Piroxicam is a new nonsteroidal anti-inflammatory drug(NSAID) and widely used in the management of rheumatoid arthritis and osteaorthritis. We experienced. two cases of photosensitive dermatitis developed while taking piroxicam. Both had pruritic and eczematous skin lesions on sun-exposed areas and showed positive reactions to 0. 1 % piroxicam solution in photopatch test in contrast with control group, which suggest a photoallergy mechanism. To our knowledge, these are the first reported cases in the Korean literature.
Arthritis, Rheumatoid ; Dermatitis ; Dermatitis, Photoallergic* ; Piroxicam ; Skin

Malignant schwannoma is a malignant neoplasm of nerve sheath origin. It develops in an unaltered nerve or in a neurofibroma, and rarely, if ever, within a neurilernmoma. We experienced a malignant schwannoma in a 75-year-old man without von Recklinghausen's syndrome. The lesion was solitary and polypoid, fungating nodule in the posterior portion of the left thigh, The tumor cells had some features of Schwann cells and positively stained to S-100 protein and neuron-specific enolase. Complete excision was performed but the associated nerve could not be demonstrable.
Aged ; Humans ; Neurilemmoma* ; Neurofibroma ; Phosphopyruvate Hydratase ; S100 Proteins ; Schwann Cells ; Thigh

We report herein a case of bullous pemphigoid(BP) associated with Graves' disease(GD) The patient was 43-year-old female who had suffered frorn GD for 8 years. She had annular, erythematous atrophic plaques with a margin of small vesicles on the frontal and temporal areas, Histopathologic findings of the skin lesion showed subepiderrnal bulla, and numerous eosinophilic infiltrate in the bulla cavity and dermis. Direct immunofluorescent study of perilesional skin revealed linear IgG deposition at the dermo epidermal junction. We think our case shows a higher than chance association of BP and GD because both are basecl on autoimmune mechanism.
Adult ; Dermis ; Eosinophils ; Female ; Graves Disease* ; Humans ; Immunoglobulin G ; Pemphigoid, Bullous* ; Skin

Nodular-cystic fat necrosis is an unusual, distinctive entity characterized by histologically en-capsulated fat necrosis in the subcutis. We report two cases of nodular-cystic fat necrosis. The lesions were subcutaneous nodules. Histopathologically, the nodules showed strong periodic acid-Schiff -positive necrotic adipose tissue with lipomembranous changes and calcification.
Adipose Tissue ; Fat Necrosis*

An immunohistochemical and electron microscopic study of an atypical fibroxanthoma of the skin (AFX) was reported. The lesion developed on the left scapulararea in a 70-year-old man. The result using antibody to S-100 protein was negative and the tumor cells observed with electron microscope were undifferentiated, fibroblast-like, histiocyte-like and multinucleated giant cells. But Langerhans-like cells or Langerhans were not found.
Aged ; Giant Cells ; Humans ; S100 Proteins ; Skin*

No abstract available.
Hypertension, Portal

The connective tissue nevus represents a hamartoma of various components of dermal connective tissue elements, predominantly collagen, elastin, or glycosa minoglycan. Zosterriform connective tissue nevus, described by Steiner, in 1944, clinically shows grouped papules in a zosteriform band without extracutaneous manifestations of family history, and peculiar histopathologic findings. We experienced 3 cases of typical zosteriforrn connective tissue nevus developed on the flank area of 30-year-old male and 21-year-old male, and on the inguinal area of 15-year-old female.
Adolescent ; Adult ; Collagen ; Connective Tissue* ; Elastin ; Female ; Hamartoma ; Humans ; Male ; Nevus* ; Young Adult

PURPOSE: To evaluate abnormal neurosonographic (NSG) findings of thalami and basal ganglia in full term babies with hypoxic-ischemic encephalopathy and to correlate the findings with follow-up studies and prognosis. METHODS: We evaluated 13 full term babies with abnormal NSG findings of thalarni and basal ganglia. NSG was performed within 7 days after clinical abnormalities. Follow-up NSG was done in 11 cases; CT scan in 4 and MRI in 7. We classified NSG findings as diffuse, unilateral, and focal types according to increased echogenicity and evaluated prognosis based on follow-up studies and neurological sequelae. RESULTS: Nine cases of diffuse type had diffuse echogenic changes of bilateral thalami and basal ganglia, slit-like lateral ventricles suggesting cerebral edema, and increased parenchymal echogenicity. In diffuse type, follow-up studies showed more prominent echogencities and ventricular dilatations and cerebromalacia. One case of unilateral type caused by thromboembolism had unilateral echogenicity of right thalamus and basal ganglia with increased echogenicity of the ipsilateral cerebral hemisphere and compression of the lateral ventricle, suggesting cerebral infarction. Follow-up study showed unilateral cystic cerebromalacia. Three cases of focal type had a localized echogenic area in thalamus with lacunar infarction, which decreased in size during follow-up. Among nine cases of diffuse type, one died within 2 days, two were discharged against medical advice, and six had severe neurologic sequelae. One case of unilateral type had a moderate degree of neurologic sequelae. All 3 cases of focal type had normal development. CONCLUSION: Pattems of abnormal echogenicity in thalami and basal ganglia in fullterm infants with hypoxic-ischemic encephalopathy are correlated with the outcome and may be helpful for treatment planning.
Basal Ganglia* ; Brain ; Brain Edema ; Brain Ischemia* ; Cerebral Infarction ; Cerebrum ; Dilatation ; Encephalomalacia ; Follow-Up Studies ; Humans ; Hypoxia-Ischemia, Brain ; Infant* ; Lateral Ventricles ; Magnetic Resonance Imaging ; Prognosis* ; Stroke, Lacunar ; Thalamus* ; Thromboembolism ; Tomography, X-Ray Computed

Respiratory syncytial virus (RSV) and Influenza virus are the most common pathogen for causing severe upper respiratory infection in all age groups. A multiplex reverse transcription polymerase chain reaction (RT-PCR) has been developed to detect and subtype influenza A (H3N2 and H1N1), B virus and RSV simultaneously in one tube reaction. Amplification with primers derived from conserved sequences within the nucleocapsid for RSV and hemagglutinin subunit for Influenza A (H3N2 and H1N1) and B viruses yielded a 384 bp, a 300 bp, a 236 bp and a 151 bp, respectively. Assay specificity was confirmed by pulse field gel electrophoresis and autosequencing method. Assay sensitivity was 3 PFU/ml of RSV, 22 PFU/ml, 45 PFU/ml of Influenza type A (H3N2 and H1N1) and 6.6 PFU/ml of Influenza B virus by plaque assay. A rapid and sensitive detection method of a one-tube with multiplex RT-PCR capable of identifying more than one viral template as well as synchronizing reverse transcription and PCR had the potential to produce considerable savings of time and cost effectiveness in the diagnostic laboratory.
Conserved Sequence ; Cost-Benefit Analysis ; Electrophoresis ; Hemagglutinins ; Herpesvirus 1, Cercopithecine ; Humans* ; Income ; Influenza B virus ; Influenza, Human* ; Nucleocapsid ; Orthomyxoviridae* ; Polymerase Chain Reaction* ; Respiratory Syncytial Virus, Human* ; Respiratory Syncytial Viruses ; Reverse Transcription* ; Sensitivity and Specificity

PURPOSE: To analyze the characteristies of traumatic brainstem injury by CT and MR MATERIALS AND METHODS: CT and MR studies of 10 patients with traumatic brainstem lesion in MR were retrospectively reviewed, particularly attended to location, signal intensity and associated lesions. RESULTS: CT failed to depict 8 of 10 brainstem lesions. All lesions were detected in MR images with T2-weighted images showing higher detection rate (n=10) (100%) than Tl-weighted images (n=3) (30%) or CT (n=2) (20%). The brainstem lesions located in the dorsolateral aspects of the rostral brainstem(mid brain and upper pons)in 7 (70%) cases, in ventral aspects of rostral brain in 2 (20%) cases and in median portion of pons in 1 (10%) case. Corpus callosal (n=5), Iobar white matter(n=5) diffuse axonal injury, and 2 hemorrhagic lesions in basal ganglia were the associated findings. CONCLUSION: MR imaging is more helpful than CT in the detection of brainstem injury, especially T2 weighted images. Primary brainstem lesions were typically located in the dorsolateral aspect of rostral brainstem(midbrain and upper pons). Corpus callosum and white matter lesions were frequently associated.
Basal Ganglia ; Brain ; Brain Stem* ; Corpus Callosum ; Diffuse Axonal Injury ; Humans ; Magnetic Resonance Imaging ; Pons ; Retrospective Studies