1.Delayed-onset unilateral facial paralysis after mastoidectomy: A case report
Elbert Digger Q. Baloco, MD ; Jose B. Orosa III, MD
Philippine Journal of Otolaryngology Head and Neck Surgery 2023;38(1):50-53
Objective:
To discuss the case of a 36-year-old man who presented with left unilateral facial paralysis 11 days after mastoidectomy.
Methods:
Design: Case Report
Setting: Tertiary Government Training Hospital
Patient: One
Results:
A 36-year-old man with recurrent left ear discharge of 30 years duration underwent left canal wall-down mastoidectomy and was discharged well after 3 days. On follow up after 8 more days, he was noted to have House Brackmann IV left facial paralysis. Following 5 days methylprednisolone, neurologic evaluation and physical therapy rehabilitation, facial paralysis improved in the ensuing weeks until House-Brackmann I was achieved at week 12.
Conclusion
Delayed-onset Facial Palsy (DFP) following tympanomastoid surgery may be approached conservatively, including steroids, acyclovir, and, if with a history of herpes or varicella infection, immunization can be given. Prognosis for DFP is good especially when the facial nerve is identified intraoperatively during otologic surgeries
facial nerve
;
mastoidectomy
2.Human Papillomavirus Serologic Profiles of Selected Filipinos with Head and Neck Squamous Cell Carcinoma
Pia Marie ALBANO ; Christianne SALVADOR ; Jose OROSA ; Sheryl RACELIS ; Modesty LEAÑO ; Angelika MICHEL ; John Donnie RAMOS ; Dana HOLZINGER ; Michael PAWLITA
Journal of Pathology and Translational Medicine 2019;53(5):273-279
BACKGROUND: The low prevalence of human papillomavirus (HPV) DNA and mRNA in biopsy samples of Filipinos with head and neck squamous cell carcinoma (HNSCC) has been reported previously. Here, the HPV serologic profiles of HNSCC cases were analyzed and associated with lifestyle and sexual practices. METHODS: Serum samples were collected between May 2012 and September 2013 from HNSCC patients (n = 22) in the northwest region of the Philippines, and age- and sex-matched clinically healthy controls. Antibodies to capsid and early oncoproteins of HPV16, 18, 31, 33, 45, 52, 58, 6, and 11 were analyzed using multiplex serology. RESULTS: Most of the cases were males with tumors of the oral cavity or larynx. Two of the cases tested positive for at least one of the early oncoproteins (E6, E7, E1, and/or E2) of HPV16, and 11 did not display reactivity to any HPV early or late oncoproteins. Of the controls, four tested positive for at least one of the HPV16 early oncoproteins, and 10 were non-reactive to all HPV types. Titers to HPV16 E6 or E7 of the seropositive cases and controls were considerably lower than those typically observed in economically developed countries. CONCLUSIONS: The low HPV titers seen here are consistent with the results of molecular analyses for this population. Hence, the seropositivity of some of the HNSCC cases is likely an indication of prior exposure to the virus and not the presence of HPV-driven tumors.
Antibodies
;
Biopsy
;
Capsid
;
Carcinoma, Squamous Cell
;
Developed Countries
;
DNA
;
Epithelial Cells
;
Head
;
Humans
;
Larynx
;
Life Style
;
Male
;
Mouth
;
Neck
;
Oncogene Proteins
;
Philippines
;
Prevalence
;
RNA, Messenger