1.Type III Hyperlipoproteinemia.
Beom Joo LEE ; Seung Kyung HANN ; Sung Ku AHN ; Sung Bin IM ; Seung Hun LEE
Korean Journal of Dermatology 1993;31(2):236-240
We report a case of type III hyperlipoproteinemia which is called a broad-beta disease. A 53 year old female patient visited our clinic for the evaluation of multiple yellowish papules on extremities and eyelids. The patient showed various types of xanthoma includiiig eruptive, tuberous, tendinous xanthomas and xanthelasma palpebrarum, xanthoma striatum palmare. The blood chemistry revealed a marked elevstion of cholesterol and triglycerides and agarose gel electrophoresis showed a single peak at prebeta and beta portion without separation. On histopathologic studies, typical foam cells were showen.
Chemistry
;
Cholesterol
;
Electrophoresis, Agar Gel
;
Extremities
;
Eyelids
;
Female
;
Foam Cells
;
Humans
;
Hyperlipoproteinemia Type III*
;
Hyperlipoproteinemias
;
Middle Aged
;
Triglycerides
;
Xanthomatosis
2.Clinical analysis of low back pain.
Myo Kyung CHOI ; Sung Hun HA ; Choo Yon CHO ; Joo Ja KIM ; Taik Sung NAM
Journal of the Korean Academy of Family Medicine 1991;12(3):17-22
No abstract available.
Low Back Pain*
3.Leukemic Macrocheilitis Associated with Chronic Lymphocytic Leukemia.
Tae Kee MOON ; Beom Joo LEE ; Seung Hun LEE ; Sung Ku AHN ; Won Soo LEE
Korean Journal of Dermatology 1994;32(6):1114-1118
Specific cutaneous infiltrates in chronic lymphocytic leukemia(CLL) presenting as tumor and large nodule on face, scalp and upper trunk and involvement of oral mucsa is extremly rare. In 7% of cases, leukemic infiltrates of the skin precede the diagnosis of Leuke. We report herein leukemic macrocheilia which occured 3 years before a diagnosis of CLL.
Diagnosis
;
Leukemia
;
Leukemia, Lymphocytic, Chronic, B-Cell*
;
Scalp
;
Skin
4.A Case of Atrial Septal Defect in Identical Twins.
Jong Tae LEE ; Hun Kwan LIM ; Tae Myeung CHOI ; Sung Koo KIM ; Young Joo KWON
Korean Circulation Journal 1994;24(5):722-725
Atrial septal defect is one of the most common congenital heart diseases in adult, of which absolute causes is not confirmed, but explained by multifactorial inheritance. In Korea, there has been no case report of atrial septal defect in identical twins in spite of some reports of atrial septal defect in relatives and twins in other countries. We present a first case of atrial septal defect in identical twins whose mother had no infection or medication history during pregnancy.
Adult
;
Heart Diseases
;
Heart Septal Defects, Atrial*
;
Humans
;
Korea
;
Mothers
;
Multifactorial Inheritance
;
Pregnancy
;
Twins
;
Twins, Monozygotic*
5.Clinical and histopathologic study of sparganosis.
Beom Joo LEE ; Sung Ku AHN ; Soo Chan KIM ; Seung Hun LEE
Korean Journal of Dermatology 1992;30(2):168-174
We reviewed the clinical epidermiologic features and skin biopaies of 23 patients who were diagonosed with sparganosis. Clinically, the parasites were obtained from the lesions and confirmed histopathologically. The purpose of this study was to evaluate the elinical, epidemiological, and histopathological charaeteristics of sparganosis. The results are summurized as follows : 1. There were no difference between male (48%) and female (52%) patients. 2. Age distribution, at first visit, were variable, ranging from 7 to 75, with the mean age of 40 years-old. 3. Duration of symptoms were variable, ranging from 10 years to 15 years, with a mean duration of 3 years. 4. Frequency of clinical features were as follows; movable or fixed subcutaneous nodule (16 cases), subcutaneous nodule with pain & focal warmth t.o touch (6 cases), seizure (I case). 5. Number of parasites per lesion were single lesion with single, parasite (21 cases), single lesion with two parasites (2 cases) and three parasites (3 case). 6. Frequency of location of lesion were abdominal wall (8 cases), thigh (4 cases), breast (3 cases), scrotum (3 cases), arm (3 cases), buttoek (1 cases), ciiest wall (1 case), brain (1 case). 7. The histological change of the affected tissue were characterized as follows ; 1) necrotizing and granulomatous tissue with or without parasif os in the lesions. 2) some cases were associated with marked fibrosis or formation of lymphoid follicles. 3) There were many lympho-histocytes, eosinophils, giant cel1s and some plasma cells near the lesions.
Abdominal Wall
;
Adult
;
Age Distribution
;
Arm
;
Brain
;
Breast
;
Eosinophils
;
Female
;
Fibrosis
;
Humans
;
Male
;
Parasites
;
Plasma Cells
;
Scrotum
;
Seizures
;
Skin
;
Sparganosis*
;
Thigh
6.A case of rifampicin induced thrombocytopenic purpura.
Jin Hyoung WON ; Won HUR ; Sung Ku AHN ; Seung Hun LEE ; Kyung Joo LEE
Korean Journal of Dermatology 1991;29(6):817-821
No abstract available.
Purpura, Thrombocytopenic*
;
Rifampin*
7.Preservation of antigenicity of autoimmune blistering diseases according to different methods of dermo-epidermal separation.
Beom Joo LEE ; Soo Chan KIM ; Sung Ku AHN ; Seung Hun LEE
Korean Journal of Dermatology 1993;31(1):19-27
There are many known methods of dermo-epidermal separation for the investigation of autoimmune blistering diseases. Investigators should select a proper method since many differences exist preservation of antigenicity. In order to determine the stabilization of antigenirity by different separation methods, we have separated dermo-epidermal junction by means of 1M s;ilt, 56C PBS, 20mM EDTA and dispase. Indirect immunofluarescence and immunoblotting were performed on each specimen with sera of patients with pemphigus vulgaris, pemphigus foliaceus, paraneoplastic pemphigus, bullous pemphigoid and epidermolysis bullosa acquisita. The results are as follows : 1. In indirect immunofluorescence study of pemphigus group, best, result were obtained when normal skin without dermo-epidermal separation was used. Dispase well preserved antigenicity of pemphigus after dermo-epidermal separation, but no differences were noted in antigenicity stabilization among separation mehods by immunoblotting. 2. In indirect immunofluorecence study for differentiation of bullous pemphigoid and epidermolysis bullosa acquisita, we recommend EDTA and dispase methods in addition to 1M salt induced skin separation that have been most popularly used. 3. Results of the immunoblotting of bullous pemphigoid showed that 1M salt, EDTA and heat preserved the antigenicity well but the antigenicity was lost by dispase. 4. Results of the immunoblotting of epidermolysis bullosa acquisita she wed that antigen did not exist in epidermal extract. 5. Antigen preservation according to the different methods of demo-epidermal separation was not identical between indirect immunofluorescence and immunoblotting.
Blister*
;
Edetic Acid
;
Epidermolysis Bullosa Acquisita
;
Fluorescent Antibody Technique, Indirect
;
Hot Temperature
;
Humans
;
Immunoblotting
;
Pemphigoid, Bullous
;
Pemphigus
;
Research Personnel
;
Skin
8.Trend of Serum Lipid Levels in Normal Koreans.
Sung Wook HAN ; Dong Ho SHIN ; Sang Eun JOO ; Bang Hun LEE ; Chung Kyun LEE
Korean Circulation Journal 1983;13(1):107-112
The authors underwent the serum lipid study, involving the lipoprotein fraction, and the HDL-cholesterol mean values in normal Korean adults visited to Hanyang University Hospital, and also compared with the previously reported serum lipid studies. The results are as follows; 1) The mean values of triglyceride, total cholesterol, and phospholipid were 103.3+/-17.1mg%, 188.9+/-18.2mg%, and 196.7+/-19.8mg%, respectively. 2) Compared with the past 7 years triglyceride showed increasing tendency with significance, and cholesterol and phospholipid showed slightly increasing tendency. 3) In the serum lipoprotein fraction, the mean values of alpha-lipoprotein, pre-beta-lipoprotein, and beta-lipoprotein were 37.2+/-5.9%, 16.0+/-4.2%, and 48.6+/-5.2%, respectively. 4) Compared with the past 10 years, the alpha-, and pre-beta-lipoprotein showed increasing tendency, meanwhile, beta-lipoprotein revealed decreasing tendency. 5) The mean value of HDL-cholesterol was 52.3+/-14.6mg%, and the ratio of HDL-cholesterol to total cholesterol(HDL-cholesterol/total cholesterol) was 28.2+/-7.9. 6) Compared with the past 2 years, HDL-cholesterol level showed slightly increasing tendency.
Adult
;
Cholesterol
;
Humans
;
Lipoproteins
;
Triglycerides
9.Clinicopathologic Study of Pustular Drug Eruption.
Soo Jung KIM ; Seung Hun LEE ; Sung Ku AHN ; Won Soo LEE ; Beom Joo LEE
Korean Journal of Dermatology 1994;32(4):554-561
BACKGROUND: Pustular eruptions due to drugs are uncommonly reported. We studied the characteristics of clinical and histopathologic findings of pustular drug eruption. OBJECTIVE: We observed th.e causative agents, clinical featurs and histopathologic findings of pustular drug eruption and identified differential points of generlized pustular eruption. METHODS: We evaluated t,he clinical and histopathologic findings of 8 patients with pustular drug eruption and reviewed the literatures reported cases of pustular drug eruption. RESULTS: All patients diagnosed pustular drug eruption suffered from generalized pustular eruption associated with systemic symptoms such as fever, headachened myagia one to three days after treatment with causative agents. The causative agents of putular drug eruption are antibiotics such as ceftriaxone, analgesics and antipyretics. The pustule resolved after a few days of treatment with systemic corticosteroids and antihistamines. Laboratory findings revealed leukocytosis, neutrophilia, and analevated erythrocyte sedimentation rate, On histopatologic findings, we observed subcorneal pustuls containing neutrophils, eosinophils and some lymphocytes and spongiosis, exocytosis of acute iiflammatory cells. Perivascular infiltration of lymphocyte ancl edema of papillary dermis was also bserved in the dermis. CONCLUSION: Pustular drug eruption is characterized by generalized pustular eruption associated with systemic symptoms and histopathologic findings of that are sterile subcorneal pustules. Therefore differential diagnosis of other generalized pustular erupticns are relatively easy by careful history of medication, clinical and histopathologic findings.
Adrenal Cortex Hormones
;
Analgesics
;
Anti-Bacterial Agents
;
Antipyretics
;
Blood Sedimentation
;
Ceftriaxone
;
Dermis
;
Diagnosis, Differential
;
Drug Eruptions*
;
Edema
;
Eosinophils
;
Exocytosis
;
Fever
;
Histamine Antagonists
;
Humans
;
Leprosy
;
Leukocytosis
;
Lymphocytes
;
Neutrophils
10.Clinicopathologic Study of Pustular Drug Eruption.
Soo Jung KIM ; Seung Hun LEE ; Sung Ku AHN ; Won Soo LEE ; Beom Joo LEE
Korean Journal of Dermatology 1994;32(4):554-561
BACKGROUND: Pustular eruptions due to drugs are uncommonly reported. We studied the characteristics of clinical and histopathologic findings of pustular drug eruption. OBJECTIVE: We observed th.e causative agents, clinical featurs and histopathologic findings of pustular drug eruption and identified differential points of generlized pustular eruption. METHODS: We evaluated t,he clinical and histopathologic findings of 8 patients with pustular drug eruption and reviewed the literatures reported cases of pustular drug eruption. RESULTS: All patients diagnosed pustular drug eruption suffered from generalized pustular eruption associated with systemic symptoms such as fever, headachened myagia one to three days after treatment with causative agents. The causative agents of putular drug eruption are antibiotics such as ceftriaxone, analgesics and antipyretics. The pustule resolved after a few days of treatment with systemic corticosteroids and antihistamines. Laboratory findings revealed leukocytosis, neutrophilia, and analevated erythrocyte sedimentation rate, On histopatologic findings, we observed subcorneal pustuls containing neutrophils, eosinophils and some lymphocytes and spongiosis, exocytosis of acute iiflammatory cells. Perivascular infiltration of lymphocyte ancl edema of papillary dermis was also bserved in the dermis. CONCLUSION: Pustular drug eruption is characterized by generalized pustular eruption associated with systemic symptoms and histopathologic findings of that are sterile subcorneal pustules. Therefore differential diagnosis of other generalized pustular erupticns are relatively easy by careful history of medication, clinical and histopathologic findings.
Adrenal Cortex Hormones
;
Analgesics
;
Anti-Bacterial Agents
;
Antipyretics
;
Blood Sedimentation
;
Ceftriaxone
;
Dermis
;
Diagnosis, Differential
;
Drug Eruptions*
;
Edema
;
Eosinophils
;
Exocytosis
;
Fever
;
Histamine Antagonists
;
Humans
;
Leprosy
;
Leukocytosis
;
Lymphocytes
;
Neutrophils