No abstract available.
Acne Vulgaris* ; Female* ; Humans ; Multicenter Studies as Topic*

No abstract available.
Sexually Transmitted Diseases*

Between September to October 1985, 61 male patients with uncomplicated genital gonorrhea, including 33 PPNG urethritis, were treated with single oral dose of rosoxaci, a new oral quinolone derivative, 300 mg Fifty-three patients returned for a test of cure 3 5 days after the treatment. When a patient was found to be not cured, a second course of treatment was given and followed as above. The overall failure rate of initial treatment was 11.3%(6/53). It was 15. 2%(5/33) for PPNG urethritis and 5%(1/20) for non-PPNG urethritis. During the course of this trial the rate af PPNG among pretreatment isolates was exceptionally high(62.2g) compared to 277. during the period of 198l~4. If the PPNG prevalance rate had been a little lower, for instance 30g the overall failure rate would have been much lower(4.9%). When the second treatment was given to the failure cases 4-6 days after the first treatment. The overall failure rate dropped to 3.8%, 3.1% for PPNG urethritis and 5.0% for non-PPNG urethritis. Ten patients (2l, 3p,) developed postgoriococcal urethritie. Susceptibility test, with disks containing rosoxacin 5mcg, showed the inhibition zone to be greater than 34mm. Eight patients developed minor side effects: dizziness or gastritis. The rosoxacin, oral dose of 300 mg, regimen gave the best result yet by oral treatment for gonorrheae in recent years in Korea.
Dizziness ; Gastritis ; Gonorrhea ; Humans ; Korea ; Male* ; Urethritis*

The effect of thiamphenicol on hematopoietic system has to be evaluated. One hundred and fifteen male patients had been given oral 2. 5 gm thiamphenicol for uncomplicated gonococcal infection. ln this study, hemoglobin, WBC, hematocrit, reticulocyte and differential WBC counts were evaluated before, R days, 10 days and 1 month after the treatment. Hemoglobin, WBC, reticulocyte and differential WRC counts did not show any differences between pre and 3 days, l0days and 1 month post-treatment. In jailed cases, WBC count was found to be raiseri pretreatment(7,500 1-1.700, n='30) and 3 days after the treatment(v, 1pp+1,6p0, n=Rp) from normal value (Ii,100.:>1,600 in NMC biochemistry). In cured cases, WBC count was also found to be raised pre-treatment(7,50Q-i- 2,100, n=54) from normal value(6, 1001, 500), but returned to norrna1 3 days (6, 100 ! 1, 500, n = 54) and 10 days after the treatment, no cases showed any significant changes for WBC count(v,ppp-+1,gpp, n=7) from normal value(6,1%)- 1,500). Other side effect of thiamphenicol, such as hematologic toxicity and aplastic anemia had not been observed. Therefore, thiamphenicol 2. 5 gm p.o. is well tolerated and non-toxic treatment.
Anemia, Aplastic ; Gonorrhea* ; Hematocrit ; Hematopoietic System ; Humans ; Male* ; Reference Values ; Reticulocytes ; Thiamphenicol*

In search of suitable long wave ultraviolet light source which is not available in Korea for photopatch tests and for the treatment of vitiligo and psoriasis. We picked high pressure mercury lamp used for out-door illumination for evaluation. On spectrophotometric examinatio., it is disclosed that the lamp emitted enough long wave ultraviolet rays for our purpose. It requires 6 minutes for photopatch tests at 50 cm for 200 watt bulb. It is recommanded that the commercially available cheap out door illumination lamp should be used for dermatological parposes until equivalent medical equipment is available. The construction and principle of mercury vapor lamp is reviewed.
Korea ; Lighting* ; Psoriasis ; Ultraviolet Rays ; Vitiligo

A cutaneous angiitis showing evidence of leukocytoclastic angiitis in a 17 year old girl is presented. The patient showed multiple pinhead to pea sized erythematoue papular lesions on both legs, right axillary region, left upper chest, palms and especially around the ankles, The lesions did not fade on diascopy and caused mild pruritus and were slightly tender. The lesions had been present for about six months. The definition, classification, pathogenesis and therapeutic aspects of cutan- eous angiitis are reviewd.
Adolescent ; Ankle ; Classification ; Female ; Humans ; Leg ; Peas ; Pruritus ; Thorax ; Vasculitis*

Bleomycin is a glycopetide antibiotic isolated from Streptomyces verticillus which has a wide spectrum of antiturnor and antimicrobial activities and is currently used in treatment of certain neoplasms. Its selective effect on Squamous cell carcinoma was confirmed by Ichikawa(1969) and Ueno(1970). Bleomycin inhibits the synthesis of K)NA in animal cells and has sorne degree of selective toxicity against DNA virus infections. The drug has been reported to be useful in the topical treatment of verrucae by Fujita et al., in 1971. Since then many physicians have been using Bleomycin as topical therapeutic agent on. warts, esecially in Japan. The authors used Bleomycin as topical antiwart agent utilizing needle free syringe ." Dermo-Jet. 29 patients are studied, the clinical and histopathologial cha.nges are followed and reported. The advantages of utilizing Dern:o-Jet compared to that of usual needle syringe method are a) More accurate dosage of the drug can be infiltrated to the lesion, especially in the epidermis. b) Resulting pain is shorter in duration c) The fear, especially of children, created by the introduction of a hypodermic needle is diminished, d) The manipulation of this peculiar syringe n-ay give the patients hypnotic effect. Clinically 3 different ways of regressing processes are observed. 1. Casting off of dried keratinous r.naterial 2. Vesicle or pustule formation 3. Frogressive diminution of the size of warts. Histologic studies are carried out on 24, 48, 72 hours and I week after the injection. 1. The findings of specimens taken 24, 48, 72 hours after the injections include; a) Cells with small elongated deeply basophilic nuclei and eosinophilic cytoplasm whose boundaries are indistinct appeared in some areas of the epidermis. In the lower most layer of the epidermis several rows of small cells with. minute basopbilic nuclei lie in palisade arrangement. b) Loss of basal cell layer c) Necrosis of epidermal cells d) Subepidermal abscess 2. The findings of specimen taken 7 days after the injection are; In the mid part of horny laycr band like collection of yellowish-brown hemorrhage born material and small elongated deeply basophilic nuclei which were observed in l. a) are seen. Directly beneath this area the epidermis showes no basal cell layer and many finger like projectians of rete ridges whir,h is far more in number than normal skin, It is thought that healing process of wart through Bleomycin local injection can be accomplished by 1. The altered epidermal cells reject further wart virus replication and heals by casting off of all altered part of the epidermis. 2. The subepidermal abscess may brings wart to be cast off, 3. The wart virus be destroyed directly by Bleomycin. Bleomycin treatment with Dermo-Jet has a definite place in the management of warts.
Abscess ; Animals ; Basophils ; Bleomycin* ; Carcinoma, Squamous Cell ; Child ; Cytoplasm ; DNA Virus Infections ; Eosinophils ; Epidermis ; Fingers ; Hemorrhage ; Humans ; Hypnotics and Sedatives ; Japan ; Necrosis ; Needles ; Skin ; Streptomyces ; Syringes ; Virus Replication ; Warts*

The effect of retinoic acid. on hyperkeratotic diseases and. Acne as being published. To confirm the effect of topical retinoic acid, vre subjected 50 patients with mild to severe Acne vulgaris of the face, The patients chosen were not previously treated. with any remedy at least for the past 2 weeks. Eudyna' cream or gel were applied. once or twice a day to the face keeping some distance from the mucous membrane. We checked the number of closed comedones, open comedones, papules, pustules and scara before the treatment and every week for 14 wks during the treatment, The result were as follows: l. 42 patients began to improve in 2 to 8 wks and markedly improved in 6 to 8 wks. 3 patients dropped out because of severe side effects. Very good: 13 patients(26%) Good: 14 patinets(28%) Satisfactory: 15 patients(80%) None: 5 patients(10%) 2. The side effects: Most of patients suffered from mild to severe erythema, scaling and buming sensation in 2 to 3 days after the initiation of application. In severe cases developed severe erythema, vesicles, pustules, edema and exudation within a week.
Acne Vulgaris* ; Edema ; Erythema ; Humans ; Mucous Membrane ; Sensation ; Tretinoin

In previous paper we reported on the radiation spectrum of commercially ava ilable out-door illumination lamp and suggested the use of this lamp as long ultraviolet light source until such time we have adquate medical equipments availahle. We tried to dectermine the erythema dose of above lamps in conjunction with topical psoralen and tar. The skin lamp distance was kept 50cm. The test sites were the backs of 30 young volunters. 200 watt bulbs were used. l. 30 minutes topical application of 0.25% Meladoxen solution required 2 to 6 minutes of exposure to inducs erythema in 48 hours. 2. 6 hours of topical tar application needed 2 to 8 minutes of exposure. 3. With 0.25% Meladoxen solution; 30 minutes of topical application produced more phototoxic effect tnan 2 or 24 hours. 4. With 5% Tar ointment; the longer the duration of topical application the stronger was the phototoxic effect. But topical application time exceeding 6 hours failed to increase phototoxic effect furtber. 5. With 0.3% Meladoxen cream the thicker the applied cream the stronger was the phototoxic effect up to 25mg per cm, over which phototoxic effect decreased, probably due to the screening effect of the cream, It is concluded that in the photochemical treatment of vitiligo and psoriasis psoralen sould be applied for 80 minutes, the tar for 6 hours or ovemight before irradiating the lesions with long wave ultraviolet rays. In this way the time required for each session of photochemical treatment of psoriasis or vitiligo will be greatly reduced while obtaining maximum effect. This is more significant in the view of long term treatmant required for the management of these embarrasing dermatoses.
Erythema ; Ficusin ; Lighting* ; Mass Screening ; Psoriasis ; Skin ; Skin Diseases ; Ultraviolet Rays ; Vitiligo

Gout is not very rare disorder in high economic countries and it is seldom observed in our country and is hard to find its report in Korean dermatologic literature. Gout is a disease of inbom metabolic and/or acquired form of the disease chara-cterized by hyperuricemia, tophaceous deposits of sodium urate and recurrent attacks of arthrit.is which dramatically responds to Colchine. A case of tophaceous gout in a 56 year old Korean male is reported. The patient showed pea to waInut size, yellowish tender subcutaneous masses on right great toe and both solee of 15 year duration which are adherented to the overIying skin. The hiatology of the lesion revealed variously sized, sharply demarcated aggregates of needle shaped urate crystals in bund.his and sheaves which are surrounded by fibrous connective tissue which are in tum surrounded by granulomatous infiltrate containing small round cells and foreign body glant cells. The urate crystals have a brownish color and are doubly refractile on polariscopic examination. The use of colchine, in a initial dose of 1mg foIIowed by 0. 5mg every hour for 6 hours. The patient failed to attend the clinic regularly and was lost for folIow up.
Connective Tissue ; Foreign Bodies ; Gout* ; Humans ; Hyperuricemia ; Male ; Middle Aged ; Needles ; Peas ; Skin ; Toes ; Uric Acid