Soft tissue perineurioma is a very rare tumor composed of entirely of neoplastic perineurial cells. A 54-year-old woman presented with a palpable mass in the right lower leg. The mass was excised. Grossly, the tumor measured 2.0x2.0x1.5 cm. The cut surface was well circumscribed, pale pinkish gray, and rubbery soft. Histological examination showed that the tumor was composed of spindle cells within collagenous and myxoid stroma. The tumor cells had elongated, tapering nuclei with long and thin cytoplasmic processes, and were arranged in fascicular, whorled, and storiform pattern. The tumor cells were positive for epithelial membrane antigen and collagen type IV and negative for S-100 protein. Ultrastructurally, tumor cells showed long and thin cytoplasmic processes, pinocytic vesicles, and incomplete external lamina. The diagnosis of soft tissue perineurioma was confirmed by immunohistochemical stain and ultrastructural study.
Collagen ; Collagen Type IV ; Cytoplasm ; Female ; Humans ; Immunohistochemistry ; Leg ; Middle Aged ; Mucin-1 ; Nerve Sheath Neoplasms ; S100 Proteins

PURPOSE: We report two cases of tube erosion after Ahmed valve implantation, treated with Amniotic Membrane Transplantation. METHODS: Erosion of conjunctiva over tube occured in 2 female patients with Ahmed valve implantation. They were treated with pericardial patch grafts and conjunctival free graft with amniotic membrane epithelial side up transplantation. RESULTS: No recurrent tube erosion has been found since then. Intraocular pressure has been maintained well for 12-14 months of follow-up. CONCLUSIONS: In cases of tube erosion, additional amniotic membrane transplantation can improve surgical success.
Amnion* ; Conjunctiva ; Female ; Follow-Up Studies ; Glaucoma* ; Humans ; Intraocular Pressure ; Transplants

Patients with inflammatory bowel disease are known to have hypercoagulability and an increased risk for venous thromboembolism. The deep veins of the lower extremities and the pulmonary veins are the most common sites of thrombosis in ulcerative colitis. However, hepatic vein thrombosis (Budd-Chiari syndrome) is a very rare extra-intestinal complication of ulcerative colitis in children. We describe a case of hepatic vein thrombosis in a 15-year-old girl with ulcerative colitis who presented with abdominal pain and hematochezia. Doppler ultrasonography and an abdominal CT scan revealed the characteristic filling defects caused by large thrombi in both hepatic veins. These lesions were successfully treated with conventional management for ulcerative colitis and anticoagulation therapy.
Abdominal Pain ; Adolescent ; Budd-Chiari Syndrome ; Child ; Colitis, Ulcerative ; Gastrointestinal Hemorrhage ; Hepatic Veins ; Humans ; Inflammatory Bowel Diseases ; Lower Extremity ; Pulmonary Veins ; Thrombophilia ; Thrombosis ; Ulcer ; Ultrasonography, Doppler ; Veins ; Venous Thromboembolism

We present a case which seems identical to REM(Reticular Erythematous Mucinosis) syndrome in 26 year-old male. The lesion was initiated about 2 years ago and waxed and waned. The clinical findings were localized, grouped, erythematous papules and vesicles on the anterior middle chest with intermittent mild itching. Histopathology showed normal epidermis, extensive mucin deposition, telangiectasia and mild perivascular round cell infiltrations on the upper dermis. The mucin was stainable with alcian blue at pH 2. 5, but was not stained by either PAS or mucicarmine. Skin lesions were not responded to the oral steroid, but improved slowly after topical application of 5% para-aminobenzoic acid in ethanol for 9 months. The lesion does not recur until present time.
4-Aminobenzoic Acid ; Adult ; Alcian Blue ; Dermis ; Epidermis ; Ethanol ; Humans ; Hydrogen-Ion Concentration ; Male ; Mucins ; Pruritus ; Skin ; Telangiectasis ; Thorax

No abstract available.
Mycobacterium tuberculosis* ; Mycobacterium* ; Polymerase Chain Reaction* ; Sputum*

The purpose of this study is to assess clinical outcomes of the patients who underwent Ahmed glaucoma valve implantation. Twelve eyes of 11 patients underwent Ahmed valve implantation for intractable glaucoma unresponsive to conventional management from March 1997 to April 1998 at department of ophthalmology of Kangbuk Samsung Hospital and had minimum follow-up of three months. Success(survival)was defined as an intraocular pressure(IOP)between 6 and 21 mmHg and with no additional glaucoma surgery, phthisis, implant removal, or loss of light perception. The mean follow-up period was 8 months(range, 3-17 months). There were 7 neovascular glaucomas, 3 secondary angle close glaucomas and 2 juvenile open angle glaucomas. The postoperative 1 year cumulative survival rate (Kaplan-Meier survival analysis)was 83. 3%. High survival rate was shown in secondary angle close glaucoma and JOAG(100%). The survival rate was not affected by sex, age, preoperative IOP, preoperative diagnosis, or number of preoperative glaucoma medications. There was failure in 2 eyes. One eye had qualified success by secondary Ahmed valve implantation. In the other eye, the tube in anterior chamber was too short and was plugged by blood clot and inflammatory membrane. This patient could not be reoperated due to poor general condition. Complications were hyphema and hypotony, and they were well controlled. Ahmed valve implantation in patients with intractable glaucoma may offer a better chance of surgical success.
Anterior Chamber ; Diagnosis ; Follow-Up Studies ; Glaucoma* ; Glaucoma, Neovascular ; Glaucoma, Open-Angle ; Humans ; Hyphema ; Membranes ; Ophthalmology ; Survival Rate

PURPOSE: This study was designed to find out whether protein kinase C (PKC) may affect telomerase activity in human ovarian cancers. MATERIALS AND METHODS: To determine whether PKC modulators influence PKC activities, NIH: OVCAR-3 and CUMO-2, cells were treated with PKC inhibitors, G 6976 and bisindolyl maleimide I, and PKC activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA). Telomerase acti vity was determined by telomeric repeat amplification protocol (TRAP). Analysis of the expres sion of each telomerase subunits, human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT), was performed by RT-PCR. We also examined the alternative splicing of hTERT. RESULTS: G 6976 and bisindolylmaleimide I inhibited PKC activity. Telomerase activities appeared to be affected in a time-dependent manner by these two PKC inhibitors. PKC activities were increased in parallel with telomerase activity by TPA at the low dose (10 nM), but their activities were down-regulated at the high dose (1 micrometer). RT-PCR demonstrated the presence of hTR and hTERT mRNA before and after the treatment of PKC modulators, respectively, and showed the presence of one alternatively spliced transcript and full-length hTERT transcripts. CONCLUSION: These results showed that telomerase activity was affected by PKC and suggested PKC modulation may serve as an useful tool in the regulation of telomerase activity.
Alternative Splicing ; Cell Line* ; Humans* ; Ovarian Neoplasms* ; Protein Kinase C* ; Protein Kinases* ; RNA ; RNA, Messenger ; Telomerase* ; Tetradecanoylphorbol Acetate

We reviewed 20 cases for the surgical effect of the vertical transposition of the horizontal rectus muscle for AV syndrome without significant oblique dysfuction. We performed vertical tranposition of the horizontal rectus muscle with standard recession and resection procedure and followed up at least six months. Sixteen cases were V syndrome and four cases were A syndrome. Medial rectus was moved toward the apex of the A or V, and the lateral rectus was moved to the opposite side of the apex of the A or V. The amount of transposition was adjusted according to the amount of vertical incomitance. If the vertical incomitance was 10delta, 15delta, 20deltaand 25delta, vertical transposition of rectus muscle was 1/4 TW[tendon width], 1/2 TW, 3/4 TW amd 1 TW, respectively. We achieved an average of 12.9deltareduction by 1/4 TW transposition, 14.4deltareduction by 1/2 TW transposition, 13.3delta reduction by 3/4 TW transposition, 19.0deltareduction by 1 TW transposition. We also achieved an average of 5.2delta/mm effect by 1/4 TW transposition, 2.9delta/mm effect by 1/2 TW transposition, 2.4 delta/mm effect by 3/4 TW transposition, 1.9delta/mm effect by 1 TW transposition. The vertical transposition of the horizontal rectus muscle for AV syndrome without significant oblique dysfuction showed good result and the amount of correction per mm of vertical transposition seemed to decrease as the amount of transposition increased, even though the total amount of correction showed a trend toward increasing [Fig.1, 2].
Muscles*

PURPOSE: It is important to know the accurate refractive error of the patients before LASIK because the amount of ablation is determined by that. We analyzed whether there are differences among the preoperative and postoperative results of cycloplegic retinoscopy (CR), module setting value, and autorefraction with and without cycloplegia (ACR, AMR). METHODS: The manifest and cycloplegic refractions of 104 eyes of 104 patients who underwent LASIK from February 2001 to July 2001 were reviewed. The preoperative and postoperative cycloplegic refraction, autorefraction by Canon RK-5, and module setting value were analyzed. RESULTS: In comparison of the preoperative values, AMR showed myopic shift compared to CR, module setting, and ACR (p<.001). ACR showed hyperopic shift compared to CR (p<0.001). The module setting showed myopic shift compared to CR, but it was not statistically significant. Postoperative mean spherical equivalent was 0.04 +/- 0.67D(range: -1.75 ~ +1.5). In comparison of the postoperative results, ACR showed hyperopic shift compared to CR (p<0.001) and AMR showed myopic shift compared to CR (p<0.001). CONCLUSIONS: As there is a difference between autorefraction and cycloplegic refraction, it is inappropriate to decide the amount of ablation only by one method. Hence when LASIK or LASIK retreatment is planned, cycloplegic refraction as well as autorefraction is necessary.
Humans ; Keratomileusis, Laser In Situ* ; Refractive Errors ; Retinoscopy ; Retreatment

Superficial gastritis has been classified as a type of chronic gastritis, since a report of Schindler in GASTRLTIS, 1947. Howev~er, Benedict reported that superficial gastritis is only acute gastritis or shows normal mucosa histologically. The com mon endopical findings of chronic superficial gastritis were adherent mucus, edema, redness. The common redness which were encounterd are patchy redness and comb-like redness(Kammrotung). We studied the relationship between the redness of superficial gastritis and acute inflammatory changes histologically. Each case of superfieial gastritis was biopsied to redening and non-redening mucosa respectively. We collected 24 cases with 48 biopsy specimens. The results are as follows: Acute inflammatory changes were found only one case in redness and none in non-redness groups. There was no difference in acute inflammatory changes in two groups. The degree of mucosal atrophy were 62.5%, 66.7% in normal mucosa, 12.5%, 16.7~% in mild atrophy, 25%, 12.5% in moderate atrophy, 0%, 4.l% in severe atrophy with respect to redness and non-redness mucosa respectively. There was no difference in degree of mucosal atrophy in two groups. Mucosal atrophies were higher in older ages above 41 years old than below 40 and with increasing age, there was increasing tendency of mucosal atrophy. In conclusion, There was no relationships between mucosal redness and acute in flammatory changes histologically and also between mucosal redness and degree of atrophy.
Adult ; Atrophy ; Biopsy ; Edema ; Gastritis* ; Humans ; Mucous Membrane ; Mucus