1.Nucleolar Organizer Regions in Normal Tissue and Hyperplastic and Neoplastic Lesions.
Joon Mee KIM ; In Sun KIM ; Seung Yong PAIK
Korean Journal of Pathology 1989;23(2):208-222
For the identification of proliferating cells in tissue, the argyrophilic method for the demonstration of nucleolar organizer regions (Ag-NORs) have been described. To evaluate the applicability of Ag-NORs in surgical pathology, the authors have done Ag-NORs staining on 144 cases of routinely processed, formalin-fixed paraffin sections of various tissues; 15 normal tissues, 12 reactive and hyperplastic lesions, 30 benign neoplasms, 4 borderline lesions, and 83 malignant tumors. The results were summerized as follows; 1) In normal tissues, the mean numbers of Ag-NORs were highter in labile cells, especially in actively proliferating cells such as germ cells of testis, crypt epithelial cells in gastrointestinal mucosa, and lymphocytes from germinal center of tonsil and lymph node, than those of stable cells. 2) The mean numbers of Ag-NORs in reactive and hyperplastic lesions, benign neoplasms, and borderline lesions were similar to those of normal labile cells. 3) The mean numbers of Ag-NORs in carcinomas and sarcomas, (usually more than 2) significantly exceeded those of normal and non-malignant conditions. However, certain cases of carcinomas such as papillary carcinomas of thyroid, mucinous carcinoma of stomach, bronchioloalveolar carcinoma of lung, and adenoid cystic carcinoma of lung, and some of the leiomyosarcoma, malignant fibrous histiocytoma, and malignant schwannoma showed relatively lower numbers of Ag-NORs. 4) In non-Hodgkin's lymphomas, the high grade lymphomas showed more Ag-NORs than the low grade ones. From above results, it is suggested that the Ag-NORs technique is helpful in differentiation between malignant and non-malignant lesions. However, further evaluation on the significance of Ag-NORs upon the behavior of the cancer is to be made.
2.A case of traumatic pseudoaneurysm of the dorsalis pedis artery.
Sun Heum KIM ; Jai Koo CHOI ; Joon Buhm KIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(8):1526-1530
An aneurysm occurs in association with trauma, atherosclerosis, infection and congenital diseases. Among these, the traumatic arterial aneurysms developed from blunt trauma, crushing injury, perforation, and lacerations of vessels. Generally, most traumatic arterial aneurysms are false type, so called pseudoaneurysm. A pseudoaneurysm occurs by incomplete laceration of the vessel wall or partial division of the vessel. The vascular injury will make hematoma and fibrosis of neighboring tissues. After two to eight weeks post-trauma, the organized hematoma is liquefied and the fibrous tissue acts as an aneurysmal sac. We have experienced a case of dorsalis pedis artery pseudoaneurysm associated with arterial cannulation. So, we report a case of traumatic pseudoaneurysm with a review of literature.
Aneurysm
;
Aneurysm, False*
;
Arteries*
;
Atherosclerosis
;
Catheterization
;
Fibrosis
;
Hematoma
;
Lacerations
;
Vascular System Injuries
3.A case of Leiner's disease.
Nam Joon CHO ; Un Sun CHOI ; Dong Kun KIM
Korean Journal of Dermatology 1992;30(4):543-545
In 1908 Leiner described the peculiar skin condition among infants to which he applied the name erythroderma desquamativa. The four cardinal features of Leiners disease are generalized seborrheic dermatitis, intractable severe diarrhea, recurrent local and systemic infections usually of gram negative etiology, and marked wasting and cyst rophy. A 2-month-old female presented to our clinic with generalized seborrheic erythrodermic eruption and intractable diarrhea. She had sufferd from these symptoms since birth. Her body weight was 3.4kg (below 3rd percentile). Her scalp was covered with thick yellowish crsts. There was generalized erythroderma covered vith scales and crusts. Laboratory result; revealed gram negative sepsis and DIC. Chest X-ray showed the findings of minimal aspir ition pneumonia in the right upper lobe. She expired on the following day.
Body Weight
;
Dacarbazine
;
Dermatitis, Exfoliative
;
Dermatitis, Seborrheic
;
Diarrhea
;
Female
;
Humans
;
Infant
;
Parturition
;
Pneumonia
;
Scalp
;
Sepsis
;
Skin
;
Thorax
;
Weights and Measures
4.The Effects of Immunosuppressant and Immunostimulant on the Splenic Cell Subset of Rats Having Undergone Experimentally Induced Septal Fibrosis of Liver.
Mee Young SOL ; Joon Yeon KIM ; Sun Kyoung LEE
Korean Journal of Pathology 1995;29(5):572-583
Although there have been many reports about the importance of the spleen's role in hepatic fibrogenesis, the exact mechanism is still uncertain. The author designed this study to evaluate splenic function on hepatic fibrogenesis. The degree of hepatic fibrosis and the population of splenocyte subsets were studied in the experimental animal model with fibrosis produced by injecting normal swine serum intra-peritoneally into Sprague-Dawley rats. The animals were divided into three groups; group A was subjected to injection of swine serum only, group B swine serum and complete Freund's adjuvant and group C swine serum and cyclosporin A. The experimental hepatic fibrogenesis by swine serum was augumented by coinjection with the adjuvant and inhibited by cyclosporin A. The study of the splenocyte subset revealed increased percentages of spienic B cell and CD4+ cell and a decreased percentage of CD8+ cell, and these changes of splenocyte subset were also augumented by the adjuvant and inhibited by cyclosporin A. The percent of monocytes was not significantly altered, although a tendancy of early decrease by the adjuvant was noted.
Rats
;
Animals
5.Solar Urticaria: A Case Report.
Jae Joon LEE ; Sun Wook HWANG ; Young Pio KIM
Korean Journal of Dermatology 1985;23(1):63-66
We herein described a 27 year-old male who has been suffering from pruritic erythematous wheal and flare on sun-exposed areas, especially the midback for the past, ten months. The action spectrum of this patient was between 320 and 400 nm, .Passive and reverse passive transfer tests were negative. According to the classification by Harber et al, the current case seemed to belong to type II.
Adult
;
Classification
;
Humans
;
Intradermal Tests
;
Male
;
Urticaria*
6.Positive rate of anti-HCV in patients with abnormal liver function test.
Ho Sun CHANG ; Joon Suh SONG ; Young Sik KIM
Journal of the Korean Academy of Family Medicine 1992;13(1):49-56
No abstract available.
Humans
;
Liver Function Tests*
;
Liver*
7.The effects of long-term lithium treatment on the parathyroid hormone and calcium level.
In Joon PARK ; Seung Hyun KIM ; Sun Ho HAN
Journal of Korean Neuropsychiatric Association 1991;30(6):974-981
No abstract available.
Calcium*
;
Lithium*
;
Parathyroid Hormone*
8.Periosteal chondroma arising in the Phalangeal Bone: Report of Three Cases
Key Yong KIM ; Joon O YOUN ; Yong Sun CHO
The Journal of the Korean Orthopaedic Association 1994;29(3):1049-1053
Periosteal chondroma is a slowly growing cartilage tumor of limited size, which develops within and beneath the periosteal connective tissue and characteristically erodes and induces sclerosis of the contiguous cortical bone. The typical morphology of this tumor consists of an area of outer cortex scalloping involving the metaphyseal lesion of a long bone with slightly overhanging edges and a small amount of cartilage calcified matrix adjacent to the scalloping. Histologically this benign tumor can mimic chondrosarcoma. Awareness of this fact is important in order to avoid overdiagnosis and resultant overtreatment of the benign lesion. We report three cases of periosteal chondromas arising in the phalangeal bones of the hand. All were treated by curettage. No local recurrence was seen following this treatment.
Cartilage
;
Chondroma
;
Chondrosarcoma
;
Connective Tissue
;
Curettage
;
Cytochrome P-450 CYP1A1
;
Hand
;
Medical Overuse
;
Pectinidae
;
Recurrence
;
Sclerosis
9.Selective arterial thrombolysis with urokinase.
Jae Hyung PARK ; Kil Sun PARK ; Jin Wook CHUNG ; Joon Koo HAN ; Dae Young KIM ; Sang Joon KIM
Journal of the Korean Radiological Society 1991;27(4):441-446
No abstract available.
Urokinase-Type Plasminogen Activator*
10.Induction of ovulation by intermittent subcutaneous injection of pure follicle-stimulating hormone in polycystic ovarian syndrome.
Dong Suk KIM ; Seung Joon SHIN ; Hye Young KIM ; Hae Yang LEE ; Joon Young PARK ; Young Sun PARK
Korean Journal of Fertility and Sterility 1993;20(2):125-130
No abstract available.
Female
;
Follicle Stimulating Hormone*
;
Injections, Subcutaneous*
;
Ovulation*
;
Polycystic Ovary Syndrome*