Search Results

4.The influence of the fistula blood flow on the fistula patency after internal arteriovenous fistula.

Chang Nam KIM ; Won Hyun CHO ; Joong Shin KANG

Journal of the Korean Surgical Society 1992;42(4):525-532

5.Expression of c-myc oncogene in 1-2 DMH induced colon cancer of Wistar rats.

Kwang Kook CHO ; Ok Seak BAE ; Joong Shin KANG

Journal of the Korean Cancer Association 1991;23(3):518-523

6.A clinical study of significance of serum carcinonoembryonic antigen in colorectal patients.

Suk Kon KIM ; Seong Dal PARK ; Joong Shin KANG

Journal of the Korean Surgical Society 1991;41(4):473-481

7.Induction chemotherapy in the treatment of locally advanced breast cancer.

Sam Gee CHOI ; You Sah KIM ; Joong Shin KANG

Journal of the Korean Surgical Society 1992;42(1):21-29

8.Complications and patency of internal arteriovenous fistula for hemodialysis

Han Hong YANG ; Won Hyun CHO ; Joong Shin KANG

Journal of the Korean Society for Vascular Surgery 1991;7(1):124-133

9.Changes of phospholipase D activity in TNF-alpha and anti-Fas/Apo1 monoclonal antibody induced apoptosis in HL-60 and A20 cells.

Jin Ho KANG ; In Cheol SHIN ; Joong Soo HAN

Experimental & Molecular Medicine 1998;30(1):21-27

The changes of phospholipase D (PLD) activity were investigated during the courses of apoptotic process induced by tumor necrosis factor (TNF)-alpha or anti-Fas/Apo1 antibody in human premyelocyte HL-60 and murine B cell lymphoma A20 cells. The treatment of recombinant TNF-alpha to HL-60 cells resulted in the increased PLD activity as determined by the phosphatidylethanol formation in the presence of 1% ethanol. The enhancement of PLD activity was also observed in the anti-Fas/Apo1 monoclonal antibody-treated A20 cells. However, the activity of PLD was maximized when HL-60 and A20 cells were treated with either TNF-alpha or anti-Fas/Apo1 monoclonal antibody for 6 h. Both TNF-alpha and anti-Fas/Apo1 monoclonal antibody increased PLD activity in a dose-dependent manner up to 200 U/ml and 200 ng/ml, respectively. When the intracellular activity of protein kinase C (PKC) was interrupted by treatment of calphostin-C, both the PLD activation and the apoptosis induced by TNF-alpha and anti-Fas/Apo1 monoclonal antibody appeared to be inhibited. Since PKC is reported to activate PLD, the results indicate that the intracellular signaling cascade via PLD may play a role in the induction of apoptosis induced by TNF-alpha and anti-Fas/Apo1 monoclonal antibody.
Animal ; Antibodies, Monoclonal/pharmacology ; Antigens, CD95/metabolism* ; Antigens, CD95/immunology ; Apoptosis* ; DNA Fragmentation ; Dose-Response Relationship, Drug ; Enzyme Activation ; HL-60 Cells ; Human ; Leukemia, Promyelocytic, Acute ; Lymphoma, B-Cell ; Mice ; Naphthalenes/pharmacology ; Phospholipase D/metabolism* ; Protein Kinase C/antagonists & inhibitors ; Receptors, Tumor Necrosis Factor/metabolism* ; Signal Transduction ; Tumor Necrosis Factor/pharmacology*

10.Clinical and pathologic characteristics of uterine sarcoma.

Soon Beom KANG ; Jong Hyeok KIM ; Sung Gi SON ; Joong Shin PARK ; Hyo Pyo LEE

Journal of the Korean Cancer Association 1991;23(4):769-776

1.Traumatic injuries to the diaphragm.

2.New modified method ofsouthern blot to search for oncogene alteration in breast cancer.

3.Pancreatoduodenectomy for resectable periampullary tumor.