the first branchial fistula.

Objective:To further understand the advantage of radiofrequency treatment of hemangioma ofnasal cavity under nasal endoscopy. Method:Fifteen cases with hemangioma of nasal cavity were treated withradiofrequency under nasal endoscopy. Result:The hemangioma of fifteen cases could be removed completely. Thecomplication was absent. None of them recured in six months to four years following up. Conclusion:This methodhas many advantages such as clear operation visual field,less hemorrhage and postoperative pain,no facial scar.The radiofrequency under endoscopy is valuable in treatment for hemangioma of nasal cavity.

Objective:For the diagnosis of occult nasophargngeal carcinoma. Method:Epstein-Barr virus in 58 fine needle aspirations from cervical metastatic lymphnodes were detected with polymerase chain reaction. Result: The positive reaction was found in 28/35 metastatic carcinoma samples from middle or upside neck. Negative reaction was found in 3 lymphomas,4 metastatic carcinomas in clavicular superior lymphnodes and 15/ 16 inflammatory diseases of cervical lymphnodes. The sensibility of this method for the diagnosis of nasopharyngeal carcinoma was 89.3%. The specificity was 86.7%. Conclusion: The detection of Epstain-Barr virus in metastatic carcinoma from cervical lymphnodes had some clinical values for the diagnosis of occult nasopharyngeal carcinoma.

Objective:To understand the nasopharyngeal submucous carcinoma with the first show of cervicallymph node swell. Method:To collect the clinical data of 4 patients with such disease. Result:The 4 cases ofnasopharyngeal submucous carcinoma were not diagnosed until 3～6 months after cervical lymphnode metastasis.All patients received radiotherapy,three died within 1 year and another survived. Conclusion: If some patientshave cervical lymph node swell,pay attention to the meastasis of nasopharyngeal submucous carcinoma firstly.Even the examinations such as cytologic test,VCA-IgA,CT,MRI were negative,or even tuberculomas had beendiagnosed,nasopharyngeal submucous carcinoma still can not be excluded.

Objective:To assess the potential or limitation of MRI for demontrating the pathological cervicallymphnodes. Method :A prospective diagnostic study on cervical lymphnode metastasis from laryngeal carcinomawas performed for 19 cases undergone neck dissection (5 cases undergone bilateral neck dissection, 24 specimensof neck dissection were collected in total). With pathological findings as the criterion, sensitivity and specificityand accuracy were calculated for palpation and MRI examination of all patients. Result:MRI had obviously highersensitivity specificity and accuracy than palpation. Besides the changes in size and shape of the metastaticlymphnodes, the intensity of MRI inside the metastic lymphnodes was showed as mixed hypo-isointensity inT1WI and hyper intensity in T2WI. Conclusion:MRI examination was accurate in detecting cervical lymphnodemetastasis and could image occult lymphnodes which are inaccessible on palpation. Thus, MRI will probably playan important role in the evaluation of malignant lymphnode metastasis.

Objective: To study the correlation between the expression of CD44s, CD44v6 and theclinicopathological characters of laryngeal squamous cell carcinoma (LSCC) so as to analyze the role of them inoccurrence and progression of LSCC. Method:Expression of CD44 and CD44v6 in 46 cases of LSCC and 20 casesof adjacent normal tissues was inspected with immunohistochemical SP method. Result:The expression of CD44sincreased significantly in lymphnode metastasis group (94.4％) and stage Ⅲ～Ⅳ group (96.2％),but decreasedin non-lymphnode metastasis group (67.9％) and stage Ⅰ～Ⅱ group (55.0％). The expression of CD44v6 waslower (21.7％),which wasn′t associated with any clinicopathological characters. Conclusion:The role of CD44and CD44v6 in carcinoma maybe dependent on the species,type of carcinoma, and the expression of CD44s maybe a biologic marker to evaluate metastasis of LSCC.

Objective:To study the application and clinical significance of autotransfusion hemodilution inlaryngectomy. Method:Autotransfusion hemodilution was adopted in 30 patients with Ⅲ or Ⅳ stage laryngealcarcinoma during operation as the experimental group, and the blood transfusion only was adopted in the patientswith excessively blood loss. The other 30 patients with the same stages of disease and the same kinds ofoperation were performed as the control group, without autotransfusion hemodilution and the blood transfusionwas adopted if necessary. Result: Blood transfusion was necessary to be performed only in 8 patients of theexperimental group, on the contrary,it was necessary in 19 of 30 patients of the control group (P＜0.01).There were no complications during the operations , and the postoperative complications were no significance (P＞0. 05) between two groups. Conclusion:The application of autotransfusion hemodilution may be of help to aplenty of patients with laryngeal carcinoma in advanced stage to keep off the blood transfusion duringlaryngectomy.

Objective:To reconstruct middle ear structure for open mastoid antrum with external auditorycanal after radical mastoidectomy in one-stage. Method: 71 ears of post-mastoidectomy (discharging 53 ears anddried up 18 ears) were undergone with reconstruction of middle ear. The posterior wall of external auditorycanal, mastoid cavity and chain of ossicles were reconstructed with homologous costal cartilage. Result: 69 ears of71 cases were near normal structure followed up 6 months to 5 years after operations. The result showed hearingimprovement over 15 dB were 55 ears (77.5％) and under 15 dB were 11 cases (15.5％). Five cases (7.0％)were failed. Conclusion: Reconstruction of middle ear with homologous costal cartilage is a ideal surgery toreconstruct hearing structure and avoid infection of middle cavity after radical mastoidectomy.