1.The Basic Studies on the Application of Galectin - 3 as a Target Protein for Delivering Anticancer Agents.
Korean Journal of Immunology 1997;19(1):83-90
Gastric cancer cells express large amounts of galectin-3 on the cell surface. This fact may provide the possibility to use galectin-3 protein as a surface target for delivering cytotoxic anticancer agents. To investigate the possibility of application of galectin-3 protein as a target protein in delivering cytotoxic anticancer agents, we synthesized doxorubicin immunoconjugate by using maleimidocaproic acid and conjugated doxorubicin immunoconjugate to anti-galectin-3 mAb. The anticancer effect of immunotoxin was assayed on NIH3T3, AGS and KATO III cell lines. The anticancer effect of immunotoxin on AGS cell line is highest and that of KATO III is higher than that of NIH3T3. This results relate to that of flow cytometry analysis previously shown and indicate that galectin-3 protein can be used as a target protein on the surface of gastric cancer cell for delivering cytotoxic anticancer agents.
Antineoplastic Agents*
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Cell Line
;
Doxorubicin
;
Flow Cytometry
;
Galectin 3
;
Galectins*
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Immunoconjugates
;
Immunotoxins
;
Staphylococcal Protein A
;
Stomach Neoplasms
2.Total anomalous pulmonary venous connection: 1 case report.
Woo Chul SONG ; Byung Joo KIM ; Ki Woo HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(12):1465-1470
No abstract available.
4.The surgical correction for pectus excavatum.
Woo Chul SONG ; Ho Seung SHIN ; Byung Joo KIM ; Hee Chul PARK ; Ki Woo HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(7):712-718
No abstract available.
Funnel Chest*
5.Persistence of antibodies after immunization with the inactivated vaccine against hemorrhagic fever with renal syndrome in humans.
Chang Hong LEE ; Kwan Soo BYUN ; Woo Joo KIM ; Young Dae WOO ; Ho Wang LEE
Journal of the Korean Society of Virology 1992;22(2):239-243
No abstract available.
Antibodies*
;
Hemorrhagic Fever with Renal Syndrome*
;
Humans*
;
Immunization*
6.Mediastinal lipoma: one case report.
Chang Lyul MYUNG ; Ho Seung SHIN ; Byung Joo KIM ; Hee Chul PARK ; Ki Woo HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(8):795-799
No abstract available.
Lipoma*
7.Mediastinal tuberculous abscess: report of two cases.
Hyeon In PYO ; Ho Seong SHIN ; Byeong Joo KIM ; Hee Chul PARK ; Ki Woo HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(8):830-835
No abstract available.
Abscess*
9.Clinical evaluation of 111 cases of open heart surgery.
Hyeon In PYO ; Ho Seong SHIN ; Byeong Joo KIM ; Hee Chul PARK ; Ki Woo HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(9):870-880
No abstract available.
Heart*
;
Thoracic Surgery*
10.MRI of Vertebral Compression Fractures: Differentiation between Benign and Malignant Causes.
Won Hong KIM ; Gham HUR ; Joung Joo WOO ; Wu Ho CHO ; Myeong Ja JUNG
Journal of the Korean Radiological Society 1995;33(5):673-679
PURPOSE: To evaluate the MR image in the differentiation of benign and malignant lesion in compression of the vertebral body. MATERIALS AND METHODS: MR images of 47 benign(acute traumatic within one month:19, chronic traumatic longer than one month or nontraumatic:28) and 21 metastatic compression fractures were respectively reviewed in terms of margin of lesions, signal intensity, paraspinal mass formation, soft tissue change, and involvement of posterior element of vertebra. MR images of TI-(T1WI) and T2*-weighted gradient echo (GE T2WI) sequences were obtained on 0.5T unit in sagittal and axial orientation with 5mm section thickness. RESULTS: The margin of benign compression fracture was usually indistinct (acute fracture:90% (17/19), chronic fracture:68% (19/28)), whereas it was sharply delineated in metastatic compression fracture (92%, (12/13) (p<0.001). Paraspinal mass was seen in both acute traumatic and metastatic compression fractures (acute fracture :26% (5/19), metastatic fracture: 52% (11/21). Soft tissue change was seen only in acute cornpression fractures (58%, 11/19). Involvement of posterior element of vertebra was noted in metastatic fracture (71%, 15/21), acute fracture (32%, 6/19) and chronic fracture (7%, 2/28) CONCLUSION: On MR imaging, involvement of entire portion of a given vertebral body, sharp margin between normal and abnormal areas in partially involved cases, paraspinal mass formation, and posterior element involvement are more frequently seen in metastatic compression fractures, which are considered to be useful in differentiation between benign and malignant causes of compression fracture.
Fractures, Compression*
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Magnetic Resonance Imaging*
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Spine