No abstract available.
Prostheses and Implants* ; Tooth*

The purpose of this study was to evaluate the stress patterns developed in abutment and residual ridge according to removable denture design in case of remaining mandibular cannies The removable denture design in this study were as foolows ; 1. Removable partial denture with non-splinted abutment 2. Removable partial denture with splinted abutment 3. Overdenture with telescopic crown 4. Overdenture with O-Ring attachment 5. Overdenture with combination bar attachment Photoelastic stress analysis was used to record the isochromatic fringe patterns and to calculate principal stress components at measuring points. The results were as follows : 1. In case of removable partial denture with non-splinted abutment, stress of root area at the loaded side was the largest. No significant differences in stress of root area were observed between loaded side and unloaded side. 2. No significant differences in stress of residual ridge at the loaded side were observed between removable partial denture with splinted abutment and removable partial denture with non-splinted abutment 3. In case of combination bar attachment retained overdenture stress of root area was the largest and in case of telescopic crown retained overdenture stress of root area was lowest. 4. In case of attachment retained overdenture, stress of residual ridge was lower but stress of root area was larger than in case of removable partial denture
Crowns ; Denture Design* ; Denture, Overlay ; Denture, Partial, Removable ; Dentures* ; Periodontium* ; Splints ; Tooth*

No abstract available.
Cleft Lip* ; Diagnosis* ; Ultrasonography*

In the late 1950, Greifenstein and associates have studied the properties of phenylcyelohexylamine derivatives and reported that these chemicals produced amnesia, analgesia, catatonia and catalepsy. Phencyclidine was the first of these drugs used in clinical anesthesia, but convulsive movement as well as excitatory behavior discouraged the use of the agent in human beings. Continued research for a more suitable derivative of phencyclidine with similar analgesic action, but shorter duratoin and lesser psychotomimetic action led McCarthy and Chen to investigate the pharmacologic properties of a large series of compounds. One of these, 2-ochlorophenylcyclohexylamine, was shown to have some advantages. Ketamine hydrochloride, chemically related to both phencyclidine and cyclohexylamine, proved to be more satisfactory for clinical anesthesia. Clinical investigations were begun in 1965 by Dominos group who first termed it dissociative anesthesia. As noted by Pender, the clinical signs of anesthesia with ketamine are completely different from those seen with conventional intravenous agents and gaseous compounds. Ketamine acts rapidly on intravenous or intramuscular administration to produce a state chracterized by catalepsy, analgesia and amnesia. It is devoid of sedation, hypnotic or convulsive properties. Normal pharyngeal-laryngeal reflexes are maintained and skeletal tone remains normal or increased. Since the introduction of ketamine by Domino's group, numerous reports have appeared to explain various aspects of the cardiovascular response(increased cardiac output, hypertention, little or no change in peripheral resistance) and respiratory response. However there are few reports on the effect of ketamine on intestinal motility. Thus we have made a study to observe the effect of ketamine on the intestinal motility of chickens. Strips of isolated muscle, 1 cm long, from adult fowl weighing l.2-1.5 kg and isolated smooth muscle of a patient with stomach cancer, were suspended in a muscle chamber containing Tyrode's solution into which was bubbled oxygen gas. The solution was. kept constant at 38 degrees C and contraction of the preparations was recorded on a polygraph. After being washed several times with fresh solution, the muscle strips attained constant motility and tonus. Ketamine and other drugs were added in various concentrations to the chamber. The results are as follows: 1) Ketamine did not exert any effect on human intestinal motility. It relaxed fowl intestinal muscle strips and potentiated the effect of epinephrine, norepinephrine, and isoproterenol. 2) The relaxing effects of ketamine on fowl intestinal muscle strips were not abolished by adrenergic blocking agents. 3) Ketamine demonstrated anticholinergic effect on the intestinal motility of the human and fowl. From the above results, it may be concluded that ketamine exerts a anticholinergic effect and depressant effect on intestinal motility of fowl without relation to adrenergic receptors.
Adrenergic Antagonists ; Adult ; Amnesia ; Analgesia ; Anesthesia ; Cardiac Output ; Catalepsy ; Catatonia ; Chickens* ; Cyclohexylamines ; Epinephrine ; Gastrointestinal Motility* ; Humans ; Isoproterenol ; Ketamine* ; Muscle, Smooth ; Norepinephrine ; Oxygen ; Phencyclidine ; Receptors, Adrenergic ; Reflex ; Stomach Neoplasms

This study was performed to investigate the influence of lateral guidance pattern and chewing pattern on masticatory muscle activity and occlusal contact pattern. Twenty-five patients with temporomandibular disorders and thirty students without temporomandibular disorders were selected for this study. Electromyographic examination and occlusal contact examination were performed simultaneously with Bio-Pak System(Bioresearch Inc.,U.S.A.) and T-Scan System(Tekscan Co., USA). The obtained results were as follows : 1. The EMG activity of masseter and anterior temporal muscle in patient group with canine guidance was higher than with non-canine guidance, but there was no significant difference(p>0.05). 2. The EMG activity of anterior temporal muscle in normal group with non-canine guidance was higher at preferred chewing side than at opposite side(p<0.05). 3. The EMG activity of masseter muscle was higher in normal group than in patient group (p<0.05). 4. The number of occlusal contact in patient group with canine guidance was higher than with non-canine guidance, but there was no significant difference(p>0.05). 5. The occlusal contact force at preferred chewing side was higher in patient group than in normal group(p<0.05).
Dental Occlusion ; Humans ; Masseter Muscle ; Mastication* ; Masticatory Muscles* ; Temporal Muscle ; Temporomandibular Joint Disorders

The muscular branches of the ophthalmic artery have been described as the superior muscular artery and the inferior muscular artery. However, the definition of the muscluar arteries and their distribution has not been clarified. Therefore, the muscular branches of the ophthalmic artery in 80 orbits of Korean adults were observed under the surgical microscope. The inferior muscular artery was observed in 87.5% of the materials and the superior muscular artery was observed in 32.5%. The commen muscular branch distributing to the adjacent two muscles was observed more frequently(81.3%). The superior muscular artery and the common muscular branches were similar in their distribution according to their site of origin. Therefore, they were classified into the superolateral and superomedial arteries. The superolateral muscular artery was observed in 58.6%. and the superomedial muscular artery was observed in 71.3%. This study suggests that the ocular muscular arteries are better classified into 3 groups, namely inferior, superolateral, and superomedial muscular arteries.
Adult ; Arteries* ; Humans ; Muscles ; Ophthalmic Artery ; Orbit

The muscular branches of the ophthalmic artery have been described as the superior muscular artery and the inferior muscular artery. However, the definition of the muscluar arteries and their distribution has not been clarified. Therefore, the muscular branches of the ophthalmic artery in 80 orbits of Korean adults were observed under the surgical microscope. The inferior muscular artery was observed in 87.5% of the materials and the superior muscular artery was observed in 32.5%. The commen muscular branch distributing to the adjacent two muscles was observed more frequently(81.3%). The superior muscular artery and the common muscular branches were similar in their distribution according to their site of origin. Therefore, they were classified into the superolateral and superomedial arteries. The superolateral muscular artery was observed in 58.6%. and the superomedial muscular artery was observed in 71.3%. This study suggests that the ocular muscular arteries are better classified into 3 groups, namely inferior, superolateral, and superomedial muscular arteries.
Adult ; Arteries* ; Humans ; Muscles ; Ophthalmic Artery ; Orbit

No abstract available.
Electroencephalography* ; Neuronal Ceroid-Lipofuscinoses ; Neurons*

BACKGROUND: TSH receptor blocking antibody (TRBAb) is a pathogenic factor in the vast majority of patients with primary myxedema. It has been reported that TRBAbs are found in some patients with chronic goitrous autoimmune thyroiditis (Hashimoto's thyroiditis), but the significance or the role of TRBAb in Hashimotos thyroiditis is not clear, We recently reported that hTSHR-CHO cells which express the functional human TSH receptors are more sensitive and are better in detecting functional TSH receptor antibodies in Graves patients than FRTL-5 cells. We are to investigate the biological role of TRBAb in Hashimotos thyroiditis by measuring thyroid stimulation blocking antibody (TSBAb) activities of Hashimoto's IgG's using hTSHR-CHO cells. Moreover, we are to see if there is any difference in epitope recognition between Hashimotos TRBAb and myxedema's TRBAb by measuring TSBAb activities with mutant receptor expressing cell lines, Mcl+2 and Mc 2 in those patients. METHOD: We measured TSBAb activities of IgGs from patients with primary myxedema (PM, n= 10) and those with hypothyroid (n 20) or euthyroid (n 17) Hashimoto's thyroiditis (HT) using wild type hTSHR-CHO cells (WT) and two chimeric receptor expressing cell lines, Mcl+2 and Mc2. RESULTS: TSBAb activities measured by WT were higher in hypothyroid HT than in euthyroid HT (30.0+-23.2% vs. 6.1+-28.7, p<0.05), and TSBAb-positive rate tend to be higher in the former (20%, 5/20) than in the latter (0%, 0/17, p=0.07). TRBAbs from PM (n=4) had high TBII activities and had persistent blocking activities despite of the replacement of amino acid residue 8~165 of extracellular domain of TSHR with those of rat LH/CGR (Mcl +2). However, TRBAbs from HT (n=4) had no TBII activity at all and lost blocking activities when measured with Mcl+2. CONCLUSION: TRBAbs are found in 20% of hypothyroid patients with Hashimotos thyroiditis in assay using hTSHR-CHO cells, and they seem to play a role in the development of hypothyroidism in some patients with Hashimotos thyroiditis. TRBAbs of Hashimotos thyroiditis are different in epitope recognition from TRBAbs of primary myxedema.
Animals ; Antibodies* ; Cell Line ; Humans ; Hypothyroidism ; Immunoglobulin G ; Myxedema ; Rats ; Receptors, Thyrotropin* ; Thyroid Gland* ; Thyroiditis* ; Thyroiditis, Autoimmune

BACKGROUND: Rapid and accurate identification of Mycobacterium tuberculosis complex is important in the diagnosis, treatment, and assessment of prognosis of tuberculosis. But, the conventional identification procedures such as niacin test usually requires considerable time. In this study, we compared the diagnostic value of a gene probe method with that of the niacin test for the differentiation of M. tuberculosis complex from mycobacteria other than tuberculosis (MOTT). METHODS: Commercially available gene probe kit(AccuProbeTM, Gen-Probe, Inc. , San Diego, Calif.) and Niacin test strip were used to identify 78 strains of mycobacteria isolated from patients at Asan Medical Center. One ATCC strain (M. tuberculosis complex) and one MOTT strain were used as controls. Polymerase chain reaction(PCR) was used when the above two tests yielded discordant results. RESULTS: Fifty isolates were identified as M. tuberculosis complex by both gene probe method and niacin test. Likewise 25 isolates were identified as MOTT by the both methods. For the remaining 5 isolates, the results of the two tests differed from each other: M. tuberculosis complex by gene probe and MOTT by niacin test. By PCR, however. these strains were identified as M. tuberculosis. The time required for identification was 1 to 2 hours by gene probe method and 1 to 3 weeks by niacin test. CONCLUSION: Gene probe is simple, rapid and reliable and is a very practical diagnostic tool that can be used in any clinical laboratory.
Chungcheongnam-do ; Diagnosis ; Genes, vif* ; Humans ; Mycobacterium tuberculosis* ; Mycobacterium* ; Niacin ; Polymerase Chain Reaction ; Prognosis ; Tuberculosis