1.Clinical application of Halo Apparatus
Kwang Yoon SEO ; Young Koo LEE ; Joon Wha CHUNG
The Journal of the Korean Orthopaedic Association 1980;15(4):781-792
Ten cases of unstable spine were treated with various surgical procedures under control of Halo apparatus and following results wen obtained. 1. Six cases of unstable cervical spine were treated with Halo apparatus and were able to obtain solid fusion for permanent stability. 2. Three cases of tuberculous kyphosis were corrected with halo-pelvic hoop on, and were able to obtain mean correction angle of 42 (65%) with little danger. 3. With halo on, staged operations such as anterior and posterior osteotomy, gradual distraction, anterior and posterior fusion of the spine for correcting deformity were carried out securely. 4. Average duration of halo application was eight weeks, no more twelve weeks, and there was no irreversible complication with halo apparatus per se.
Congenital Abnormalities
;
Kyphosis
;
Osteotomy
;
Spine
2.A Clinical Study of Ankle Fractures
Chil Soo KWON ; Kwang Yoon SEO ; Young Koo LEE ; Tae Young CHUNG ; Joon Wha CHUNG
The Journal of the Korean Orthopaedic Association 1978;13(3):399-408
The authors have reviewed 71 cases (70 patients) of the ankle fractures that were treated through the admission in Orthopedic Department, Paik Foundation Hospital, from June 1972 to April 1978. The average duration of the follow-up waa 15 months. The summary of the results were as follows; 1. Of the 71 cases, male was 54 cases and female 17 cases. The average age of the patients was 32. 2. The main cause of the injuries was traffic accident, and the other causes were sliding down and falling from a height, industrial accident, and sports injury in order. 3. By the classification of Lauge-Hansen, the pronation-external rotation and,supination-adduction types were commoner than the other types. 4. Open reduction was performed in 48 cases, and closed reduction in 23 cases. 5. The average duration of the cast immobilization after the closed reduction was 8 weeks, and that of the open reduction was 6 weeks. 6. The result of the treatment was better in those cases of the open reduction than that of, the closed reduction. 7. The good clinical results could be achieved by obtaining the anatomical position of the talus in the mortise and the reduction was achieved more satisfactorily when the key role of the lateral malleolus in complete reduction was well understood.
Accidental Falls
;
Accidents, Occupational
;
Accidents, Traffic
;
Ankle Fractures
;
Ankle
;
Athletic Injuries
;
Classification
;
Clinical Study
;
Female
;
Follow-Up Studies
;
Humans
;
Immobilization
;
Male
;
Orthopedics
;
Talus
3.Effect of stimulus parameters on auditory brainstem response.
Joon KWON ; Yang Sang LIM ; Joong Wha KOH ; Woo Kyung CHUNG
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(3):450-457
No abstract available.
Evoked Potentials, Auditory, Brain Stem*
4.A longitudinal study on the interrelationship between the growth change of the gonial angle and IMPA.
Chin Su CHUNG ; Young Kyu RYU ; Byung Wha SOHN ; Young Joon KIM
Korean Journal of Orthodontics 1999;29(4):435-444
This study was undertaken to investigate the growth change of gonial angle and interrelationship between the growth change of gonial angle and IMPA in the longitudinal data from 7 years to 15 years. By analyzing the serial lateral cephalograms of 15 males and 18 females of 7 years old to 15 years old who had no abnomality in growth and development and no history of orthodontic treatment, the following conclusion were obtained. 1. Gonial angle gradually decreased with aging in 25 children and in 9 children increased or maintained. 2. There was a tendency that children who decreased gonial angle with aging showed gradual increase of IMPA and children who increased of maintained gonial angle with aging showed decrease of IMPA 3. There was a tendency that regardless of the change of gonial angle, interincisal angle decreased with aging.
Adolescent
;
Aging
;
Child
;
Female
;
Growth and Development
;
Humans
;
Longitudinal Studies*
;
Male
5.Usefulness and Limitation of 3D-Ultrasoud Diagnosis of Breast Masses.
Yong Seok CHEON ; Soo Young CHUNG ; Ik YANG ; Kyung Won LEE ; Hong Dae KIM ; Sang Joon SHIN ; Bong Wha CHUNG
Journal of the Korean Radiological Society 2001;45(3):317-324
PURPOSE: To compare 3D ultrasound (3D-US) with 2D ultrasound (2D-US) in terms of their usefulness and limitations in the diagnosis of breast masses. MATERIALS AND METHODS: We obtained 2D and 3D US images of 37 breast lesions present in 20 cases of fibroadenoma, nine of cancer, and eight of fibrocystic disease proven in a total of 26 cases [fibroadenoma (n=13), breast cancer (n=9), fibrocystic disease (n=4)] by histologic examination, and by clinical evaluation and clinical evaluation with sonographic imaging in eleven. When comparing 3D and 2D-US images we had no prior information regarding detection rate according to the size of lesions, whether or not internal and boundary echo patterns could be interpreted, accurate differentiation between tumorous and non-tumorous lesions, or the accuracy with which benign and malignant tumors could be differentiated. RESULTS: For lesions of 1 cm or less in diameter the detection rate of 3D-US was lower than that of 2D-US, but for lesions over 1 cm there was no difference between the two modalities. In fibroadenoma and breast cancer, 3D-US was more useful than 2D-US for the evaluation of both internal and boundary echo, but with fibrocystic disease and in the diagnosis of tumor/non-tumor, there was no significant difference. In breast cancer, however, 3D-US more accurately determined malignancy, and in fibroadenoma, because of the pseudospicule revealed by 3D-US, this modality was less exact in determining benignancy. CONCLUSION: In the evaluation of internal and boundary echo in breast mass diagnosis, 3D-US was more useful than its 2D counterpart. For lesions of 1 cm or less in diameter, however, the detection rate of 3D-US was low, and since in some benign cases a pseudospicule was apparent, the possibiliy of confusion with malignancy arose. For these reasons, the usefulness of 3D-US was limited.
Breast Neoplasms
;
Breast*
;
Diagnosis*
;
Fibroadenoma
;
Ultrasonography
6.Diagnostic Value of the Lung Perfusion Scan in Foreign body Aspiration.
Ki Hong PARK ; Chong Woo BAE ; Sa Joon CHUNG ; Yong Mook CHOI ; Chang Il AHN ; Sun Wha LEE ; Chang Il CHA
Journal of the Korean Pediatric Society 1988;31(10):1301-1307
No abstract available.
Foreign Bodies*
;
Lung*
;
Perfusion*
7.The Effect of delta12PGJ2 and PPARgammaAgonist on the Proliferation and Differentiation of Osteoblast.
Jeong Mi HEO ; Kyoung Wha KIM ; Kyoung Wook CHUNG ; Hye Joon LEE ; In Chul RHYU ; Young KU ; Chong Pyoung CHUNG
The Journal of the Korean Academy of Periodontology 2005;35(1):133-152
No abstract available.
Osteoblasts*
;
PPAR gamma
8.Development of Rat Prostatitis Model by Oral Administration of Isoflavone and Its Characteristics.
Soo Mee KWON ; Sun Il KIM ; Dong Chan CHUN ; Nam Hoon CHO ; Bong Chul CHUNG ; Byung Wha PARK ; Sung Joon HONG
Yonsei Medical Journal 2001;42(4):395-404
Inflammation of the prostate can be induced experimentally in rats by the subcutaneous administration of estrogen. However, it is usually achieved at the price of some alteration in the sex steroid hormone balance and morphological changes in the prostate. In this study, a soy-extracted isoflavone mixture with weak estrogenic activity was administered orally in an attempt to induce prostatitis in a more physiologic way and to characterize the inflammation induced. A total of 36 male Sprague-Dawley rats, 8 weeks old, were divided into 2 groups. The control group was fed with only an AIN-76A diet containing no detectable phytoestrogen and the experimental group was fed with AIN-76A and a soy- extracted isoflavone mixture (genistein 60.0% and daidzein 19.6%), 300mg/kg body weight for 9 weeks. The sequential body weight and prostate weight at necropsy were measured. A histologic examination and histomorphometry assessed the changes in the prostate. The serum concentrations of testosterone and dihydrotestosterone were measured to estimate the effects on the androgen level. Intraprostatic concentrations of genistein and daidzein were measured by gas chromatography/ mass spectroscopy (GC/MS). While no sign of prostate inflammation was apparent in the control group, severe inflammatory changes in the stroma, increased epithelial detachment and inflammatory exudates within the glandular lumen of the dorsolateral prostate were observed in more than 80%(15/18) of the experimental group. However, there was no significant difference in the ventral prostate between the two groups. The daidzein and genistein concentrations in both the lateral and ventral prostates were significantly higher in the experimental group than in the control group where no isoflavone was detectable. In addition, the concentrations were much higher in the dorsolateral than in the ventral prostate. Although the body weight gain was not consistent in the experimental group, there were no significant differences in the prostate weight and serum androgen level between groups. In summary, when a soy-extracted genistein and daidzein-rich isoflavone mixture was administered orally into rats, prostatic inflammation with characteristic lobe specificity developed. The present method of inducing prostatitis seems to be a more physiologic than an estrogen-induced experimental model, and sequential pharmacokinetic studies might help in establishing this model as a more valuable tool in assisting future research in this field.
Administration, Oral
;
Androgens/blood
;
Animal
;
Body Weight/drug effects
;
Isoflavones/metabolism/*toxicity
;
Male
;
Organ Weight/drug effects
;
Prostatitis/*chemically induced/pathology
;
Rats
;
Rats, Sprague-Dawley
9.The Effect of Load Sharing Wiring on the Fixation of Transverse Fracture of Porcine Patella.
Jung Man KIM ; Chang Whan HAN ; Jae Duk RYU ; Cheong Ho CHANG ; Jin Wha CHUNG ; Seung Joon RYOO
Journal of Korean Orthopaedic Research Society 1998;1(1):91-97
Among many kinds of internal fixation techniques for the transverse fracture of the patella, AO modified tension band wiring technique and Pyrford technique have been widely used. However, it seems that those techniques are not strong enough to withstand immediate full weight bearing and full range of motion exercise postoperatively. Instead, a load sharing wiring technique seems to be more effective fixation technique. A comparative study was performed to evaluate the load sharing wiring technique using porcine patellae. Transverse fractures of thirty knees were made and were fixed with 3 different fixation technique. 1) AO modified tension band wiring technique, 2) Pyrford technique, and 3) Load sharing wiring technique. Then, those knees were mounted on the material testing system (Instron 4204(R)) and longitudinal traction was applied. The result showed that the separation of the fracture fragments was much less with the load sharing wiring technique than with the AO modified tension band wiring technique and the Pyrford tehchnique when 5 kg to 25 kg of traction was applied(P<0.05). The load sharing wiring technique showed less than 0.4mm of separation at 25~50kg of traction, where other techniques led specimen to failure. From this study, it was suggested that the load sharing wiring technique was proved to be more effective fixation technique compared to other techniques.
Knee
;
Patella*
;
Range of Motion, Articular
;
Traction
;
Weight-Bearing
10.Expression of TRH Receptor Gene in GH-Secreting Piruitary Adenomas.
In Myung YANG ; Seung Joon PARK ; Jeong Wha RYU ; Joo Ho CHUNG ; Mee Sook RYU ; Jeong Taek WOO ; Sung Woon KIM ; Jin Woo KIM ; Young Seol KIM ; Young Kil CHOI
Journal of Korean Society of Endocrinology 1997;12(3):349-356
Background: To test the hypothesis that Galphas gene mutation may suppress the expression of TRH-R gene, we investigated whether hTRH-R gene expression is lower in human GH-secreting pituitary adenomas with Galphas mutation than in tumors without the mutation. Method: TRH-induced paradoxical response of GH was observed in 8 acromegalic patients. The mutation of gene was identified by direct sequencing of the genomic DNA prepared from GH-secreting pituitary adenomas. The expression of hTRHT mRNA was quantitated by RT-PCR. Results: The transcript of hTRH-R gene was detected in 6 of 8(75%) tumors. Three of these(50%) showed the paradoxical GH response to TRH and the other three patients did not show the response. The relative expression of hTRH-R mRNA in the tumors from patients with the paradoxical response of GH to TRH did not differ from that in the tumors from patients without the paradoxical response. Direct PCR sequencing of Galphas disclosed a mutant allele and a normal allele only at codon 201 in 4 of 8 tumors. The paradoxical response to TRH was observed in 2 of 4 patients without the mutation, and 2 of 4 patients with the mutation. The hTRH-R gene expression of pituitary adenomas did not differ between the tumors without the mutation and those with mutation. Conclusion: This study suggests that the expression of TRH-R gene is not likely to be a main determinant for the paradoxical response of GH to TRH, and that Galphas mutation does not seem to suppress the gene expression of TRH-R in GH secreting adenoma.
Acromegaly
;
Adenoma*
;
Alleles
;
Codon
;
DNA
;
Gene Expression
;
Growth Hormone-Secreting Pituitary Adenoma
;
GTP-Binding Proteins
;
Humans
;
Pituitary Neoplasms
;
Polymerase Chain Reaction
;
Receptors, Thyrotropin-Releasing Hormone*
;
RNA, Messenger