1.Erratum to: Aberrant Expression of Cancer Stem Cells Marker Prominin-1 in Low-Grade Tubulobular Breast Carcinoma: A Correlative Study between qRT-PCR, Flow-Cytometric and Immunohistochemistry Analysis.
Maurizio DI BONITO ; Francesca COLLINA ; Monica CANTILE ; Rosalba CAMERLINGO ; Margherita CERRONE ; Laura MARRA ; Giuseppina LIGUORI ; Giuseppe PIROZZI ; Gerardo BOTTI
Journal of Breast Cancer 2013;16(1):132-132
This article was initially published on Journal of Breast Cancer with misspelled title of the article.
2.If Progesterone Is Blamed for Breast Cancer Development, Why Are We Still Using Tamoxifen?.
Enis OZKAYA ; Vakkas KORKMAZ ; Tuncay KUCUKOZKAN ; Fadil KARA
Journal of Breast Cancer 2013;16(1):131-131
No abstract available.
Breast
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Breast Neoplasms
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Progesterone
3.Total Cholesterol and Triglyceride Levels in Patients with Breast Cancer.
Umesh KAPIL ; Ajeet Singh BHADORIA ; Neha SAREEN ; Preeti SINGH ; Sada N DWIVEDI
Journal of Breast Cancer 2013;16(1):129-130
No abstract available.
Breast
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Breast Neoplasms
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Cholesterol
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Humans
4.Profound Hypotension after an Intradermal Injection of Indigo Carmine for Sentinel Node Mapping.
Youn Yi JO ; Mi Geum LEE ; Soon Young YUN ; Kyung Cheon LEE
Journal of Breast Cancer 2013;16(1):127-128
Intradermal injections of indigo carmine for sentinel node mapping are considered safe and no report of an adverse reaction has been published. The authors described two cases of profound hypotension in women that underwent breast-conserving surgery after an intradermal injection of indigo carmine into the periareolar area for sentinel node mapping.
Breast Neoplasms
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Female
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Humans
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Hypotension
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Indigo Carmine
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Indoles
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Injections, Intradermal
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Mastectomy, Segmental
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Nitriles
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Pyrethrins
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Sentinel Lymph Node Biopsy
5.Prolonged Regression of Metastatic Leptomeningeal Breast Cancer That Has Failed Conventional Therapy: A Case Report and Review of the Literature.
Andrew VINCENT ; Glenn LESSER ; Doris BROWN ; Tamara VERN-GROSS ; Linda METHENY-BARLOW ; Julia LAWRENCE ; Michael CHAN
Journal of Breast Cancer 2013;16(1):122-126
Approximately 5% of breast cancer patients develop leptomeningeal metastases over the course of their disease. Though several treatments options are available for these patients, their prognosis is typically considered to be poor. We report a case of leptomeningeal failure after a patient underwent prior radiotherapy, radiosurgery, surgery, chemotherapy, and biologic therapy. This patient experienced a prolonged response after receiving bevacizumab and capecitabine. The literature currently contains several reports regarding the use of systemic therapy to manage leptomeningeal metastases from breast cancer, which we summarize. Finally, we review the relevant effects of the patient's treatment modalities and provide a rationale for the mechanism that led to her prolonged response.
Antibodies, Monoclonal, Humanized
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Biological Therapy
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Breast
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Breast Neoplasms
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Deoxycytidine
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Fluorouracil
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Humans
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Meningeal Neoplasms
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Neoplasm Metastasis
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Prognosis
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Radiosurgery
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Bevacizumab
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Capecitabine
6.Skeletal Muscle Metastases from Breast Cancer: Two Case Reports.
Young Woo KIM ; Kyung Jin SEO ; Su Lim LEE ; Ki Wook KWON ; Joon HUR ; Ho Jung AN ; Yoon Ho KO ; Jeong Soo KIM ; Hye Sung WON
Journal of Breast Cancer 2013;16(1):117-121
The skeletal muscle is an unusual site for metastasis from breast cancer. We present two cases of breast cancer that relapsed as skeletal muscle metastasis without other distant organ metastasis. We performed the core needle biopsy of metastatic sites and confirmed discordance in estrogen receptor, progesterone receptors, and human epidermal growth factor receptor 2 expression between primary breast cancer and skeletal muscle metastases. In the second case, we found the skeletal muscle metastasis through F-18 fluorodeoxyglucose positron emission tomography/computed tomography scans (PET/CT). Intramuscular hot spots on PET/CT scans should be considered as a sign of metastasis even in the absence of abnormalities on computed tomography scans. Our patients received systemic chemotherapy, and showed a partial response. Further studies are needed to determine the prognosis and proper management of isolated skeletal muscle metastasis in breast cancer.
Biopsy, Large-Core Needle
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Breast
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Breast Neoplasms
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Electrons
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Estrogens
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Humans
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Muscle, Skeletal
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Neoplasm Metastasis
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Prognosis
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Receptor, Epidermal Growth Factor
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Receptor, erbB-2
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Receptors, Progesterone
7.Granulocytic Sarcoma in Breast after Bone Marrow Transplantation.
Seung Jin KIM ; Woo Sung HONG ; Sung Hyun JUN ; Seong Hyun JEONG ; Seok Youn KANG ; Tae Hee KIM ; Doo Kyoung KANG ; Hyun Ee YIM ; Yong Sik JUNG ; Ku Sang KIM
Journal of Breast Cancer 2013;16(1):112-116
Granulocytic sarcoma is a localized extramedullary solid tumor composed of immature myeloid cell and is usually associated with acute myeloid leukemia or myelodysplastic syndrome. Although it can involve any site, commonly in lymph nodes, skin, bone and soft tissue, the involvement of breast is unusual. Especially, the involvement of the breast as a pattern of relapse after bone marrow transplantation is extremely rare. We have experienced 2 cases of granulocytic sarcoma after bone marrow transplantation. One case was a 39-year-old woman with right breast mass diagnosed with granulocytic sarcoma. She had received an unrelated bone marrow transplantation due to biphenotype acute leukemia 3 years before our presentation. Another case was a 48-year-old woman with acute myeloid leukemia, who was diagnosed with granulocytic sarcoma on both breasts 8 months after allogenic bone marrow transplantation. We also discuss the clinicopathologic features of granulocytic sarcoma in breast after bone marrow transplantation.
Bone Marrow
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Bone Marrow Transplantation
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Breast
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Female
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Humans
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Leukemia
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Leukemia, Myeloid, Acute
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Lymph Nodes
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Myelodysplastic Syndromes
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Myeloid Cells
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Recurrence
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Sarcoma, Myeloid
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Skin
8.Evolution of Health-Related Quality of Life in Breast Cancer Patients during the First Year of Follow-Up.
David MORO-VALDEZATE ; Salvador PEIRO ; Elvira BUCH-VILLA ; Antonio CABALLERO-GARATE ; M Dolores MORALES-MONSALVE ; Angel MARTINEZ-AGULLO ; Felix CHECA-AYET ; Joaquin ORTEGA-SERRANO
Journal of Breast Cancer 2013;16(1):104-111
PURPOSE: The objective of this study was to describe the evolution of health-related quality of life (HRQOL) in a cohort of breast cancer patients over 1 year after surgery and to analyse the predictive ability of HRQOL measurement instruments. METHODS: Observational, multicenter and prospective study of a cohort of breast cancer patients, assessing HRQOL at 1, 6, and 12 months after surgery using three questionnaires: EuroQol-5D-3L, EORTC QLQ-C30, and EORTC QLQ-BR23. RESULTS: A total of 364 women participated in the study. Visual Analogue Scale (VAS) scores from the EuroQol improved (1 month vs. 1 year: 70 vs. 80; p<0.0001); however, the EuroQol score showed no significant change (0.81 vs. 0.83; p=0.1323). In contrast, Global Health Status on the EORTC QLQ-C30 improved (66.67 vs. 100.00; p<0.0001), as did all of this instrument's scales and most of its independent items. The EORTC QLQ-BR23 dimensions showed improvement, except for sexual functioning (100.00 vs. 86.67; p=0.0030) and future perspective (33.33 vs. 66.67; p<0.0001). Patients with good HRQOL outcomes at 1 month showed improved levels of HRQOL at 1 year; HRQOL measured at 1 month was predictive of HRQOL at 1 year. CONCLUSION: HRQOL improved during the follow-up period. Likewise, HRQOL measurement instruments can predict early HRQOL.
Breast
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Breast Neoplasms
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Cohort Studies
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Female
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Follow-Up Studies
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Humans
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Prospective Studies
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Quality of Life
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Weights and Measures
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Surveys and Questionnaires
9.Validation of a Web-Based Tool to Predict the Ipsilateral Breast Tumor Recurrence (IBTR! 2.0) after Breast-Conserving Therapy for Korean Patients.
Seung Pil JUNG ; Sung Mo HUR ; Se Kyung LEE ; Sangmin KIM ; Min Young CHOI ; Soo Youn BAE ; Jiyoung KIM ; Min Kuk KIM ; Won Ho KIL ; Jun Ho CHOE ; Jung Han KIM ; Jee Soo KIM ; Seok Jin NAM ; Jeoung Won BAE ; Jeong Eon LEE
Journal of Breast Cancer 2013;16(1):97-103
PURPOSE: IBTR! 2.0 is a web-based nomogram that predicts the 10-year ipsilateral breast tumor recurrence (IBTR) rate after breast-conserving therapy. We validated this nomogram in Korean patients. METHODS: The nomogram was tested for 520 Korean patients, who underwent breast-conserving surgery followed by radiation therapy. Predicted and observed 10-year outcomes were compared for the entire cohort and for each group, predefined by nomogram-predicted risks: group 1, <3%; group 2, 3% to 5%; group 3, 5% to 10%; group 4, >10%. RESULTS: In overall patients, the overall 10 year predicted and observed estimates of IBTR were 5.22% and 5.70% (p=0.68). In group 1, (n=124), the predicted and observed estimates were 2.25% and 1.80% (p=0.73), in group 2 (n=177), 3.95% and 3.90% (p=0.97), in group 3 (n=181), 7.14% and 8.80% (p=0.42), and in group 4 (n=38), 11.66% and 14.90% (p=0.73), respectively. CONCLUSION: In a previous validation of this nomogram based on American patients, nomogram-predicted IBTR rates were overestimated in the high-risk subgroup. However, our results based on Korean patients showed that the observed IBTR was higher than the predicted estimates in groups 3 and 4. This difference may arise from ethnic differences, as well as from the methods used to detect IBTR and the healthcare environment. IBTR! 2.0 may be considered as an acceptable nomogram in Korean patients with low- to moderate-risk of in-breast recurrence. Before widespread use of this nomogram, the IBTR! 2.0 needs a larger validation study and continuous modification.
Breast
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Breast Neoplasms
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Cohort Studies
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Delivery of Health Care
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Humans
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Mastectomy, Segmental
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Nomograms
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Recurrence
10.Dose Reduction in Automatic Optimization Parameter of Full Field Digital Mammography: Breast Phantom Study.
Myung Su KO ; Hak Hee KIM ; Joo Hee CHA ; Hee Jung SHIN ; Jeoung Hyun KIM ; Min Jeong KIM
Journal of Breast Cancer 2013;16(1):90-96
PURPOSE: We evaluated the impact of three automatic optimization of parameters (AOP) modes of digital mammography on the dose and image quality. METHODS: Computerized Imaging Reference Systems phantoms were used. A total of 12 phantoms with different thickness and glandularity were imaged. We analyzed the average glandular dose (AGD) and entrance surface exposure (ESE) of 12 phantoms imaged by digital mammography in three modes of AOP; namely standard mode (STD), contrast mode (CNT), and dose mode (DOSE). Moreover, exposure factors including kVp, mAs, and target/filter combination were evaluated. To evaluate the quality of the obtained digital image, two radiologists independently counted the objects of the phantoms. RESULTS: According to the AOP modes, the score of masses and specks was sorted as CNT>STD=DOSE. There was no difference in the score of fiber among the three modes. The score of image preference was sorted as CNT>STD>DOSE. The AGD, ESE, and mAs were sorted as CNT>STD>DOSE. The kVp was sorted as CNT=STD>DOSE. The score of all test objects in the phantom image was on a downtrend with increasing breast thickness. The score of masses was different among the three groups; 20-21%>30%>50% glandularity. The score of specks was sorted as 20-21%=30%>50% glandularity. The score of fibers was sorted as 30%>20-21%=50% glandularity. The score of image preference was not different among the three glandularity groups. The AGD, ESE, kVp, and mAs were correlated with breast thickness, but not correlated with glandularity. CONCLUSION: The DOSE mode offers significant improvement (19.1-50%) in dose over the other two modes over a range of breast thickness and breast glandularity with acceptable image quality. Owning knowledge of the three AOP modes may reduce unnecessary radiation exposure by utilizing the proper mode according to its purpose.
Breast
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Mammography
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Phantoms, Imaging
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Radiation Dosage