1.No title in English
Journal of the Korean Medical Association 1997;40(6):772-777
No abstract available.
2.The Relation of Antipsychotic Drug Induced-Acute Dystonia and Serum Iron Level.
Dong Jin LEE ; In Joon PARK ; Young Joon KWON ; Hee Yeon JEONG ; Sun Ho HAN
Journal of the Korean Society of Biological Psychiatry 1998;5(2):248-252
OBJECT: This study was performed in order to examine the correlation between acute neuroleptic-induced dystonic reactions and serum iron level. METHOD: Serum iron levels were measured in psychiatric inpatients who had developed acute neuroleptic-induced dystonia(N=41) and in control patients with no history of acute dystonic reactions(N=37). Serum iron levels were compared in acute dystonic inpatients before starting treatment with neuroleptics and after acute dystonic reaction. RESULTS: The patients exhibiting acute dystonic reactions had significantly lower serum iron levels than the patients without acute dystonic reactions. CONCLUSION: This result supports an association between low serum iron and the occurrence of neuroleptic-induced acute dystonic reactions.
Antipsychotic Agents
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Dystonia*
;
Humans
;
Inpatients
;
Iron*
3.Effects of the Sanjoin on the Rat Brain: Focused on Serotonin, Sleeping Time, Sleep EEG and Autonomic Activity.
Hee Yeon JEONG ; Young Joon KWON ; In Joon PARK ; Joon Taek KWON ; Byung Hoon HAN ; Sung Pil LEE
Journal of the Korean Society of Biological Psychiatry 1997;4(1):54-59
OBJECTS: Sanjoin, the seeds of Zizyphus vulgaris var. spinosus has been used as the most important hypnotic agent in chinese medicine to treat insomnia. This research was performed in order to examine the effect of betulinic acid and sanjoinine-A which are components of Sanjoin. METHOD: Sleeping time, sleep recordings of EEG, serum serotonin level, and locomotor activity were measured in rats which received betulinic acid and sanjoinine-A as sleep induction material extracted from Sanjoin. RESULTS: 1) Groups received betulinic acid, sanjoinine-A, and lorazepam showed increased sleep time than control group with saline. 2) Groups with betulinic acid, sanjoinine-A, lorazepam and saline recorded beta-wave in sleep recording of EEG. In there was no significant difference among all groups. 3) No significant difference in serum serotonin level among all groups was found. 4) In autonomic activity testing, groups of betulinic acid, sanjoinine-A, and lorazepam showed significantly more decreased in activity than saline group. In comparison of groups of betulinic acid and sanjoinine-A with a group of lorazepam, there was no significant difference. CONCLUSION: These results suggests that betulinic acid and sanjoinine-A have the sedative effect like lorazepam rather than sleep effect.
Animals
;
Asian Continental Ancestry Group
;
Brain*
;
Electroencephalography*
;
Humans
;
Hypnotics and Sedatives
;
Lorazepam
;
Motor Activity
;
Rats*
;
Serotonin*
;
Sleep Initiation and Maintenance Disorders
;
Ziziphus
4.Relationship of Estrogen to Extrapyramidal Symptoms in Female Schizophrenic Patients.
Dong Seon CHUNG ; Hee Yeon JUNG ; Young Joon KWON ; In Joon PARK ; Sun Ho HAN ; Han Yong JUNG
Journal of the Korean Society of Biological Psychiatry 2001;8(1):147-152
OBJECTIVE: It has been thought that estrogen has neuroleptic like effect in women schizophrenic patients. This study aimed to investigate neuroleptic side-effects severity in women with schizohrenia and to investigate their putative association with variations in sex steroids over menstrual cycle. Based on the estrogen theory, The author hypothesized that parkinsonian side-effects would be exacerbated when estrogen levels were high. METHOD: 26 schizophrenic women were assessed using the ESRS(Extrapyramidal Symptom Rating Scale) and estrogen analysis. Tests were conducted twice, in the mid luteal and mid follicular phase. RESULT: It was hypothesized that high level of estrogen would lead to an exacerbation of parkisonian side-effects but the results indicated that parkinsonian side effects decreased overall when estrogen levels were high. This effects were more marked for the group taking typical neuroleptics than those taking atypical neuroleptics. CONCLUSION: The results of this study suggest that estrogen and progesteron may reduce the severity of neuroleptic indeced extrapyramidal side effects over menstrual cycle in women with schizophrenia. It was concluded that estrogen has different effects on dopamine dynamics in the mesolimbic and mesostriatal pathways according to estrogen, progesteron, catecol estrogen, prolactine.
Antipsychotic Agents
;
Dopamine
;
Estrogens*
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Female*
;
Follicular Phase
;
Humans
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Menstrual Cycle
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Prolactin
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Schizophrenia
;
Steroids
5.The effects of commonly eaten Korean foods on glycemic index and beta-cell secretory function in normal and diabetic patients
Hyung Joon RYU ; Duk Hee HAN ; Kyung Ah HAN ; Doo Man KIM ; O Keum SONG
Journal of the Korean Diabetes Association 1991;15(1):131-133
No abstract available.
Glycemic Index
;
Humans
6.MR imaging of oral cavity malignancy.
Dong Gyu NA ; Moon Hee HAN ; Sang Joon KIM ; Kwang Hyun KIM ; Kee Hyun CHANG
Journal of the Korean Radiological Society 1993;29(2):179-185
We retrospectively analyzed the Magnetic Resonance (MR) imaging findings in 41 cases of histologically proved malignant tumors of oral cariey. The diagnostic value of MR imaging in detection and delineation of the lesions was assessed. The value of MRI was compared with that of Computed Tomography (CT) in 14 patients. Thirty-four cases of 41 malignant tumors were squamous cell carcinomas. Adenoic cystic carcinomas (2 cases), malignant melanomas (2 cases), non-Hodgkin lymphomas (2 cases) and mucoepidermoid carcinoma(1 cases) were also included in this study. Most of the lesions were isointense or slightly hyperintense to muscle on T1 weighted images and showed variable degrees of high signal intensity on T2 weighted images. Two cases of malignant melanomas showed characteristic hyperintensity on T1 weighted images. T2 weighted image was better in detection and delineation of tumor in most of the cases. In 6 cases, Gd-DTPA-enhanced T1 weighted image was better than T2 weighted image. T2 weighted image was useful for the evaluation of deep tissue infiltration and T1 weighted image was useful for the evaluation of bone invasion and superficial tissue plane invasion. The lesion was detected only by MR in 3 cases of 14 in which CT was also performed. MR imaging was more sensitive in the evalustion of bone marrow involvement. MR imaging is very useful modality in evaluating oral cavity malignany and is superior to CT in delineation of the as well as in the evaluation of mandible invasion.
Bone Marrow
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Carcinoma, Squamous Cell
;
Humans
;
Lymphoma, Non-Hodgkin
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Magnetic Resonance Imaging*
;
Mandible
;
Melanoma
;
Mouth*
;
Retrospective Studies
7.Clinical and electrophysiological studies of subacute combined degeneration.
Hee Joon BAE ; Han Bo LEE ; Kwang Woo LEE
Journal of the Korean Neurological Association 1997;15(5):1085-1096
BACKGROUND & OBJECTIVES: Subacute combined degeneration (SCD) is a disease of spinal cord involving the posterior and lateral column due to vitamin B12 deficiency. The clinical and electrophysiologic findings of SCD are various. METHODS: From 1989 to 1996, 7 patients were diagnosed with SCD in our hospitals. The diagnosis was made by the neurologic and laboratory findings and electrophysiolgic studies such as nerve conduction studies(NCS) and evoked potential(EP). RESULT: Four patients received gastrectomy. Two had chronic atrophic, gastritis; one of them was assumed to have food-cobalamin malabsorrtion. The remaining one was a heavy drinker. The mean duration of neurologic symptoms was 35.7 months. The most common initial complaint was paresthesia (in 4) and impairment of cutaneous sensation was the most common neurologic sign At the time of diagnosis, 5 patients had myelopathy with was supported by EP in 3(60%). There were abnormal NCS findings in 5 f 6 patients with peripheral neuropathy. In one patient, there was no symptom and sign compatible with myelopathy but median nerve SEP showed bilateral central conduction delay. No one had visual symptoms but prolongation of P 100 was detected in 2 patients. Sural nerve biopsy was done in 2 case, which revealed chronic nonspecific neuropatby in one and chronic axonopathy in the other. Megaloblastic anemia was found in 4 cases and improved by cobalamin therapy in all the parents, in which the follow up hematologic data were available. There as a tendency that nonanemic patients had more severe neurologic symptoms than anemic ones. We could not find any relationship between the duration and severity of neurologic menifestations was best in the patients with the shortest duration of neurologic manifestations and hematologic feature festations. CONCLUSIONS: The authors suggest that early detection and treatment is very important for the improvement of symptoms in SCD.
Anemia, Megaloblastic
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Biopsy
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Diagnosis
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Follow-Up Studies
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Gastrectomy
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Gastritis
;
Humans
;
Median Nerve
;
Neural Conduction
;
Neurologic Manifestations
;
Parents
;
Paresthesia
;
Peripheral Nervous System Diseases
;
Sensation
;
Spinal Cord
;
Spinal Cord Diseases
;
Subacute Combined Degeneration*
;
Sural Nerve
;
Vitamin B 12
;
Vitamin B 12 Deficiency
8.Seroepidemiologic Analysis of Acute Febrile Illness from Korea in 1996.
Jin Won SONG ; Luck Ju BAEK ; Yong Ju LEE ; Ki Joon SONG ; Sung Hee HAN
Journal of the Korean Society of Virology 1998;28(4):377-382
Hemorrhagic fever with renal syndrome (HIFRS), scrub typhus, murine typhus and leptospirosis have been the principal acute febrile diseases in Korea. To evaluate the seroepidemiologic patterns of acute febrile illness, sera collected from 2,423 patients in 1996 were examined for antibodies against Hantaan virus, Orientia tsutsugamushi, Rickettsia typhi, and Borrelia burgdorferi by indirect immunofluorescent antibody technique (IFA) and macroscopic agglutination test for Leptospira interogans. Seropositive cases against O. tsutsugamushi, Rickettsia typhi, Leptispira interogans and Hantaan virus were 192 (7.9%), 193 (8.0%), 12 (0.5%) and 324 (13.4%), respectively. Male was more affected in HFRS and murine typhus contrasting to scrub typhus and leptospirosis in female. Most positive cases occurred during October and November for scrub typhus, and during November and December for HFRS. These results showed similar patterns with previous epidemical data for recent couple of years, and possibly implied no significant changes occurred in ecologic situations for acute febrile diseases in Korea.
Agglutination Tests
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Antibodies
;
Borrelia burgdorferi
;
Female
;
Hantaan virus
;
Hemorrhagic Fever with Renal Syndrome
;
Humans
;
Korea*
;
Leptospira
;
Leptospirosis
;
Male
;
Orientia tsutsugamushi
;
Rickettsia typhi
;
Scrub Typhus
;
Typhus, Endemic Flea-Borne
9.Brain abscess: MR imaging features.
Sung Moon KIM ; Kee Hyun CHANG ; Moon Hee HAN ; Sang Joon KIM ; Sang Hon CHA
Journal of the Korean Radiological Society 1992;28(4):513-518
The MR images of 13 patients with brain abscesses were retrospectively reviewed. The abscesses were solitary in 11 patients and multiple in 2 patients. They were located in the corticomedullary junction of the cerebral hemispheres(11) and cerebellum (2).: The sizes of the abscesses were variable, ranging from 1 cm to 5 cm in diameter. They were round (5), oblong (4) or multilobulated (4) in shape. Massive surrounding edema was found in 12 patients. The signal intensity of the abscess contents was hypointense to gray matter and hyperintense to CSF on T1-weighted images, and hyperintense to gray matter on both proton-density-and T2-weighted images. In 5 patients the abscess contents were heterogeneous on both T1-and T2-weighted images. The signal intensity of the abscess walls was isointense(11), slightly hyperintense (1) or hypointense (1) relative to gray matter on T1-weighted images, whereas they were isointense (4) or hypointense (9) on T2-weighted images. Of 10 patients with Gd-enhanced-T1-weighted images, 5 patients(50%) showed thin, smooth, rim enhancement, while the other 5 patients revealed somewhat irregular thick wall enhancement Satellite or daughter abscesses were found in 6 patients. Meningeal or ventricular wall enhancement suggesting meningitis or ventriculitis was associated in 3 and 1 patient, respectively. In conclusion, the characteristic morphology and intensity of the abscess capsule, massive surrounding edema, satellite abscess and associated meningitis or ventriculitis are characteristics of the brain abscess, even though they are not entirely specific to allow for accurate diagnosis in all patients.
Abscess
;
Brain Abscess*
;
Brain*
;
Cerebellum
;
Diagnosis
;
Edema
;
Gray Matter
;
Humans
;
Magnetic Resonance Imaging*
;
Meningitis
;
Nuclear Family
;
Retrospective Studies
10.A case of vascular sling.
Jong Hyun KIM ; Moon Soo HAN ; Jong Wan KIM ; Joon Sung LEE ; Hak Hee KIM
Journal of the Korean Pediatric Society 1993;36(7):1034-1038
Pulmonary artery sling is an uncommon and potentially lethal vascular anomaly that can produce airway obstruction. Despite the availibility of a corrective operation, the mortality rate remains very high due to the high incidence of associated obstructive anomalies of the tracheobronchial tree. We experienced a 70-day-old male infant who was admitted to our unit because of sudden dyspnea, cyanosis, coarse expiratory wheezing and inspiratory stridor. At first, he was treated with bronchodilator and steroid under the impression of infantile asthma, but the symptoms went on without interval change. We performed magnetic resonance imaging study followed esophagography and two dimensional echocardiography. Finally he was diagnosed as a vascular sling. We report this with a brief review and related literatures.
Airway Obstruction
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Asthma
;
Cyanosis
;
Dyspnea
;
Echocardiography
;
Humans
;
Incidence
;
Infant
;
Magnetic Resonance Imaging
;
Male
;
Mortality
;
Pulmonary Artery
;
Respiratory Sounds