MRI and arthrograms were used to diagnose the disc displacement of temporomandibular joint, but most of these trials focused on the anterior disc displacement. The discs could be displaced laterally or medially and in some case this sideway displacement may play a role as a main problem of temporomandibular disorder. In this study, 45 patients(31 unaffected sites, 59 affected sites) and 20 asymptomatic volunteers' sagittal and coronal MRI views were reviewed, then some results were found as follows 1. In sagittal plan, anterior disc displacements were found 15% in normal sites, 45% in unaffected sites and 69% in affected sites. 2. In coronal plan, sideways disc displacements were found 15% as medial in normal, 6% as medial and 13% as lateral in unaffected, 8% as medial and 14% as lateral diaplacement in affected sites. 3. In asymptomatic sites involving unaffected sites, medial disc displacements(11.3%) but in symptomatic joints, lateral disc displacements(13.8%) were prevalent. 4. The sideways disc displacement were observed 10.1% as medial and 2.9% as lateral dispalcement without and 9.8% as medial and 16.4% lateral dispalcements with anterior disc displacement. And, the coronal views of MRI were beneficial to evaluate the sideways disc displacement. Further studies may be needed on evaluation of the relations between sideways displacements and clinical symptoms or the treatment results.
Joints ; Magnetic Resonance Imaging ; Temporomandibular Joint Disorders ; Temporomandibular Joint*

No abstract available.
Temporomandibular Joint*

The present study proposes a method delineating the extent of the anterior displacement of the temporomandibular articular disc through the angle formed by the deepest point in the glenoid fossa, the center of the mandibular condyle and the junction between the end of the posterior band and the retrodiscal tissue. The method was applied to the normal group and TMD group. The TMD group was further divide into 3 groups Group I(little disc displacement), Group II(anterior disc displacement with reduction) and Group III(anterior disc displacement without reduction). The results were as follows. 1. The normal group showed the location of the articular disc within -10-0degree or with a wider allowance, within -10-10degree from the reference line GC. 2. The TMD group showed the disc located within -21.0-125.8degree,with two peaks at 0-100 and 60-800, suggesting that the group may be composed of more than two different subgroups. 3. The threshold point delineating the normal and TMD states was 0degree, because 82.5% of normal group appeared below 0degree and 94.8% of TMD group appeared above 0degree. 4. Since the angular disc displacement tends to increase from Group I to Group III, the angular displacement increases as the overall severiety of the disease increases, and the chance for a reduction of the disc decreases. 5. The normal group, Group I, Group II, and Group III can be categorized into statistically different groups. The normal group and TMD group can be distinguished in reference to 0degree, while the presence-absence of the anterior disc displacement is judged in reference to 10degree, and the probability of the disc reduction can be estimated in reference to 50degree. The present study assesses the location of the articular disc from the sagittal central section offering a supplementary clinical classification. This system provides an additional information concerning the location of the disc, thereby offering an objective mean to evaluate the progress of the disease. Further studies may be needed on the clinical changes according to location of the disc, as well as the relationship between the morphological changes and the anterior or sideways displacement of the disc.
Classification ; Mandibular Condyle ; Temporomandibular Joint Disc ; Temporomandibular Joint*

No abstract available.
Gels* ; Lipopolysaccharides* ; Silver* ; Sodium*

Vascular dementia is one of the few remediable causes of dementia among the eldery. Prevention of the disease can be best achieved by primary or secondary prevention of controllable risk factors for strokes. Therefore, early and accurate diagnosis of vascular cognitive impairment prior to the dementia stage is essential to the prevention and treatment of vascular dementia. Pharmacological and non-pharmacological methods for prevention of vascular dementia are listed in this article. Recent epidemiologic data, suggesting a direct correlation between vascular risk factors and Alzheimer type dementia, emphasized the importance of controlling vascular risk factors in the prevention of dementia. Treatment strategies for patients diagnosed as vascular dementia are also discussed. Several clinical trials for symptomatic improvement of vascular dementia are ongoing and their success can be a hope to patients with vascular dementia.
Alzheimer Disease ; Cognition Disorders ; Dementia ; Dementia, Vascular* ; Diagnosis ; Hope ; Humans ; Risk Factors ; Secondary Prevention ; Stroke

Disc displacement, deformation, perforation or osteoarthritis may induce the joint space narrowing. This study was designed to get the normal joint space width which could be used as a standard comparing with damaged joints. Twenty asymptomatic volunteers' MR images were evaluated and coronal images of thirty joints having normal disc position in sagittal and coronal views, were selected. The joint spaces were measured at center, medial and lateral side on the coronal views. In normal joints, the mean joint space was 3.57+/-0.63mm at center, 2.77+/-0.51mm at medial and 2.41+/-0.41mm at lateral side of mandibular condyle. The mean of joint space of male was wider than that of female at center, but not significantly different at medial and lateral side of the condyle.
Female ; Humans ; Joints ; Magnetic Resonance Imaging ; Male ; Mandibular Condyle ; Osteoarthritis ; Temporomandibular Joint*

BACKGROUND: The Chinese hamster ovary cells transfected with human TSH receptor cDNA (hTSHR-CHO), expressing functional human TSH receptors, are known to be more sensitive in detection of thyroid stimulating antibodies than FRTL-5 cells. There has been no report on the usefulness of these cells to measure thyroid stimulation blocking antibody (TSBAb) activity which is frequently found in patients with primary myxedema, METHODS: We established the optimal assay condition of measurement of TSBAb using hTSHR-CHO cells, and simultaneously measured TSBAb activities with FRTL-5 cells and with hTSHR-CHO cells in 49 patients with primary myxedema, compared them with their thyrotropin binding inhibitor immunoglobulin (TBII) activities. RESULTS: 1) hTSHR-CHO cells specifically bound bTSH and were stimulated by bTSH in terms of cyclic AMP generation in a dose dependent manner. 2) Myxedema IgG suppressed TSH-stimulated cAMP production of hTSHR-CHO cells in a dose dependent manner reaching plateau at the concentration of I g/L. Normal pooled IgG has no suppressive action at the concentration of less than 1 g/L, but caused significant suppression at the concentration of greater than 1g/L. 3) TSBAb activities measured by hTSHR-CHO cells in 49 patients with primary myxedema were as follows: Four of 25 TBII-negative cases (16%) and 22 of 24 TBII-positive cases (92%) had TSBAb activities. Most of TSBAb positive patients (95%), especially in TBII positive cases, showed very high activities of more than 90%. 4) TSBAb activities measured by hTSHR-CHO cells and those by FRTL-5 cells were both positive in 24 patients (49%), both negative in 18 patients (37%), and were discrepant in 7 patients (14%). The TSBAb activities measured with hTSHR-CHO cells and those measured with FRTL-5 cells were significantly correlated (r=0.71, p< 0.01). 5) Forty five percent of patients with primary myxedema had all of 3 kinds of activities (TBII, hTSHR-CHO cell TSBAb, FRTL-5 cell TSBAb), 37% of them had none of 3 activities and 18% of them had 1 or 2 kinds of activities only. CONCLUSION: The usefulness of hTSHR-CHO cells in measurements of TSBAb activities were confirmed. The TSBAb activities of most patients with primary myxedema measured by hTSHR-CHO cells were concordant with those measured by FRTL-5 cells. However, a small subset of patients (18%) had discrepant results in assays of TSH receptor antibodies according to the differences in TSH receptors (rat, human and porcine) used in assay. Such discrepancy may be explained by heterogeneity in epitopes for blocking TSH receptor antibodies.
Animals ; Antibodies ; Asian Continental Ancestry Group* ; Cricetinae ; Cricetulus* ; Cyclic AMP ; DNA, Complementary ; Epitopes ; Female ; Humans ; Humans* ; Hypothyroidism* ; Immunoglobulin G ; Immunoglobulins ; Immunoglobulins, Thyroid-Stimulating ; Myxedema ; Ovary* ; Population Characteristics ; Receptors, Thyrotropin* ; Thyroid Gland* ; Thyrotropin

Primary angiosarcoma of the female reproductive system is extremely rare, and its management is not well understood. We experienced a very rare case of angiosarcoma arising in the uterus of a 37-year-old woman who presented abdominal distension. At laparotomy, the uterus was observed to be enlarged and deformed by multilobulated hemorrhagic mass. Tumor deposits were present on both ovaries and the omentum. The operation consisted of total abdominal hysterectomy with salpingo-oophorectomy, and omentectomy. Microscopic examination showed that the tumor consisted mostly of solid sheets of pleomorphic and spindle cells forming irregular, communicating cleft-like spaces. Well-formed vascular channels lined by atypical endothelial cells were seen in differentiated areas. Some vessels were partially lined by normal endothelial cells and partially by neoplastic endothelial cells. Papillary architecture composed of epithelioid tumor cells was noted in a focal area. The tumor cells were immunoreactive for factor VIII-related antigen, Ulex europaeus agglutinin-1, CD31 and CD34. Weibel-Palade bodies were not seen in the tumor cells. She received adjuvant chemotherapy, but died 13 months after the diagnosis.
Adult ; Chemotherapy, Adjuvant ; Diagnosis ; Endothelial Cells ; Female ; Hemangiosarcoma* ; Humans ; Hysterectomy ; Laparotomy ; Omentum ; Ovary ; Ulex ; Uterus* ; von Willebrand Factor ; Weibel-Palade Bodies

Soft tissue tumor is defined as a tumor occurring in voluntary muscles, fat, fibrous tissue, along with the vessels serving these tissue and peripheral nervous system. It is difficult to make a diagnosis by conventional microscopic observation because of their pleuripotentiality and similar growth characteristics. Although their morphological findings of tumors are similar to one another, their clinical courses, treatment and prognosis are different. So early, correct diagnosis and proper treatment are neccessary. The present study is aimed to evaluate a value of immunoperoxidase staining to make definite diagnosis of soft tissue tumors and its application to surgical pathology. The material consisted of 106 cases of fibrohistiocytic tumors and malignant soft tissue tumors which are morphologically similar to malignant fibrohistiocytic tumors for 5 years period lasting from 1980 to 1984 at the Department of Pathology, Yonsei University College of Medicine. After the classificationof fibrohistiocytic tumors by the Enzinger (1983), clinical finndings were reviewed and peroxidase antiperoxidase(PAP) method with alpha1-antichymotrypsin was done in 15 cases of all fibrohistiocytic tumors. Other soft tissue tumors which were difficult to differentiate from MFH by light microscopic observation were liposarcoma, rhabdomyosarcoma, fibrosarcoma and malignant schwannoma. These 21 cases of tumors including MFH were stained with PAP method for alpha1-antichymotrypsin, S-100 protein and myoglobin. Results obtained were as follows: 1) The cases on study consisted of 19 cases of malignant fibrous histiocytoma, 2 dermatofibrosarcoma protuberans, 45 fibrohistiocytic tumors and 11 other benign fibrohistiocytic tumors. 2) The male to female ratio was 1 : 1.8 in benign and intermediate group of fibrohistiocytic tumor, but 2.2 : 1 in malignant histiocytic tumor. 3) Most cases of benign fibrohistiocytic tumors were occurred in 4th and 5th decade of life. Intermediate and malignant fibrohistiocytic tumors were mostly found in late adult life and their mean age was 43.6 year. 4) The most common sites were trunk and both extrimities in benign fibrohistiocytic tumors(88.9%), but head, neck and lower extremities in MFH (78.9%). Two cases of dermatofibrosarcoma protuberans were occurred in turnk and upper extremity. 5) The PAP stain for alpha1-antichymotrypsin was done in 15 cases of 77 fibrohistiocytic tumors which included MFH, dermatofibrosarcoma protuberans, xanthoma, xanthofibroma, dermatofibroma showed variable degree of positivity to alpha1-antichymotrypsin. The positivity of alpha1-antichymotrypsin revealed no significant difference according to differentiation of the tumors, such as benign, intermediate and malignant. 6) The PAP stain for alpha1-antichymotrypsin revealed diffuse positivity in all cases of MFH and also in a case of malignant schwannoma, fibrosarcoma, liposarcoma and rhabdomyosarcoma, but myoglobin and S-100 protein were negative. In three cases of leiomyosarcoma, two of rhabdomyosarcoma and three of malignant schwannoma, alpha1-antichymotrypsin, S-100 protein and myoglobin were negative, although a few positive tumor cells were present, which may the considered as metatypci differentiation. Another possibility of this discordance was loss of antigenicity by improper procedure of paraffin embedding and poor differentiation of tumor cells. In summary, PAP method for specific tumor marker is important for proper diagnosis of soft tissue tumors, and application to surgical pathology.
Adult ; Male ; Female ; Humans ; Tumor Markers, Biological

No abstract available.
Longitudinal Ligaments* ; Spine*