1.The prognostic factors of the facial nerve paralysis in herpes zoster oticus.
Deok Jun KIM ; Joong Gahng KIM ; Jong Hoon KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(2):286-293
No abstract available.
Facial Nerve*
;
Herpes Zoster Oticus*
;
Herpes Zoster*
;
Paralysis*
2.Clinical analysis of vestibular nuritis.
Byung Hoon AHN ; Jong Hoon KIM ; Joong Gahng KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(1):50-55
No abstract available.
3.Endoscopic sinus surgery for pyocele of frontochemoidal sinuses.
Sung Hyuk BANG ; Dong Cheal KIM ; Joong Gahng KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(3):561-566
No abstract available.
4.A study of ostiomeatal lesions in paranasal sinusitis.
Young Tak SOHN ; Sung Hyuk BANG ; Joong Gahng KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(2):263-270
No abstract available.
Sinusitis*
5.Mondini dysplasia and recurrent meningitis.
Jong Hoon KIM ; Joong Gahng KIM ; Tae Hwi LEE ; Il Tae KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(4):493-499
No abstract available.
Meningitis*
6.Morphologic study of the ototoxicity of povidone-iodine preparation to the guinea pig middle ear.
Joong Gahng KIM ; Jong Hoon KIM ; Byung Hoon AHN ; Kwan Kyu PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(4):624-632
No abstract available.
Animals
;
Ear, Middle*
;
Guinea Pigs*
;
Guinea*
;
Povidone-Iodine*
7.Carotid cavernous fistula as complication of facial fractures: A case report of embolization.
Ju Seon AHN ; Sung Hyuk BAND ; Tae Hwe LEE ; Joong Gahng KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(5):1085-1089
No abstract available.
Fistula*
8.Clinical study of the neck dissection.
Dal Won SONG ; Young Tak SOHN ; Byung Jun CHI ; Joong Gahng KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(1):107-115
No abstract available.
Neck Dissection*
;
Neck*
9.Clinical study of corrosive esophagitis.
Young Tak SOHN ; Joong Gahng KIM ; Dal Won SONG ; Sung Sook LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(2):346-353
No abstract available.
Esophagitis*
10.Effect of Melatonin on the Cisplatin Induced Ototoxicity in Rats.
Joong Gahng KIM ; Sun Ho PARK ; Sung Il NAM ; Eun Ju CHANG ; Kyo Cheol MUN ; Sang Pyo KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 2003;46(10):808-814
BACKGROUND AND OBJECTIVES: Cisplatin (CP), an antitumor agent widely used in the treatment of head and neck cancers, has side effects such as ototoxicity and nephrotoxicity. These side effects are closely related to oxidative stress. In the present study, we attempted to suppress CP-induced ototoxicity in rats by administering melatonin, an antioxidant. MATERIALS AND METHOD: Male Sprague-Dawley rats were divided into different groups and were treated as follows: 1) saline control, 2) CP (16 mg/kg, i.p.), 3) CP plus melatonin (10 mg/kg, i.p.). The rats were sacrificed at the 6th day after CP treatment. RESULTS: CP-treated rats showed increase in cochlear malondialdehyde, hydrogen peroxide, glutathione peroxidase and glutathione reductase levels, and the decrease in cochlear superoxide dismutase (SOD) and catalase levels. CP-treated rats showed markedly decreased in the number of stereocilia on the inner hair cells and mildly decreased in the number of outer hair cells in organ of Corti under the light and scanning electron microscopic examination. Light and electron microscopic findings, and cochlear hydrogen peroxide, malondialdehyde, SOD, catalase, glutathione peroxidase and glutathione reductase levels were restored in the rats injected with CP plus melatonin than those with CP alone. CONCLUSION: These results suggest that melatonin suppresses CP-induced ototoxicity via the suppression of the increased production of reactive oxygen species.
Animals
;
Catalase
;
Cisplatin*
;
Glutathione Peroxidase
;
Glutathione Reductase
;
Hair
;
Head
;
Humans
;
Hydrogen Peroxide
;
Male
;
Malondialdehyde
;
Melatonin*
;
Neck
;
Organ of Corti
;
Oxidative Stress
;
Rats*
;
Rats, Sprague-Dawley
;
Reactive Oxygen Species
;
Stereocilia
;
Superoxide Dismutase
Result Analysis
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