1.A Case of Collapsing Glomerulopathy in Renal Allograft.
Ji Hwan KIM ; Jung IM JUNG ; Ju Yeon NAM ; Jong In KIM ; Joong Kyung KIM ; Yeon Soon JUNG ; Hark RIM ; Min Jung JUNG
Korean Journal of Nephrology 2008;27(1):162-165
Collapsing glomeruopathy (CG) is a clinicopathologic variant of focal segmental glomerulosclerosis (FSGS) and is characterized by severe nephrotic syndrome, rapid progression to end stage renal disease, and features of visceral epithelial cell injury and glomerular capillary collapse. Such characteristics closely resemble those of HIV associated nephropathy. The frequency of CG has increased over the last decade. The cause of CG is unknown. The lesion has rarely been described in renal allografts with features similar to CG in native kidney. We recently identified allograft CG in a 44 year-old male patient who underwent biopsy for graft dysfunction after autodermic graft. The biopsy showed typical characteristics of CG. Serologically, the patient had no evidence of HIV infection. The renal function was not restored to normal in spite of methylprednisolone pulsing therapy. Now he is on conservative treatment with a functioning graft.
AIDS-Associated Nephropathy
;
Biopsy
;
Capillaries
;
Epithelial Cells
;
Glomerulosclerosis, Focal Segmental
;
HIV Infections
;
Humans
;
Kidney
;
Kidney Failure, Chronic
;
Male
;
Methylprednisolone
;
Nephrotic Syndrome
;
Transplantation, Homologous
;
Transplants
2.The Natural Course of Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease undergoing Hemodialysis
Ye Na KIM ; Yeonsoon JUNG ; Ho Sik SHIN ; Hark RIM ; Jung Gu PARK ; Dong Yeol LEE ; Joong Kyung KIM
Kosin Medical Journal 2021;36(2):109-115
Objectives:
The natural course of native kidneys after hemodialysis initiation in patients with autosomal dominant polycystic kidney disease (ADPKD) remains poorly understood.
Methods:
We measured the total volumes of native kidneys in 12 patients who had at least one enhanced computed tomography (CT) image both before and after initiation of hemodialysis (group 1) and in 18 patients who had no image before dialysis but more than two images after dialysis (group 2). In patients with images, the last image was used for analysis only after dialysis.
Results:
The mean total kidney volume (TKV) (± SD) before hemodialysis initiation was 3132 ± 1413 mL and the mean TKV of the last image was 3047 ± 1323 mL in group 1. The mean TKV change rate (%) was - 5.2 ± 27.4% (P > 0.05) during follow-up of 3.9 ± 1.9 years in group 1. The mean TKV change rate was 2.8 ± 34.4% (P > 0.05) in group 2. The follow-up period after dialysis initiation ranged from 4.2 ± 4.7 to 8.0 ± 5.2 years.
Conclusions
The results suggest that the TKV of native polycystic kidneys decreases substantially after hemodialysis initiation. This reduction occurs mainly during the early post-hemodialysis period and followed by a slow enlargement of TKV.
3.Two Cases of Acute Respiratory Distress Syndrome with Pulmonary Hemorrhage Induced by Injection of Silicone at Perineum.
So Eun KANG ; Suk Joong YONG ; Won Yeon LEE ; Pyo Jin SHIN ; Mi Hae KIM ; Hark Cheon PARK ; Myung Sook SHIM ; Hyun Min CHOI ; Kye Chul SHIN ; Mi Ae LIM ; Kyung Moo YANG
Tuberculosis and Respiratory Diseases 2001;51(2):166-172
Silicone fluid is a biomaterial widely used in modern cosmetic procedures because there are few side effects, considerable chemical stability and predictable physical properties. However, many local and systemic adverse reactions have reported. In particular some serious pulmonary complications have been reported such as pulmonary thromboembolism, acute respiratory distress syndrome with some cases leading to mortality. Most of the serious complicated cases were induced by an illegal silicone fluid injection. We experienced two cases of acute respiratory distress syndrome with pulmonary hemorrhage induced by an illegal silicone fluid injection. The patients were 41 & 51 year old women, who complained of dyspnea. The chest X-ray and HRCT scan findings showed a bilateral ground glass attenuation on the bilateral dependent portion of the upper and middle lung zone. The patients clinical symptoms and the radiologic and other laboratory findings were compatible with acute respiratory distress syndrome induced by the silicon fluid injection. Here we report two cases of acute respiratory distress syndrome with pulmonary hemorrhage induced by an illegal silicone injection with a review of the relevant literature.
Dyspnea
;
Female
;
Glass
;
Hemorrhage*
;
Humans
;
Lung
;
Mortality
;
Perineum*
;
Pulmonary Embolism
;
Respiratory Distress Syndrome, Adult*
;
Silicon*
;
Silicones*
;
Thorax
4.Combined Skin Moisturization of Liposomal Serine Incorporated in Hydrogels Prepared with Carbopol ETD 2020, Rhesperse RM 100 and Hyaluronic Acid.
Hyeongmin KIM ; Jieun RO ; Sonia BARUA ; Deuk Sun HWANG ; Seon Jeong NA ; Ho Sung LEE ; Ji Hoon JEONG ; Seulki WOO ; Hyewon KIM ; Bomi HONG ; Gyiae YUN ; Joong Hark KIM ; Young Ho YOON ; Myung Gyu PARK ; Jia KIM ; Uy Dong SOHN ; Jaehwi LEE
The Korean Journal of Physiology and Pharmacology 2015;19(6):543-547
We investigated the combined moisturizing effect of liposomal serine and a cosmeceutical base selected in this study. Serine is a major amino acid consisting of natural moisturizing factors and keratin, and the hydroxyl group of serine can actively interact with water molecules. Therefore, we hypothesized that serine efficiently delivered to the stratum corneum (SC) of the skin would enhance the moisturizing capability of the skin. We prepared four different cosmeceutical bases (hydrogel, oil-in-water (O/W) essence, O/W cream, and water-in-oil (W/O) cream); their moisturizing abilities were then assessed using a Corneometer(R). The hydrogel was selected as the optimum base for skin moisturization based on the area under the moisture content change-time curves (AUMCC) values used as a parameter for the water hold capacity of the skin. Liposomal serine prepared by a reverse-phase evaporation method was then incorporated in the hydrogel. The liposomal serine-incorporated hydrogel (serine level=1%) showed an approximately 1.62~1.77 times greater moisturizing effect on the skin than those of hydrogel, hydrogel with serine (1%), and hydrogel with blank liposome. However, the AUMCC values were not dependent on the level of serine in liposomal serine-loaded hydrogels. Together, the delivery of serine to the SC of the skin is a promising strategy for moisturizing the skin. This study is expected to be an important step in developing highly effective moisturizing cosmeceutical products.
Hyaluronic Acid*
;
Hydrogel*
;
Hydrogels*
;
Liposomes
;
Serine*
;
Skin*
;
Water
5.A Case of Theophylline-Induced Hepatitis.
Dae Wook RHIM ; Soon Koo BAIK ; Yong Soon PARK ; Hark Cheon PARK ; Jeong Ihn SEO ; Hyun Soo KIM ; Won Yeon LEE ; Suk Joong YONG ; Kye Chul SIN ; Dong Ki LEE ; Sang Ok KWON ; Tae Heon KIM ; Mee Yon CHO
The Korean Journal of Hepatology 2001;7(2):213-215
Theophylline has been widely used in the treatment of asthma and chronic obstructive lung disease. To date, there have been very few reports on hepatotoxicity due to theophylline. We diagnosed, through biochemical testing and a liver biopsy, a case of acute cholestatic hepatitis developed after oral consumption of theophylline. A 43 year-old man was admitted to the department of internal medicine due to jaundice and pruritus which developed after ten days administration of oral theophylline (Etheophyl ). Liver function tests showed elevated serum bilirubin at 13.2 mg/dL with AST and ALT of 71 U/L and 194 U/L. Alkaline phosphatase and gamma-GTP were also elevated at 175 U/L and 301 U/L. There was no evidence of viral or autoimmune hepatitis in laboratory tests. The patient's symptoms and liver function tests were improved after conservative treatment. After 9 months oral theophylline was readministered for the control of relapsed asthma. Then, jaundice and pruritus again developed again. A liver biopsy showed a few lymphocytes and eosinophilic inflammatory cell infiltration in portal tract and cholestasis in the lobule. Drug-induced hepatitis was diagnosed with a typical clinical course; the exclusion of all possible causes of acute hepatic dysfunction; and a positive response to accidental readministration of drug. We report this case with a review of the literature.
Adult
;
Alkaline Phosphatase
;
Asthma
;
Bilirubin
;
Biopsy
;
Cholestasis
;
Drug-Induced Liver Injury
;
Eosinophils
;
Hepatitis*
;
Hepatitis, Autoimmune
;
Humans
;
Internal Medicine
;
Jaundice
;
Liver
;
Liver Function Tests
;
Lymphocytes
;
Pruritus
;
Pulmonary Disease, Chronic Obstructive
;
Theophylline