1.Clinical Studies on Congenital Anomalies.
Hyeon Joo CHAI ; Kyung Hee KIM
Journal of the Korean Pediatric Society 1990;33(6):754-761
No abstract available.
2.Etiologic studies in amenorrhea.
Hyeon Gyeong CHOI ; Sung Hee JUNG ; Cung Suk KIM ; Soo Mee LEE ; Hyeon Joo KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):1571-1576
No abstract available.
Amenorrhea*
;
Female
3.A Case of Recurrent Fetal Cystic Hygroma with Polycystic Kidney.
Seong Hee KIM ; Ji Won SIN ; Hyeon Joo KIM ; Seong Sook SEO ; Hyeon Mi HA
Korean Journal of Obstetrics and Gynecology 1997;40(8):1756-1762
This is a case report of a cystic hygroma with polycystic kidney in a fetus which was suspected by ultrasonography and was confirmed by autopsy. Recently, we have experienced this case in 25-year old woman repeatedly and we report that with a brief review of relevant literature.
Adult
;
Autopsy
;
Female
;
Fetus
;
Humans
;
Lymphangioma, Cystic*
;
Polycystic Kidney Diseases*
;
Ultrasonography
4.A Pathological and Immunohistochemical Study of 9 Cases of Inflammatory Fibroid Polyp.
Nam Hoon CHO ; Hyeon Joo JEONG ; Ho Guen KIM
Korean Journal of Pathology 1989;23(1):20-28
We aimed to study the clinicopathologic features of inflammatory fibroid polyp by histological and immunohistochemical methods. The materials used in this study consisted of 9 cases of inflammatory fibroid polyp: 4 in the stomach, 4 in the small intestine and 1 in the cecum. The results were as follows: Females were affected more frequently than males and the average age was 45 years(range:27-61). In cases of gastric lesion, the size tended to be smaller, the mass was mainly located along the greater curvature side of antrum, and confined to the submucosa. However inflammatory fibroid polyp of the small intestine was over 2.5 cm in size, located along the antemesenteric border, and involved the proper muscle layer. In addition, intussusception was accompanied by polyp in 2 cases of small intestinal lesions. Histologically inflammatory fibroid polyps of the stomach were characterized by prominent lymphocytic infiltration and occasional onion-skinning of stromal cells, whereas plasmocytic infiltration was prominent in those of the small intestine. Main component cells comprising this lesion were confirmed to be fibroblasts by immunohistochemistry which revealed strong reactivity to vimentin in the cytoplasm of slindle cells.
Female
;
Male
;
Humans
5.Acute Renal Failure Associated with Gross Hematuria in a Patient with Focal Glomerulonephritis.
Hee Jung KIM ; Hyeon Joo JEONG ; Dae Suk HAN
Korean Journal of Pathology 1997;31(3):263-268
A 58-year-old female with an episode of gross hematuria two months before and fever and chill for the past three days presented oliguric acute renal failure. She has taken NSAID intermittently for 18 years due to rheumatoid arthritis, and herb medicine for one week two months ago when gross hematuria developed. Physical examination revealed mild tenderness on costovertebral angles. Her blood pressure was 170/100 mmHg, the urinalysis showed >300 mg protein with many RBCs and 10-20 WBCs and the serum creatinine was 5.8 mg/dl. A renal biopsy performed on the 4th hospital day showed that it was overwhelmed by severe tubular lesions which reveal intratubular obstruction by massive erythrocyte casts and tubular necrosis. The glomeruli showed focal minimal crescents with many red blood cells entrapped in the crescents and in the capillaries. Immune deposits were not present. A renal failure resolved spontaneously and the patient was discharged three weeks later with creatinine of 2.4 mg/dl. In this patient, acute renal failure was considered to be due to a tubular lesion related to the glomerular bleeding from focal glomerulonephritis revealing minimal crescents.
Acute Kidney Injury*
;
Arthritis, Rheumatoid
;
Biopsy
;
Blood Pressure
;
Capillaries
;
Creatinine
;
Erythrocytes
;
Female
;
Fever
;
Glomerulonephritis*
;
Hematuria*
;
Hemorrhage
;
Humans
;
Middle Aged
;
Necrosis
;
Physical Examination
;
Renal Insufficiency
;
Urinalysis
6.Melanocyte Colonization and Pigmentation of Breast Carcinoma: Report of a case.
Kyu Rae KIM ; Hyeon Joo JEONG ; Yoo Bock LEE
Korean Journal of Pathology 1985;19(4):446-448
Colonization of mammary cancers by melanocytes with heavy pigmentation of cancer cells by melanin can occur very rarely. It is not certain which mechanism operates to achieve this transfer. However, the melanocytes might inject melanin through their dendritic processes or alternatively, the cancer cells phagocytose the terminal parts of the dendritic processes with subsequent dispersal of the contained melanin contained melanin granules. We report a case of infiltrating ductal carcinoma of breast with melanocyte colonization and pigmentation in a 59-year old female.
Female
;
Humans
7.Glomerular Basement Membrane Thickness in Minimal Change Disease.
Yoon Mee KIM ; Soon Hee JUNG ; Hyeon Joo JEONG
Korean Journal of Pathology 2000;34(12):994-1000
The thickness of the glomerular basement membrane may vary not only in glomerular disease, but also in normal persons according to age and sex. But there has been no data on the normal thickness of the basement membrane in Korea. This study was designed to determine the glomerular basement membrane thickness as a reference value according to age and sex, in 50 cases of minimal change disease obtained from patients aged 2~67 years. Measurement of glomerular basement membrane was made on electron micrograph using an image analyzer. The thickness of each case was estimated by the arithmetic and harmonic mean methods. The mean thickness of the glomerular basement membrane was 291.9 47.9 nm by harmonic mean method and 284.2 43.7 nm by arithmetic mean method. And the harmonic mean thickness of the glomerular basement membrane according to age was 249.1 32.5 nm (1~5 years), 256.6 45.3 nm (6~10 years), 279.2 57.9 nm (11~15 years), 303.2 43.8 nm (16~20 years), 335.3 37.5 nm (21~30 years), and 291.1 22.5 nm (over 30 years), respectively. There was a trend that the thickness of glomerular basement membranes increased with the age till 30 years of age. There was no significant sex-related difference. In conclusion, the mean glomerular basement membrane thickness is comparable to the data from western people and shows a trend of increasing thickness according to the age.
Basement Membrane
;
Glomerular Basement Membrane*
;
Humans
;
Kidney
;
Korea
;
Nephrosis, Lipoid*
;
Reference Values
8.MR Imaging of the Trachea:In Vivo and In Vitro Study.
Hyeon Joo JEONG ; Jin Suck SUH ; Myung Joon KIM
Journal of the Korean Radiological Society 1994;30(6):1051-1056
PURPOSE: To establish signal intensity characteristics of the trachea according to the histologic layers, we performed in vivo and in vitro MR studies. MATERIALS AND METHODS: We performed MR imaging of the trachea at 1.5T unit in 11 patients mediastinal masses, vascular anomalies, tracheal stenosis or iatrogenic tracheoesophageal fistula, aryepiglottic fold thickening or mass, tracheal carcinoid, one healthy volunteer and one cadaveric trachea. By using anterior, volume neck or 3 inch dual coil with various pulse sequences, axial and coronal images of the trachea were obtained. The tracheal layers with different signal intensity on MR images were correlated with the histology. RESULTS: In vivo and in vitro MR studies revealed two layers of the trachea ;the inner layer had intermediate to high signal and the outer had low signal. The tracheal cartilage showed low signal intensity in all pulse sequences. The submucosa appeared as intermediate signal intensity on T1 weighted images but high signal intersity on other images due to its abundant mucous and mucoserous glands. However, the mucosa and perichondrium could not be defined on MR images. CONCLUSION: Characterization of the signal intensity according to the histologic layers of the trachea might be helpful for the evaluation of intrinsic lesions of the irachea or the possibility of tracheal invasion from the adjacent tumors.
Cadaver
;
Carcinoid Tumor
;
Cartilage
;
Healthy Volunteers
;
Humans
;
Magnetic Resonance Imaging*
;
Mucous Membrane
;
Neck
;
Trachea
;
Tracheal Stenosis
;
Tracheoesophageal Fistula
9.Immunohistochemistry of Fibrohistiocytic Tumor and Malignant Soft Tissue Tumor Simulating Malignant Fibrous Histiocytoma.
Young Bae KIM ; Hyeon Joo JEONG ; In Joon CHOI
Korean Journal of Pathology 1986;20(1):1-11
Soft tissue tumor is defined as a tumor occurring in voluntary muscles, fat, fibrous tissue, along with the vessels serving these tissue and peripheral nervous system. It is difficult to make a diagnosis by conventional microscopic observation because of their pleuripotentiality and similar growth characteristics. Although their morphological findings of tumors are similar to one another, their clinical courses, treatment and prognosis are different. So early, correct diagnosis and proper treatment are neccessary. The present study is aimed to evaluate a value of immunoperoxidase staining to make definite diagnosis of soft tissue tumors and its application to surgical pathology. The material consisted of 106 cases of fibrohistiocytic tumors and malignant soft tissue tumors which are morphologically similar to malignant fibrohistiocytic tumors for 5 years period lasting from 1980 to 1984 at the Department of Pathology, Yonsei University College of Medicine. After the classificationof fibrohistiocytic tumors by the Enzinger (1983), clinical finndings were reviewed and peroxidase antiperoxidase(PAP) method with alpha1-antichymotrypsin was done in 15 cases of all fibrohistiocytic tumors. Other soft tissue tumors which were difficult to differentiate from MFH by light microscopic observation were liposarcoma, rhabdomyosarcoma, fibrosarcoma and malignant schwannoma. These 21 cases of tumors including MFH were stained with PAP method for alpha1-antichymotrypsin, S-100 protein and myoglobin. Results obtained were as follows: 1) The cases on study consisted of 19 cases of malignant fibrous histiocytoma, 2 dermatofibrosarcoma protuberans, 45 fibrohistiocytic tumors and 11 other benign fibrohistiocytic tumors. 2) The male to female ratio was 1 : 1.8 in benign and intermediate group of fibrohistiocytic tumor, but 2.2 : 1 in malignant histiocytic tumor. 3) Most cases of benign fibrohistiocytic tumors were occurred in 4th and 5th decade of life. Intermediate and malignant fibrohistiocytic tumors were mostly found in late adult life and their mean age was 43.6 year. 4) The most common sites were trunk and both extrimities in benign fibrohistiocytic tumors(88.9%), but head, neck and lower extremities in MFH (78.9%). Two cases of dermatofibrosarcoma protuberans were occurred in turnk and upper extremity. 5) The PAP stain for alpha1-antichymotrypsin was done in 15 cases of 77 fibrohistiocytic tumors which included MFH, dermatofibrosarcoma protuberans, xanthoma, xanthofibroma, dermatofibroma showed variable degree of positivity to alpha1-antichymotrypsin. The positivity of alpha1-antichymotrypsin revealed no significant difference according to differentiation of the tumors, such as benign, intermediate and malignant. 6) The PAP stain for alpha1-antichymotrypsin revealed diffuse positivity in all cases of MFH and also in a case of malignant schwannoma, fibrosarcoma, liposarcoma and rhabdomyosarcoma, but myoglobin and S-100 protein were negative. In three cases of leiomyosarcoma, two of rhabdomyosarcoma and three of malignant schwannoma, alpha1-antichymotrypsin, S-100 protein and myoglobin were negative, although a few positive tumor cells were present, which may the considered as metatypci differentiation. Another possibility of this discordance was loss of antigenicity by improper procedure of paraffin embedding and poor differentiation of tumor cells. In summary, PAP method for specific tumor marker is important for proper diagnosis of soft tissue tumors, and application to surgical pathology.
Adult
;
Male
;
Female
;
Humans
;
Tumor Markers, Biological
10.A Case of Crescentic Glomerulonephritis Superimposed on Membranous Glomerulonephropathy.
Baek Nam KIM ; Jin Won YOOK ; Ji Hong KIM ; Pyung Kil KIM ; Hyeon Joo JEONG
Journal of the Korean Society of Pediatric Nephrology 1999;3(1):95-99
Cytologic findings of pleural effusion in three cases of rhabdomyosarcoma are reported. Case 1 was a pleomorphic rhabdomyosarcoma which had devoped at the chest wall of an elderly male patient and caused pleural effusion. The cytologic features were consistent with pleomorphic rhabdomyosarcoma, that was, showing loose clusters, cellular pleomorphism, and abundant finely vesicular cytoplasm. Cases 2 and 3 were embryonal rhabdomyosarcomas in young adults. Primary site was the oral cavity in case 1, but unknown in case 2 and case 3. The effusion cytology was similar in these cases. Clustered or isolated small round cells with hyperchromatic nuclei and scanty cytoplasm were smeared. The cohesiveness of tumor cells was weak and the cells did not show linear arrangement or nuclear molding. Effusion cytology in a sarcoma patient would be diagnostic when the primary site and the type of sarcoma were already known.
Aged
;
Cytoplasm
;
Fungi
;
Glomerulonephritis*
;
Glomerulonephritis, Membranous*
;
Humans
;
Male
;
Mouth
;
Pleural Effusion
;
Rhabdomyosarcoma
;
Rhabdomyosarcoma, Embryonal
;
Sarcoma
;
Thoracic Wall
;
Young Adult