This is an attempt to investigate the histopathological change of 246 cases of leprosy especially in the healing stage of leprosy. The results are summerized as follows: 1. Histopathological findings in the healing stage of leprosy, a) More than half of the cases showed only a slight degree of inflammatory cell infiltration in the group that had received treatment for more than 7 years. b) About half the cases (46.9%) showed marked changes of collagen fiber that is mainly swelling and hypertrophy. c) In 40.6% of the cases, elastic fiber manifested hypertrophy, coarseness and curling. d) Changes of elastic fiber was markedly decreased in the cases which had received more than 7 years treatment. e) Inflammatory infiltration was located mainly in the upper dermis and the infiltration around the blood vessels and skin appendages were not changed and remained regardless of duration of treatment. Histopathological findings in the group of lepromatous type. a) The free zone of the upper dermis disappeared in most cases. b) The cases with moderate inflammatory infiltration were most common and they were located mainly in the mid dermis. The degree of infiltration was not markedly changed according to the duration of treatment. c) Inflammatory infiltration around the blood vessels and skin appendages were more common than that of the healing stage. d) Changes of collagen fiber was manifested mainly hypertrophy and swelling and it was recognized throughout the entire course of the treatment. Elastic fiber found to be curled and coarse in most cases of lepromatous leprosy. Atrophy of elastic fiber was observed in cases of long treatment. 3. Histopathological findings in the group of tuberculoid type. Changes of collagen fiber was slighter than that of the lepromatous type and was manifested swelling and hypertrophy. Elastic fiber coarseness was observed in many cases.
Atrophy ; Blood Vessels ; Collagen ; Dermis ; Elastic Tissue ; Hypertrophy ; Leprosy ; Leprosy, Lepromatous ; Skin*

Pityriasis Circinata is a rare, symptomless, etiologically uncertain disease, but often associated with chronic illness such as Tuberculosis, diseases of uterus and ovaries. It was first described- in Japan by Toyama(1906), Matsura(1906), then reported in South Africa, France, England, Germany, and North-Africa. However, much more frequent evidence noted in Far East. Many authers agree that this condition is a specific localized type of acquired ichthyosis. This disease is manifested by strictly round scaly, light or dark brownish ichthyotic patches of variable number and diameter. Mainly distributed on trunk, and extremities with freedom of flexure. And having history of winter exacerbation and summer remission. These two cases of pityriasis Circinata are, although Toyama quoted 4 Korean patients reports and 2 cases of Manchuria, the first report in Korea, which have been associated with tuberculous empyema and meningitis, respectively.
China ; Chronic Disease ; Empyema, Tuberculous ; England ; Extremities ; Far East ; Female ; France ; Freedom ; Germany ; Humans ; Ichthyosis ; Japan ; Korea ; Meningitis ; Ovary ; Pityriasis* ; South Africa ; Tuberculosis ; Uterus

A case of 24 years old male patient with Acrodermatitis continua(Hallopeau) is reported. Clinically, the skin lesions were characterized by the pustular eruption on digit of extremities. Diagnosis was conformed by characteristic clinical appearance, laboratory findings and histopathology finding. He has been treated with prednisolone 20 mg daily, antibiotics and symptomatic therapy and relieved temporaly.
Acrodermatitis* ; Anti-Bacterial Agents ; Diagnosis ; Extremities ; Humans ; Male ; Prednisolone ; Skin ; Young Adult

PURPOSE: Metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs) have been linked to the angiogenic process in general. In order to understand the potential roles of MMPs and TIMPs in corneal neovascularization process, we examined the expression and activities of MMP-2, MMP-9, TIMP-1 and TIMP-2 during the course of suture-induced corneal neovascularization in rat model. METHODS: Corneal neovascularization of rat cornea was induced by suturing. The expression of MMP-2, MMP-9, TIMP-1 and TIMP-2 in sutured corneas was examined by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). The activities of MMP-2 and MMP-9 were measured before and after suture by gelatin zymography. RESULTS: MMP-2 proenzyme, and TIMP-1, -2 were expressed in normal corneas, predominantly in corneal epithelium. After injury, expression of MMP-2, MMP-9, TIMP-1 and TIMP-2 increased, notably in healing corneal epithelium, infiltrating inflammatory cells, stromal fibroblasts, and ingrowing vascular endothelial cells. The intensity of immunostaining and enzymatic activities of MMP-2 and MMP-9 paralleled the magnitude of inflammatory cell infiltration, which peaked around day 7 after suture. Immunoreactivity of MMP/TIMP decreased significantly two weeks after suturing. At day 35 after suture, staining of MMP-2, TIMP-1, -2 remained visible only in corneal epithelium and vascular endothelial cells. CONCLUSIONS: MMPs as well as TIMPs were upregulated during suture-induced corneal neo-vascularization, suggesting that both may take part in extracellular matrix remodeling in the corneal wound healing, inflammatory, and neovascularization processes.
Animals ; Cornea ; Corneal Neovascularization* ; Endothelial Cells ; Epithelium, Corneal ; Extracellular Matrix ; Fibroblasts ; Gelatin ; Immunohistochemistry ; Matrix Metalloproteinase 2* ; Matrix Metalloproteinases ; Metalloproteases ; Models, Animal ; Rats ; Stromal Cells ; Sutures ; Tissue Inhibitor of Metalloproteinase-1* ; Tissue Inhibitor of Metalloproteinase-2 ; Wound Healing

PURPOSE: To evaluate the findings and the role of contrast enhanced magnetic resonance imaging in avascular necrosis of femoral head. MATERIALS AND METHODS: Sixteen patients with avascular necrosis of femoral head were examined with MRI. Tl-weighted and T2-weighted images and contrast-enhanced Tl-weighted images were obtained. Enhancing characteristics of the necrotic area and synovium were determined. Also a change of the disease extent after enhancement was assessed. RESULTS: Twenty seven avascular necrosis of the femoral head including 11 cases of bilateral lesion were detected. Fifteen cases revealed collapse of the femoral head. The portions of the lesion with low signal intensity on Tl-weighted images and high signal intensity on T2-weighted images showed contrast enhancement in 15 cases. However, the portions with low signal intensities both on T1 and T2-weighted images showed enhancement in one case. There was no significant change of the disease extent after enhancement. Synovium showed enhancement in 18 cases, and joint effusion was detected in 23 cases. CONCLUSION: Contrast enhanced MR images may be helpful in predicting histopathologic findings of avascular necrosis of the femoral head, but not useful for evaluating the extent of disease.
Head* ; Humans ; Joints ; Magnetic Resonance Imaging* ; Necrosis* ; Synovial Membrane

During the last three years, from 1967 to 1970, three hundred and three cases of psoriasis were treated by Goeckrman's regimen and oral methotrexate, 270 cases and 33 cases respectively. Authors evaluated the clinical effectivness and side effect of methotrexate and it compared with the result of Goeckermans method and review about the articles. Of the 303 psoriatics, 140 were male(44%) and 163 were female(55.6%). The majority of the primary manifestation appeared in 16 to 30 year .age group with maximal occurence in the 16 year to 20 year age group (53 cases), but 33 cases were noted below the 10 years old age(Fig.2). The duration of the disease in most cases was 1 to 10 years,but the highest number, in 72 cases, was 1 to 5 years group(Fig 3 A, 3 B). 40 cases was in below 6 months. The methotrexate were administered orally, 2. 5 mg. tab., twice daily(5 mg) for 5 to 7 days, followed by 3 to 5 days resting in accordance with the, patient's condittion. The Goeckerman regirnen of 2% coal tar and 2% salicylic acid in vaselin applied to whole skin lesions in the night and the excess tar was removed frorn skin by gentle wiping with a gauze pat, saturated with Arachis oil, in the next morning, follawed by ultra-violet ray irradiation for 30 second at first day, then the dose increased 30 second daily to reach 5 min. After the ultra-violet irradiation bath was done, and one hour later 2% coal tar and 2% salicylic acid vaselin were applied again. These schedules were repeated 2 to 3 courses (20 to 30 days) in mast cases. In occasion of Goeckerman treatment, among the completely cleared 93 cases during the preveous treatment, the most cases were recurred within 3 to 12 months but 16 cases within 1 month. In occasion of methotrexate, the lesions recurred within 6 months to 2 years in 17 cases of the 33 cases, but 3 cases were within one month after completely cured preveously. The starting of remission, in Goeckerman methods, was noted within 7 to 14 days in most cases(13 cases), and in 3 cases it started within 3 to 4 days. And the completely clearing of the lesions noted within 20 to 25 days in most cases(16 to 21 cases). The starting of remission, in methotrexate treatment of 33 cases, was occurred within 1 to 2 weeks in most cases(27 cases), and completely clearing of lesions noticed within 14 ta 20 days in 28 cases. But in 2 cases it needed only 7 days to make completely clearing the skin lesions. The side effects of the Goeckerman's method were as follow : 1) Contact dermatitis due to tar hypersensitivity in 3 cases. 2) Mild local burn due to over dose irradiation of ultra-violet ray in 5 eases, otherwise no appreciable side effects were noted. The side effecst of methotrexate were noted in 17 cases among the 33 cases. 1) Aphtous ulcer in 4 cases, 2) Peptic ulcer in one case, 3) Tinitus in one case, 4) Other side effects such as dizziness, loss of appetite, headache, fatiguability were notable in 10 cases. 5) In addition to above mentioned sidle effects the blood chemistry include L.P.T., wbc count, platelet count, ESR, Hgb, and creatinine showed as follow before and after administration of methotrexate. a) The white blood cells, platelet count were tend to decrease after the administration of methotrexate than before one. b) Among 33 cases the SGPT levels were checked in 16 cases, and in most cases it raised more and less than before the administration of methotrexate, but only 8 cases were ahove the normal ranges(35 units). The SGOT level also raised after one course, but only 8 cases were above normal ranges(40 units). c) Hgb, ESR, creatinine showed no remarkable changes. In many references the effects and side effects of methotrexate were discussed, but their view were not uniform and variable. In the clinical improvement, recurrency, and side effects, the large single weekly dose of methotrexate had no fundamental differences compare with the author's small daily doses. We agree with the Ryan's report(11), in which the large single dose were not always safer and more effective than the small dose. Still there are many important problems to study about the dosage, interval of administration, and resting period in the treatment of psoriasis with methotrexate.
Alanine Transaminase ; Appetite ; Appointments and Schedules ; Arachis ; Aspartate Aminotransferases ; Baths ; Burns ; Chemistry ; Child ; Coal Tar ; Creatinine ; Dermatitis, Contact ; Dizziness ; Headache ; Humans ; Hypersensitivity ; Leukocytes ; Methotrexate* ; Peptic Ulcer ; Platelet Count ; Psoriasis* ; Salicylic Acid ; Skin ; Ulcer ; Ultraviolet Rays

No abstract available.
Fluconazole* ; Humans

No abstract available.
Knee*

No abstract available.

PURPOSE: To describe the magnetic resonance (MR) findings of pigmented villonodular synovitis(PVNS) of the knee, and to evaluate the clinical value of MR in the diagnosis of PVNS. MATERIALS AND METHODS:MR imagings of seven patients with PVNS were studied. The type of lesion, presence of bony erosion, the signal intensity, and the relationship between contrast enhancement and signal intensity on T2-weighted images were analyzed, retrospectively. RESULTS: The lesion was mainly villous in three patients and nodular in four, and bony erosion was seen in one patient. On T2-weighted image, the signal intensity of the villous form was mixed iso- and hypointense in two, hypointense in one, and that of the nodular form was heterogeneous with hypo-, iso-, and hyperintensities. The hypointense portion on T2-weighted image showed poor contrast enhancement, which may suggest hemosiderin deposition or advanced fibrosis. The iso- or hyperintense portion on T2-weighted image showed strong enhancement, which suggest active cellular proliferation. CONCLUSION:MR imaging could be a very useful modality in the diagnosis as well as prediction of histological findings of the PVNS.
Cell Proliferation ; Diagnosis ; Fibrosis ; Hemosiderin ; Humans ; Knee* ; Magnetic Resonance Imaging* ; Retrospective Studies ; Synovitis, Pigmented Villonodular*