The objectives of this study are to estimate the prevalence of diabetes mellitus(DM) and to identify risk factors associated with fasting blood sugar in a rural adult population. We carried out a cross-sectional study on the residents over 30-year old. Among the 1077 eligible subjects, 725 persons responded to the study; the study consisted of interview on family and past history of DM, anthropometry, blood pressure, and blood sugar level in each subjects. Only 707 subjects of 725 participants had fasting blood sugar(FBS) examined and the rest, 18 subjects were had casual blood sugar examined due to failure of fasting over 8-hour. When subjects had FBS >or= 140mg/dl, 2 hours postprandial blood sugar level was checked after 75g oral glucose loading. The prevalence of DM was 8.9%, and age standardized prevalence rate adjusted to Korean population of 1995 was 5.8%. Mean and SD of fasting blood sugar in men was 99.8 +/- 22.6, and in women was 111.5 +/- 29.9. Mean levels of fasting blood sugar were significantly higher in women than in man and as their ages advanced the prevalencies in creased in both sexes. PP2 blood sugar levels were significantly higher in elder age and in persons with higher FBS levels than others. The risk factors associated with FBS were past history of diabetes, sex, socioeconomic status and waist-to-hip circumference ratio; the risk of diabetes was increased in female, people with past DM history, central obesity and low socioeconomic state. The low socioeconomic status associated with DM in this study, which is different from other study results, should be pursued in further studies.
Adult* ; Anthropometry ; Blood Glucose ; Blood Pressure ; Cross-Sectional Studies ; Diabetes Mellitus* ; Fasting ; Female ; Glucose ; Humans ; Male ; Obesity, Abdominal ; Prevalence* ; Risk Factors ; Social Class

No abstract available.
Animals ; Korea* ; Population Characteristics* ; Rats*

In order to understand epidemiologic characteristics of dioxins related health impacts, 107 diox in-related literatures published up to May, 1993 were thoroughly reviewed. The results obtained are as follows: 1. Review studies on dioxins can be classified into two types : one is studies concentrated on one specific subject related to dioxins such as the effects on skin, birth outcomes, metabolic machanisms in the human body, major sources of exposure to the general population, immunotoxicity, association between dioxins and cancers, and research methods on effects of dioxins. The other is review studies dealing with overall aspects of dioxins, among which the report published by Academy of Science of United Stateds of America in 1993 is the most recent one. 2. Judging by consistency of results and biological plausibility, there were three groups of diseases ; diseases having causal relationship, having possibilities of causal relationship, and having no causal relationship for the time being. 1) The diseases showing causal relationship were lung cancer, Hodgkin 'disease, non-Hodgkin 'lymphoma, soft tissue sarcoma, chlordane, and polyneuropathy 2) the diseases showing possibilities of causal relationship were stomach cancer, lymphatic and haematopoietic cancer, multiple myeloma, skin cancer, diseases of digestive system, and CNS deformity among children born to the people exposed. 3) The diseases showing no causal relationship were oral and laryngeat cancer, esophageal cancer, prostate cancer, kidney cancer, bladder cancer, brain and CNS cancer, diseases of circulatory and respiratory systems. There were numerous diseases of digestive system, which showed difficulty in establishing definite causal relationship owing to the lack of consistency among researchers. 3. Even though papers dealt with dioxinrelated mortality and morbidity studies showed high mortality rate from accident, biological plausibility explaining causal relationship between them should be sought further. 4. There was a high prevalence of hearing loss among Vietnam veterans, and it seemed rather related to the explosive noise in combat than dioxin itself. 5. The current TCDD levels of Vietnam veterans were almost the same as those of the general population.
Americas ; Brain Neoplasms ; Child ; Chlordan ; Citrus sinensis* ; Congenital Abnormalities ; Digestive System ; Dioxins ; Esophageal Neoplasms ; Hearing Loss ; Human Body ; Humans ; Kidney Neoplasms ; Lung Neoplasms ; Mortality ; Multiple Myeloma ; Noise ; Parturition ; Polyneuropathies ; Prevalence ; Prostatic Neoplasms ; Respiratory System ; Sarcoma ; Skin ; Skin Neoplasms ; Stomach Neoplasms ; Tetrachlorodibenzodioxin ; Urinary Bladder Neoplasms ; Veterans ; Vietnam

This study was conducted on 4,003 inhabitants of six villages, Southern County of Che Ju lsland from April 18 to July 30, 1974 with purpose of studying. Relationship between intradermal reaction and egg detection rate, Egg detection rate by the number of sputum examination on the same subject, Comparison of direct sputum examination method (Whole volume of sputum in vinyl bag pressed between petri dishes) with concentration (2per cent NaOH) method, Estimation of sensitivity and specificity of the intradermal test in screening paragonimiasis. The results obtained are as follows: Overall positive skin reaction rate was 57.7 per cent and egg positive rate regardless of skin reaction was 17.1 per cent the population studied. Egg positive rate for negative skin reactors(wheal size smaller than 70mm(2)) was l0.l per cent, and that of positive reactors was 22.8 per cent. Positive skin reaction rate increased as age increased, egg positive rate, however, revealed rather inconsistent distribution by age. The egg positive rate showed a tendency of increase by increase of wheal size, though not so remarkably. 2.9 per cent of egg positives by direct sputum examination method was negative when re-examined by concentration method; 2.6 per cent of egg negative sputum by direct method was egg positive by concentration method. It was found that the sputa showing discrepant result by two different methods had only a few eggs in whole sputum collected. Egg positive rate by single sputum examination was 8.l per cent, by two examinations 14.6 per cent by three 19.2 per cent, by four 24.5 per cent, and by five examinations on the same individual was 20.5 per cent. The estimated sensitivity and specificity of the skin test were 76.5 per cent and 42.7 per cent respectively under the postulation that all infected persons could be detected by four sputum examinations.
parasitology-helminth-trematoda-Paragonimus westermani ; skin test ; sputum ; sensitivity-specificity ; diagnosis

Disfiguring hyperpigmentation of the exposed areas may have impartant and lasting effects on the emotional well-being of the patient. And many attempts to treat areas of hyperpigmentation have been earried out, but all of them are not very successful. Recently 4-isopropylcatechol has been known to inhibit melanin pigmentation with a selective action on melanocytes either destroying or inactivating the melanocytes experimentally. There is no report on its clinical trial till now. In this study, 1% 4-isopropylcatechol cream was topieally applied to the hyperpigmented lesions of 29 patieots of melasma, freckle, and cafe-au-lait spot. The bleaching effect on meiasmas was very satisfactory in all patients but coantact dermatltis in 3 patients and reticular hyperpigmentation with areas of depigmented spots in one patient were developed as the side effects of the drug. Freckle and cafe-au-Iait spots were not bleached.
Cafe-au-Lait Spots ; Humans ; Hyperpigmentation ; Melanins ; Melanocytes ; Melanosis ; Pigmentation

Morning sickness during pregnancy is a very common functional problem with different kinds of symptom, but little data are available concerning the nutrition intervention program for pregnant women in local area. A total of 152 pregnant women who had experienced morning sickness were surveyed to investigate the relationships between morning sickness, nutrient intakes and pregnancy outcome. The results showed that prevalent symptoms were nausea (68.4%), heartburn (59.2%), morning sickness (48.7%), vomiting (42.1%), and constipation (44.7%). The onset of the symptom occurred during the first 3 months (9.3 +/- 2.3 weeks); 21.1% of the subjects was experienced two symptom at the same time. This significantly correlated with vomiting (p < 0.01), nausea (p < 0.001), morning sickness (p < 0.001), and heartburn (p < 0.01) with pregnancy weight. There were also correlations between the four symptoms and nutrient intakes. Mean birth weight of 21 newborns was 3.06 +/- 0.42 kg, and the one and five minutes of Apgar scores were 7.74 +/- 0.99 and 8.84 +/- 0.69, respectively. There were negative correlations between vomiting and pregnancy outcomes (p < 0.05). Our data support that morning sickness, especially vomiting during pregnancy is associated with Apgar score and body weight of newborn.
Apgar Score ; Birth Weight ; Body Weight ; Constipation ; Female ; Heartburn ; Humans ; Infant, Newborn* ; Morning Sickness ; Nausea ; Nutritional Status* ; Pregnancy Outcome ; Pregnancy* ; Pregnant Women ; Vomiting

The purpose of this study was to examine the effect of nutrition education about the Korean food guide to middle school students on food intake measured by food frequency. Three hundred first graders were sampled from two coeducational middle schools located in the small city of Chungnam area, and divided into 167 (74 boys, 93 girls) education groups of one school and 133 (70 boys, 63 girls) non education groups of the other school. Nutrition education was given to the education group for a total of 16 hours and no education to the non education group during the same period. After education, average nutrition knowledge scores of education group increased from 6.40 +/- 2.17 to 6.81 +/- 1.56 significantly, especially boys with a high range of increase and girls no increase. Dietary habit scores improved significantly from 46.2 +/- 6.5 to 49.1 +/- 6.2 in both boys and girls of education group. Of the knowledge and dietary habits, ability of choosing a balanced meal, biased eating to some food, and taking diverse foods at every meal improved significantly in education group. In non education group no significant increases of either nutrition knowledge scores and dietary habit scores were shown. In addition education group showed significant increases after education, in the intake frequencies of rice noodle loaf bread, kimchi, green and yellow vegetables, and soybean soybean curds by 0.27, 0.23, 0.40 and 0.32 servings per day, compared with non education group. These changes were greater in girls than in boys. According to these results, it can be concluded that nutrition education about the Korean food guide improved effectively not only student's nutrition knowledge and dietary habits, but also healthy food intake ability. It is necessary to prepare long-term and continuous school-based nutrition education programs for the students to get into a habit of healthy food intake.
Adolescent* ; Bias (Epidemiology) ; Bread ; Chungcheongnam-do ; Eating* ; Education* ; Female ; Food Habits ; Humans ; Meals ; Soybeans ; Vegetables

PURPOSE: The activator of protein kinase A, cyclic AMP, has been a recognized growth inhibitor of certain cell types. The present study aimed to investigate the effects of dibutyryl cAMP on the growth of cancer cells which lack wild-type p53 and to determine the mechanism of growth inhibition. MATERIALS AND METHODS: Prostate and breast cancer cells were treated with dibutyryl cAMP and compared with untreated cells. Growth patterns of cells were assessed by trypan blue-excluding method and western blot was done to determine protein levels of cell cycle regulatory proteins which govern G1 and G1/S phase. Northern blot and immunoprecipitation were done to determine the level of mRNA of p21 and the association between cell cycle regulatory proteins. In vitro immune complex kinase assay was done to assess the activity of cdk2. RESULTS: cAMP reduced cell growth by 48 h. Cyclin D3 level was downregulated and RB protein level was decreased and mostly unphosphorylated forms remained. The association of RB with E2F1 was increased. While cdk2 levels remained constant throughout cAMP treatment, the activity of cdk2/cyclin E complex, which is responsible for entry into S phase, was downregulated. Cdk inhibitors, p27 and p21 were induced with cAMP treatment. CONCLUSION: These observation suggest that the growth inhibitory effects of dibutyryl cAMP on prostate and breast cancer cells were mediated by induction of cdk inhibitors such as p21 and p27 and RB activation in accordance with downregulation of cdk2.
Antigen-Antibody Complex ; Blotting, Northern ; Blotting, Western ; Breast Neoplasms ; Cell Cycle Proteins ; Cyclic AMP* ; Cyclic AMP-Dependent Protein Kinases ; Cyclin D3 ; Down-Regulation ; Immunoprecipitation ; Phosphotransferases ; Prostate ; Retinoblastoma Protein ; RNA, Messenger ; S Phase

BACKGROUND: This study was purposed to study the therapeutic value of intraluminal oxygen insufflation on the oxygenation of gut mucosa in a feline model subjected to a hemorrhagic shock followed by reperfusion. METHODS: Eighteen cats were divided into three groups : For group 1, 6 cats were subjected to sham operation as a control group ; for group 2, 6 cats were subjected to a hemorrhagic shock for 2 hours prior to reperfusion as a hemorrhagic shock(HS) group ; for group 3, 6 cats were subjected to a simultaneous insufflation of intraluminal oxygen, continued during the shock and reperfusion periods as a oxygenated hemorrhagic shock(OHS) group. Mesenteric PvO2, mesenteric venous arterial(v-a) lactate difference, mesenteric P(v-a)CO2 and mesenteric pH(a-v) were measured for every 30 minutes during the shock and reperfusion. RESULTS: The lactate(v-a) was increased during the shock. For group OHS, the lactate(v-a) returned to the baseline value after reperfusion, but for group HS, it did not return. The values of pH(v-a) and P(v-a)CO2 were increased during the shock and returned to the baseline value for group OHS, but for group HS, the increase was greater than group OHS(p<0.05), but not returned to the baseline value after reperfusion. For both pH(v-a) and P(v-a)CO2, there were statistically significant differences(p<0.05) between group HS and group OHS during the shock and reperfusion. CONCLUSIONS: We conclude that the insufflation of intraluminal oxygen improves the oxygenation of gut mucosa in the feline model undergone a hemorrhagic shock followed by reperfusion.
Animals ; Cats* ; Insufflation* ; Lactic Acid ; Mucous Membrane* ; Oxygen* ; Reperfusion ; Shock ; Shock, Hemorrhagic

This study identifies the number of pneumoconiosis patients after eliminating deceased patients between 2003 and 2008 as of January 1st and estimates it for the next five years. From 2003 to 2008, the pneumoconiosis patients were 16,929, 17,224, 17,366, 17,566, 17,542, and 17,546, respectively. The number of pneumoconiosis patients will have increased by 1,014 from 2008 to 18,560 in 2013 after applying the average change rates taken from 2003 to 2007. It takes 15-20 yr to develop coal workers' pneumoconiosis (the main cause in Korea) and patients will continue to be diagnosed with pneumoconiosis for some years to come since it has only been 20 yr since the decline of the coal mining industry in Korea. In addition, pneumoconiosis patients are increasing in industries in which the risk of pneumoconiosis was relatively low shows the necessity to improve dust-exposed workplace environments.
Adult ; Aged ; Aged, 80 and over ; Air Pollutants, Occupational/adverse effects ; Anthracosis/*epidemiology ; Coal Mining ; Dust ; Female ; Humans ; Male ; Middle Aged ; Occupational Exposure/adverse effects ; Pneumoconiosis/*epidemiology/etiology ; Republic of Korea/epidemiology