1.Malignant Mixed Mullerian Tumor of the Ovary: A case report.
Hae Joo NAM ; Won Hee CHOI ; Tae Sook LEE
Korean Journal of Pathology 1987;21(4):303-307
The clinical and pathological features of a case Malignant mixed mullerian tumor of the ovary in 45 year-old female patient with a brief review of the literature are presented. She had both ovarian tumors. The masses are multilocular cystic tumor with interspersed solid component. The cystic component is filled with serous fluid. Microscopically the tumor is composed of epithelial element & intimately related mesenchymal element. The epithelial element shows the findings of adenocarcinoma of solid, glandular and papillary growth. The mesenchymal element is composed of malignant-looking stroma with cartilage formation.
Female
;
Humans
;
Adenocarcinoma
2.Benign Fibrous Histiocytoma of Spinal Cord.
Hae Joo NAM ; Won Hee CHOI ; Tae Sook LEE
Korean Journal of Pathology 1988;22(4):510-514
Fibrous histiocytoma composed of fibroblasts and histiocytes is quite variable in histologic pattern. The biologic behavior is unpredictable by histologic ground. This tumor is well-known in subcutaneous tissue and deep soft tissue, but quite rare in central nervous system. We experienced a case of the fibrous histiocytoma involving the dura mater of spinal cord in a 26 year old female patient. In gross findings, the mass was a well demarcated, ovoid mass attached to the dura matter, and measured 2.5x1.5 cm in diameter. The cut surface was rubbery, solid, gray-white or yellow. Microscopically, the lesion consisted of polyhedral cells with round or oval nuclei and faintly eosinophilic or vaculoated cytoplasm, and multinucleated giant cells. Some giant cells were Touton-type. Composing cells were bland-looking. Mitotic figures were average 3 per 10 high power fields.
Female
;
Humans
3.A case of velamentous insertion of umbilical cord in a discordant twins conceived by in vitro fertilization.
Won Il PARK ; Jong Yun NAM ; Joo Oh KIM ; Jong Eun JOO
Korean Journal of Obstetrics and Gynecology 2000;43(10):1884-1888
No abstract available.
Fertilization in Vitro*
;
Humans
;
Twins*
;
Umbilical Cord*
4.Clinical significance of cellular immunity in the renal interstitium of IgA nephropathy.
Tae See CHUNG ; Young Joo KWON ; Won Yong CHO ; Hyoung Kyu KIM ; Nam Hee WON
Korean Journal of Nephrology 1991;10(2):157-165
No abstract available.
Glomerulonephritis, IGA*
;
Immunity, Cellular*
;
Immunoglobulin A*
5.Clinical significance of cellular immunity in the renal interstitium of IgA nephropathy.
Tae See CHUNG ; Young Joo KWON ; Won Yong CHO ; Hyoung Kyu KIM ; Nam Hee WON
Korean Journal of Nephrology 1991;10(2):157-165
No abstract available.
Glomerulonephritis, IGA*
;
Immunity, Cellular*
;
Immunoglobulin A*
6.Modulatory effects of the fruits of Tribulus terrestris L. on the function of atopic dermatitis-related calcium channels, Orai1 and TRPV3
Nam Hyun Joo ; Jung Won Hyo ; Chin Young-Won ; Kim Kyung Woo ; Bae Sang Hyo
Asian Pacific Journal of Tropical Biomedicine 2016;6(7):580-585
Objective: To examine the effects of Tribulus terrestris L. (T. terrestris) extract on the modulation of calcium channels to evaluate its use in topical agents for treatment of atopic dermatitis. Methods: The 70% methanol extract of T. terrestris was prepared. Human HEK293T cells with over-expressed calcium release-activated calcium channel protein 1 (Orai1), transient receptor potential vanilloid 1, or transient receptor potential vanilloid 3 (TRPV3) were treated with T. terrestris extract. Modulation of ion channels was measured using a conventional whole-cell patch-clamp technique. Results: T. terrestris extract (100 mg/mL) significantly inhibited Orai1 activity in Orai1-stromal interaction molecule 1 co-overexpressed HEK293T cells. In addition, T. terrestris extract significantly increased the TRPV3 activity compared with 2-Aminoethyl diphe-nylborinate (100 mmol/L), which induces the full activation of TRPV3. Conclusions: Our results suggest that T. terrestris extract may have a therapeutic po-tential for recovery of abnormal skin barrier pathologies in atopic dermatitis through modulating the activities of calcium ion channels, Orai1 and TRPV3. This is the first study to report the modulatory effect of a medicinal plant on the function of ion channels in skin barrier.
7.The etiologies and the clinical manifestations of hypoglycemia in infancy and childhood.
Nam Seon BECK ; Dong Joo SHIN ; Heon Seok HAN ; Sei Won YANG ; Hyung Ro MOON
Journal of the Korean Pediatric Society 1991;34(4):480-486
No abstract available.
Hypoglycemia*
8.Clinical Efficacy and Safety of Gepefrin in the Treatment of Hypotension.
Kun Joo RHEE ; Suck Koo CHOI ; Byong Ok KIM ; Kyung Jae NAM ; Won Sang YOO
Korean Circulation Journal 1994;24(2):307-312
BACKGROUND: The proper management of the patients with hypotention remains a difficult clinical problem. This study was designed to evaluate the efficacy and safety of gepefrin in the treament of symptomatic hypotensive patients in outpatient clinic of university hospital. METHODS: Thirty milligrams of Gepefrin was given twice daily for 4 weeks in 30 patients with hypotension(6 males, 24 females ; 23-60 years of age). Blood pressure, heart rate, subjective symptoms and side effects were checked before medication and at the end of 1st, 2nd, 3rd, 4th week of medication. RESULTS: 1) Grpefrin increased sitting systolic blood pressure significantly(p<0.05) by the end of 1st week and thereafter. 2) Hypotensive symptoms were improved in 76% of hypotensive patients and overall rate of usefulness was 70%. 3) Heart rate did not change significantly. 4) One patient complained of loose bowel movement and another one, of anorexia among 30 study patients and all laboratory parameters were within normal limits before and after drug treatment, thus the rate of safety was 93%. CONCLUSION: Results from this study suggests that gepefrin 60mg daily increases the blood pressure mildly and improves the symptoms moderately in symptomatic hypotensive patients.
Ambulatory Care Facilities
;
Anorexia
;
Blood Pressure
;
Female
;
Heart Rate
;
Humans
;
Hypotension*
;
Male
;
Quality of Life
9.Effects of carbon tetrachloride on structures in hepatocytes following DMN induced hepatotoxicity.
Young Chun KANG ; Hae Joo NAM ; Dong Suk KIM ; Won Hee CHOI ; Tae Sook LEE
Yeungnam University Journal of Medicine 1991;8(2):84-94
The purpose of this study was to evaluate the influence of high dose carbon tetrachloride (CCI4) on the hepatotoxic effect of dimethylnitrosamine (DMN) which induces acute hemorrhagic necrosis in liver. Rats were injected intraperitoneally DMN dissolved in physiologic saline by a dose of 40 mg/kg. For changes related to CCI⁴ pretreatment, rats were injected intraperitoneally CCI⁴ dissolved in olive oil by a dose of 0.4 mg/kg, and then injected DMN. The livers were extracted from the rats 3, 6, 12, 24, 48, 72, and 120 hours after CCI⁴ and/ or DMN injection. Liver tissues were examined with light and electron microscopes. The results were summarized as follows; Light microscopic findings: Severe centrilobular hemorrhagic necrosis developed from 12 hours after injection of DMN and continued to 120 hours. On injection of DMN after CCI4 pretreatment, Massive necrosis occurred early. But active regenerative changes were produced in 24 hours. In 120 hours, the liver recovered in almost normal appearance. The degree of necrosis in pretreated group was similar to that in DMN injection only, and the time of recovery was faster in pretreated group. Electron microscopic findings: The early change was mainly disorganization of RER in DMN injection, and clumping and vesicular dilatation of ER in injection of CCI4. In pretreatment group, the early change was similar in appearance with CCI4 group, but severer in degree. According to the results, it was revealed that acute toxic effect of DMN was recovered more rapidly in pretreatment group. Thus it was suggested that CCI4 had protective effect in DMN hepatotoxicity.
Animals
;
Carbon Tetrachloride*
;
Carbon*
;
Dilatation
;
Dimethylnitrosamine
;
Hepatocytes*
;
Liver
;
Necrosis
;
Olive Oil
;
Rats
10.Histopathological study of gastric adenoma.
Dong Sug KIM ; Hae Joo NAM ; Won Hee CHOI ; Tae Sook LEE ; Moon Kwan CHUNG
Yeungnam University Journal of Medicine 1991;8(2):76-83
A total of 53 gastric adenomas from endoscopically biopsied gastric mucosa were examined histopathologically. The average age at the time of endoscopic biopsy was 59 years, and gastric adenomas were found to be more frequent in the aged, particularly above the age of 50. The majority of adenomas occurred at the antrum. Concerning the shape of the adenomas, Yamada type II was more frequent (55%). All adenomas were accompanied by varying degree of intestinal metaplasia, and this findings suggest that gastric adenoma develops from intestinal metaplasia. In adenomas with severe atypia (grade III), endocrine cells (argyrophil and argentaffin cells) were markedly decreased or absent. Gastric adenocarcinomas coexistent with adenoma were seen in 5 (9.4%) out of 53 cases, and were more frequent in male than female patients (sex ratio, 4:1) and the average age was 61.4 years. It is suggested that there is a necessity of thorough follow-up study for definitive correlation between gastric adenoma and adenocarcinoma.
Adenocarcinoma
;
Adenoma*
;
Biopsy
;
Endocrine Cells
;
Female
;
Follow-Up Studies
;
Gastric Mucosa
;
Humans
;
Male
;
Metaplasia
;
Stomach