1.A clinical study on cardiovascular disease of children taken cardiac catheterization and cineangiography.
Gi Yeon SONG ; Seog Beom CHO ; Pyoung Han HWANG ; Chan Uhng JOO ; Jung Soo KIM
Journal of the Korean Pediatric Society 1992;35(7):949-956
No abstract available.
Cardiac Catheterization*
;
Cardiac Catheters*
;
Cardiovascular Diseases*
;
Child*
;
Cineangiography*
;
Heart Defects, Congenital
;
Humans
2.A Case Report of Complete Androgen Insensitivity Syndrome.
Sun Young KIM ; Kyung Joo HWANG ; Hyun Soo AHN ; Hee Jae JOO ; Yeon Jong JOO ; Hyuck Chan KWON ; Kie Suk OH
Korean Journal of Obstetrics and Gynecology 1999;42(5):1146-1150
The androgen insensitivity syndrome is a heterogeneous disorder with a wide spectrum of phenotypic abnormalities, ranging from complete female to ambiguous forms that more closely resembles males. Mutations of the androgen receptor gene are responsible for a variable degree of impaired androgen action. The complete androgen insensitivity syndrome is characterized by normal female external appearance in spite of the normal male karyotype 46XY with testes and normal testosterone production and metabolism. This is transmitted by X-linked recessive manner. Wolffian duct does not develop. However, m llerian development does not occur in presence of antim llerian hormone activity. Recently we experienced a case of complete androgen insenditirity syndrome. We reported a case with concerned literatures.
Androgen-Insensitivity Syndrome*
;
Female
;
Humans
;
Karyotype
;
Male
;
Metabolism
;
Receptors, Androgen
;
Testis
;
Testosterone
;
Wolffian Ducts
3.The Mechanism of Antiallodynic Effect of Intrathecal Morphine in Neuropathic Pain Induced by Spinal Nerve Ligation.
Jai Hyun HWANG ; Young Kook KIM ; Jong Yeon PARK ; Eun Joo LEE
Korean Journal of Anesthesiology 2001;40(2):244-251
BACKGROUND: Although the efficacy of morphine in a neuropathic pain state is somewhat controversial, intrathecally administered morphine reversed the mechanical allodynia in a previous animal study. Using a behavioral test, we investigated the mechanism of the antiallodynic action of intrathecal morphine by administering opioids, alpha2 adrenergic and cholinergic receptor antagonists in a rat model of neuropathic pain induced by a spinal nerve ligation injury. METHODS: Male Sprague Dawley rats were prepared with a tight ligation of the left lumbar 5th and 6th spinal nerves and insertion of a chronic lumbar intrathecal catheter. Morphine 1 microgram was administered intrathecally to attenuate the mechanical allodynia. Naloxone 10 microgram, yohimbine 30 microgram, prazosin 30 microgram, atropine 10 microgram, pirenzepine 10 microgram, and methoctramine 10 microgram was administered intrathecally before and after the injection of morphine in order to investigate the reversal of an increased allodynic threshold by morphine. The allodynic thresholds for the left hindpaw withdrawal to von Frey hairs were assessed and converted to %MPE. RESULTS: A reduction of mechanical allodynia by intrathecal morphine was produced. Naloxone pretreatment, but not posttreatment, reversed the antiallodynic effect of intrathecal morphine (P < 0.01). All alpha2 adrenergic and cholinergic receptor antagonists used here did not reverse it. CONCLUSIONS: The results suggest that the reversal mechanism of mechanical allodynia by intrathecal morphine appears to be mediated mostly by the opioid receptor system, but not the alpha2 adrenergic and cholinergic receptor systems, at the spinal level in a rat model of a spinal nerve ligation injury.
Analgesics, Opioid
;
Animals
;
Atropine
;
Catheters
;
Cholinergic Antagonists
;
Hair
;
Humans
;
Hyperalgesia
;
Ligation*
;
Male
;
Models, Animal
;
Morphine*
;
Naloxone
;
Neuralgia*
;
Pirenzepine
;
Prazosin
;
Rats, Sprague-Dawley
;
Receptors, Opioid
;
Spinal Nerves*
;
Yohimbine
4.The Effect of the Vocational Rehabilitation Program on the Quality of Life of the Chronic Schizophrenics.
Tae Yeon HWANG ; Joo Hyeon KIM ; Eun Seun HAN ; Choong Soon RHEE
Journal of Korean Neuropsychiatric Association 1998;37(6):1087-1098
OBJECTIVES: The purpose of this study was to examine the effect of the vocational rehabilitation program on the quality of life of the chronic schizophrenics, and to evaluate how chronic schizophrenics felt about their lives. METHOD: The subjects were 39 chronic schizophrenics who had participated in the vocational rehabilitation program(participant group) and now lived in the community. The control group were 43 chronic schizophrenics who were outpatients without vocational rehabilitation(non-participant group). The scale for quality of life was divided into two subscales, i.e., the objective and the subjective areas. The subscales are composed of living situation, family situations, interpersonal relations, work, health, finances, leisure activities, autonomy, and self-esteem. RESULTS: 1) In the demographic characteristics such as age, sex, duration of illness, and duration of education, two groups were not different significantly. However, dosage of antipsychotics were lower in participant group than non-participant group. 2) In the objective quality of life subscale, the scores of living situation, interpersonal relations, work, health, economic state, and leisures were higher in participant group than non-participant group. But, family relations score were lower in participant group than in non-participant group. autonomy were not different between two groups. 3) In the subjective quality of life subscale, the score of living situation, family relations, interpersonal relations, work, health, economic states, leisure activities, and autonomy were all higher in participant group than in non-partcipant group. 4)Self-esteem was significantly higher in participant group than in non-participant group. CONCLUSION: The results from this study suggest that the objective and subjective quality of life of participant group in the vocational rehabilitation program were higher than those of non-participant group. The vocational rehabilitation program of Yong-In Mental Hospital seems to have been effective for the chronic schizophrenics. And the psychosocial rehabilitation program, vocational rehabilitation program, and family education program should be developed more and implemented in the community.
Antipsychotic Agents
;
Education
;
Family Relations
;
Gyeonggi-do
;
Hospitals, Psychiatric
;
Humans
;
Interpersonal Relations
;
Leisure Activities
;
Outpatients
;
Quality of Life*
;
Rehabilitation
;
Rehabilitation, Vocational*
5.Pneumonectomy Case in a Newborn with Congenital Pulmonary Lymphangiectasia.
Joon Ho HWANG ; Joo Heon KIM ; Jung Ju HWANG ; Kyu Soon KIM ; Seung Yeon KIM
Journal of Korean Medical Science 2014;29(4):609-613
Congenital pulmonary lymphangiectasia (CPL) is a rare lymphatic pulmonary abnormality. CPL with respiratory distress has a poor prognosis, and is frequently fatal in neonates. We report a case of pneumonectomy for CPL in a newborn. An infant girl, born at 39 weeks' after an uncomplicated pregnancy, exhibited respiratory distress 1 hr after birth, which necessitated intubation and aggressive ventilator care. Right pneumonectomy was performed after her symptoms worsened. Histologic examination indicated CPL. She is currently 12 months old and developing normally. Pneumonectomy can be considered for treating respiratory symptoms for improving chances of survival in cases with unilateral CPL.
Female
;
Gestational Age
;
Humans
;
Infant, Newborn
;
Lung/pathology
;
Lung Diseases/*congenital/diagnosis/pathology/radiography
;
Lymphangiectasis/*congenital/diagnosis/pathology/radiography
;
Lymphatic Vessels/pathology
;
Tomography, X-Ray Computed
6.Evaluation of the Appropriateness of Approved Antibiotic Usage Guidlines in Korea: Comparison of Domestic Package Inserts with Physicians' Desk Reference.
Jae Gab LEE ; Yeon Joo LEE ; Byung Yoen HWANG ; Hyewon JEONG ; Sung Joo JUNG ; Sung Bum KIM ; Hee Jin CHEONG ; Woo Joo KIM ; Min Ja KIM ; Seung Chull PARK
Infection and Chemotherapy 2003;35(5):256-270
BACKGROUND: The appropriate usage of antibiotics needs informations such as its effectiveness for a given infection, administration route, the amount of effective dose, and the dose intervals. In this study, in order to find any significant discrepancy regarding to the details of explanation of the necessary information for appropriate antibiotic usages, we compares informations about 51 antibiotics, one from package inserts in Korea and the other from physician's desk reference (PDR) certified by FDA in the United States of America. MATERIALS AND METHODS: Package inserts about antibiotics, only oral or parenteral agent, were perused to collect three categories of data: the recommended dosage, dose interval, and adjustment of dose to indications or the severity of infection. These data available in Korea were compared with 61 antibiotics (32 oral and 29 parenteral agents) cited in PDR. RESULTS: Package inserts for 51 antibiotics were gathered, because the remaining 10 antibiotics in PDR are not domestically commercialized. Among data on antibiotics comparable with those in PDR, 59% (30 cases:15 oral and 15 parenteral agents) suggested the dose similar to that of PDR, 37% (19 cases:8 oral and 11 parenteral agents) recommend less dose, and 4% in only 2 oral agents showed more dose. About half of the drugs recommending lower dosage were imported from Japanese pharmaceutical company, and the recommended doses of these antimicrobial agents were similar to those in Japan. About 59% (30 cases: 15 oral and 15 parenteral agents) directed dose interval or duration similar to those of PDR and 17% (9 parenteral agents) suggested less administration or longer duration. Surprisingly, in contrast to only 6% (3 cases) of PDR, 24% (12 cases:10 oral and 2 parenteral agents) recommended more administration or shorter duration. About 39% (24 cases:13 oral and 7 parenteral agents) revealed no information for dose adjustment commens to indications or the severity of infection. CONCLUSION: This study revealed that many guidelines in Korea recommend lower doses and/or unreasonable dose intervals. In future studies, improved antibiotic usage guidelines should be established based on pharmacokinetic and pharmacodynamic researches, on the aspect of optimal dosage, dose interval, and dose adjustment commensurate to the indications and the severity of the infection.
Americas
;
Anti-Bacterial Agents
;
Anti-Infective Agents
;
Asian Continental Ancestry Group
;
Humans
;
Japan
;
Korea*
;
Product Labeling*
;
United States
7.Evaluation of the Appropriateness of Approved Antibiotic Usage Guidlines in Korea: Comparison of Domestic Package Inserts with Physicians' Desk Reference.
Jae Gab LEE ; Yeon Joo LEE ; Byung Yoen HWANG ; Hyewon JEONG ; Sung Joo JUNG ; Sung Bum KIM ; Hee Jin CHEONG ; Woo Joo KIM ; Min Ja KIM ; Seung Chull PARK
Infection and Chemotherapy 2003;35(5):256-270
BACKGROUND: The appropriate usage of antibiotics needs informations such as its effectiveness for a given infection, administration route, the amount of effective dose, and the dose intervals. In this study, in order to find any significant discrepancy regarding to the details of explanation of the necessary information for appropriate antibiotic usages, we compares informations about 51 antibiotics, one from package inserts in Korea and the other from physician's desk reference (PDR) certified by FDA in the United States of America. MATERIALS AND METHODS: Package inserts about antibiotics, only oral or parenteral agent, were perused to collect three categories of data: the recommended dosage, dose interval, and adjustment of dose to indications or the severity of infection. These data available in Korea were compared with 61 antibiotics (32 oral and 29 parenteral agents) cited in PDR. RESULTS: Package inserts for 51 antibiotics were gathered, because the remaining 10 antibiotics in PDR are not domestically commercialized. Among data on antibiotics comparable with those in PDR, 59% (30 cases:15 oral and 15 parenteral agents) suggested the dose similar to that of PDR, 37% (19 cases:8 oral and 11 parenteral agents) recommend less dose, and 4% in only 2 oral agents showed more dose. About half of the drugs recommending lower dosage were imported from Japanese pharmaceutical company, and the recommended doses of these antimicrobial agents were similar to those in Japan. About 59% (30 cases: 15 oral and 15 parenteral agents) directed dose interval or duration similar to those of PDR and 17% (9 parenteral agents) suggested less administration or longer duration. Surprisingly, in contrast to only 6% (3 cases) of PDR, 24% (12 cases:10 oral and 2 parenteral agents) recommended more administration or shorter duration. About 39% (24 cases:13 oral and 7 parenteral agents) revealed no information for dose adjustment commens to indications or the severity of infection. CONCLUSION: This study revealed that many guidelines in Korea recommend lower doses and/or unreasonable dose intervals. In future studies, improved antibiotic usage guidelines should be established based on pharmacokinetic and pharmacodynamic researches, on the aspect of optimal dosage, dose interval, and dose adjustment commensurate to the indications and the severity of the infection.
Americas
;
Anti-Bacterial Agents
;
Anti-Infective Agents
;
Asian Continental Ancestry Group
;
Humans
;
Japan
;
Korea*
;
Product Labeling*
;
United States
8.Effect of Delayed Intensification on Survival of Childhood Acute Lymphoblastic Leukemia.
Jie Yeon LEE ; Sue YOUN ; Byoung Chul KWON ; Chuhl Joo LYU ; Hwang Min KIM
Journal of the Korean Pediatric Society 2003;46(12):1260-1265
PURPOSE: In 1970, the Berlin-Frankfurt-Munster(BFM) group introduced an intensification therapy after remission induction to reduce relapse of acute lymphoblastic leukemia(ALL) in childhood. Delayed intensification(DI) phase has been included for treatment of ALL in our hospital since the mid-1990s. The purpose of this study is to evaluate the outcome with vs. without DI phase and the outcome with two vs. one DI phase for intermediate risk patients. METHODS: One hundred and thirty nine children with ALL who were treated at the Department of Pediatrics of Wonju Christian Hospital and Yonsei University Medical Center between March, 1990 and July, 2002 were analysed retrospectively. RESULTS: Thirty-eight patients were treated with a DI phase, and 101 patients were treated without a DI phase. Among the DI patients, seven patients were treated with a double DI phase. Five-year overall survival(OS) in the low, intermediate, and high risk groups were 68%, 66% and 58%, respectively. 5-year OS in DDI, DI, and control were 95%, 86% and 40%, espectively. In the low risk group, 5-year event free survival(EFS) in DI, and control were 94% and 58%, respectively. CONCLUSIONS: Delayed intensification improved EFS on childhood ALL in all risk groups.
Academic Medical Centers
;
Child
;
Gangwon-do
;
Humans
;
Pediatrics
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
;
Recurrence
;
Remission Induction
;
Retrospective Studies
9.Heptachlor induced nigral dopaminergic neuronal loss and Parkinsonism-like movement deficits in mice.
Seokheon HONG ; Joohyun HWANG ; Joo Yeon KIM ; Ki Soon SHIN ; Shin Jung KANG
Experimental & Molecular Medicine 2014;46(2):e80-
Epidemiological studies have suggested an association between pesticide exposure and Parkinson's disease. In this study, we examined the neurotoxicity of an organochlorine pesticide, heptachlor, in vitro and in vivo. In cultured SH-SY5Y cells, heptachlor induced mitochondria-mediated apoptosis. When injected into mice intraperitoneally on a subchronic schedule, heptachlor induced selective loss of dopaminergic neurons in the substantia nigra pars compacta. In addition, the heptachlor injection induced gliosis of microglia and astrocytes selectively in the ventral midbrain area. When the general locomotor activities were monitored by open field test, the heptachlor injection did not induce any gross motor dysfunction. However, the compound induced Parkinsonism-like movement deficits when assessed by a gait and a pole test. These results suggest that heptachlor can induce Parkinson's disease-related neurotoxicities in vivo.
Animals
;
*Apoptosis
;
Astrocytes/drug effects/pathology
;
Cell Line, Tumor
;
Cells, Cultured
;
Dopaminergic Neurons/*drug effects/pathology
;
Gait
;
Heptachlor/*toxicity
;
Humans
;
*Locomotion
;
Mice
;
Neurotoxicity Syndromes/etiology/physiopathology
;
Parkinsonian Disorders/chemically induced
;
Pesticides/*toxicity
;
Substantia Nigra/*drug effects/pathology/physiopathology
10.Benign Anal Diseases on Patients with HIV Disease.
Do Yeon HWANG ; Joo Shil LEE ; Seo Gue YOON ; Jai Hyun RHYOU ; Seok Gyu SONG ; Jong Kyun LEE
Journal of the Korean Society of Coloproctology 2003;19(1):1-5
PURPOSE: The number of patients with HIV disease has been increasing rapidly, with anorectal discomfort being the most common complaint of these patients. However, there are no data on HIV disease relating to the benign anorectal area in Koreans. METHODS: A retrospective chart review was performed on patients diagnosed with benign anal diseases, combined with HIV disease, between 1996 and 2001. Their clinical aspects were compared with HIV patients registered with the National Institute of Health in Korea between 1985 and 2001. RESULTS: A total of 1,613 patients were registered, with the National Institute of Health in Korea, as having HIV disease. The ratio of sex was 7.2:1, with a male predominance. The disease was most common in the 3rd & 4th decades, with 64.2%, of the patients in this age range. As for the routes of transmission, sexual contact was the most common (96.9%), followed by blood transfusion (including blood products) (2.8%), vertical transmission (0.1%) and drug injection (0.1%). With regard to the sexual contact routes, homosexuality accounted for 28.0%. Of the cases of HIV disease presenting with a benign anal disease, 32 patients, with a sex ratio of 31:1, with an overwhelming male predominance, were selected. Twenty-six cases had been newly diagnosed at our hospital. As for the routes of the transmission, the disease had been transmitted by sexual contact in all cases. In 43.8% of these cases, the disease had been transmitted by homosexual contact, which showed a marked difference to that of the National database (P<0.05). For those associated with an anal diseases, there were 10 cases of anal fistula, 9 of perianal abscess, 7 of condyloma acuminata, 7 of anal fissure, 5 of hemorrhoids and 2 of ulceration on the lower rectum, noted. CONCLUSIONS: Nowadays, the numbers of anorectal-disease patients with HIV are increasing in Korea. Since HIV is common in the area of benign proctology, all proctologists must consider the possibility of HIV when managing patients.
Abscess
;
Blood Transfusion
;
Colorectal Surgery
;
Fissure in Ano
;
Hemorrhoids
;
HIV Infections
;
HIV*
;
Homosexuality
;
Humans
;
Korea
;
Male
;
Rectal Fistula
;
Rectum
;
Retrospective Studies
;
Sex Ratio
;
Ulcer