1.Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies.
Arturo DOMINGUEZ ; Miquel BAYO ; Jesus MUNOZ-RODRIGUEZ ; Jose Antonio BELLIDO ; Jose Maria ABASCAL-JUNQUERA ; Naim HANNAOUI ; Josep Maria BANUS
Korean Journal of Urology 2015;56(11):785-787
Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in some cases. We present herein the case of a 52-year-old man with repeated spurious elevation of prostate-specific antigen, reaching levels of 108.7 ng/mL, that were suspected to be caused by heterophilic antibodies. The interference was solved by changing the analysis technique. Real values of prostate-specific antigen were less than 1 ng/mL.
Antibodies, Heterophile/*immunology
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False Positive Reactions
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Humans
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Luminescence
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Male
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Middle Aged
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Prostate-Specific Antigen/*blood
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Prostatic Neoplasms/blood/*diagnosis/immunology