Many investigators have attempted to elucidate the basic pathogenic mechanisms of atopic dermatitis through clinical and laboratory investigations and have no longer attached to the etiological significance to IgE which is known to be a mediator of the so-called atopic diseases. In recent years, many authors have reported some abnormalities not onIy in the humoral but also in cellular immune status of patients with atopic dermatitis. although such findings are more or less controversial. (countinued..)
Dermatitis* ; Dermatitis, Atopic ; Humans ; Immunoglobulin E ; Research Personnel

Psoriasis is common cutaneous disorder involving 0.1~3% Of the general population and is characterized by its marked chronicity and recurrence. A variety of factors, rarging from heredity, environment to abnormal cytodynamics and biochemical perturbation have been implicated but never proved as causative. In recent years, many studies on psoriasis have been reported, showing the presence of certain immunologic abnormalities in patients with psoriasis, and some authors postulated that these immunologic abnormalities, particularly in cell mediated immunity, may play a key role in the pathogenesis of psoriasis. This study was undertaken to evaluate cell mediated immune status of patients with paoriasis using several immunologic parameters. A total of 70 patients (35 were male and 35 were female) between the ages of l:l and 70 years entered this study at the Department of Dermatology of Seoul National University Hospital from January 1980 through September 1980. Peripheral blood T lymphocytes(early and total) were enumerated by E-rosette technique in 55 patients. Delayed cutaneous hypersensitivity reaction was measured in 3O patients using intradermal candidin, trichophytinand PPD. Active sensitization with DNCB was performed in 30 patients.
Dermatology ; Dinitrochlorobenzene ; Heredity ; Humans ; Hypersensitivity ; Immunity, Cellular ; Male ; Psoriasis* ; Recurrence ; Seoul

OBJECTIVE : Bone mineral density is influenced by genetic, hormonal and exogenous factor that adversely affect peak mineral density include cigarette smoking, physical disability, poor calcium intake and certain medication include steroid and anticonvulsant drugs. We studied epileptic children receiving 6months above, to document change of bone mineral density by anticonvulsant drugs. METHODS: From July 1, 1996 to September 1, 1996 lumbar bone mineral density was measured by dual-energy X-ray absorptiometry in 27 children treated with anticonvulsant drugs 6months above (age ranged : 4-13 year) in Soonchunghyang University hospital. The subjects were classified into 3 groups : treated with carbamazepine alone, valproate alone and combined group. RESULTS: 1) Mean age of carbamazepine group was 10.2+/-2.42yrs(6-l4yr), duration of therapy was 22.1+/-13.9 months(6-44 months), mean value of bone mineral densities were 0.668+/-0.128g/cm2(0.548-0.927). Though it was lower than control group in 8, 9, 10, 12, 13 year, had not statistical significance. 2) Mean age of valproate group was 9.8+/-2.92yrs(6-l3yr), duration of therapy was 40.5 +/-22.2months(17-79month), mean value of bone mineral densities were 0.618+/-0.097g/cm2(0.516-0.788). Though it was lower than control group in 7, 10, 13 year, had not statistical significance. 3) Mean age of combined group was 7.9+/-3.2yrs(4-l4yr), duration of therapy was 37.5 +/-24.7months(12-88month), mean value of bone mineral densities were 0.602+/-0.109 g/cm2(0.552-0.807). Though it was lower than control group in 7, 8, 10 year, had not statistical significance. CONCLUSION: Because growing children is more sensitive than adult, in case of receiving long-term anticonvulsant therapy, it is important that early detection and prevention of abnormal bone mineralization by appropriate monitoring.
Absorptiometry, Photon ; Adult ; Anticonvulsants* ; Bone Density* ; Calcification, Physiologic ; Calcium ; Carbamazepine ; Child* ; Humans ; Smoking ; Valproic Acid

anserine folliculosis (Padilha-Gonqalves, 1977) is a skin disease occurring on the limited areas of the skin receiving prolonged friction and/or pressure by the other part(s) of the naked skin of the patient. Padilha-Goncalves named traumatic anserine folliculosis by stressing the etiologic factor, the pressure and friction, the goose skin appearance and the follicular nature of the basic skin lesions. A 7-year-old girl developed typical features of traumatic anserine folliculosis on the chin who had the habit of resting the chin on the right knee for 5 years while painting.

Dermabrasion involves the removal of the epidermis and the upper dermis by means of a motor-driven rotary abrasive instrument or a brush using ethyl chloride or dichlorotetrafluoroethane(Freon) as the evaporative refrigerant-anesthetic. Kurtin(1952) developed this refrigeration-abrasion method and named it skin planing. The technique of skin planing was introduced to Korea in early 1960s and it was extensively used for corrective surgery of scar induced by small pox until early 1970s. The indication for dermabrasion includes correction of scars, prophylaxis and correction of aging of the skin, removal of congenital nevoid anomalies, malignant and benign skin tumors, tattoos and others. The authors dermabased the cutaneous lesions of xeroderma pigmentosum, angiofibroma (adenoma sebaseum), nevus sebaceus of Jadassohn, epidermal verrucous nevus and linear porokeratosis, using Stryker' pneumatic powered dermabrader, with successful results. The technique of dermabrasion and the literature were briefly reviewed.
Aging ; Angiofibroma ; Cicatrix ; Dermabrasion* ; Dermis ; Epidermis ; Ethyl Chloride ; Korea ; Nevus, Sebaceous of Jadassohn ; Porokeratosis ; Skin ; Skin Diseases* ; Xeroderma Pigmentosum

No abstract available.
Drug Therapy* ; Lung*

No abstract available.
Stevens-Johnson Syndrome*

Chronic granulomatous disease (CGD) is one of congenital immunodeficient disease and a rare X-linked or autosomal recessive disease characterized by recurrent life- threatening infections and granuloma formation. We observed clinical features, laboratory findings and genetic subgroups of 33 children who were diagnosed with chronic granulomatous disease in the Department of Pediatrics, Seoul National University Children's Hospital. There were 23 males and 10 females. Activated NBT test of all patients revealed 0% positive cell and mothers of 15 patients had 25%- 75% normal neutrophils in the activated NBT test. According to the result of activated NBT test and family history, the ratio of X-linked and autosomal recessive inheritance was 2:3. There was a significant difference for the age at onset of the first infection in the different genetic subgroups. The X-linked group had the mean onset at 1.98 months of age and autosomal recessive group had a mean onset as late as 3.82 months (p<0.05). The most common type of the first infection was lymphadenopathies (41%) and other infections were skin pustules, fever, perianal abscess, pneumonia and chronic diarrhea. However, the age at diagnosis was not significant in the different genetic subgroups. Lymphadenitis (27%) was the most common infection, and pneumonia, gastrointestinal tract infection, skin infection were also common. The most common infectious agent was Candida sp. (5%) and other microorganisms involved were BCG, coagulase-negative staphylococcus, S. aureus, K/ebsiella pneumoniae, Aspergi/lus sp., and Enterococcus faecium. Chronic condition associated with CGD were hepatomegaly (59%), splenomegaly, and anemia of chronic disease, underweight, and lymphadenopathy. The leukocyte count of patients at diagnosis was within normal limit except in three patients and leukopenia was not observed in any of the patients. The humoral and cellular immunity and complement system were normal, but the level of Ig E in four patients was elevated. Early diagnosis of CGD can be made by suspicion if there are lymphadenitis after BCG vaccination and recurrent pyogenic infections under the first year of age. Though progression in the treatment of CGD, like gene therapy, is concerned, genetic counseling and prenatal diagnosis by carrier detection and molecular genetic analysis is thought to be necessary.
Abscess ; Anemia ; Candida ; Child ; Chronic Disease ; Complement System Proteins ; Diagnosis ; Diarrhea ; Early Diagnosis ; Enterococcus faecium ; Female ; Fever ; Gastrointestinal Tract ; Genetic Counseling ; Genetic Therapy ; Granuloma ; Granulomatous Disease, Chronic* ; Hepatomegaly ; Humans ; Immunity, Cellular ; Korea* ; Leukocyte Count ; Leukopenia ; Lymphadenitis ; Lymphatic Diseases ; Male ; Molecular Biology ; Mothers ; Mycobacterium bovis ; Neutrophils ; Pediatrics ; Pneumonia ; Prenatal Diagnosis ; Seoul ; Skin ; Splenomegaly ; Staphylococcus ; Thinness ; Vaccination ; Wills

No abstract available.
Sinus of Valsalva*

No abstract available.
Humans