Objective To investigate the effect of probiotics on the immune function and clinical efficacy in children with recurrent respiratory tract infection (RRTI). Methods A total of92 RRTI children were continuously enrolled and were randomly divided into study group and control group, with 46 cases in each group. Both groups were given oral treatment of pidotimod, and the study group added Bifid Triple Viable Bifidobacterium Power, all the children were treated for 3 months, and followed-up time lasted for more than 1 year. The changes of serum C-reactive protein (CRP), procalcitonin (PCT), immunoglobulin G (IgG), pmmunoglobulin A (IgA) and T cell subgroups were compared between the two groups, and the clinical efficacy between the two groups were compared. Results After treatment, serum CRP and PCT concentrations significantly decreased, serum IgG and IgA level significantly increased, the peripheral blood T cell count of CD4+was significantly increased, CD8+was significantly decreased in both groups when compared with that treatment before (P ＜ 0. 05). At the same time, the study group showed lower serum CRP and PCT concentration, higher serum IgG and IgA levels, higher peripheral blood CD4+T cell count, and lower CD8+T cell count after treatment, when compare to the control group (P ＜ 0. 05). However, there was no statistically difference between two groups in clinical efficiency (P＞ 0. 05). Conclusion Probiotics can effectively improve the immune function and reduce the inflammation level in RRTI children.

Objective To explore the efficiency of prophylactic peduncle ligature combined with high-frequency electrocoagulation in treatment of patients by peduncluated polyps of gastrointestinal tract. Methods A total of 41 patients with peduncluated polyps of gastrointestinal tract by treatment of high-frequency electrocoagulation resection were selected, and all patients were treated with prophylactic peduncle ligature by nylon rope or titanium clip before resection. The resection efficiency and complications were observed. Results All the patients underwent one-time removal of peduncluate polyps with a success rate of 100. 0％. One case had small amount of bleeding in the wound and was clipped with titanium clip. No complications such as perforation and delayed hemorrhage were observed in all patients. All the patients were followed up for 3 to 6 months, and wound healed well without recurrence. Conclusion For the large peduncluated polyps of gastrointestinal tract, prophylactic peduncle ligature before resection is a safe and effective method.

Objective To compare the efficacy of proximal femoral nail antirotation (PFNA) and internal fixation with locking plate in the treatment of elderly patients with femoral intertrochanteric fracture. Methods Totally 90 elderly patients with femoral intertrochanteric fracture were randomly divided into two groups. Patients in the PFNA group received PFNA, and patients in locking plate group were treated with internal fixation of locking plate. Perioperative indicators, complications, the Harris score and long-term prognosis were compared between the two groups. Results The operation time, length of incision, intra-operative blood loss, postoperative drainage volume, time to walking and fracture healing time in the PFNA group were significantly better than those in the locking plate group (P ＜ 0. 05 or P ＜ 0. 01). The total score of Harris, physical function, physical pain and overall health score at final follow up in the PFNA group were significantly higher than those in locking plate group (P ＜ 0. 01). The total incidence rate of complications in the PFNA group was significantly lower than that in the locking plate group (P ＜ 0. 05). Conclusion PFNA has less trauma, faster recovery speed and fewer complications when compared with internal fixation with locking plate.

Objective To investigate the effect of ultrasound-guided lumbar plexus-sciatic nerve block on perioperative oxidative stress response in elderly patients with hip replacement. Methods A total of 79 elderly patients with hip replacement were divided into two groups. The control group was treated with general anesthesia, and the observation group was treated with ropivacaine for lumbar plexus-sciatic nerve block. The perioperative hemodynamics indexes and oxidative stress response indexes were compared between the two groups. The number of effective analgesic pump presses and the number of adverse reactions were recorded. Results At the time points of before anesthesia (T0), skin incision (T1), 30 minutes after operation (T2), at the end of operation (T3) and1 hour after operation (T4), the hemodynamic indexes of the control group changed significantly, and the levels of indexes at T1 were the lowest (P ＜ 0. 05). The hemodynamic indexes of the observation group did not change significantly with time, and there were no significant differences in indexes between each time point (P＞ 0. 05). The levels of serum C-reactive protein (CRP) and cortisol (COR) from T1 to T4 increased significantly with time in both groups (P ＜ 0. 05), norepinephrine (NE) level was the lowest at T2 and increased significantly from T3 to T6 (P ＜ 0. 05). The changes of hemodynamic indexes and oxidative stress indexes in observation group were significantly smaller than those in control group at different time points (P ＜ 0. 05). Compared with the control group, the number of effective analgesic pump presses and cases with adverse reactions in the observation group were significantly less than those in the control group (P ＜ 0. 05). Conclusion Ultrasound-guided lumbar plexus-sciatic nerve block has a high safety in hip replacement for elderly patients with femoral neck fracture, which can better stabilize hemodynamic parameters, inhibit oxidative stress reaction and reduce the using number of analgesic pump after operation.

Objective To evaluate the effect of hyperbaric oxygen chamber (HBO) in treating neonatal severe hypoxic ischemic encephalopathy (HIE) at different time points. Methods A total of 103 neonates with severe hypoxic-ischemic encephalopathy admitted to our hospital were randomly divided into control group (n = 51) and observation group (n = 52). Routine treatment was given to all the patients. The observation group was additionally given HBO immediately after admission, and the control group began the therapy at 48 hours after admission. The therapeutic effects of the two groups were compared. Results After treatment, the neonatal behavioral neurological assessment (NBNA) score in the observation group was significantly higher, malondialdehyde (MDA) level was lower, superoxide dismutase (SOD) was higher, and creatine kinase, lactate dehydrogenase and creatine kinase isoenzyme (CK) levels were lower than that of the control group (P ＜ 0 05). Conclusion Early hyperbaric oxygen chamber for neonates with severe hypoxic-ischemic encephalopathy is more beneficial to the elimination of oxidative stress.

Objective To analyze the effect of extralateral approach interbody fusion in the treatment of degenerative lumbar diseases. Methods A total of 50 patients with lumbar degenerative diseases admitted to our hospital were selected, and were treated with extralateral approach interbody fusion, and the therapeutic effect was observed and analyzed. Results All patients successfully completed the operation. The average amount of bleeding during operation was (145. 5 ± 4. 7) m L, the average operation time was (56. 3 ± 2. 2) min, and the average hospitalization time was (7. 2 ± 1. 5) days. Four patients suffered from hip flexion weakness after operation, and the symptoms recovered completely after two months. Six patients suffered from sensory numbness in front of thighs after operation, and the symptoms disappeared or relieved after 6 to 8 weeks. No complications such as abdominal organs and blood vessels injury, cerebrospinal fluid leakage, mislocation of intervertebral space, paralytic intestinal obstruction and permanent injury of genitofemoral nerve occurred. All patients were followed up for 24 months. The results showed that at the last follow-up, the Visual Analogue Scale (VAS) scores of low back pain and lower limb pain were significantly lower, and the lumbar spine scores of Japanese Orthopaedic Association (JOA) were significantly higher than before operation (P ＜ 0. 05). Conclusion Extralateral approach interbody fusion can achieve satisfactory results in the treatment of lumbar degenerative diseases, with fewer complications and higher fusion rate.

Objective To explore the clinical efficiency of laparoscopic ovarian perforation combined with clomiphene citrate (CC) and human chorionic gonadotropin (HCG) in treating infertility induced by polycystic ovary syndrome (PCOS). Methods Totally 68 patients with infertility induced by PCOS were randomly divided into two groups, with 34 cases in each group. The control group was treated with laparoscopic ovarian perforation and HCG, while the observation group was treated with laparoscopic ovarian perforation combined with CC and HCG. Therapeutic effect and pregnancy condition were compared between the two groups. Results After treatment, the levels of luteinizing hormone, estradiol and testosterone in the observation group were significantly better than those in the control group (P ＜ 0. 05). In the observation group, the ovulation rate and one-year pregnancy rate were 91. 18％ and 58. 82％ respectively, which were significantly higher than 58.82％ and 32. 35％ in the control group (P ＜ 0. 05). There were no adverse reactions in the control group, and the incidence rate of adverse reactions in the observation group was 5. 58％. There was no significant difference between the two groups (P＞ 0. 05). Conclusion Laparoscopic ovarian perforation combined with CC and HCG is effective in the treatment of infertility induced by PCOS, which can improve sex hormone level and increase ovulation rate and pregnancy rate.

Objective To compare the effect of external fixation and internal fixation on the treatment of patients with oral and maxillofacial trauma. Methods Totally 150 patients with oral and maxillofacial trauma were randomly divided into control group (n = 75) and observation group (n =75), and the patients in the two groups were treated with external fixation and internal fixation respectively. The operation indexes and recovery condition were compared between the two groups. Results In the observation group, the operation time, hospital stay, degree of mouth opening, the incidence rates of postoperative infection, nonunion of wounds, skin erosion and nerve injury, and quality of life score were significantly better than those in the control group (P ＜ 0. 05). Conclusion Compared with external fixation, internal fixation can significantly shorten the time of postoperative recovery and improve surgical efficiency in patients with oral and maxillofacial trauma.

Objective To explore the effect of evidence-based nursing on toxicity and side effects of breast cancer patients undergoing chemotherapy. Methods Forty-five patients with breast cancer treated in our department from January to March 2018 were selected as control group, receiving routine nursing. Forty-five patients with breast cancer treated by chemotherapy in our department from April to June 2018 were selected as observation group, given evidence-based nursing to prevent side effects on thebasis of routine nursing. The mastery of health knowledge of chemotherapy and related toxicity and side effects were compared between the two groups. Results The scores of health knowledge in basic knowledge of chemotherapy, bone marrow suppression, digestive tract and dietary nutrition in the observation group were higher than that in the control group (P ＜ 0. 05). The incidence of gastrointestinal adverse reactions, bone marrow suppression and stomatitis in the observation group was lower than that in the control group (P ＜ 0. 05). The compliance of the observation group was higher than that of the control group (P ＜ 0. 05). Conclusion Evidence-based nursing can increase the health knowledge of breast cancer patients undergoing chemotherapy, reduce toxicity and side effects, and improve their compliance with chemotherapy.

Objective To compare the clinical nursing effect of peripherally inserted central venous catheter (PICC) versus totally implantable venous-access ports (TIVAP) in breast cancer patients with chemotherapy. Methods A total of 82 patients with breast cancer treated by chemotherapy in our hospital were randomly divided into PICC group and TIVAP group, with 41 cases in each group. The two groups were given corresponding nursing measures. Anxiety, depression and clinical efficacy were analyzed. Results The success rate of catheterization in the two groups was 100％, but PICC group had more complications. Before treatment, the total anxiety and depression scores in two groups showed no significant differences (P＞ 0. 05), were lower after treatment than treatment before, and TIVAP group decreased more significantly than PICC group after treatment (P ＜ 0. 05).Conclusion TIVAP and PICC in breast cancer patients with chemotherapy can ensure the smooth implementation of treatment, effectively control the anxiety and depression of patients, and TIVAP has better treatment efficacy than PICC.