1.Long term psychosocial outcomes of congenital heart disease in adolescents and young adults.
Maria Emilia Guimãraes AREIAS ; Catarina I PINTO ; Patrícia F VIEIRA ; Flávio TEIXEIRA ; Rosália COELHO ; Isabela FREITAS ; Samantha MATOS ; Marta CASTRO ; Sofia SARMENTO ; Victor VIANA ; Jorge QUINTAS ; José C AREIAS
Chinese Journal of Contemporary Pediatrics 2013;15(10):810-816
OBJECTIVECongenital heart disease (CHD) is a chronic illness with a high frequency in the worldwide population, and is normally diagnosed at birth or in uterus. Because of better conditions in diagnosis and early medical and surgical treatment, patients have survival rates of 90% and go further and further in life, facing different challenges in life cycle. In this study, we tested the effects of different demographic, clinical and psychosocial variables on the perception of quality of life (QOL), on psychosocial adjustment (PSA) and psychiatric morbidity (PM) of adolescents and young adults with CHD. We aimed to evaluate QOL, PM and PSA of adolescents and young adults with CHD and to determine which variables (demographic, clinical, and psychosocial) play a role in buffering stress and promoting resilience and which ones have a detrimental effect.
METHODSThe study enrolled 150 CHD patients (87 males and 63 females), 12 to 26 years (17.45±3.373 years). The participants were interviewed regarding social support, family educational style, self-image, demographic information and physical limitations. They responded to questions in a standardized psychiatric interview (SADS-L) and completed self-reports questionnaires for assessment of QOL (WHOQOL-BREF) and PSA (YSR/ASR).
RESULTSWe found a 18.7% lifetime prevalence of psychopathology in our participants (25.4% in females and 13.8% in males). 57.1% had retentions in school (1.53±0.804 year). The perception of QOL of CHD patients is better compared to the Portuguese population in the social relationships, environmental, physical and general dimensions. However, it is worse in female CHD patients and patients with poor academic performance and social support as well as in patients with complex or cyanotic CHD, moderate-to-severe residual lesions and physical limitations, and undergoing surgery. All of these variables, except presence of cyanosis, are also associated to a worse PSA.
CONCLUSIONSFemale patients and patients with poor academic performance and poor social support refer worse PSA and QOL.
Adaptation, Psychological ; Adolescent ; Adult ; Child ; Female ; Heart Defects, Congenital ; psychology ; Humans ; Male ; Morbidity ; Quality of Life ; Social Support ; Young Adult
2.Application of antigenic biomarkers for Mycobacterium tuberculosis.
Elba RODRÍGUEZ-HERNÁNDEZ ; Laura Itzel QUINTAS-GRANADOS ; Susana FLORES-VILLALVA ; Jorge Germinal CANTÓ-ALARCÓN ; Feliciano MILIÁN-SUAZO
Journal of Zhejiang University. Science. B 2020;21(11):856-870
The study and characterization of biomolecules involved in the interaction between mycobacteria and their hosts are crucial to determine their roles in the invasion process and provide basic knowledge about the biology and pathogenesis of disease. Promising new biomarkers for diagnosis and immunotherapy have emerged recently. Mycobacterium is an ancient pathogen that has developed complex strategies for its persistence in the host and environment, likely based on the complexity of the network of interactions between the molecules involved in infection. Several biomarkers have received recent attention in the process of developing rapid and reliable detection techniques for tuberculosis. Among the most widely investigated antigens are CFP-10 (10-kDa culture filtrate protein), ESAT-6 (6-kDa early secretory antigenic target), Ag85A, Ag85B, CFP-7, and PPE18. Some of these antigens have been proposed as biomarkers to assess the key elements of the response to infection of both the pathogen and host. The design of novel and accurate diagnostic methods is essential for the control of tuberculosis worldwide. Presently, the diagnostic methods are based on the identification of molecules in the humoral response in infected individuals. Therefore, these tests depend on the capacity of the host to develop an immune response, which usually is heterogeneous. In the last 20 years, special attention has been given to the design of multiantigenic diagnostic methods to improve the levels of sensitivity and specificity. In this review, we summarize the state of the art in the study and use of mycobacterium biomolecules with the potential to support novel tuberculosis control strategies.