No abstract available.
Disease Outbreaks* ; Epidemiology* ; Foodborne Diseases ; Japan* ; Korea* ; Mortality

OBJECTIVES: High serum Lp(a) concentration is associated with a high risk of coronary artery disease(CAD). This study was initiated to determine whether increased Lp(a) levels are associated with diabetic vascular complications in Korean patients with NIDDM. METHODS: A total of 183 NDDM patients were studied cross-sectionally for the presence of various vascular complications. Lp(a) levels were measured by 1-step sandwich ELISA method. RESULTS: The patients with overt proteinuria had higher Lp(a) levels than the patients with mormoalbuminuria or microalbuminuria(26.8mg/dl vs 13.8 mg/dl and 17.3mg/dl, p<0.05), The patients with proliferative retinopathy and/or those treated by photocoagulation had higher Lp(a) levels than those without retinopathy or those with background retinopathy(34.1mg/dl vs 13.3mg/dl and 16,9mg/dl, p<0.05), The Lp(a) levels were also higher in the patients with CAD than those without CAD(30.9mg/ dl vs 16.3mg/dl, p<0.05). Multiple logistic regression analysis revealed that high Lp(a) levels were independantly associated with CAD and severe diabetic retinopath3. CONCLUSION: High Lp(a) levels are associated with CAD and proliferative retinopathy in Korean patients with NIDDM.
Coronary Artery Disease ; Coronary Vessels ; Diabetes Mellitus, Type 2 ; Diabetic Angiopathies ; Diabetic Nephropathies ; Diabetic Retinopathy ; Enzyme-Linked Immunosorbent Assay ; Humans ; Light Coagulation ; Lipoprotein(a)* ; Logistic Models ; Proteinuria