An epidemiological study is to observe and analyse 100 cases of lung cancer in Korean, which had been diagnosed actually at the general hospitals in Korea from 1970 through 1974, to discover the tendency of the lung cancer by sex, age, occupation, duration of clinical symptoms before diagnosis, site of cancer in lung, size of cancer, occurrence, treatment, prognosis, smoking and pathological findings as follows. 1. Males were affected 5.7 times more than females, the peak incidence of lung cancer were 50 years old age group. 2. The occupations of the cases were commerce, agriculture, industry, laborers and teachers, etc. in thht order. 3. The average duration symptoms from onset to diagnosis were 5.5 months. 4. The cancers were affected more right side than left side of the lungs, Particularly the most of them were affected in the upper lobes of the lungs. 5. The average diameter of the tumors was 5.5crX6.5cm, However the largest of them was 10cm X 13cm. 6. The most cases of the lung cancers were occurred primarily. 7. Out of the 100 cases, 58 cases had no treatment, 23 cases had palliative-symptomatic treatment, of cases by special chemo-therapy, 7 cases by surgery, and 5 cases by cobalt 60 or X-gay. 8. In the view point of prognosis, the most cases of the lung cancers died within one year atfer diagnosis. 9. The smoking was one of the causative factor of lung cancer, but there was no significant diferentiation by means of the amount of smoking. 10. The most cases of the lung cancers diangosed histo-pathologically, were epidermoid(squamous) type.
Agriculture ; Cobalt ; Commerce ; Diagnosis ; Epidemiologic Studies* ; Female ; Hospitals, General ; Humans ; Incidence ; Korea ; Lung Neoplasms* ; Lung* ; Male ; Middle Aged ; Occupations ; Prognosis ; Smoke ; Smoking

No abstract available.
Cleft Lip* ; Congenital Abnormalities* ; Nose*

No abstract available.
Korea* ; Leprosy*

No abstract available.
Animal ; Child ; Clinical Trials ; Dapsone/therapeutic use* ; Haplorhini ; Human ; Leprosy/drug therapy* ; Mycobacterium leprae/growth & development ; Sciuridae/microbiology ; Time Factors

No abstract available.
Hepatitis* ; Humans

The detection of the tubercle bacilli is absolutely necessary to make definite diagnosis of patients with genitourinary tuberculosis. Recently it has been reported that the detection rate of tubercle bacilli from the patient's urine is decreasing because of abuse of the anti-tuberculous drugs and the resistance developed in the experimental animals such as mouse and guinea pig (Marks, 1972). Therefore the necessity of the development of better diagnostic methods has been mandatory. Recently it was reported that the Korean chipmunks(Tamias sibiricus asiaticus. Gmelin) are highly susceptible to tubercle bacilli (Chang et al., 1971). The specific objection of this study is to pursue the possibility of using the chipmunks for the early diagnosis of genitourinary tuberculosis. Twenty-four hour urines of 34 patients with suspected genitourinary tuberculosis were tested for tubercle bacilli with smear, culture, and inoculation ink chipmunks and mice intraperitoneally. The results are briefly summarized as follows: 1. 18 cases out of 34 patients with suspected genitourinary tuberculosis were confirmed to be positive by any means of stained smear, culture and animal inoculation. Of 18 proved genitourinary tuberculosis. 12 cases were confirmed by smear, culture and mouse inoculation, and on the other hand. 14 cases by chipmunks inoculation. 2. In the group of chipmunks inoculation, 8 cases were found to be positive on the 10th day and 14 cages on the 20th day. 3. These findings suggest that the period required for the detection of tubercle bacilli was shorter and the positive rate was higher than that of other animals and other methods. For the clinical applications of the Korean chipmunks as a diagnostic tools, further effort is considered to be necessary.
Animals ; Diagnosis ; Early Diagnosis ; Guinea Pigs ; Hand ; Humans ; Ink ; Mice ; Sciuridae* ; Tuberculosis*

BACKGROUND: Primary hyperhidrosis is the disease of production of exessive sweat which is mainly localized in palm, sole, and axilla, treatment of the disease is usually accomplished with topical 20% aluminum chloride solution, an iontophoretic device, and surgery(sympathectomy) being reserved for recalcitrant cases. OBJECTIVE: We have compared the therapeutic effects with each treatments for hyperhidrosis using a skin surface hydrometer. METHODS: Thirty six patients(11 ; male, 25 ; femlale) with primary hyperhidrosis were evaluated in this study. Nineteen patients used topical 20% aluminum chloride solution, 10 patients used iontophoretic device, and 7 patients in recalcitrant cases. had sympathectomy. We have measured the conductance on the stratum corneum of the palm and sole suing skin surface hydrometer before and after treatment every weeks for a month. the control group were composed of healthy 10 males and 2 females. RESULTS: 1) In the patients of primary hyperhidroisis the conductances of palm, sloe and axilla were higher than that of control group(P<0.01). 2. There was a marked reduction of conductance after the treatment for one week by topical 20% aluminum chloride solution, an lontophoretic device, and sympathectomy(P<0.01). 3. After 2-4 week of treatment by the change obsetved after treatment for one week. 4. By iontophoretic device, there was a slight increasement of conductance of the palm after 2-3weeks of treatment. 5. We obseved a sustained decrease in the conductance by sympathectomy into 4 week. CONCLUSION: Topical 20% aluminum chloride solution, iontophoretic device, and sympathectomy were effective for treatment of hyperhirosis. Among hem sympathectomy showed the best effect. We observed that the skin surface hydrometer is useful to evaluate of the efficacy of the treatment.
Aluminum ; Axilla ; Female ; Humans ; Hyperhidrosis* ; Male ; Skin* ; Sweat ; Sympathectomy

These studies were carried out to detect the presence of mycotoxin producing fungi in various foodstuffs in Korea. The experiments were divided into three parts: bacteriologic, toxicologic and electron microscopic studies. From the 133 various samples, 425 colonies of fungi were isolated. In 405 of the 426 colonies it was possible to identify 17genera. Among the identified strains the predominant genera were Penicillum, Aspergillus and Alternaria. In the cytotoxicity test, 18 strains showed imld to severe toxic effects in mice, 19 strains showed toxic effects on HeLa cells. In electron microscopic studies of liver cells from aninals which had been treated with toxin-like substances, the liver cells showed the cytoplasmic changes dilatation of endoplasmic reticulum, swelling of mitochondria and increased number of lipid and glycogen particles. Alterations of nuclear envelape were also noted.
Animal ; Aspergillus/isolation & purification ; Cereals* ; Food Microbiology* ; Fungi* ; Hela Cells ; Human ; Liver/ultrastructure ; Mice ; Mice, Inbred ICR ; Mycotoxins/isolation & purification* ; Penicillium/isolation & purification

Botulinum toxin chemodenervation is widely used for the treatment of acute paralytic strabismus. We reviewed the effect of botulinum toxin chemodenervation for the treatment of chronic paralytic strabismus. Between 1996 and 1998, 13 patients with chronic paralytic strabismus were treated with botulinum toxin chemodenervation. The palsy of extraocular muscle persisted for at least 6 months. Each patient received an injection of 1.25 to 5 units of botulinum toxin[Botox]to the antagonist muscle of the paralytic muscle and two patients received injections two times. The follow-up was more than 6 months [mean 7.62 months].2 patients were treated with surgery of horizontal muscles and 3 patients were treated with muscle transposition surgery before injection. The mean preinjection deviation was 36.7PD and the mean strabismus angle after injection was 19.2PD and improving rate of the strabisbismus angle was 47.6%. The final deviations of 6 patients were within 10PD[46.2%]and 4 of 7 patients with final deviation above 10PD were treated with surgery later. Ptosis occurred in 4 patients[30.8%]and hypertropia occurred in 4 patients[30.8%]. In addition to the prevention of muscle contracture with botulinum toxin injection, it is likely that the therapeutic effect of botulinum toxin is produced by permanent alteration in the muscle and influence on the peripheral and central nervous system. Therefore botulinum toxin chemodenervation can be considered as a primary therapy or a subsequent therapy of surgery for chronic paralytic strabismus and further study is needed.
Botulinum Toxins* ; Central Nervous System ; Contracture ; Follow-Up Studies ; Humans ; Muscles ; Nerve Block* ; Paralysis ; Strabismus*

A line of fibroblast-type cells derived from embryos of a domestic rabbit has been cultivated continuously for over 3 years by serial passages up to the level of the moth passage. The cell line was tentatively named rabbit embryo fibroblast (REF). The establishment of primary culture, serial passages, growth rate and cytology are described in this communication. In addition some of the results of experiments on the detection of Mycoplasma contamination, on storage of the frozen cells and on its susceptibility to vaccinia virus infection are included.
Animal ; Cell Line ; Embryo/cytology* ; Fibroblasts* ; Rabbits ; Tissue Culture*