1.Congenital Pulmonary Lymphangiectasis.
Korean Journal of Legal Medicine 1999;23(1):82-87
Congenital pulmonary lymphangiectasis is a rare cause of severe respiratory distress in the newborn period and most of these patient die, usually within the first 24 hours of life. The light microscopic characteristics of the lungs are a network of partly tubular, partly cystically enlarged lymph vessels within large areas of connective tissue and they have thin wall lined by endothelium. Also congenital pulmonary lymphangiectasis is closely associated with cardiovascular malformation, and most frequently occurs in the clinical setting of congenital heart disease with or without pulmonary venous obstruction(total anomalous venous return, atresia of large pulmonary veins) The authors describe three typical cases of congenital pulmonary lymphangiectasis.
Connective Tissue
;
Endothelium
;
Heart Defects, Congenital
;
Humans
;
Infant, Newborn
;
Lung
;
Lymphangiectasis*
;
Lymphangioleiomyomatosis
2.Endoscopic Removal of Upper Gastrointestinal Tract Foreign Body.
Woo Joong KIM ; Myung Seok LEE
Korean Journal of Gastrointestinal Endoscopy 1992;12(2):227-230
The clinical review was done on 17 cases with the foreign body in the upper gastrointestinal tract who underwent endoscopic removal of foreign body at Kang Nam Sacred Heart Hospital from Dec. 1981 to Dec. 1991. The results were as follows: 1) The age distribution varies from 3 months to 72 years of age, being most prevalent under 5 years of age. 2) The incidence of foreign body in the order of frequency was coin, fish bone, safety pinring, peanut, keyring, food bolus, artificial teeth and medal. Among 17 cases, 9 cases(53.0%) were lodged in the esophagus and 8 cases(47.0%) were lodged in the stomach. 3) Dysphagia or globus was the common symptom in 8 cases(47.2%), followed by absence of symptom in 7 cases(41.2%), upper abdominal discomfort in 1 case(5.8%) and vomiting in 1 case (5.8%). 4) l0 cases(58.8%) of foreign body were removed within 72 hours and 7 cases(41.2%) of foreign body were removed after 72 hours.
Age Distribution
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Deglutition Disorders
;
Esophagus
;
Foreign Bodies*
;
Heart
;
Incidence
;
Numismatics
;
Stomach
;
Tooth, Artificial
;
Upper Gastrointestinal Tract*
;
Vomiting
4.Unusual Cutaneous Manifestations of Connective Tissue Diseases III. Lupus Erythematosus Profundus Developed on the Discoid Cutaneous Lesions.
Chang Woo LEE ; Jin Tack LEE ; Joong Hwan KIM
Korean Journal of Dermatology 1986;24(2):296-299
A 56-year-old woman presenting a 10-year history of atrophic discoid patches with underlying subcutaneous nodules was seen. These skin lesions were distributed on the upper arms bilaterally. Biopsy specimens taken from the lesional skin showed epidermal and dermal changes consistent with the discoid lesions of the cutaneous lupus erythematosus. Deep dermis and subcutaneous fat tissue revealed sclerosis and fibrinoid alterations of the collagen and necrosis of fat cells, the features corresponding to the lupus ei ythematosus profundus. She had no laboratory evidences suspective of systemic lupus erythematosus or other connective tissue diseases. This patient with lupus erythernatosus profundus which cleveloped subsequent to the discoid lesion is consiclered to be a rarely encounteririg observation in lupus erythematosus.
Adipocytes
;
Arm
;
Biopsy
;
Collagen
;
Connective Tissue Diseases*
;
Connective Tissue*
;
Dermis
;
Female
;
Humans
;
Lupus Erythematosus, Cutaneous
;
Lupus Erythematosus, Systemic
;
Middle Aged
;
Necrosis
;
Panniculitis, Lupus Erythematosus*
;
Sclerosis
;
Skin
;
Subcutaneous Fat
5.Effects of Adenosine 5'-Tetraphosphate on the Cardiac Activity*.
Joong Woo LEE ; Kyu Sang PARK ; In Deok KONG
Korean Circulation Journal 1996;26(3):704-712
BACKGROUND: Adenosine 5'-tetraphosphate(ATPP), an endogenous nucleotide, is stored in cells and released into the extracellular space upon stimulation. Some of the biological responses to ATPP were reported, but characteristics of its receptor were not well known. Present study was conducted to investigate the effects of ATPP on mechanical contractility, resting membrane potential and action potential of rat left atrium. METHODS: Left atrium was isolated from Sprague-Dawley rat. Mechanical contraction induced by electrical field stimulation(EFS) was recorded on polygraph using force transducer. With glass microelectrodes(10 MOmega), potential difference across the membrane was measured and recorded on an oscilloscope and a polygraph. RESULTS: ATPP reduced the left atrial contractility with concentration-dependent manner. ATPP also hyperpolarized the resting membrane potential and decreased the action potential duration of the left atrial cell. Nucleotides other than ATPP, such as ATP, ADP, AMP and adenosine, have the same effect as ATPP. However, there is no difference among the nucleotides. Prior treatment of DPCPX, a P1-purinoceptor blocker, inhibited the ATPP-induced negative inotropism and changes of the membrane potential. But suramin, a nonselective P2-purinoceptor blocker, did not alter the effects of ATPP. alpha, beta methylene ADP and adenosine deaminase, which attenuates hydrolysis of adenine nucleotides and inactivates adenosine respectively, did not influence the effects of adenine nucleotides except for adenosine. CONCLUSION: ATPP reduced the mechanical contractility, hyperpolarized the resting membrance potential and decreased duration of action potential of rat left atrium. These effects were induced by ATPP directly, not by adenosine from hydrolyzed ATPP.
Action Potentials
;
Adenine Nucleotides
;
Adenosine Deaminase
;
Adenosine Diphosphate
;
Adenosine Triphosphate
;
Adenosine*
;
Animals
;
Extracellular Space
;
Glass
;
Heart Atria
;
Hydrolysis
;
Membrane Potentials
;
Membranes
;
Muscle Contraction
;
Nucleotides
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, Purinergic
;
Suramin
;
Transducers
6.An Echophonocardiographic Study on Left Ventricular Isovolumic Relaxation Time.
Joong Gil LEE ; Yung Woo SHIN ; Yung Kee SHIN
Korean Circulation Journal 1982;12(2):109-119
Cardiac relaxation is impaired in many cardiac disorders and is the subject of extensive investigation. Though measurement of isovolumic relaxation time ought to prove a simple means of quantifying such abnormalities in clinical practice, the problem of defining the timing of mitral valve opening at the onset of ventricular filling has been a difficulty. previous studies have used the 'O' point of the apexcardiogram, but more recently it has been shown that this may be open to considerable error. It was the purpose of the present study to determine the duration of true isovolumic relaxation and the factors influencing its duration, and to evaluate its use as a simple noninvasive measurement of cardiac dynamics in terms of the present approach. True isovolumic relaxation time (IRT) was measured noninvasively from the onset of the aortic component of the second heart sound to the onset of rapid opening of the mitral leaflets from simultaneous recording of echocardiogram, phonocardiogram, electrocardiogram and carotid tracing in 60 normal subjects, 30 male and 30 female and in 50 with hypertension, 28 male and 22 female ranging in age from 20 to 45 years. 1. The duration of IRT was 53.6+/-9.9 msec in normal subjects with no relation to sex. 2. IRT was related to heart rate, systemic blood pressure, and systolic and diastolic time intervals. 1) IRT tended to decrease with increasing heart rate and a regression equation for predicting it in relation to heart rate was 'IRT(msec)=88.97-0.466xH.R.(beats/min)' (P<0.01). 2) IRT tended to increase with increasing systemic blood pressure and a regression equation for predicting it in relation to aortic closing pressure was 'IRT(msec)=5.09+0.459xaortic closing pressure(mmHg)' (P<0.01). IRT was prolonged in patient with hypertension. 3) IRT was in close relation to left ventricular contraction indices such as preejection period(PEP), isovolumic contraction time and preejection period/left ventricular ejection time ratio. 4) There was no relation between IRT and left ventricular pump performance indices such as stroke volume, ejection fraction, fractional shortening and left ventricular dimension. 5) There was strong association between IRT and diastolic time intervals. Authors were impressed through this study that IRT is a useful measurement of left ventricular dynamics in early diastole.
Blood Pressure
;
Diastole
;
Electrocardiography
;
Female
;
Heart Rate
;
Heart Sounds
;
Humans
;
Hypertension
;
Male
;
Mitral Valve
;
Relaxation*
;
Stroke Volume
7.A Case of Benign Lichenoid Keratosis.
Hoon HUR ; Chang Woo LEE ; Joong Hwan KIM
Korean Journal of Dermatology 1987;25(2):260-263
A case of benign lichenoid keratosis(BLK) developed in a 25-year-old female is presented. She had two erythematous plaques with slightly verrucous surfaces on the lips for 4 weeks. A biopsy specirnen taken from the periphery of the lesion revealed a focal parakeratosis, the absence of granular cells, and hydropic degeneration of the basal cells in the epidermis. The upper dermal infiltrate composed chiefly of lymphacytes intermingled with a few histiocytes was also seen. The direct immunofluorescent study showed depositions of a few cytoid bodies and fibrin around the areas of the dermoepidermal junction. These plaques on her lips, demonstrating lichenoid tissue changes, cleared in 8 weeks from the evalution, without any treatment.
Adult
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Biopsy
;
Epidermis
;
Female
;
Fibrin
;
Histiocytes
;
Humans
;
Keratosis*
;
Lip
;
Parakeratosis
9.The Spitz Nevus on the Areola.
Yu Ri WOO ; Dae Won KOO ; Joong Sun LEE
Korean Journal of Dermatology 2014;52(4):281-283
No abstract available.
Nevus, Epithelioid and Spindle Cell*
10.An Immunofluorescent Study of Majocchi' s Disease.
Chang Woo LEE ; Hee Chul EUN ; Joong Hwan KIM
Korean Journal of Dermatology 1984;22(5):467-470
Majocchi's disease is one of chronic vascular disorders of the skin, histologically showing capillaritis with lymphoid cell infiltration. Although the hypothesis of delayed type hypersensitivity reaction against foreign antigen is proposed as the mechanism producing this condition, there are much yet to be defined. We tried to examine the lesional skin of five patients with Majocchi's disease by the direct immunofluorescence with anti-human immunoglobulins, C 3, and fibrin. As a result we found the deposition of immunoglobulins (M, and G) in papillary blood vessels in four patients, and C 3 and fibrin were found in all five patients. C3 was also found at the dermoepidermal junction in three patients. These findings suggest the posssibility that antibody mediated immunologic processes may alsobe involved in the pathogenesis of this disorder. With this observation Majocchis disease could be considered as a chronic immune vasculitis.
Blood Vessels
;
Fibrin
;
Fluorescent Antibody Technique, Direct
;
Humans
;
Hypersensitivity
;
Immunoglobulins
;
Lymphocytes
;
Skin
;
Vasculitis