PURPOSE: Intraductal papilloma (IDP) is a benign breast disease with malignant potential, for which complete surgical excision is usually recommended. The aim of the present study was to investigate predictive factors for upgrading patients with a benign papillary lesion (BPL). METHODS: This study was an observational study using a prospectively collected cohort. In total, 13,049 patients who underwent a core needle biopsy (CNB) for a breast lesion between January 2009 and May 2015 were enrolled. We reviewed all patients with pathologically confirmed BPL from a CNB. RESULTS: Surgical treatment was performed for 363 out of a total of 592 lesions. According to the pathological differences, the lowest upgrade rate was shown in IDP without atypia (without atypia, 6.0%; with atypia, 26.8%; papillary neoplasm, 31.5%; p<0.001). The univariate analysis showed that, in IDP without atypia, the age at diagnosis, size of BPL on ultrasonography, and density on mammography were associated with upgrading. The multivariate analysis revealed that age >54 years and lesion size >1 cm were significantly associated with upgrade to malignancy (odds ratio [OR]=4.351, p=0.005 and OR=4.236, p=0.001, respectively). CONCLUSION: The indications for surgical treatment can be defined as age >54 years and mass size >1 cm, even in IDP without atypia in the CNB results; this also includes cases of IDP with atypia or papillary neoplasm. Therefore, we suggest that close observation without surgery is sufficient for younger women with a small IDP without atypia.
Biopsy ; Biopsy, Large-Core Needle* ; Breast Diseases ; Breast Neoplasms ; Breast* ; Cohort Studies ; Diagnosis ; Female ; Humans ; Mammography ; Multivariate Analysis ; Observational Study ; Papilloma, Intraductal ; Prospective Studies ; Ultrasonography

No abstract available.
Epidermal Cyst

OBJECTIVE: The purpose of this retrospective study was to report the outcome of the endovascular treatment of eight patients with eight saccular posterior inferior cerebellar artery (PICA) aneurysms. MATERIALS AND METHODS: Over the last seven years (1999-2006), eight consecutive patients with saccular PICA aneurysms were treated by endovascular methods. Five of the aneurysms were presented with subarachnoid hemorrhaging, whereas three were discovered incidentally. Four of the aneurysms (3 ruptured and 1 incidental) were treated by intrasaccular coiling, whereas the remaining four (1 ruptured and 3 incidental) were treated by vertebral artery (VA) occlusion. RESULTS: Of the four aneurysms treated by intrasaccular coiling, three were completely packed with coils and one was partially packed. In three of four patients who underwent vertebral artery occlusions, follow-up digital subtraction angiographies demonstrated thrombosed aneurysms and PICA. No procedure-related morbidity occurred and no re-bleed was encountered during a follow-up examination (mean; 31 months). CONCLUSION: As a result of this study, we found that the endovascular management of saccular PICA aneurysms should be considered as safe and effective.
Adult ; Aged ; Aneurysm, Ruptured/radiography/*therapy ; Cerebellum/blood supply/*radiography ; Cerebral Angiography ; Embolization, Therapeutic/*methods ; Female ; Humans ; Incidental Findings ; Intracranial Aneurysm/radiography/*therapy ; Male ; Middle Aged ; Retrospective Studies ; Subarachnoid Hemorrhage/radiography/*therapy ; Treatment Outcome

No abstract available.
Genioplasty*

PURPOSE: To examine the relationship between injury severity and patterns of associated injury in spinal fracture. MATERIALS AND METHODS: From March 2004 to March 2010, a retrospective study was conducted on 291 patients who had undergone surgeries due to spinal fractures. Spinal fractures were categorized as upper cervical, lower cervical, thoracic, thoracolumbar, and lumbar region, and the severity of fracture was measured using the Abbreviated Injury Scale and Injury Severity Score (ISS). We evaluated the correlation between the fracture site and the incidence and injury severity of the associated injury, and compared the neurologic damage according to the presence/absence of the associated injury. RESULTS: Spinal fracture occurred in the thoracic (43.5%) and lower cervical (30.0%) levels, and associated injury developed in 134 patients (47%). The area of associated injury was in the extremity (41.2%), thorax (25.5%), head, neck, and face (21.9%). Lower cervical fracture (34.5%) had a lower prevalence than thoracic (81%) and lumbar fracture (61%). The average ISS of the associated injury was 17.14 for the thoracic fracture, 12.30 for the lower cervical fracture, 8.7 for the thoracolumbar fracture and 5.69 for the lumbar fracture. Neurologic damage was highly frequent in the lower cervical fracture and included 54 patients (62.1%) and was less frequent in the upper cervical fracture, which included 7 patients (17.9%) (p=0.032). CONCLUSION: Although the associated injury was less frequent in the lower cervical spine among the spinal fractures that underwent surgical treatment, there was a high risk of neurologic damage in the case of associated injury; therefore, there is a need to pay special attention to patients that suffer damage in this area. In addition, since the degree of the associated injury in the thoracic and lower cervical fracture is significant, an appropriate management strategy for the associated injury must be considered.
Abbreviated Injury Scale ; Extremities ; Head ; Humans ; Incidence ; Injury Severity Score ; Lumbosacral Region ; Multiple Trauma ; Neck ; Prevalence ; Retrospective Studies ; Spinal Fractures ; Spine ; Thorax

PURPOSE: Aims to analyze the occlusal wear patterns in maxillary posterior teeth with palatal side abfractions and study the association between occlusal force and abfractions. MATERIALS AND METHODS: This study was conducted in a total of 308 teeth from 148 patients with palatal side abfractions in maxillary posterior teeth. The occlusal wears in maxillary premolars and molars with palatal side abfractions were classified and recorded. The classification was done by type of teeth, age, and gender, and in order to evaluate the statistical significance between groups, chi-square test was conducted (α = 0.05). RESULTS: Palatal side abfractions in maxillary posterior teeth were observed at the highest frequency in the 1st molars, and in all teeth with palatal side abfractions, more than one occlusal wear was observed. In classification by type of teeth, by age, and by gender, the occlusal wears in teeth with palatal side abfractions were observed at high frequency in cuspal inclined plane, central fossa, and marginal ridge, and there was a statistical significance (P < 0.05). CONCLUSION: Palatal side abfractions were observed at the highest frequency in maxillary 1st molars, and in all maxillary posterior teeth where palatal side abfractions were found, the occlusal wears were observed. And the occlusal wears were observed at high frequency in cuspal inclined plane, central fossa and marginal ridge. Such results show that abfraction is associated with occlusal force.
Bicuspid ; Bite Force ; Classification ; Humans ; Molar ; Tooth Attrition ; Tooth Fractures ; Tooth

It has been generally believed that the impaction or eruption of mandibular third molars has significant correlations with the growth of the mandible, size of mandibular arch and size of teeth. The purpose of this study was to examine if there is any correlation between the status of eruption of mandibular third molars and the amount of mandibular crowding. The effect of missing of third moalrs to mandibular crowding was studied as well. 140 adult students of Yonsei University were selected and divided into three groups according to the status of mandibular third molars, Group 1) congenital missing group, Group 2) eruption group, and Group 3) impaction group. The tooth size, dimensions of the mandibular dental arch, and the amount of crowding were measured and compared. Results were as follows; 1. There was no statistically significant difference in tooth size between the missing group and the eruption group(p<0.05). Impaction group showed larger total tooth material, incisal tooth material, and individual tooth size except central incisors compared to missing group (p<0.05). Impaction group showed larger total tooth material, incisal tooth material compared to eruption group as well(p<0.05). When individual tooth size was compared, impaction group had larger central incisors, canines, and second premolars than eruption group(p<0.05). 2. Missing group showed larger intermolar width than impaction group and it was statistically significant(p<0.05). 3. When compared the amount of total crowding, impaction group showed the largest amount of crowding, then eruption group, and missing group showed the least amount of crowding respectively(p<0.05). There was no statistically significant difference between missing group and eruption group in the amount of incisal crowding (p<0.05). Impaction group showed the largest amount of incisal crowding among all three groups(p<0.05).
Adult ; Bicuspid ; Crowding* ; Dental Arch ; Humans ; Incisor ; Mandible ; Molar, Third* ; Tooth

OBJECTIVE: To investigate the prevalance of carpal tunnel syndrome (CTS) and polyneuropathy (PNP) in chronic hemodialysis patients, and to know the relationships between the clinical symptoms and electrophysiological evidence of CTS, the edema of the hand and CTS, and the shunt side and CTS. METHOD: We carried out a standardized nerve conduction study on 30 patients who had undergone a chronic dialysis for varying lengths of time. Differential diagnosis between CTS and PNP was done on the basis of difference of the median-ulnar motor and sensory latencies in the patients with a prolonged distal median motor or sensory latency. RESULTS: Sixteen (54%) had a combined PNP with the CTS; Seven (23%) patients had a PNP only; Two (7%) patients had a CTS only. There was no definite findings of peripheral neuropathy in five (17%) patients. Among eighteen patients with the CTS, sixteen were subclinical and two were overt CTS. Presence of edema and shunt was not crucial for the development of CTS. CONCLUSION: Prevalence of CTS in chronic hemodialysis patients was 60%. Subclinical CTS was more frequent compared to the overt CTS. Dialysis patients need a frequent nerve conduction study for the early identification of carpal tunnel syndrome and to avoid the irreversible nerve damage.
Carpal Tunnel Syndrome* ; Diagnosis, Differential ; Dialysis ; Edema ; Hand ; Humans ; Kidney Failure, Chronic ; Neural Conduction ; Peripheral Nervous System Diseases ; Polyneuropathies ; Prevalence ; Renal Dialysis*

PURPOSE: Most of studies dealing with abfractions are limited to the buccal surfaces of the teeth. In this study, we analyzed the cause for abfraction by investigating the incidence of palatal side abfractions in maxillary posterior teeth. MATERIALS AND METHODS: We investigated a total of 3193 maxillary posterior teeth by an intraoral examination, model observation, and observation of virtual model fabricated using model scanning. We recorded the results and classified them depending on the type of teeth, age, gender, and side of arches. We also performed Chi-square test to evaluate the statistical significance among the groups (α = 0.05). RESULTS: The incidence of palatal side abfraction of the maxillary molars (10.8%) was higher than the premolars (6.8%), and among them, the incidence of the 1st molars (39.1%) were the highest. The incidence of palatal side abfraction increased with age and was statistically significant (P < 0.05). There was no statistical significance in the difference by gender (P > 0.05); in the case of arches, left arch showed higher incidence and it was statistically significant (P < 0.05). CONCLUSION Palatal side abfraction in maxillary posterior teeth was frequently observed in the maxillary 1st molars, and the incidence increased with age. This result suggests that the main reason for abfraction is due to occlusal force.

Isolated ACTH deficiency is a rare disorder, and usually characterized by its chronic course. The 59 year-old woman patient who had been healthy until 2 months ago, admitted because of abdomial pain, general weakness and loss of weight about 12kg for 2 months. She looked a little pallor but color of skin was not remarkable. Blood pressure, serum electrolyte, and glucose on admission were within normal range. Serum calcium was elevated with the value of 12.6mg/dL, which was normalized after hydration. Cortisol response to RI induced hypoglycemia did not show any response. Anterior pituitary hormone except ACTH showed normal response during combined pituitary hormone stimulation test. These clinical and laboratory finding reveals that isolated ACTH deficiency was developed in a short term period. There were no abnormalities in sellar MRI except pineal cyst. Her complaints were disappeared dramatically after hydroccetisone replacement at 4th. hospital day. Here we report a case of isolated ACTH deficiency, which was rapidly developed, with hypercalcemia, abdominal pain, and loss of weight about 12kg for 2 months.
Abdominal Pain ; Adrenocorticotropic Hormone* ; Blood Pressure ; Calcium ; Female ; Glucose ; Humans ; Hydrocortisone ; Hypercalcemia ; Hypoglycemia ; Magnetic Resonance Imaging ; Middle Aged ; Pallor ; Reference Values ; Skin ; Weight Loss