55 patients which were clinically erythema multiforme and were diagnosed by punch biopsy, were studied clinically and histologically. The results obtained were as follows; l. Erythema multiforme was more common in female than in male and they were most frequently occured in 3rd decade. 2. In most patients individuaIs had various type of skin lesions (macule, papuIe, bullous and iris) and the skin lesions were scattered on the various sites of thc body. 3. 30 patients out of 55 patients had seasonal variation, especially frequently occured in spring k autumn. 4. In the histopathological study while dermal disturbance was a predominant finding in the macular lesion, epidermal necrosis was seen high frequency in bullous & iris lesions, 5. The papillary edema showed in most cases, however 2 cases out of 55 lesions had not papillary edema. 6. The dermal inflammatory infiltrates were composed chiefly of lyrnpho-histiocytic and significant number of eosinophils were present in the inflammatory infiltrate in 27 % of the bullous lesions.
Biopsy ; Blister ; Dronabinol ; Edema ; Eosinophils ; Erythema Multiforme ; Erythema* ; Female ; Humans ; Iris ; Male ; Necrosis ; Seasons ; Skin

No abstract available.
Humans

No abstract available.
Emergencies* ; Emergency Medical Services*

No abstract available.
*Attitude of Health Personnel ; Bone Diseases/*therapy ; Humans ; Joint Diseases/*therapy ; *Orthopedics

The following results were obtained in the present study concerning the effectiveness of thiabendazole upon the larvae of the migrating stages. In the early observation group: The average number of larvae of the group treated with single dose and the group treated with three doses were reduced in proportion of 52.2%, 58.5 % respectively compared with control group. In the late observation group: The reduction rate in the group treated with singel dose and group treated with three doses were 59.3 % and 63.2 % respectively compared with control group. The reduction rates of larvae from liver and lungs in the early drug administration group were 72.9 % and 59.7 % respectively, and 14.9 % and 54.8 % in the delayed drug administration group. In the group of drug given before and after infection, the number of recovered larvae were reduced 42.2 % and 31.1 % respectively compared with the control group. The peak number in organs was delayed 1 to 2 days in the treated group than that of control group. The survival period of the infected mouse was prolonged by the drug administration. The pathological changes were reduced by the administration of the drug. Through above results, it was concluded that thiabendazole reduced the number of migrating larvae and delayed the normal migration of the larvae in tissues and reduced the pathological changes in the tissues.
parasitology-helminth--nematode-Ascaris lumbricoides ; chemotherapy-thiabendazole ; migration ; thiabendazole

No abstract available.
Emergencies* ; Emergency Medical Services*

No abstract available.
Asthma* ; Cough*

Oblique single-plane trochanteric osteotomy, in which an oblique cut is made through the femoral trochanteric area and the bony fragments are rotated at the face of the cut in direct contact with each other, allows simulatenous correction of the femoral neck-shaft angle, femoral anteversion as well as flexion/extension effect. Only approximate methods of calculating the correction effects of this procedure have been introduced. Considering unique spatial orientation of femoral neck, we developed a rigorous method to calculate preoperatively the obliquity of the single-plane osteotomy and the amount of rotation required to achieve the target femoral conformation, through geometric analysis. The correction effect by oblique trochanteric osteotomy on the geometry of proximal femur was dependent not only on the amount of change of the neck-shaft angle and femoral anteversion but also on the preoperative neck-shaft angle and femoral anteversion themselves. The flexion/extesion effect was determined by the direction of the correction and the preoperative neck orientation. Computer graphic simulation study confirmed the validity of this method. A program written in QBASIC was introduced to make this complex calculation method more useful in the clinical practice.
Computer Graphics ; Femur Neck ; Femur ; Methods ; Neck ; Osteotomy

Ischemia causes tissue necrosis in a wide variety of pathologic conditions. Permanent deprivation of blood flow is lethal to any tissue and the prudent therapy for ischemia unquestionably is reperfusion. While reperfusion is necessary to reverse the progression towards ischemic death, reperfusion is also thought to be accompanied by its own component of injury. Oxygen free radicals, formed during ischemia/reperfusion, have been proposed as one of the main causes of reperfusion injury. Free radical attacks on biological membrane, such as mitochondria and endoplasmic reticulum, and can lead to the oxidative destruction of the polyunsaturated fatty acids of the membranes through lipid peroxidation. However, direct association between microsomal lipid peroxidation in vivo after ischemia/reperfusion and changes in secretory function and drug metabolism on the liver have not been established. Therefore, present study was performed to evaluate the hepatic secretory function and the hepatic microsomal drug metabolizing enzyme activity after ischemia/reperfusion preparation in rat liver. Further, the effect of oxygen free radical scavengers was investigated. The animals were divided into sham operation group and ischemia/reperfusion group. The ischemia/reperfusion group was subdivided into non-treated control and treated (with superoxide dismutase, allopurinol, alpha-tocopherol, deferoxamine) groups. Hepatic ischemia was produced by clamping the left branches of portal vein and hepatic artery, resulting in complete ischemia to the median and left lobes while the right lobes remained per Fused to prevent intestinal congestion. Reperfusion was permitted by declamping after 1 hour. After 1 or 5 hours of reperfusion, bile was collected, blood was obtained from abdominal aorta, and liver microsomes were isolated. The results are as follows. Serum aminotransferase was increased 15~20 times by ischemia/reperfusion. However, this increase was attenuated by free radical scavengers, especially 5 hours of reperfusion. The wet weight-to-dry weight ratio of the liver was significantly increased by ischemia/reperfusion. alpha-tocopherol pretreatment minimized the increase of ratio. Malondialdehyde level in the liver microsomal fraction was significantly increased after ischemia/reperfusion, but this increase was attenuated by scavenger pretreatment, especially alpha-tocopherol. Bile flow and cholate output but not the bilirubin output, were decreased after ischemia/reperfusion. The free radical scavenger pretreahnent restored the secretion significantly. Cytochrome P-450 content was significantly decreased after ischemia/reperfusion and ameliorated by free radical scavenger pretreatment. NADPH cytochrome P-450 reductase activity and aminopyrine N-demethylase activity were also decreased and improved by free radical scavengers pretreatment. These results indicate that ischemia/reperfusion deteriorates the hepatic secretory function as well as hepatic microsomal drug metabolizing enzyme activity, and the oxygen free radical scavengers attenuate the functional changes of the liver induced by ischemia/reperfusion.
Allopurinol ; alpha-Tocopherol ; Aminopyrine N-Demethylase ; Animals ; Aorta, Abdominal ; Bile ; Bilirubin ; Cholates ; Constriction ; Cytochrome P-450 Enzyme System ; Endoplasmic Reticulum ; Estrogens, Conjugated (USP) ; Fatty Acids, Unsaturated ; Free Radical Scavengers ; Free Radicals ; Hepatic Artery ; Ischemia ; Lipid Peroxidation ; Liver ; Malondialdehyde ; Membranes ; Metabolism* ; Microsomes, Liver ; Mitochondria ; NADPH-Ferrihemoprotein Reductase ; Necrosis ; Oxygen ; Portal Vein ; Rats* ; Reperfusion ; Reperfusion Injury ; Superoxide Dismutase

No abstract available.
Humans ; Lymphocyte Subsets* ; Lymphocytes*