1.Correction: Mixed Neuroendocrine-non-neuroendocrine Neoplasm of the Stomach that is Distributed in Depth on the Same Tumor: Inconsistent with the Definition of Mixed Adenoneuroendocrine Carcinoma in the 2010 World Health Organization Classification of Tumors of the Digestive System
Joonho JEONG ; Kyoungwon JUNG ; Jae Hyun KIM ; Sung Eun KIM ; Won MOON ; Moo In PARK ; Seun Ja PARK
The Korean Journal of Gastroenterology 2020;75(1):63-63
This correction is being published to correct the 1st author's English name in above article.
2.A Case of Lithium-Induced Upper Extremity Peripheral Polyneuropathy and Nephrogenic Diabetes Insipidus.
Myounghun CHAE ; Jaehyung PARK ; Taehyeon HWANG ; Kyuyong KO ; Jinchul KIM ; Changhwan KIM ; Woochul JOO ; Joonho SONG ; Moon Jae KIM ; SeoungWoo LEE
Soonchunhyang Medical Science 2013;19(2):140-143
Lithium is the drug of choice for treating bipolar affective disorders. However, it has a narrow therapeutic index and acute and chronic toxicity can occur in patients with chronic ingestion. Chronic toxicity commonly presents as nephrogenic diabetes insipidus or thyroid dysfunction. Neurologic symptoms such as apathy, hyperreflexia, or clonus can also occur in acute toxicity. However, it rarely causes peripheral neuropathy. We experienced a case of lithium-induced peripheral polyneuropathy who had already nephrogenic diabetes insipidus and chronic kidney disease during 25 years of lithium ingestion due to bipolar disorder.
Apathy
;
Bipolar Disorder
;
Diabetes Insipidus
;
Diabetes Insipidus, Nephrogenic*
;
Eating
;
Humans
;
Lithium
;
Mood Disorders
;
Neurologic Manifestations
;
Peripheral Nervous System Diseases
;
Polyneuropathies*
;
Reflex, Abnormal
;
Renal Insufficiency, Chronic
;
Thyroid Gland
;
Upper Extremity*
3.Relationship between pregnancy rate and serum progesterone concentration in cases of porcine embryo transfer.
Joonho MOON ; Ji Yei CHOI ; Jung Taek KANG ; Sol Ji PARK ; Su Jin KIM ; Goo JANG ; Byeong Chun LEE
Journal of Veterinary Science 2014;15(1):167-171
The level of P4 at the time of embryo transfer (ET) is important. P4 concentrations and numbers of corpora lutea for 126 recipients were evaluated. Nuclear transfer embryos were transferred into 126 surrogates. 11 maintained their pregnancy until full-term delivery, 17 miscarried, and implantation failed in 98 animals. P4 levels in the full-term group were significantly different from those of the pigs that aborted or in which implantation failed (p < 0.05). However, the numbers of corpora lutea were not significantly different. These findings indicate that the concentration of progesterone can be an important factor for successful ET in pigs.
Animals
;
Corpus Luteum/*physiology
;
Embryo Transfer/*veterinary
;
Embryo, Mammalian/*physiology
;
Female
;
Nuclear Transfer Techniques
;
Pregnancy
;
*Pregnancy Rate
;
Progesterone/*blood
;
Retrospective Studies
;
Sus scrofa/*physiology
4.The Effect of Anti-reflux Therapy on Patients Diagnosed with Minor Disorders of Peristalsis in High-resolution Manometry.
Joonho JEONG ; Sung Eun KIM ; Moo In PARK ; Seun Ja PARK ; Won MOON ; Jae Hyun KIM ; Kyoungwon JUNG ; Youn Jung CHOI ; Jun Yeob LEE ; Young Dal LEE
The Korean Journal of Gastroenterology 2017;69(4):212-219
BACKGROUND/AIMS: Minor disorders of peristalsis are esophageal motility disorders categorized by the Chicago Classification (CC), version 3.0, which was announced in 2014. This study evaluated the efficacy of anti-reflux therapy in patients with minor peristaltic disorders. METHODS: Patients with minor peristaltic disorders in accordance with CC v3.0 were included. We reviewed the medical records of patients with esophageal high-resolution manometry findings, and investigated the demographic and clinical information as well as the medical therapy. Thereafter, the response to treatment was assessed after at least 4 weeks of treatment. RESULTS: A total of 24 patients were identified as having minor disorders of peristalsis from January 2010 to December 2015. The mean follow-up period was 497 days, and there were 17 patients (70.8%) patients with ineffective esophageal motility. In terms of anti-reflux therapy, proton pump inhibitors (PPIs) with prokinetic agents and PPIs alone were prescribed in 19 patients (79.2%) and 5 patients (20.8%), respectively. When the rate of response to the treatment was assessed, the responders rate (complete+satisfactory [≥50%] responses) was 54.2% and the non-responders rate (partial [<50%]+refractory responses) was 45.8%. Patients in the responder group were younger than those in the non-responder group (p=0.020). Among them, 13 patients underwent 24-hour multichannel intraluminal impedance-pH, and 10 patients (76.9%) were pathologic gastroesophageal reflux. CONCLUSIONS: The majority of esophageal minor peristaltic disorders were accompanied by gastroesophageal reflux, and therefore, they might respond to acid inhibitor. Further well-designed, prospective studies are necessary to confirm the effect of anti-reflux therapy in these patients.
Classification
;
Esophageal Motility Disorders
;
Follow-Up Studies
;
Gastroesophageal Reflux
;
Humans
;
Manometry*
;
Medical Records
;
Peristalsis*
;
Prospective Studies
;
Proton Pump Inhibitors
;
Proton Therapy
;
Treatment Outcome
5.Coil-Protected Technique for Liquid Embolization in Neurovascular Malformations
Keun Young PARK ; Jin Woo KIM ; Byung Moon KIM ; Dong Joon KIM ; Joonho CHUNG ; Chang Ki JANG ; Jun Hwee KIM
Korean Journal of Radiology 2019;20(8):1285-1292
OBJECTIVE: To evaluate the safety and efficacy of the coil-protected technique for liquid embolization in neurovascular malformations. MATERIALS AND METHODS: Twenty-two patients who underwent coil-protected liquid embolization for symptomatic cranial (n = 13) and spinal (n = 9) arteriovenous fistula (AVF) or arteriovenous malformations (AVMs) were identified. A total of 36 target feeder vessels were embolized with N-butyl cyanoacrylate and/or Onyx (Medtronic). This technique was used to promote delivery of a sufficient amount of liquid embolic agent into the target shunt or nidus in cases where tortuous feeding arteries preclude a microcatheter wedging techniqu and/or to prevent reflux of the liquid embolic agent in cases with a short safety margin. The procedure was considered technically successful if the target lesion was sufficiently filled with liquid embolic agent without unintentional reflux. Angiographic and clinical outcomes were retrospectively evaluated. RESULTS: Technical success was achieved for all 36 target feeders. Post-embolization angiographies revealed complete occlusion in 16 patients and near-complete and partial occlusion in three patients each. There were no treatment-related complications. Of the six patients who showed near-complete or partial occlusion, five received additional treatments: two received stereotactic radiosurgery for cerebral AVM, two underwent surgical removal of cerebral AVM, and one underwent additional embolization by direct puncture for a mandibular AVM. Finally, all patients showed complete (n = 19) or near-complete (n = 3) occlusion of the target AVF or AVM on follow-up angiographies. The presenting neurological symptoms improved completely in 15 patients (68.2%) and partially in seven patients (31.8%). CONCLUSION: The coil-protected technique is a safe and effective method for liquid embolization, especially in patients with various neurovascular shunts or malformations who could not be successfully treated with conventional techniques.
Angiography
;
Arteries
;
Arteriovenous Fistula
;
Arteriovenous Malformations
;
Cyanoacrylates
;
Follow-Up Studies
;
Humans
;
Methods
;
Punctures
;
Radiosurgery
;
Retrospective Studies
6.A Newly-Developed Flow Diverter (FloWise) for Internal Carotid Artery Aneurysm: Results of a Pilot Clinical Study
Byung Moon KIM ; Keun Young PARK ; Jae Whan LEE ; Joonho CHUNG ; Dong Joon KIM ; Dong Ik KIM
Korean Journal of Radiology 2019;20(3):505-512
OBJECTIVE: We report the results of a pilot clinical study that evaluated the safety and efficacy of a newly-developed, retrievable flow diverter (FloWise; Taewoong Medical) for the treatment of internal carotid artery (ICA) aneurysm. MATERIALS AND METHODS: A total of 10 patients were enrolled. Inclusion criteria were 1) unruptured aneurysm with a dome size of ≥ 8 mm and a neck size of ≥ 4 mm at the ICA, or 2) two or more unruptured aneurysms of any size able to be spanned by a single FloWise at the ICA. Co-primary effectiveness end points were technical success of FloWise placement, and a 50% or greater decrease in aneurysm volume at the 6-month follow-up angiogram. The primary safety end point was the new development of neurological deficits persisting for more than 1-month post-treatment. RESULTS: Ten patients harboring 14 ICA aneurysms (median diameter, 9.4 mm; range, 2.3–31.0 mm) were enrolled between January 2016 and July 2017. FloWise placement was successful in all patients. There were no newly-developed neurological deficits during the 6-month clinical follow-up period. One patient did not receive follow-up imaging due to pregnancy. Nine patients with 12 aneurysms received a 6-month angiographic follow-up. Ten aneurysms (83.3%) showed decreases in volume greater than 50% (mean volume decrease, 82.8 ± 32.9%), of which 8 (66.7%, 95% confidence interval, 35.4–98.0%) showed complete occlusion. One patient was retreated due to mass symptom aggravation. CONCLUSIONS: In this pilot study, FloWise appeared to be safe and effective for ICA aneurysm treatment. A prospective multicenter study to validate the effectiveness and safety of FloWise would be worthwhile.
Aneurysm
;
Carotid Artery, Internal
;
Clinical Study
;
Follow-Up Studies
;
Humans
;
Intracranial Aneurysm
;
Neck
;
Pilot Projects
;
Pregnancy
;
Prospective Studies
7.Expression of Growth Factors and Cytokines in Patients withDegenerated Disc Disease and Herniated Nucleus Pulposus.
Chan Sam MOON ; Seung Cheol LEE ; Woon Won JUNG ; Donggeun SUL ; Young Ki HONG ; Hyun Sook KIM ; Joonho WANG ; Sang Heon LEE
Journal of the Korean Academy of Rehabilitation Medicine 2009;33(3):304-308
OBJECTIVE: To investigate the expression of cytokines and growth factors in disc specimens obtained from small numbers of patients with herniated nucleus pulposus (HNP) and degenerated disc disease (DDD). METHOD: A total of ten human intervertebral disc samples consisted of five painful degenerative discs and five herniated intervertebal discs were obtained from surgery. MRI and Western blot analyses on these disc samples were performed to determine the levels of disc degeneration and the expression levels of cytokines and growth factors. RESULTS: The levels of IL-6 were significantly greater in the DDD patients than in the HNP patients, but no statistical differences were observed in the expression of IL-1beta, IL-8 and TNF-alpha between the HNP and DDD patients. In addition, the expression of TGF beta was significantly higher in the DDD patients than in the HNP patients. CONCLUSION: The higher levels of cytokine and growth factor expression in the DDD than in the HNP show why discogenic patients usually have more severe back pain than patients with herniated discs.
Back Pain
;
Blotting, Western
;
Cytokines
;
Dichlorodiphenyldichloroethane
;
Humans
;
Intercellular Signaling Peptides and Proteins
;
Interleukin-6
;
Interleukin-8
;
Intervertebral Disc
;
Intervertebral Disc Degeneration
;
Intervertebral Disc Displacement
;
Tumor Necrosis Factor-alpha
8.Longitudinal Observation of Early-Onset Alzheimer’s Disease Dementia with Positive CSF Biomarkers/Negative Amyloid-β Positron-Emission Tomography
Min Hye KIM ; Joonho LEE ; Hong Nam KIM ; In Ja SHIN ; Keun LEE ; Yoon Seob KIM ; Sun Min LEE ; Sun Ah PARK ; So Young MOON
Journal of the Korean Neurological Association 2021;39(3):214-218
We report a 61-year-old woman with clinical course for Alzheimer’s disease (AD) dementia and discordant amyloid-β positron-emission tomography (PET) and cerebrospinal fluid biomarkers. Brain magnetic resonance imaging revealed remarkable atrophy in the hippocampus. However, repeated delayed 18F-flutemetamol brain amyloid PET images with 1 year-interval revealed no amyloid deposition, whereas her CSF revealed low Aβ42, high total tau and p-tau181. This discordant amyloid-β PET and CSF biomarkers in this early-onset AD dementia might be associated with her low resilience or mixed pathology.
9.Asymmetric Amyloid-β Burden and Neurodegeneration in Late-Onset Alzheimer’s Disease Dementia
Joonho LEE ; Hong Nam KIM ; Min Hye KIM ; In Ja SHIN ; Keun LEE ; Yoon Seo KIM ; Sun Min LEE ; So Young MOON
Journal of the Korean Neurological Association 2021;39(3):197-201
We report herein a 78-year-old woman with insidiously progressive cognitive impairment and asymmetric amyloid deposition and neurodegeneration. Brain magnetic resonance imaging revealed remarkable atrophy in the right-sided temporal lobe and hippocampus. Early dynamic 18F-flutemetamol brain amyloid positron-emission tomography images showed decreased uptake in the right temporoparietal regions. Delayed images revealed amyloid deposition which was most remarkable in the right frontotemporoparietal regions. Asymmetries of amyloid burden and neuronal dysfunction are positively correlated in Alzheimer’s disease in cortical regions with high amyloid load.
10.Longitudinal Observation of Early-Onset Alzheimer’s Disease Dementia with Positive CSF Biomarkers/Negative Amyloid-β Positron-Emission Tomography
Min Hye KIM ; Joonho LEE ; Hong Nam KIM ; In Ja SHIN ; Keun LEE ; Yoon Seob KIM ; Sun Min LEE ; Sun Ah PARK ; So Young MOON
Journal of the Korean Neurological Association 2021;39(3):214-218
We report a 61-year-old woman with clinical course for Alzheimer’s disease (AD) dementia and discordant amyloid-β positron-emission tomography (PET) and cerebrospinal fluid biomarkers. Brain magnetic resonance imaging revealed remarkable atrophy in the hippocampus. However, repeated delayed 18F-flutemetamol brain amyloid PET images with 1 year-interval revealed no amyloid deposition, whereas her CSF revealed low Aβ42, high total tau and p-tau181. This discordant amyloid-β PET and CSF biomarkers in this early-onset AD dementia might be associated with her low resilience or mixed pathology.