No abstract available.
Congenital Abnormalities* ; Humerus* ; Osteotomy*

We present a case of severe intracranial hypotension syndrome following lumbar drainage. A 60-year-old woman developed recurrent attacks of vertigo, nausea and vomiting a week prior to admission. Brain MRI revealed a homogeneously well-enhanced mass in the right frontal lobe ; this was found to be a meningioma, and was totally removed. Dural defect was covered with fat and fascia, and postoperative cerebrospinal fluid(CSF) leakage through the frontal sinus was noted. Lumbar drainage was initiated, and about 36 hours later, the patient complained of bouts of headache, nausea and vomiting. Her mental state then gradually deteriorated, and she became stuporous. Brain CT was performed immediately and revealed bifrontal subdural fluid collection and signs of severe brain edema including obliteration of ventricles and basal cisterns. The lumbar drain was then clamped and she regained consciousness 12 hours later. This case clearly demonstrates that to avoid complications such as severe intracranial hypotension syndrome in a patient who has undergone lumbar drainage, the rate and amount of CSF drainage should be closely monitored.
Brain ; Brain Edema ; Consciousness ; Drainage* ; Fascia ; Female ; Frontal Lobe ; Frontal Sinus ; Headache ; Humans ; Intracranial Hypotension* ; Magnetic Resonance Imaging ; Meningioma ; Middle Aged ; Nausea ; Stupor ; Vertigo ; Vomiting

The present study was designed to investigate the interposed joint capsule at the femorotibial space following meniscectomy which could contribute to the regeneration of meniscus. Thirty two rabbits were used for this study. The anterior half of the medial meniscus was resected and the joint capsule was cut transversely 4mm above the joint line. It was reflected and interposed at the meniscectomized site. Gross findings at 2, 6, 8, and 12 weeks were recorded, respectively. Hematoxylin-Eosin(H-E) and safranin-O staining were done for histological and histochemical study, respectively. The results were as follows : 1 . With tile passage of time, interposed joint capsules looked like normal meniscus in shape, and the surface was glistening. 2. At 12 weeks, the width and thickness of interposed tissue were gradually decreased until it became normal size (P>0.05). 3. Histologically(H-E stain), the interposed tissue consisted of dense connective tissue with fibrocyte at 2 weeks. The interposed tissue changed to wedge shape and consisted of dense connective tissue with fibrocyte and prolifelated synovial cells at 6 weeks. Immature chondrocytes appeared at the lower portion and fat cells appeared at the upper portion of the tissue at 8 weeks. The fat cells disappeared and more mature chondrocyte were found in the central portion of interposed tissue at 12 weeks after operation. 4. Histochemical study(safranin-O stain) showed the interstitial tissue was not stained at 2 and 6 weeks, but glycosaminoglycan synthetic activity increased in the newly formed chondrocytes at postoperative 8 weeks and 12 weeks. From these results, the interposed capsule at the femorotibial space could be a substitute material for postmeniscectomy patients.
Adipocytes ; Chondrocytes ; Connective Tissue ; Humans ; Joint Capsule* ; Joints* ; Menisci, Tibial ; Rabbits* ; Regeneration

Purpose: Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea. Materials and Methods: Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively. Results: Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×109/L than in those with initial WBC ≥ 10×109/L (p=0.020). Conclusion This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment.

The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, as well as the future of fertility-sparing treatments, minimally invasive/radical/debulking surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. Clinical guidelines and position statement of Asian countries were presented by experts. Asian clinical trials for gynecologic cancers were reviewed and experts emphasized the point that original Asian study is beneficial for Asian patients. In Junior session, young gynecologic oncologists presented their latest research on gynecologic cancers.
Antineoplastic Agents ; Asian Continental Ancestry Group ; Drug Therapy ; Education ; Endometrial Neoplasms ; Female ; Gyeonggi-do ; Humans ; Immunotherapy ; Korea ; Ovarian Neoplasms ; Radiotherapy ; Uterine Cervical Neoplasms