No abstract available.
Follow-Up Studies* ; Humans ; Stomach Neoplasms*

No abstract available.
Stomach Neoplasms* ; Biomarkers, Tumor*

No abstract available.

OBJECTIVES: To evaluated the relation of familial history of alcoholism and plasma level of beta-endorphin, ethanol, beta-endorphin, cortisol and blood glucose were compared in 48 male alcoholics and 29 normal controls. METHODS: Subjects are divided into two groups by family history of alcoholism. Blood samples were obtained before and after 0.75mg/kg of ethanol consumption a 7th admission day. RESULTS: 1) The ratio of family history positive to negative of the patient group was 2 to 1. 2) The age at admission of positive family history group was younger than negative groups. 3) There was no significant difference in change of plasma ethanol level among three groups. 4) There was no significant difference in change of plasma beta-endorphin level among three group. 5) There was no significant difference in change of plasma cortisol level among three groups. 6) There was no significant difference in change of fasting blood sugar level between two patients groups.
Alcoholics ; Alcoholism* ; beta-Endorphin* ; Blood Glucose ; Ethanol ; Fasting ; Humans ; Hydrocortisone ; Male ; Plasma

OBJECTIVE: Asymmetries in evoked potential P300 topography of schizophrenia and bipolar disorder are still controversial. The purpose of this study was to examine the difference in P300 topography between schizophrenia and bipolar disorder. METHOD: P300 was recorded from 16 schizophrenic, 15 bipolar manic, and 16 control subjects. All were right-handed. Subjects silently counted target stimuli(2.0kHz) among trains of standard stimuli(1.0 kHz). Averages were constructed from brain responses to target stimuli. RESULTS: 1) Schizophrenics displayed significantly smaller peak amplitude of P300 over Cz, Pz, T3 than controls. 2) Schizophrenics displayed significantly smaller peak amplitude of P300 over T3 than bipolar manics. 3) Schizophrenics displayed significantly smaller peak amplitude of P300 over T3 than their T4. 4) Schizophrenics displayed significantly delayed latency of P300 over T3 than bipolar manics. 5) Schizophrenics displayed significantly delayed latency of P300 over T3 than their T4. CONCLUSION: Left-sided P300 abnormality, especially left superior temporal gyrus, in schizophrenics, relative to bipolar manics and controls suggests that psychophysiological cause of schizophrenia and bipolar disorder is different and P300 asymmetry is specific to the psychophysiological cause of schizophrenia.
Bipolar Disorder* ; Brain ; Evoked Potentials ; Schizophrenia*

No abstract available.

The authores did clinical analysis of 150 cases of the Degenerative Joint Disease of the Knee and reviewed literature.
Joint Diseases ; Joints ; Knee

OBJECTS: Sanjoin, the seeds of Zizyphus vulgaris var. spinosus has been used as the most important hypnotic agent in chinese medicine to treat insomnia. This research was performed in order to examine the effect of betulinic acid and sanjoinine-A which are components of Sanjoin. METHOD: Sleeping time, sleep recordings of EEG, serum serotonin level, and locomotor activity were measured in rats which received betulinic acid and sanjoinine-A as sleep induction material extracted from Sanjoin. RESULTS: 1) Groups received betulinic acid, sanjoinine-A, and lorazepam showed increased sleep time than control group with saline. 2) Groups with betulinic acid, sanjoinine-A, lorazepam and saline recorded beta-wave in sleep recording of EEG. In there was no significant difference among all groups. 3) No significant difference in serum serotonin level among all groups was found. 4) In autonomic activity testing, groups of betulinic acid, sanjoinine-A, and lorazepam showed significantly more decreased in activity than saline group. In comparison of groups of betulinic acid and sanjoinine-A with a group of lorazepam, there was no significant difference. CONCLUSION: These results suggests that betulinic acid and sanjoinine-A have the sedative effect like lorazepam rather than sleep effect.
Animals ; Asian Continental Ancestry Group ; Brain* ; Electroencephalography* ; Humans ; Hypnotics and Sedatives ; Lorazepam ; Motor Activity ; Rats* ; Serotonin* ; Sleep Initiation and Maintenance Disorders ; Ziziphus

No abstract available.
Child* ; Humans ; Thyroid Gland* ; Thyroid Nodule*

BACKGROUND: The main purpose of bypass surgery in unresectable distal gastric cancer is to improve quality of life. However, the results of a conventional gastro-enterostomy are very dismal and include continuous bleeding due to contact of food material with the tumor surface and early obstruction of the stoma by tumor growth. METHODS: Eight hundred sixty two gastric-cancer patients were operated on between June 1992 and July 1999 at the Department of General Surgery, Hanyang University Medical Center, and 3.7% (32/862 cases) of them were unresectable. In this study, various kinds of gastro-jejunostomies (G-Jstomies), including conventional G-Jstomies (n=14), antral exclusion G-Jstomies (n=7), and gastric partitioning G-Jstomies (n=5) were retrospectively compared based on of survival and postoperative quality of life. Palliative gastrectomy cases (n=111) and explo-laparotomy only cases (n=6) were used as a control group for this study. RESULTS: The mean survival duration of the palliative gastrectomy group (20 2 months) was longer than those of the G-Jstomy (7 1 months) and the explo-laparotomy (4 1 months) groups (P=0.0000). However, there was no survival difference according to the type of G-Jstomy, and there was no statistically significant difference in hospital stay, diet start date, postoperative transfusion volume, or body weight change. Although the number of cases was too small and the clinicopathological profiles were not similar among the various G-Jstomy groups, the gastric partitioning G-Jstomy was very useful for endoscopically evaluating the tumor and for minimizing food contact with the tumor surface. CONCLUSIONS: The gastric partitioning G-Jstomy can be recommended as the choice of bypass surgery for unresectable distal gastric cancer due to its superiority in some aspects.
Academic Medical Centers ; Body Weight Changes ; Diet ; Gastrectomy ; Hemorrhage ; Humans ; Length of Stay ; Quality of Life ; Retrospective Studies ; Stomach Neoplasms*