1.Treatment of Herpes Simplex Keratitis with IDU and Cryocautery.
Do Joon SONG ; Yong Ho KWON ; Hyung Jeon KIM
Journal of the Korean Ophthalmological Society 1967;8(3):27-29
The effect of IDU and cryocautery in the treatment of Herpes Simplex Keratitis was presented. The cryoapplicator was a model of Krwawlcz probe (2 mm in diameter) which was refrigerated in a mixture of dry ice and methyl alcohol. The applicator was appJied on the lesions 7 seconds each and antibiotics and atropine solutions were instilled. A good result was experienced in the treatment of several cases of dendritic kenititis by freezing the corneal lesions by means of cryoappJicator, which had not been responded to IDU therapy speedy. The deep neovascularization of the cornea in a case of stromal keratitis was disappeared after cryocautery for the treatment of the superficial corneal ulcers.
Anti-Bacterial Agents
;
Atropine
;
Cornea
;
Dry Ice
;
Freezing
;
Herpes Simplex*
;
Keratitis
;
Keratitis, Herpetic*
;
Methanol
;
Ulcer
2.Imbalance in T Lymphocyte Subsets in Erythema Nodosum Leprosum.
Hyang Joon PARK ; Chang Yong CHA ; Woo Hyun CHANG ; Do Il KIM
Korean Journal of Dermatology 1987;25(4):476-485
A study was performed to investigate a relationship between the status of T lymphocyte subsets in the peripheral blood and the pathogenesis of erythema nodosum leprosum (ENL) reactions. T lymphocyte subsets, B lymphocytes and serum immnnoglobulin levels were explored in 40 leprosy patients (10 tuberculoid (TT), 17 lepromatous (LL), and 13 lepromatous with ENL). In patients with LL, suppressor cells increased and helper cell diminished, resulting in a decrease in the helper/suppressor (Th/Ts) ratio to 0.86 + 0.20, as compared with controls (1. 77 + 0.41). But in ENL patients, there was a significant diminution of suppressor cells and an increase of helper cells, resulting in an increase in Th/Ts ratio to 2.08 + 0.30. Four weeks after treatment of ENL, Th/Ts ratio decreased to l.18+ 0.31 again. The mean percentages of B cells and serum immunoglobulin levels in with LL. and ENL increased significantly compared with controls. Only IgG increased in patients with ENL compared with patients with LL. The results in patiients with TT did not differ significantly from those of controls. The findings suggest that cell-mediated immune responses, imbalance in T lymphocyte subsets, may play a role in the pathogenesis of ENL, either directly or by inducing an antibody critical to the formation of the immune complex
Antigen-Antibody Complex
;
B-Lymphocytes
;
Erythema Nodosum*
;
Erythema*
;
Humans
;
Immunoglobulin G
;
Immunoglobulins
;
Leprosy
;
T-Lymphocyte Subsets*
;
T-Lymphocytes, Helper-Inducer
3.An Analytic Study on the Effect of Carbon Disulfide on the Blood Pressure.
Jong Tae PARK ; Hae Joon KIM ; Yong Tae YUM ; Do Myung PAEK
Korean Journal of Preventive Medicine 1994;27(3):581-596
To investigate the effect of carbon disulfide on blood pressure, the BP measurements in the periodic health examination results and the medical records of factory clinic were reviewed The study subjects were composed of 1336 male and 544 female workers, who were categorized into three groups by the exposure status-highly exposed, moderately exposed and non-exposed group. The results of the study were as follows; 1. The age-adjusted mean systolic and diastolic BP of male workers were 122.35 mmHg/79.11mmHg in highly exposed, 121.57mmHg/79.05mmHg in moderately exposed and 122.67mmHg/82.27mmHg in non-exposed group. For female workers, BP were 115.13mmHg/74.49mmHg in moderately exposed and 113.48mmHg/74.30mmHg in non-exposed group. 2. In multiple regression analysis of maximum BP against Age and tenure, the slope coefficients of age and tenure on the systolic BP were 0.379, 0.667 respectively and those on the diastolic BP were 0.331, 0.405 respectively in highly exposed male workers. Tenure was a significant variable in this study. For female workers, however, the slope coefficients of tenure on BP were significant only for systolic BP of moderately- expected group. 3. In multiple regression analysis of Bp against age, cumulative exposure index(CEI), cholesterol, all the variables showed significant slope coefficients in male, but age and CEl on systolic BP were significant for female workers (P<0.05). 4. In the multiple analysis of the amount of Bp change and the velocity of Bp change among male workers, the slope coefficients of tenure tended to increase as exposure level increased. Among female workers, the slope coefficients of tenure were significant on the amount of Bp change and the velocity of Bp change in moderately exposed group.
Blood Pressure*
;
Carbon Disulfide*
;
Carbon*
;
Cholesterol
;
Female
;
Humans
;
Male
;
Medical Records
4.Pregnancy outcome following 108 cases of tuboplasties.
Jae Chul SHIN ; Do Keun LEE ; He Jung KIM ; Joon Yong HUR ; Ho Seok SUH ; Yong Kyun PARK ; Kap Soon JU ; Soo Yong CHOUGH
Korean Journal of Obstetrics and Gynecology 1991;34(7):999-1007
No abstract available.
Female
;
Pregnancy
;
Pregnancy Outcome*
;
Pregnancy*
5.Detection of Epstein-Barr Virus in Laryngeal Squamous Cell Carcinoma.
Joon Han LEE ; Nam Yong DOH ; Young Hwan CHOI ; Han Jo NA ; Do Yong LEE ; Geun Hong KI
Korean Journal of Otolaryngology - Head and Neck Surgery 2000;43(3):306-311
BACKGROUND AND OBJECTIVES: The Epstein-Barr virus (EBV) is a human herpes virus which causes certain type of lymphoma and some epithelial neoplasm such as undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head and neck tumor especially, in laryngeal squamous cell carcinoma is not fully elucidated. The aim of this study was to analyze the relationship between the prescence of EBV in laryngeal squamous cell carcinoma and clinicopathologic characteristics. MATERIALS AND METHODS: 65 cases of laryngeal squamous cell carcinoma were retrieved from formalin-fixed, paraffin-embedded blocks and analyzed for EBV by immunohistochemical staining. Results : The EBV was detected in 26(40%) of the 65 patients with laryngeal squamous cell carcinoma and 2(10%) of the 20 control ases. In 26 cases of EBV-positive patients, 13(46.4%) cases were supraglottic cancer and 13(35.1%) cases were glottic cancer. CONCLUSION: These results suggest that EBV may possibly play an etiologic role in the pathogenesis of laryngeal squamous cell carcinoma.
Carcinoma, Squamous Cell*
;
Head
;
Herpesvirus 4, Human*
;
Humans
;
Lymphoma
;
Neck
;
Neoplasms, Glandular and Epithelial
6.In Vivo Feasibility Test of a New Flexible Ureteroscopic Robotic System, easyUretero, for Renal Stone Retrieval in a Porcine Model
Joonhwan KIM ; Hae Do JUNG ; Young Joon MOON ; Hyunho HAN ; Byungsik CHEON ; Jungmin HAN ; Sung Yong CHO ; Joo Yong LEE ; Dong-Soo KWON
Yonsei Medical Journal 2022;63(12):1106-1112
Purpose:
Using a new robotic endoscopic platform system developed for retrograde intrarenal surgery (RIRS) called easyUretero (ROEN Surgical Inc.), we evaluated the feasibility and safety of renal stone retrieval in a porcine model.
Materials and Methods:
Six female pigs were used for our in vivo study. First, 0.3-cm-sized phantom stones were inserted into the kidneys of each pig via the ureteral access sheath. Next, renal stone retrieval was attempted using manual RIRS in three pigs and robotic RIRS in three pigs. Three surgeons performed extraction of 10 stones in each session.
Results:
The mean stone retrieval time by manual RIRS was significantly shorter than that by robotic RIRS (399.9±185.4 sec vs. 1127.6±374.5 sec, p=0.001). In contrast, the questionnaire regarding usability showed high satisfaction in the surgeons’ fatigue category for surgeons using robotic RIRS. The radiation exposure dose was also lower in robotic RIRS than in manual RIRS (0.14 μSv vs. 45.5 μSv). Postoperative ureteral injury assessment revealed Grade 0 in manual RIRS cases and Grades 0, 1, and 2 in robotic RIRS cases.
Conclusion
The easyUretero system is a new robotic RIRS system that was developed in Korea. The results of the present study suggest that using easyUretero for stone retrieval during RIRS is safe and ergonomic.
7.The Significance of Homocysteine in Epileptic Patients.
Ok Joon KIM ; Nam Keun KIM ; Hyun Jo KIM ; Jung Ho SEO ; Gue Yong LEE ; Byung Ok CHOI ; Jung Yong AHN ; Do Yeun OH ; Se Hyun KIM
Journal of Korean Epilepsy Society 2002;6(1):20-26
PURPOSE: Hyperhomocysteinemia was observed in epileptic patients receiving anticonvulsants, especially homozygotes for mtehylenetetrahydrofolate reductase (MTHFR) gene 677C->T mutation. Hyperhomocysteinemia induce atherosclerosis, fetal anticonvulsant syndrome, etc. Therefore, we examined any other factors that might affect the level of homocysteine in epileptic patients. METHODS: We investigated the plasma total homocysteine level in 145 patients with epilepsy. And then we analyzed various factors (clinical findings, neuro-image finding, drugs, MTHFR gene, serum folate and vitamin B12 level) affecting the level of homocysteine. RESULTS: Among the various factors, male, present neurological deficits, frequent seizure attacks, MTHFR gene 677 TT genotype, polypharmacy, and conventional drug (phenytoin, carbamazepine, valproic acid, phenobarbital, primidone, benzodiazpines) than new drug (lamotrigine, vigabatrin, topiramate, oxcarbazepine zonisamide) were related with elevated homocysteine levels. CONCLUSION: We recommend monotherapy with new drugs and higher vitamin requirement in the male epileptic patients of MTHFR TT genotype with neurological deficits and frequent seizure attacks.
Anticonvulsants
;
Atherosclerosis
;
Carbamazepine
;
Epilepsy
;
Folic Acid
;
Genotype
;
Homocysteine*
;
Homozygote
;
Humans
;
Hyperhomocysteinemia
;
Male
;
Oxidoreductases
;
Phenobarbital
;
Plasma
;
Polypharmacy
;
Primidone
;
Seizures
;
Valproic Acid
;
Vigabatrin
;
Vitamin B 12
;
Vitamins
8.Extensive Spinal Epidural Abscess: The Usefulness of Minimal Invasive Surgical Technique using Epidural Irrigation Catheter.
Joon Soo KIM ; Kang Hyun SUNG ; Yong Woon CHO ; Kyu Hong KIM ; Sang Do BAE
Korean Journal of Spine 2011;8(3):221-224
Spinal epidural abscess (SEA) is a rare infection but may be devastating and fatal. We describe a case of a42-year-old male who presented with a posteriorly located SEA extending from C2 to the sacrum with severe neurologic deficits. We had the emergency surgery with the minimal invasive technique using epidural irrigation catheter, and then obtained an excellent recovery. The purpose of this report introduces the usefulness of minimal invasive surgical technique for extensive SEA.
Catheters
;
Emergencies
;
Epidural Abscess
;
Humans
;
Male
;
Neurologic Manifestations
;
Sacrum
9.Risk Factors of and Treatments for Pharyngocutaneous Fistula Occurring after Oropharynx and Hypopharynx Reconstruction.
Su Bin DO ; Chul Hoon CHUNG ; Yong Joon CHANG ; Byeong Jun KIM ; Young Soo RHO
Archives of Plastic Surgery 2017;44(6):530-538
BACKGROUND: A pharyngocutaneous fistula is a common and difficult-to-manage complication after head and neck reconstruction. It can lead to serious complications such as flap failure, carotid artery rupture, and pharyngeal stricture, and may require additional surgery. Previous radiotherapy, a low serum albumin level, and a higher T stage have been proposed as contributing factors. We aimed to clarify the risk factors for pharyngocutaneous fistula in patients who underwent flap reconstruction and to describe our experiences in treating pharyngocutaneous fistula. METHODS: Squamous cell carcinoma cases that underwent flap reconstruction after cancer resection from 1995 to 2013 were analyzed retrospectively. We investigated several significant clinical risk factors. The treatment modality was selected according to the size of the fistula and the state of the surrounding tissue, with options including conservative management, direct closure, flap surgery, and pharyngostoma formation. RESULTS: A total of 127 cases (18 with fistulae) were analyzed. A higher T stage (P=0.048) and tube-type reconstruction (P=0.007) increased fistula incidence; other factors did not show statistical significance (P>0.05). Two cases were treated with conservative management, 1 case with direct closure, 4 cases with immediate reconstruction using a pectoralis major musculocutaneous flap, and 11 cases with direct closure (4 cases) or additional flap surgery (7 cases) after pharyngostoma formation. CONCLUSIONS: Pharyngocutaneous fistula requires global management from prevention to treatment. In cases of advanced-stage cancer and tube-type reconstruction, a more cautious approach should be employed. Once it occurs, an accurate diagnosis of the fistula and a thorough assessment of the surrounding tissue are necessary, and aggressive treatment should be implemented in order to ensure satisfactory long-term results.
Carcinoma, Squamous Cell
;
Carotid Arteries
;
Constriction, Pathologic
;
Cutaneous Fistula
;
Diagnosis
;
Fistula*
;
Free Tissue Flaps
;
Head
;
Humans
;
Hypopharynx*
;
Incidence
;
Myocutaneous Flap
;
Neck
;
Oropharynx*
;
Postoperative Complications
;
Radiotherapy
;
Retrospective Studies
;
Risk Factors*
;
Rupture
;
Serum Albumin
10.Pilomatrixoma in a Maltese Dog.
Jae Yong CHUNG ; Sun Hee DO ; Sang Joon PARK ; Kyu Shik JEONG
Laboratory Animal Research 2010;26(1):117-120
A 12-year-old female Maltese dog brought to a local veterinary clinic with two nodules in the subcutis of left shoulder. The nodules were grown gradually from 2 years ago. The nodules were removed surgically under anesthesia and examined histopathologically. They were 15x26 mm in diameter (oval form) and 12x15 mm in diameter (round form), respectively. Histopathologically, the lesions consisted of multilayered basaloid cells in the peripheral of the mass and ghost cells in the central region. Typical findings of these two nodules were gradually keratinized basaloid cell toward central area result in forming anuclear ghost cells. These microscopic features of cutaneous nodules were diagnosed as pilomatrixoma and the identified findings were similar to fully developed stage of human pilomatrixoma. This report may assist in the categorizing of canine pilomatrixoma using histopathological features.
Anesthesia
;
Animals
;
Child
;
Dogs
;
Female
;
Humans
;
Keratins
;
Pilomatrixoma
;
Shoulder