1.Heterotopic Glial Nodule in the Lung of an Anencephaly Patient : An autopsy case.
Hye Joung LEE ; Soo Min KANG ; Gyung Hyuck KO
Korean Journal of Pathology 1991;25(5):457-461
The heterotopic and tissues may be divided into two categories: those that are found in the head and neck region, and those that arise elsewhere. The latter type is rare and most cases are found in the lungs of patients with neural tube defect, particularly anencephaly. Our report descrives anencephalic male infant with heterotopic glial nodules in both lungs. The largest nodule is 2x1.5x1 cm, locates in the lower lobe of the left lung, and has a round gray-white cut surface with cystic spaces. Microscopically, the nodules consist of irregularly arranged astrocytes and glial fibers, in which are embedded gland-like or cystically dilated bronchioles. The astrocytes and glial fibers are strongly positive for glial fibrillary acidic protein and show astrocytic filaments on electron microscopy. This will be an additional case supporting the amniotic fluid aspiration/implantation theory of pathogenetic mechanism of distal heerotopic glial tissue.
Infant
;
Male
;
Female
;
Humans
2.Apoptosis in Rat Thymus after Bolus Intramuscular Injection of 5-Fluorouracil.
Kyung Hee KIM ; Hae Joung SUL ; Dae Young KANG
Korean Journal of Pathology 2000;34(6):413-418
We induced apoptosis in normal rats by intramuscular injection of 5-fluorouracil (5-FU) and immunohistochemically evaluated the thymus for the TdT-mediated dUTP biotin nick end labelling on the 1st, 3rd, 6th, 9th, 15th and 21st days following the bolus intramuscular injection. The injections of 5-FU induced a greater extent of apoptosis in the thymus. In the thymus, a mild increase in apoptosis was observed 24 hours after injection. The greatest number of apoptotic cells were seen at 72 hours. The size of the thymus decreased and the cortex thinned with hypocellularity. The injection of 5-FU caused massive cell loss in the thymus. Most apoptotic cells were scattered in the cortex and lower levels of apoptosis were also observed in the medulla. After 72 hours, the level of apoptosis returned to the control level. Considering the above results, we think that 5-FU induced toxicity may be related to 5-FU induced apoptosis in normal tissue, especially the thymus.
Animals
;
Apoptosis*
;
Biotin
;
Fluorouracil*
;
Injections, Intramuscular*
;
Rats*
;
Thymus Gland*
3.A Case of Prune Belly Syndrome.
Joung Sik RIM ; Young Kon JOUNG ; Kang Seen CHO
Korean Journal of Urology 1980;21(6):646-649
A case of prune belly syndrome, which was observed in a 3 month-old male, is presented. The congenital anomaly complex in which absence of abdominal muscle is associated with urinary tract abnormalities and abdominal testes has been well known. The literature is reviewed briefly.
Abdominal Muscles
;
Humans
;
Infant
;
Male
;
Prune Belly Syndrome*
;
Testis
;
Urinary Tract
4.The Effect of Splenectomy on Acute Barium Sulfate Induced Toxicity of Rat Organs.
Hae Joung SUL ; Dae Young KANG
Korean Journal of Pathology 2004;38(4):249-257
BACKGROUND: The purpose of this study was to elucidate whether or not splenectomy alters the acute toxic effects on rat tissue induced by barium sulfate. METHODS: A total of 80 Sprague-Dawely male rats were divided into three groups; the control group and the barium sulfate treated groups with and without splenectomy. The pathologic changes in the solid organs were examined at the time after intraperitoneal treatment with barium sulfate. The changes of white blood cell count were also examined. RESULTS: The barium induced toxicity was most prominent in the spleen. The changes in the other organs were proportional to the experimental duration, and the changes in the barium only treatment group were more severe than the observed changes in the splenectomy and barium treated group. CONCLUSIONS: These results suggest that the degree of barium toxicity of barium only treated group was more severe than that of the splenectomy group.
Animals
;
Barium Sulfate*
;
Barium*
;
Humans
;
Leukocyte Count
;
Male
;
Rats*
;
Spleen
;
Splenectomy*
5.Strongyloidiasis of Gastric and Colonic Mucosa in a Patient with Monoclonal Gammopathy of Undetermined Significance: A Case Report.
Jung Uee LEE ; Sang Bum KANG ; Hae Joung SUL ; Jong Ok KIM
Korean Journal of Pathology 2011;45(Suppl 1):S75-S78
Here we report a case of Strongyloides stercoralis infection of the gastric and pancolonic mucosa in a 79-year-old female with a monoclonal gammopathy of undetermined significance. Endoscopic biopsies were performed in gastric antrum, cecum, distal ascending colon, and hepatic flexure of the colon. On microscopic examination, there were many adult worms, larvae and eggs in the gastric and colonic mucosa. Worms, larvae, and eggs were located in the crypts and within the lumen of the crypts. The body wall of the adult worm was composed of cuticle and a weak muscle layer. A routine stool examination failed to detect larvae or ova. Based on the histopathologic examination, these parasites were confirmed as S. stercoralis.
Adult
;
Aged
;
Biopsy
;
Cecum
;
Colon
;
Colon, Ascending
;
Eggs
;
Female
;
Humans
;
Larva
;
Monoclonal Gammopathy of Undetermined Significance
;
Mucous Membrane
;
Muscles
;
Ovum
;
Paraproteinemias
;
Parasites
;
Pyloric Antrum
;
Stomach
;
Strongyloides stercoralis
;
Strongyloidiasis
6.Strongyloidiasis of Gastric and Colonic Mucosa in a Patient with Monoclonal Gammopathy of Undetermined Significance: A Case Report.
Jung Uee LEE ; Sang Bum KANG ; Hae Joung SUL ; Jong Ok KIM
Korean Journal of Pathology 2011;45(Suppl 1):S75-S78
Here we report a case of Strongyloides stercoralis infection of the gastric and pancolonic mucosa in a 79-year-old female with a monoclonal gammopathy of undetermined significance. Endoscopic biopsies were performed in gastric antrum, cecum, distal ascending colon, and hepatic flexure of the colon. On microscopic examination, there were many adult worms, larvae and eggs in the gastric and colonic mucosa. Worms, larvae, and eggs were located in the crypts and within the lumen of the crypts. The body wall of the adult worm was composed of cuticle and a weak muscle layer. A routine stool examination failed to detect larvae or ova. Based on the histopathologic examination, these parasites were confirmed as S. stercoralis.
Adult
;
Aged
;
Biopsy
;
Cecum
;
Colon
;
Colon, Ascending
;
Eggs
;
Female
;
Humans
;
Larva
;
Monoclonal Gammopathy of Undetermined Significance
;
Mucous Membrane
;
Muscles
;
Ovum
;
Paraproteinemias
;
Parasites
;
Pyloric Antrum
;
Stomach
;
Strongyloides stercoralis
;
Strongyloidiasis
7.Hemodynamic Change in Liver Cirrhosis.
Nam Gi JOUNG ; Chul Woong KIM ; Jae Won RHO ; Jeong Chae KANG ; Ock Kyu PARK
Korean Circulation Journal 1979;9(2):27-36
The investigation of systolic time intervals and hemodynamics was performed in 42 patients with liver cirrhosis by noninvascive methods. The patients were divided into four groups according to the presence or absence of anemia and/or ascites: i.e. group I; cirrhosis without anemia and ascites, group II; cirrhosis with ascites only, group III; cirrhosis with anemia only, and group IV; cirrhosis with ascites and anemia. In the resting state of the patients, the systolic time intervals and hemodynamic data were measured by the high speed simultaneous recordings of electrocardiogram, phonocardiogram, carotid and femoral arterial pulse tracings, and compared with those obtained from 155 normal adult subjects. 1. The pulse were increased considerably in group IV, and diastolic blood pressure was elevated in group II with significance. 2. The stroke volume and cardiac output were increased significantly in group III. 3. The peripheral resistance was reduced particularly in group III, and the volume elasticit coefficient was decreased in group IV. 4. The QS1 interval was prolonged significantly in group II and IV, but QS1 interval corrected by multiple regression equation proposed by our laboratory (illustrated in the text) did not show significant difference compared with that of normal subjects. 5. The left ventricular ejection time(LVET) and total electromechanical systole(QS 2) appeared to be shortened in group II and IV, but the corrected LVET and QS 2 were not different significantly from those of the normal subjects
Adult
;
Anemia
;
Ascites
;
Blood Pressure
;
Cardiac Output
;
Electrocardiography
;
Fibrosis
;
Hemodynamics*
;
Humans
;
Liver Cirrhosis*
;
Liver*
;
Stroke Volume
;
Systole
;
Vascular Resistance
8.Hemodynamic Change in Liver Cirrhosis.
Nam Gi JOUNG ; Chul Woong KIM ; Jae Won RHO ; Jeong Chae KANG ; Ock Kyu PARK
Korean Circulation Journal 1979;9(2):27-36
The investigation of systolic time intervals and hemodynamics was performed in 42 patients with liver cirrhosis by noninvascive methods. The patients were divided into four groups according to the presence or absence of anemia and/or ascites: i.e. group I; cirrhosis without anemia and ascites, group II; cirrhosis with ascites only, group III; cirrhosis with anemia only, and group IV; cirrhosis with ascites and anemia. In the resting state of the patients, the systolic time intervals and hemodynamic data were measured by the high speed simultaneous recordings of electrocardiogram, phonocardiogram, carotid and femoral arterial pulse tracings, and compared with those obtained from 155 normal adult subjects. 1. The pulse were increased considerably in group IV, and diastolic blood pressure was elevated in group II with significance. 2. The stroke volume and cardiac output were increased significantly in group III. 3. The peripheral resistance was reduced particularly in group III, and the volume elasticit coefficient was decreased in group IV. 4. The QS1 interval was prolonged significantly in group II and IV, but QS1 interval corrected by multiple regression equation proposed by our laboratory (illustrated in the text) did not show significant difference compared with that of normal subjects. 5. The left ventricular ejection time(LVET) and total electromechanical systole(QS 2) appeared to be shortened in group II and IV, but the corrected LVET and QS 2 were not different significantly from those of the normal subjects
Adult
;
Anemia
;
Ascites
;
Blood Pressure
;
Cardiac Output
;
Electrocardiography
;
Fibrosis
;
Hemodynamics*
;
Humans
;
Liver Cirrhosis*
;
Liver*
;
Stroke Volume
;
Systole
;
Vascular Resistance
9.a study on The Effect of The Tobacco Price Raise on The Smoking Rate and Smoking Attributable Death.
Jong Won KANG ; Joung Soom KIM
Korean Journal of Preventive Medicine 1997;30(4):697-707
This study was performed to estimate the quantity of the effects of tobacco price raise on the smoking rate, and the smoking attributable deaths in Korea. The data were collected by questionnaire survey from 538 male office workers. The questionnaire contained items on age, sex, living place, status of education, smoking history, the intention to quit smoking when the tobacco price be raised. The questionnaire were distributed to the offices of enterprises, hospitals, research centers, and public agencies and then collected. Data were analyzed by using the age specific smoking rate, relative risks of eight major smoking related diseases, vital statistics, and the population attributable risk of deaths of smoking males. On the other hand, the impact of the tobacco price raise on the population attributable risk of death due to smoking in Korea was estimated by applying the presumed smoking rate after the price raise. The results obtained were as follows: 1. The smoking rate of male white color workers in large cities was 59.5%. 2. The proportion of male smokers who has the intention to quit smoking when the tobacco price be raised was 61.5%. 3. The proportion of male smokers who has the intention to quit smoking if the price of tobacco be raised was proportional to the degree of increasing tobacco price. It is estimated that if the tobacco price were raised more than four times as now, the presumed smoking rate goes down as low as 26.7%. If the tobacco price be raised 20% each year, presumed smoking rate is 46.2%. 4. The number of attributable male death of smoking estimated by using 8 major smoking related diseases(lung cancer, laryngeal cancer, esophageal cancer, stomach cancer, pancreatic cancer, cerebrovascular disease, ischemic heart disease, chronic obstructive pulmonary disease) was 25,863 death each year. That is 20.1% of total age over 20 male deaths. 5. If the tobacco price were raised more than four times as now and all smokers who has intention to quit smoking quits smoking, 12,336 lives, or 47.7% of smoking related deaths could be saved. 6. If the actual practice rate of quitting smoking among male smokers with intention to stop smoking when the price of tobacco be raised is 10%, 25%, or 50%, then the expected decrease of death numbers when the tobacco price were raised more than four times as now can be 1,112, 3,483, 5,796 respectively.
Chronic Disease
;
Education
;
Esophageal Neoplasms
;
Hand
;
Humans
;
Intention
;
Korea
;
Laryngeal Neoplasms
;
Male
;
Myocardial Ischemia
;
Pancreatic Neoplasms
;
Surveys and Questionnaires
;
Smoke*
;
Smoking*
;
Stomach Neoplasms
;
Tobacco*
;
Vital Statistics
10.The Comparison of the Effect of Enflurane and Propofol on Arterial Oxygenation during One-Lung Ventilation.
Sung Sik KANG ; In Chul CHOI ; Jin Mee JOUNG ; Ji Yeon SHIN ; Myung Won CHO
Korean Journal of Anesthesiology 1997;33(6):1121-1128
BACKGROUND: Controversy exists as to whether or not inhalation anesthetics and intravenous anesthetics impair arterial oxygenation (PaO2) during one lung ventilation (OLV). Accordingly, we examined the effect of enflurane and propofol on PaO2 and pulmonary vascular resistance (PVR) during OLV. METHODS: Forty patients, who had prolonged periods of OLV anesthesia with minimal trauma to the nonventilated lung were studied in a cross over design. Patients were randomized to four groups; Group 1 received 1 MAC of enflurane and oxygen from induction until the first 20 min after complete lung collapse, then were switched to propofol 100 g/kg/min (P100). In group 2, the order of the anesthetics was reversed. Group 3, Group 4 received the same order of the anesthetics as Group 1, Group 2, respectively but received propofol 200 g/kg/min (P200). RESULTS: During OLV, the PaO2 values were lower than those with two lung ventilation (TLV), there were no significant differences among each groups and between propofol and enflurane in PaO2, but in the selected patients (n=10, PaO2<120 mmHg during OLV), PaO2 in propofol group was higher than that of enflurane group (p<0.05). Conversion from TLV to OLV caused a significant increase in PVR, but there were no difference in PVR between propofol and enflurane group. CONCLUSIONS: These results suggest that the usual clinical dose of propofol affords no advantage over 1 MAC of enflurane anesthesia except low PaO2 patients during OLV. Propofol might be of value in risk patients of hypoxemia during thoracic surgery when OLV is planned.
Anesthesia
;
Anesthetics
;
Anesthetics, Inhalation
;
Anesthetics, Intravenous
;
Anoxia
;
Cross-Over Studies
;
Enflurane*
;
Humans
;
Lung
;
One-Lung Ventilation*
;
Oxygen*
;
Propofol*
;
Pulmonary Atelectasis
;
Thoracic Surgery
;
Vascular Resistance
;
Ventilation