No abstract available.

PURPOSE: This study was a retrospective analysis with survey study which analyze influence of depression of patients with cancer on metastasis. METHODS: The subjects of this research were 223 patients who underwent chemotherapy or are in follow-up management with stomach, colon, or breast cancer. The questionnaires were collected in 2002 and medical documents were reviewed 400 days after the first data collection. Subjects were divided according to the depression level into over-average group and under average group. RESULTS: In survival analysis, metastasis occurred in 49 of 211 in 223 subjects for whom follow-up review was done after 400 days. The depression and anxiety level were higher in the group with metastasis than the other with no metastasis. As a result, it showed that the lower depression they have, the lesser the metastasis occurred. CONCLUSION: This research showed that patients who have higher level of depression, experienced higher risk for cancer metastasis. Nurses who take care of cancer patients are responsible for giving patients with positivity with intention to subside their depression.
Anxiety ; Breast Neoplasms ; Colon ; Data Collection ; Depression ; Follow-Up Studies ; Humans ; Intention ; Neoplasm Metastasis ; Surveys and Questionnaires ; Retrospective Studies ; Stomach ; Survival Analysis

PURPOSE: The purpose of this study was to examine the relationship between spirituality and a fighting spirit among the patients with cancer. METHODS: The participants were 223 patients diagnosed stomach, colorectal or breast cancer, and who were in chemotherapy or follow up care. The study design was cross-sectional at the time of the data collection. The degree of spirituality was measured by the Korean version of WHOQOL Spirituality, Religiousness and Personal Beliefs (SRPB) Pilot Test Module, and fighting spirit was measured by the scores of Mental Adjustment to Cancer(MAC) scale. RESULTS: The score of love appeared to be higher in the patients with follow up care than the patients with treatment(p<0.05) and the score of believing was much higher in patients with recurrence than the patients without (p<0.05). There was a statistically significant correlation among hope, believing, love, forgiveness and acceptance, and fighting spirit. In the multiple regression analysis, hope and believing explained much variance of the fighting spirit. CONCLUSION: These finding showed that the more hopeful and believing patients with cancer had higher scores of fighting spirit, which was known to be one of the most active coping style in adjusting to cancer.
Breast Neoplasms ; Data Collection ; Drug Therapy ; Follow-Up Studies ; Forgiveness ; Hope ; Humans ; Korea* ; Love ; Recurrence ; Spirituality* ; Stomach

PURPOSE: This study was conducted to identify the effects of depression on the survival of patients with cancer over a 10 year period. METHODS: A retrospective review was conducted to examine survival of 218 patients with stomach, colorectal and breast cancer, who had been treated for cancer from 2002 to 2011. Depression was assessed by using the Symptom Check List-90 Revision in 2002, and hope, fighting spirit and other potential confounders were also measured to control for their effects on the association between depression and the survival time. Data on survival were collected from the Statistics Korea and also from medical record in 2011. Kaplan-Meier survival analysis and Cox proportional hazard regression model were used to examine if depression affected survival. RESULTS: The total number of death was 106, and the non-survivors scored higher on depression than survivors. Depression was found to be one of the influencing factors on survival from cancer. CONCLUSION: Depression was significantly associated with the increased risk of death in cancer patients. Further research is needed to identify in details which type of emotional interventions can extend the survival time of cancer patients in depression.
Emotional Adjustment ; Breast Neoplasms ; Depression* ; Hope ; Humans ; Korea ; Medical Records ; Retrospective Studies ; Stomach ; Survivors

Thoracic endovascular aortic repair (TEVAR) has emerged as an effective therapy for a variety of thoracic aortic pathologies. However, various types of endoleak remain a major concern, and its treatment is often challenging. We report a case of type I endoleak occurring 19 months after zone II hybrid TEVAR. The endoleak was successfully repaired by the frozen elephant trunk technique, without removal of a previous stent graft, combined with ascending aorta and total arch replacement.
Aneurysm ; Aorta ; Blood Vessel Prosthesis ; Elephants* ; Endoleak* ; Pathology

Implant has been an effective treatment option for the patients with oligodontia. However, it still remains unclear when the implant should be placed. Skeletal growth that can appear even after the growth period can lead to infraocclusion of the implant which can cause functional or esthetic complications. In order to minimize these problems, definitive restorations should be placed after the functional and esthetic rehabilitation is achieved through the use of provisional restorations. Definitive restorations made with monolithic zirconia were created by replicating provisional restorations by using the latest CAD/CAM technology. These definitive restorations were delivered to the patient and clinical observation after the treatment showed satisfactory result.
Dental Occlusion ; Humans ; Prostheses and Implants* ; Rehabilitation

PURPOSE: The aim of this study was to examine the associations between depression, anxiety, hostility and fighting spirit among patients with stomach, colorectal or breast cancer. MATERIALS AND METHODS: 223 patients, diagnosed as with stomach, colorectal or breast cancer, undergoing chemotherapy or follow up care, were the subjects of the study. The study design was cross-sectional at the time of the survey. The degrees of depression, anxiety and hostility of the patients were assessed by the SCL-90-R scores, and the fighting spirit was measured by the Mental Adjustment to Cancer (MAC) scale score. RESULTS: The scores of anxiety and hostility of the patients at younger age were higher than those at older age (p<0.01). The patients with metastasis were more depressed than those without it (p<0.01). There was a negative association between depression and fighting spirit (p<0.001). CONCLUSION: The study showed the more depressed cancer patients had lower fighting spirit score, which was known to be one of the most active psychosocial contributors in adjusting to cancer and survival.
Anxiety* ; Breast Neoplasms ; Depression* ; Drug Therapy ; Follow-Up Studies ; Hostility* ; Humans ; Korea* ; Neoplasm Metastasis ; Stomach

Purpose: Clamshell incision offers excellent exposure and access to the pleural spaces and is a standard incision for lung transplantation. However, due to its high sternal complication rate, the clamshell incision is considered a procedure that requires improvement. In this study, we aimed to investigate the outcomes of transverse sternotomy with clamshell incision in comparison to sternum-sparing bilateral anterolateral thoracotomy (BAT). Materials and Methods: In total, 134 bilateral sequential lung transplants were performed from May 2013 to June 2022. The clamshell incision was used between May 2013 and December 2017, and the BAT was introduced in January 2018. Thirty-four patients underwent clamshell surgery, and 100 patients underwent BAT. We retrospectively compared patient characteristics and perioperative and postoperative outcomes between the two groups. Results: The clamshell group required an operation time of 745.18±101.76 min, which was significantly longer than that of the BAT group at 669.90±134.09 min (p=0.003). The mechanical ventilation period after surgery was 17.26±16.04 days in the clamshell group, significantly longer than the 11.35±12.42 days in the BAT group (p=0.028). Intensive care unit stay was also significantly longer in the clamshell group (21.54±15.23 days vs. 15.03±14.28 days; p=0.033). In-hospital mortality rates were 26.5% in the clamshell group and 22.0% in the BAT group. Conclusion Less-invasive lung transplantation via sternum-sparing BAT is a safe procedure with low morbidity and favorable outcomes. Preventing sternal instability enables more stable breathing after surgery, earlier weaning from mechanical ventilation, and faster recovery to routine activities.

PURPOSE: Interleukin (IL)-9 induces allergic responses; however, the roles of anti-IL-9 antibody in the induction of tolerance remain unclear. This study investigated the effects of anti-IL-9 antibody on oral tolerance (OT) in a mouse model of allergic rhinitis (AR). METHODS: BALB/c mice were divided into 4 groups: the control, AR, OT, and OT with anti-IL-9 antibody (OT+IL9AB) groups. Ovalbumin (OVA) was used for sensitization and challenge. Mice in the OT and OT+IL9AB groups were fed OVA for immunotherapy. During immunotherapy, OT+IL9AB mice were injected with anti-IL-9 antibody. Allergic symptoms, tissue eosinophil counts, and serum OVA-specific immunoglobulin E (IgE) were measured. The mRNA expressions of cytokines and transcription factors of T cells of nasal mucosa were determined by real-time polymerase chain reaction (PCR). The protein levels of GATA3, ROR-γt, and Foxp3 in nasal mucosa were determined by Western blot. CD4⁺CD25⁺Foxp3⁺ T cells in the spleen were analyzed by flow cytometry. RESULTS: Administration of anti-IL-9 antibody decreased allergic symptoms, OVA-specific IgE levels, and eosinophil counts. In addition, it inhibited T-helper (Th) 2 responses, but had no effect on Th1 responses. Protein levels of ROR-γt and mRNA levels of PU.1 and ROR-γt were reduced by anti-IL-9 antibody. Anti-IL-9 antibody increased Foxp3 and IL-10 mRNA expression, Foxp3 protein, and induction of CD4⁺CD25⁺Foxp3⁺ T cells. CONCLUSIONS: Anti-IL-9 antibody decreased allergic inflammation through suppression of Th2 and Th17 cells. Anti-IL-9 antibody enhanced the tolerogenic effects of regulatory T cells. These results suggest that anti-IL-9 antibody might represent a potential therapeutic agent for allergen immunotherapy in patients with uncontrolled allergic airway disease.
Animals ; Blotting, Western ; Cytokines ; Desensitization, Immunologic ; Eosinophils ; Flow Cytometry ; Humans ; Immunoglobulin E ; Immunoglobulins ; Immunotherapy* ; Inflammation ; Interleukin-10 ; Interleukin-9 ; Interleukins ; Mice ; Nasal Mucosa ; Ovalbumin ; Ovum ; Real-Time Polymerase Chain Reaction ; Rhinitis, Allergic* ; RNA, Messenger ; Spleen ; T-Lymphocytes ; T-Lymphocytes, Regulatory ; Th17 Cells ; Transcription Factors

PURPOSE: The purpose of this study is to identify the effect of mesenchymal stem cell proliferation on recombinant human transforming growth factor-beta (rhTGF-β2) / poly (D,L-lactide-co-glycolide) (PLGA) treated titanium discs by electrospray. MATERIALS AND METHODS: Anodized titanium surface coated with PLGA was used for a control group to compare anodized titanium surface coated with 125 ng/ml and 500 ng/ml rhTGF-β2 as test groups. Atomic force microscope (AFM) test was utilized to determine the difference in coating surface roughness, and field-emission scanning electron microscopy (FE-SEM) was taken to visualize even distribution of coating particles on titanium discs. The mesenchymal stem cell proliferation was tested by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl-tetrazolium bromide) assay on 1st, 4th, 7th days. RESULTS: According to AFM results, there was no statistically significant difference in titanium discs treated with PLGA and with rhTGF-β2/PLGA (P>.05). MTT assay test results showed that there was statistically significant difference in mesenchymal stem cell proliferation on test groups compared to control groups at 7th day, and cell viability on discs coated with rhTGF-β2 was significantly higher than control groups (P<.05). CONCLUSION: Titanium surface coated with rhTGF-β2/PLGA shows statistically significant higher cell proliferation and the titanium surface coated with the higher concentration of rhTGF-β2 presents faster cell growth activity.
Cell Proliferation ; Cell Survival ; Humans ; Mesenchymal Stromal Cells* ; Microscopy, Electron, Scanning ; Titanium*