The ovarian specimens obtained from the patients with 27 malignant germ cell tumors were analyzed in order to study DNA and form factor using flow cytometry and image analyzer. The malignant germ cell tumors consisted of six dysgerminomas, six endodermal sinus tumors, seven immature teratomas, three teratomas associated with squamous cell carcinoma, two embryonal carcinomas one mixed germ cell tumor and one malignant struma ovarii. Five normal ovaries used as control group. Various prognostic factors such as DNA ploidy, S-Phase and measurements of from were evaluated by flow cytometry and image analyzer. Mitotic index, histological grade, nuclear grade and tumor necrosis were assessed with microscope. These prognostic factors of DNA ploidy, S-phase, form factor histological were compared with tumor recurrence and clinical stage in this study. The results were as follows: 1. Sixteen(59%) out of 27 were aneuploidy and 11(41%) diploidy. All six dysgerminomas and six endodermal sinus tumors were aneuploidy, while six immature teratomas were diploidy. 2. S-phase fractions of malignant germ cell related significantly with those mitotic index(P=0.0201). S-phase fractions significantly increased in mitotic index gradeIII compared with grade I(P<0.01). There was no significant different between grade Iand II, and between gradeII and III. There was no difference between S-phase fractions and the remaining histological variables. 3. The incidence of aneuploidy was higher in the high s_ phase fractions(P=0.0041). However, there was no difference between S-phase fractions and tumor recurrence. 4. The incidence of aneuploidy significantly increased in clinical stage III and IV compared with stage I and II(P=0.0368). However, the difference between clinical stage histological variables was not significant. 5. The difference between form factor and histological variables, between from and tumor recurrence(P=0.3698), and between from factor and S-phase fractions(r=0.76) could not reach statistical significance. These results suggest that ploidy can give significant value for routine clinical prognostic prediction, whereas hitologic variables and form factor are poorly suitable for the prognostic evaluation.
Aneuploidy ; Carcinoma, Embryonal ; Carcinoma, Squamous Cell ; Diploidy ; DNA* ; Dysgerminoma ; Endodermal Sinus Tumor ; Female ; Flow Cytometry ; Germ Cells* ; Humans ; Incidence ; Mitotic Index ; Necrosis ; Neoplasms, Germ Cell and Embryonal* ; Ovary* ; Ploidies* ; Recurrence ; Struma Ovarii ; Teratoma

The ovarian specimens obtained from the patients with 27 malignant germ cell tumors were analyzed in order to study DNA and form factor using flow cytometry and image analyzer. The malignant germ cell tumors consisted of six dysgerminomas, six endodermal sinus tumors, seven immature teratomas, three teratomas associated with squamous cell carcinoma, two embryonal carcinomas one mixed germ cell tumor and one malignant struma ovarii. Five normal ovaries used as control group. Various prognostic factors such as DNA ploidy, S-Phase and measurements of from were evaluated by flow cytometry and image analyzer. Mitotic index, histological grade, nuclear grade and tumor necrosis were assessed with microscope. These prognostic factors of DNA ploidy, S-phase, form factor histological were compared with tumor recurrence and clinical stage in this study. The results were as follows: 1. Sixteen(59%) out of 27 were aneuploidy and 11(41%) diploidy. All six dysgerminomas and six endodermal sinus tumors were aneuploidy, while six immature teratomas were diploidy. 2. S-phase fractions of malignant germ cell related significantly with those mitotic index(P=0.0201). S-phase fractions significantly increased in mitotic index gradeIII compared with grade I(P<0.01). There was no significant different between grade Iand II, and between gradeII and III. There was no difference between S-phase fractions and the remaining histological variables. 3. The incidence of aneuploidy was higher in the high s_ phase fractions(P=0.0041). However, there was no difference between S-phase fractions and tumor recurrence. 4. The incidence of aneuploidy significantly increased in clinical stage III and IV compared with stage I and II(P=0.0368). However, the difference between clinical stage histological variables was not significant. 5. The difference between form factor and histological variables, between from and tumor recurrence(P=0.3698), and between from factor and S-phase fractions(r=0.76) could not reach statistical significance. These results suggest that ploidy can give significant value for routine clinical prognostic prediction, whereas hitologic variables and form factor are poorly suitable for the prognostic evaluation.
Aneuploidy ; Carcinoma, Embryonal ; Carcinoma, Squamous Cell ; Diploidy ; DNA* ; Dysgerminoma ; Endodermal Sinus Tumor ; Female ; Flow Cytometry ; Germ Cells* ; Humans ; Incidence ; Mitotic Index ; Necrosis ; Neoplasms, Germ Cell and Embryonal* ; Ovary* ; Ploidies* ; Recurrence ; Struma Ovarii ; Teratoma

Numerous studies on epidemiological aspects of contact dermatitis have been published in recent years since the introduction of a standardized method of patch test. We have performed the patch test on patients with contact dermatitis and on patients with other forms of dermatitis, A total of 153 patients were tested in this study between January 198l and August 1982. We have routinely attached 29 Hollister's standard batteries and 0. l% Tego, which is a commonly used antiseptic in our hospital, to the patients back. The tapes used were Leukotape and Finn chamber. Forty-eight hours after the tape had been attached, the patches were removed and read. The second reading was taken 24 or 48 hours after the patch had been removed. According to the results of this study, the most common allergens were cinnamic alcohol (11. 1%), ammoniated mercuric chloride (10. 5%), nickel sulfate (9. 2%), hydroxycitronellal(6. 5%), paraben mix(5. 9%), mercaptobenzothiazole(5. 9%) and thimerosal(5. 9%). In conclusion, cosmetics, metals, medicaments and rubber compounds were found to be the most common etiologic agents of contact dermatitis in this studyBackground and possible explanation of these rusults were discussed and a comparison was made between this report and others.
Allergens ; Dermatitis ; Dermatitis, Contact* ; Epidemiologic Studies* ; Humans ; Mercuric Chloride ; Metals ; Nickel ; Patch Tests ; Rubber

This study was undertaken to investigate the response of non-immunologic contact urticaria(NICU) test before and after ingestion of cyclo-oxygenase inhibitors such as naproxene, ibuprofen and mefenamic acid. Forty patients who showed positive reaction to 5% benzoic acid (BA) in petrolatum by 20 minutes closed patch test were chosen and divided into 3 groups. Group I was consisted of 13 patients who were taken naproxene 250mg bid, group II, 14 patients, taken ibuprofen 600mg bid, and group III, 13 patients, taken mefenamic acid 500mg bid. All the patients were tested with 5%, 2.5%, 1%, 0.5% and 0.1% BA in petrolatum using Finn chamber on Scanpor tape on the right arm before medication and next day on the left arm after medication of each day. Mefenamic acid did not show any significant differences before and after ingestion of drug. Naproxene reduced reaction about half of patients. Ibuprofen reduced reaction in almost all patients and blocked reaction completely in 9 of 13 patients. This results suggested that there was no correlation between blocking effect to BA induced contact urticaria and so called anti-inflammatory potencies of naproxene and ibuprofen, and that NICU by BA is partly mediated by prostaglandins(PG) or mediated by other mediators, which were potentiated by PG, except histamin.
Arm ; Benzoic Acid ; Cyclooxygenase Inhibitors ; Eating ; Humans ; Ibuprofen ; Mefenamic Acid ; Naproxen ; Patch Tests ; Petrolatum ; Urticaria*

Quaternium-15 (Dowicil 200) which is a water-soluble antimicrobial agent and a formaldehyde releaser is widely being used as a preservative in cosmetics and medicaments these days. However, there are scanty reports about it in the Korean literature. Recently, we have experienced two cases of Quaternium-15 contact dermatitis probably related with their cosmetics and topical medicament, respectively. We report our cases with the patch test results.
Dermatitis, Contact* ; Formaldehyde ; Patch Tests

No abstract available.
Polychondritis, Relapsing*

Favre-Racouchot syndrome(nodular elastosis with cysts and comedones) is a peculiar complication of solar elastosis in which comedones, follicular cysts, and nodules of altered elastic tissue occur mainly sround the orbits, on the cheeks, on snd around the nose, and oceasionally in other exposed areas, but sornetimes on the neck or behind the ears. We present a typical case of the Favre-Racouchot syndrome in a 66 year old man with maxillary cancer. The patient had numerous yellowish cysts and black topped comedones located on the forehead, around the orbits and the nose, on the neck, and also behind the ears of 5 years duration. The histopathology of the lesion showed dilated pilosebaceous openings and epitheliaI lined cysts filled with layered keratin in addition to pronounced solar elastosis.
Aged ; Cheek ; Ear ; Elastic Tissue ; Facial Dermatoses* ; Follicular Cyst ; Forehead ; Humans ; Neck ; Nose ; Orbit

Sebaceous carcinoma of the eyelids is rare and is usually seen in the elderly persons. The meibomian glands of the tarsus are the frequent sites of origin. The characteristic feature is a firm, painless nodule on the upper eyelid, We present a typical case of the sebaceous carcinoma in 60 year-old female. The patient had 1 * 1cm sized, hard, fixed, non-tender mass with bleeding on the right lateral canthus of 3~4 months duration. The histopathology of the lesion showed irregular sized lobules in the dermis with invasive growth to the surrounding stroma. Many fat containing sebaceous celles are seen in the center of the lobules.
Aged ; Ankle ; Dermis ; Eyelids ; Female ; Hemorrhage ; Humans ; Meibomian Glands ; Middle Aged

We present a case which seems identical to REM(Reticular Erythematous Mucinosis) syndrome in 26 year-old male. The lesion was initiated about 2 years ago and waxed and waned. The clinical findings were localized, grouped, erythematous papules and vesicles on the anterior middle chest with intermittent mild itching. Histopathology showed normal epidermis, extensive mucin deposition, telangiectasia and mild perivascular round cell infiltrations on the upper dermis. The mucin was stainable with alcian blue at pH 2. 5, but was not stained by either PAS or mucicarmine. Skin lesions were not responded to the oral steroid, but improved slowly after topical application of 5% para-aminobenzoic acid in ethanol for 9 months. The lesion does not recur until present time.
4-Aminobenzoic Acid ; Adult ; Alcian Blue ; Dermis ; Epidermis ; Ethanol ; Humans ; Hydrogen-Ion Concentration ; Male ; Mucins ; Pruritus ; Skin ; Telangiectasis ; Thorax

Superficial gastritis has been classified as a type of chronic gastritis, since a report of Schindler in GASTRLTIS, 1947. Howev~er, Benedict reported that superficial gastritis is only acute gastritis or shows normal mucosa histologically. The com mon endopical findings of chronic superficial gastritis were adherent mucus, edema, redness. The common redness which were encounterd are patchy redness and comb-like redness(Kammrotung). We studied the relationship between the redness of superficial gastritis and acute inflammatory changes histologically. Each case of superfieial gastritis was biopsied to redening and non-redening mucosa respectively. We collected 24 cases with 48 biopsy specimens. The results are as follows: Acute inflammatory changes were found only one case in redness and none in non-redness groups. There was no difference in acute inflammatory changes in two groups. The degree of mucosal atrophy were 62.5%, 66.7% in normal mucosa, 12.5%, 16.7~% in mild atrophy, 25%, 12.5% in moderate atrophy, 0%, 4.l% in severe atrophy with respect to redness and non-redness mucosa respectively. There was no difference in degree of mucosal atrophy in two groups. Mucosal atrophies were higher in older ages above 41 years old than below 40 and with increasing age, there was increasing tendency of mucosal atrophy. In conclusion, There was no relationships between mucosal redness and acute in flammatory changes histologically and also between mucosal redness and degree of atrophy.
Adult ; Atrophy ; Biopsy ; Edema ; Gastritis* ; Humans ; Mucous Membrane ; Mucus