OBJECTS: Sanjoin, the seeds of Zizyphus vulgaris var. spinosus has been used as the most important hypnotic agent in chinese medicine to treat insomnia. This research was performed in order to examine the effect of betulinic acid and sanjoinine-A which are components of Sanjoin. METHOD: Sleeping time, sleep recordings of EEG, serum serotonin level, and locomotor activity were measured in rats which received betulinic acid and sanjoinine-A as sleep induction material extracted from Sanjoin. RESULTS: 1) Groups received betulinic acid, sanjoinine-A, and lorazepam showed increased sleep time than control group with saline. 2) Groups with betulinic acid, sanjoinine-A, lorazepam and saline recorded beta-wave in sleep recording of EEG. In there was no significant difference among all groups. 3) No significant difference in serum serotonin level among all groups was found. 4) In autonomic activity testing, groups of betulinic acid, sanjoinine-A, and lorazepam showed significantly more decreased in activity than saline group. In comparison of groups of betulinic acid and sanjoinine-A with a group of lorazepam, there was no significant difference. CONCLUSION: These results suggests that betulinic acid and sanjoinine-A have the sedative effect like lorazepam rather than sleep effect.
Animals ; Asian Continental Ancestry Group ; Brain* ; Electroencephalography* ; Humans ; Hypnotics and Sedatives ; Lorazepam ; Motor Activity ; Rats* ; Serotonin* ; Sleep Initiation and Maintenance Disorders ; Ziziphus

Lymphoma of the prostate is exceedingly rare. Much more common than primary lymphoma of the prostate id secondary involvement of malignant lymphomas originating at other sites. A variety of treatments have bee n used, including prostatectomy, radiotherapy or combinations of chemotherapy and radiotherapy. Generally, the prognosis is very poor, and there is currently no consensus regarding treatment. We report on a patient with T-cell lymphoma who presented with symptoms of bladder neck obstruction. The patient has been asymptomatic and under complete remission after completion of doxorubicin-based chemotherapy for 2 cycles.
Bees ; Consensus ; Drug Therapy ; Drug Therapy, Combination* ; Humans ; Lymphoma ; Lymphoma, T-Cell* ; Prognosis ; Prostate* ; Prostatectomy ; Radiotherapy ; T-Lymphocytes* ; Urinary Bladder Neck Obstruction

No abstract available.
Cerebral Infarction* ; Craniocerebral Trauma* ; Head* ; Humans ; Oxygen*

We performed a retrospective study on evisceration and enucleation operated at Chosun University hospital and Chonnam University hospital during the period of 10 years from January 1982 to December 1991. The total number of cases was 550. The incidence was mow common in male. The male and female ratio was 1.85: 1(Male 64.9%, Female 35.1%). The frequency of enucleation and evisceration was as follows trauma; 281 cases(51.1%), glaucoma; 76 cases(13.8%), corneal ulcer; 69 cases(12.6%), panophthalmitis; 43 cases(7.8%), tumor; 33 cases(6.0%), phthisis bulbi, 26 cases(4.7%), others; 22 cases(4.0%). The most frequent cause of the trauma whitch had been eviscerated or enucleated was traffic accident; 129 cases(45.9%), followed by violence; 73 cases(25.9%), industrial accident, 37 cases(13.2%), toy and pencil; 19 cases(6.8%), sports; 12 cases(4.3%), unknown; 11 cases(3.9%). The age-related incidence was peak in the third decades 86 cases(15.6%), followed by fifth decades 85 cases(15.5%) and fourth and sixth decades 82 cases(14.9%), respectively. The mean annual incidince rate was significantly greater among males than females: 2.33 per 100,000 population and 1.93 per 100,000 population, respectively. The overall mean annual rate was 2.13.
Accidents, Occupational ; Accidents, Traffic ; Corneal Ulcer ; Female ; Glaucoma ; Gwangju* ; Humans ; Incidence ; Jeollanam-do* ; Male ; Panophthalmitis ; Play and Playthings ; Retrospective Studies ; Sports ; Violence

We performed a retrospective study on evisceration and enucleation operated at Chosun University hospital and Chonnam University hospital during the period of 10 years from January 1982 to December 1991. The total number of cases was 550. The incidence was mow common in male. The male and female ratio was 1.85: 1(Male 64.9%, Female 35.1%). The frequency of enucleation and evisceration was as follows trauma; 281 cases(51.1%), glaucoma; 76 cases(13.8%), corneal ulcer; 69 cases(12.6%), panophthalmitis; 43 cases(7.8%), tumor; 33 cases(6.0%), phthisis bulbi, 26 cases(4.7%), others; 22 cases(4.0%). The most frequent cause of the trauma whitch had been eviscerated or enucleated was traffic accident; 129 cases(45.9%), followed by violence; 73 cases(25.9%), industrial accident, 37 cases(13.2%), toy and pencil; 19 cases(6.8%), sports; 12 cases(4.3%), unknown; 11 cases(3.9%). The age-related incidence was peak in the third decades 86 cases(15.6%), followed by fifth decades 85 cases(15.5%) and fourth and sixth decades 82 cases(14.9%), respectively. The mean annual incidince rate was significantly greater among males than females: 2.33 per 100,000 population and 1.93 per 100,000 population, respectively. The overall mean annual rate was 2.13.
Accidents, Occupational ; Accidents, Traffic ; Corneal Ulcer ; Female ; Glaucoma ; Gwangju* ; Humans ; Incidence ; Jeollanam-do* ; Male ; Panophthalmitis ; Play and Playthings ; Retrospective Studies ; Sports ; Violence

PURPOSE: The reliability and validity of a Korean version of the Obsessive-Compulsive-Inventory-Revised (OCI-R) was examined in non-clinical student samples. MATERIALS AND METHODS: The Korean version of OCI-R was administered to a total of 228 Korean college students. The Maudsley Obsessive Compulsive Inventory (MOCI), Beck's Depression Inventory (BDI), and Beck's Anxiety Inventory (BAI) were administered to 228 students. RESULTS: The total and each of subscale of the Korean OCI-R demonstrated excellent internal consistency, good test-retest reliability, moderate convergent validity and good divergent validity. CONCLUSION: It was concluded that the Korean version of the OCI-R has strong psychometric properties as the original version.
Female ; Humans ; Korea ; Male ; Obsessive-Compulsive Disorder/*diagnosis ; *Psychological Tests/statistics & numerical data ; Psychometrics ; Questionnaires ; Reproducibility of Results ; Young Adult

BACKGROUND: In patients with mitral stenosis, the degree of pulmonary hypertension is expected to be related to the severity of mitral valve obstruction. However, some patients with severe mitral stenosis do not develop reactive pulmonary hypertension. MATERIALS AND METHODS: We evaluated 34 patients with symptomatic mitral stenosis undergoing percutaneous mitral valvuloplasty by clinical, echocardiographic, and invasive hemodynamic(cardiac cathrterization) data. Prevalvuloplasty data were available in 34 subjects[mean age 38+/-9 year ; women 74% ; NYHA class 1 (6 patients), class 2 (17 patients), class 3 (7 patients), class 4 (4 patients) ; in electrocardiography, NSR(23 patients), Atrial fibrillation(11 patients)]. RESULTS: 1) The pulmonary vascular bed gradient was significantly correlated with pulmonary vascular resistance(r=0.91), mean pulmonary artery pressure(r=0.82), transmitral mean pressure gradient(r=0.64) and mitral valve area(r=-0.48). The pulmonary vascular resistance was significantly correlated with mena pulmonary artery pressure(r=0.77), transmiral mean pressure gradient(r=0.61) and mitral valve area(r=-0.54), NYHA functional classification(r=0.36). However, the pulmonary vascular bed gradient and pulmonary vascular resistance was not significantly correlated with age, sex, cardiac output, the severity of mitral regurgitation and mean left atrial pressure. 2) The mean pulmonary artery pressure was significantly correlated with mean left atrial pressure(r=0.80), transmitral mean pressure gradient(r=0.72) and mitral valve area(r=-0.47). 3) When patients were divided into those with a pulmonary vascular bed gradient > 12mmHg and Atrial Pressure ; Cardiac Output ; Echocardiography ; Electrocardiography ; Female ; Heart Diseases ; Humans ; Hypertension, Pulmonary* ; Mitral Valve ; Mitral Valve Insufficiency ; Mitral Valve Stenosis* ; Pulmonary Artery ; Vascular Resistance

OBJECTIVE: To compare the perinatal outcomes in twin and singletone pregnancies delivered prematurely between 28 and 36 weeks gestational age. METHODS: We studied 80 pairs of twin delivered between 28 weeks and 36 weeks gestational age at Eulji university hospital between January 1996 and October 2000. The perinatal morbidity and mortality in premature twin pregnancies were compared to those of premature singleton pregnancies (N=402). RESULTS: The premature twin pregnancies had no significant differences of gestational age at delivery than those of singleton pregnancies, but significantly lower mean birth weight. In mean day of hospital stay, 1 and 5 min Apgar scores, there were no significant differences. There were no significant differences in the incidence of neonatal morbidity such as hyaline membrane disease, and retinopathy of prematurity, between the two groups. And also the perinatal mortality was not significantly different between the two groups. CONCLUSION: There were no significant differences in perinatal mortality and morbidity between the two groups.
Birth Weight ; Gestational Age* ; Humans ; Hyaline Membrane Disease ; Incidence ; Infant, Newborn ; Length of Stay ; Mortality ; Perinatal Mortality ; Pregnancy* ; Pregnancy, Twin ; Retinopathy of Prematurity

OBJECTIVE: This study was performed to evaluate the effects of oral administration of iron supplements during pregnancy on maternal hemoglobin concentrations and birth weights. METHOD: Data from clinical records of 141 pregnant women and their babies were analysed. Studied mothers were classified to 3 groups such as non iron supplement group (groupI), 2-3 months supplement group (group II), and over 4 months supplement group (group III) by the duration (months) of oral supplement prescribed. RESULTS: There was positive correlation between hemoglobin levels and iron supplement duration. Proportions of anemia showed decreasing basis with the increasing iron supplement duration. The maternal hemoglobin levels showed decreasing basis with the increasing birth weight. There was positive correlation between iron supplement duration and maternal hemoglobin levels, but there was no significant correlation between iron supplement duration and birth weight. For the groupI(non-supplement group), maternal hemoglobin levels were decreased with the increasing birth weight but there was no significant correlations between hemoglobin levels and birth weights with increased iron supplement duration. CONCLUSION: There was a significant inverse correlation between maternal hemoglobin levels and birth weight in non-iron supplement group but there was no significant correlations between hemoglobin levels and birth weights with increased iron supplement duration.
Administration, Oral* ; Anemia ; Birth Weight* ; Female ; Humans ; Iron* ; Mothers ; Parturition* ; Pregnancy* ; Pregnant Women

OBJECTIVE: To evaluate pattern of associated structural anomalies, abnormal karyotypes and perinatal outcomes of fetuses with prenatally diagnosed single umbilical artery and to evaluate the relation of absent side of a single umbilical artery in association with anomalies and abnormal karyotypes. MATERIALS AND METHODS: 30 fetuses with a single umbilical artery were detected by prenatal ultrasound examnination between March 1998 and June 2001 at Eul-Ji University Hospital. All medical records were reviewed for maternal demographics, associated anomalies, karyotypic analysis, pregnancy complications, and neonatal outcome. RESULTS: Of the 30 fetuses, 11 (36.7%) were terminated because of severe anomalies and 2 (6.7%) experienced neonatal death. 17 fetuses (56.7%) had an associated structural anomaly. The structural anomalies found in association with single umbilical artery were cardiovascularac system (9 cases, 30.0%), urogenital system (6 cases, 20.0%), central nervous system (5 case, 16.7%) and ectopia cordis (1 case, 5.9%) and 7 cases (20%) among these had multiple malformations. Karyotype analysis was availabe in 25 cases and 5 (20%) of these were chromosomally abnormal. All of the karyotypically abnormal fetuses had a structural defect diagnosed on prenatal ultrasound examination in addition to the single umbilical artery. Of 13 fetuses without any associated structural or chromosomal anomalies, 3 (23.1%) demonstrated growth restriction. Of the 26 cases identified the absent side of a single umbilical artery, the right umbilical artery was absent in 13 (50%) and the left in 13 (50%) fetuses. The frequency with associated structural and chromosomal anomalies was equal on right (53.8%; 15.4%) and left (69.2%; 15.4%) sides. CONCLUSION: Scanning the umbilical cord should be one of the essential parts of 2 nd trimester ultrasonographic examination. When single umbilical artery is detected, a detailed ultrasonographic examnination including fetal echocardiography and fetal karyotyping should be recommended for search of associated structural and chromosomal abnormalities. In cases where single umbilical artery is an isolated finding on prenatal ultrasound, careful attention to fetal growth is necessary.
Abnormal Karyotype ; Central Nervous System ; Chromosome Aberrations ; Demography ; Echocardiography ; Ectopia Cordis ; Fetal Development ; Fetus* ; Karyotype ; Karyotyping ; Medical Records ; Pregnancy Complications ; Single Umbilical Artery* ; Ultrasonography ; Umbilical Arteries ; Umbilical Cord ; Urogenital System