Acid ingestion causes a coagulative necrosis of the surface epithelium of the upper gastromtestinal tract. Its late sequence is luminal stenosis which frequently requires surgical repair. Nevertherless, in many cases, non-operative dilatation of luminal stenosis have been applicated, such as bouginations, balloon dilatations, endoscopic laser therapy, endoscopic electrocoagulation, endescopic microwave coagulation. These methods may give some considerable benefits in unoperable cases. Recently, we experienced a case of a 60-year-old man who had severe corrosive esophageal and gastric angular strictures by accidentally ingested hydrochloric acid and after many tiems of application of non-operative dilatation was able to have normal diet without dysphagia. So, we report this case with a review of literatures.
Constriction, Pathologic* ; Deglutition Disorders ; Diet ; Dilatation* ; Eating ; Electrocoagulation ; Epithelium ; Humans ; Hydrochloric Acid ; Laser Therapy ; Microwaves ; Middle Aged ; Necrosis ; Phenobarbital

No abstract available.
Pleural Effusion*

No abstract available.
Osteogenesis Imperfecta* ; Osteogenesis* ; Pseudarthrosis* ; Tibia*

OBJECTIVE: We undertook this study to find out clinical characteristics and prognostic factors of neonatal survival in nonimmune hydrops fetalis (NIHF). METHODS: From Oct. 1988 to Feb. 2001, 54 cases of nonimmune hydrops fetalis diagnosed at Seoul National University Hospital (SNUH) were included in our study. The incidence and perinatal mortality were investigated. The diagnostic work-up for associated conditions (or etiology) included detailed ultrasonography, karyotyping, fetal echocardiography, infection work-up (TORCH, parvovirus), and autopsy (if fetus was dead). Among 54 cases, 20 cases of liveborns were divided into two groups. Group I survived beyond neonatal period (survived>28 days) and group II did not (expired3 (OR=21, CI 1.77, 248.1; p<0.05), and 5-min AS>3 (p<0.01). CONCLUSION: Over 3 of 1-min and 5-min AS were meaningful factors for neonatal survival in NIHF.
Apgar Score ; Autopsy ; Echocardiography ; Female ; Fetofetal Transfusion ; Fetus ; Gestational Age ; Hydrops Fetalis* ; Incidence ; Karyotyping ; Parturition ; Perinatal Mortality ; Pleural Effusion ; Polyhydramnios ; Pregnancy ; Seoul ; Ultrasonography

The methanolic extract of fruiting body of Paecilomyces tenuipes DGUM 32001 showed significant cytotoxicity against human cancer cells: HepG2 and MCF-7. The methanolic extract was further fractionated with organic solvents such as chloroform and ethyl acetate in that order. Among the fractions tested, the ethyl acetate fraction showed the highest cytotoxicity against the carcinoma tested. The IC50 values of ethyl acetate fraction against HepG and MCF-7 were 40 and 9.6 microg/ml, respectively.
Chloroform ; Fruit ; Hep G2 Cells* ; Humans* ; Inhibitory Concentration 50 ; Methanol ; Paecilomyces* ; Solvents

BACKGROUND AND OBJECTIVES: There is little data to indicate that hypertrophy of adenoid and tonsil may cause short stature. However, there is no data relating short stature to allergic rhinitis in the Korean population. The aim of this study was to investigate the effect of hypertrophy of adenoid and tonsil and allergic rhinitis on children with short stature. SUBJECTS AND METHOD: One hundred and ninety-one children were included in the disease group, which consisted of three groups, allergic rhinitis only (n=83), hypertrophy of adenoid and tonsil only (n=67), and combintorial of allergic rhinitis and hypertrophy of adenoid and tonsil (n=41). There were 174 pediatric patients in the control group. Growth hormone levels, thyroid function and both wrist X-rays were checked on the children with short stature in order to exclude other chief medical problems causing short stature. For the purpose of evaluating the relationship between short stature and clinical factors, allergy parameters, eosinophil partition rate and total IgE levels were checked in the allergic rhinitis group, and the size of the adenoid and tonsil were checked in the adenoid and tonsil hypertrophy group. The relationship between the incidence of short stature and above clinical factors was evaluated. RESULTS: The incidence of short stature was significantly higher in each disease group than in the control. However, there was no statistically significant differences between each disease group. The above clinical factors were not associated with short stature. CONCLUSION: Hypertrophy in adenoid and tonsil and allergic rhinitis might be an independent cause of short stature.
Adenoids* ; Body Height ; Child* ; Eosinophils ; Growth Hormone ; Humans ; Hypersensitivity ; Hypertrophy* ; Immunoglobulin E ; Incidence ; Palatine Tonsil* ; Rhinitis* ; Thyroid Gland ; Wrist

Soft tissue sarcoma of the head and neck is a rare and heterogenous group of malignant tumors. Especially, adult soft tissue sarcomas occur rarely in nasal cavity and paranasal sinus. They are, when poorly differentiated, termed as pleomorphic sarcoma, spindle cell sarcoma, or malignant fibrous histiocytoma (MFH) like tumor. The main stay of the treatment of adult soft tissue sarcomas is surgical resection with negative margin. Tumor grade, tumor size and extension of local infiltration are recognized prognostic factors, but classification of histologic type appears to have less prognostic significance. In case of uncontrolled locoregional disease, it often results in death due to intracranial extension. We report a case of a 68-year-old female with locoregional high grade pleomorphic sarcoma in the nasal cavity. This tumor was managed by wide local excision of tumor with negative margin.
Adult ; Aged ; Classification ; Female ; Head ; Histiocytoma, Malignant Fibrous* ; Humans ; Nasal Cavity ; Neck ; Sarcoma

Hand tumors arise from the skin, subcutaneous tissue, tendons, nerves, blood vessels, and bones, and are of many different types. Most of them are benign but malignant lesions also occur, although only rarely. The authors have encountered 115 cases of tumors of the hand at Seoul National University Hospital between 1975 and 1984 and the following results were obtained; l. In our series of 115 cases of hand tumors (bone tumor; 47 cases, soft tissue tumor; 68 cases), most of them are benign (110 cases, 96%). 2. There are no demonstrable differences in the sex and distribution. 3. Of the bone tumors in the hand, enchondroma is most common (25 cases, 53%), followed by giant cell tumor (9 cases, 19%), and osteochondroma (7 cases, 15%). 4. Of the soft tissue tumors in the hand, ganglion is most common (28 cases, 41%), followed by hemangioma (16 cases, 24%), and xanthoma (8 cases, 12%). 5. Of the treatment modalities of bone tumors in the hand, the most frequent one is curettage and bone graft (26 cases, 53%), followed by excision, and en bloc resection and bone graft (8 cases, 16%, respectively). 6. Of the treatment modalities of soft tissue tumors in the hand, the most frequent one is excision (64 cases, 93%). 7. Although giant cell tumor, hemangioma, and lymphangioma are classified as benign histologically, their clinical course appears to be malignant, because of incomplete excision and recurrence.
Blood Vessels ; Chondroma ; Curettage ; Ganglion Cysts ; Giant Cell Tumors ; Hand ; Hemangioma ; Lymphangioma ; Osteochondroma ; Recurrence ; Seoul ; Skin ; Subcutaneous Tissue ; Tendons ; Transplants ; Xanthomatosis

OBJECTIVE: To examine if amniotic fluid (AF) monocyte chemotactic protein-1 (MCP-1) concentrations are useful in the identification of intrauterine infection and pregnancy outcomes in preterm labor with intact membranes. METHODS: The study population consists of 65 patients who received amniocentesis for preterm labor with intact membranes. Amniotic fluid was cultured for aerobic and anaerobic bacteria, as well as mycoplasmas. MCP-1 was determined by a sensitive and specific immunoassay. Fisher's exact test, Mann-Whitney U test, receiver operating characteristic curve, survival techniques, logistic regression, and Spearman correlation were used for statistical analysis. RESULTS: (1) Patients with a positive amniotic fluid culture had a significantly higher median AF MCP-1 concentration than those with negative results (median, 9.0 ng/mL; range, 0.45-40.5 ng/mL; vs median, 0.82 ng/mL; range, 0.06-30.1 ng/mL; P<.01). (2) Patients with AF MCP-1 concentration of >1.9 ng/mL had a significantly shorter median interval to delivery, the higher rate of histologic chorioamnionitis, preterm delivery within 2 and 5 days, and the occurrence of congenital proven or suspected sepsis than did those with AF MCP-1 concentration of <1.9 ng/mL after adjustment for gestational age (P<.05). (3) There was strong correlation between AF MCP-1 concentrations and AF interleukin-6 concentrations (r=.881, P<.001). CONCLUSION: AF MCP-1 determinations are useful in the identification of intrauterine infection, preterm delivery, and neonatal infectious complication in preterm labor with intact membranes.
Amniocentesis ; Amniotic Fluid* ; Bacteria, Anaerobic ; Chemokine CCL2* ; Chorioamnionitis ; Female ; Gestational Age ; Humans ; Immunoassay ; Interleukin-6 ; Logistic Models ; Membranes ; Monocytes* ; Mycoplasma ; Obstetric Labor, Premature* ; Pregnancy ; Pregnancy Outcome ; ROC Curve ; Sepsis

OBJECTIVE: We undertook this study to find out general characteristics of hypertensive disorder in pregnancy and to clarify whether polymorphic marker of promoter region of angiotensinogen G(-6)A polymorphism is associated with the development of hypertensive disorder in pregnancy. METHODS: From August 1998 to March 2002, we recruited 230 pregnant women complicated by hypertension in pregnancy. Retrospective chart review was done. They were assigned to each group according to a new classification. Hypertensive groups were divided into two groups: high blood pressure group (High) was defined as having diastolic blood pressure (DBP) higher than 110 mmHg and low blood pressure group (Low) as having DBP lower than 110 mmHg. Maternal blood was collected and DNA was extracted from 161 normotensive and 200 hypertensive Korean pregnant women. Genomic DNA was prepared and the relevant genomic region was amplified using polymerase chain reaction (PCR). PCR products were digested with the restriction enzyme, Mva I, size fractionated on 3% agarose gels containing ethidium bromide. RESULTS: Family history of hypertension was more common in women with chronic hypertension or superimposed preeclampsia than in women with transient hypertension or preeclampsia (p<0.05). No significant difference in genotype distribution was found between diagnostic groups and control. However, among hypertensive disorder in pregnancy, high blood pressure group had AA genotype more frequently than low blood pressure group (p<0.05). CONCLUSION: Family history is more common in women with underlying hypertension. Angiotensinogen AA genotype may be associated with high blood pressure level in hypertensive disorder in pregnancy.
Angiotensinogen* ; Blood Pressure ; Classification ; DNA ; Ethidium ; Female ; Gels ; Genotype ; Humans* ; Hypertension ; Hypotension ; Polymerase Chain Reaction ; Pre-Eclampsia ; Pregnancy* ; Pregnant Women ; Promoter Regions, Genetic ; Retrospective Studies ; Sepharose