1.The Basic Studies on the Application of Galectin - 3 as a Target Protein for Delivering Anticancer Agents.
Korean Journal of Immunology 1997;19(1):83-90
Gastric cancer cells express large amounts of galectin-3 on the cell surface. This fact may provide the possibility to use galectin-3 protein as a surface target for delivering cytotoxic anticancer agents. To investigate the possibility of application of galectin-3 protein as a target protein in delivering cytotoxic anticancer agents, we synthesized doxorubicin immunoconjugate by using maleimidocaproic acid and conjugated doxorubicin immunoconjugate to anti-galectin-3 mAb. The anticancer effect of immunotoxin was assayed on NIH3T3, AGS and KATO III cell lines. The anticancer effect of immunotoxin on AGS cell line is highest and that of KATO III is higher than that of NIH3T3. This results relate to that of flow cytometry analysis previously shown and indicate that galectin-3 protein can be used as a target protein on the surface of gastric cancer cell for delivering cytotoxic anticancer agents.
Antineoplastic Agents*
;
Cell Line
;
Doxorubicin
;
Flow Cytometry
;
Galectin 3
;
Galectins*
;
Immunoconjugates
;
Immunotoxins
;
Staphylococcal Protein A
;
Stomach Neoplasms
3.Total anomalous pulmonary venous connection: 1 case report.
Woo Chul SONG ; Byung Joo KIM ; Ki Woo HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(12):1465-1470
No abstract available.
4.Persistence of antibodies after immunization with the inactivated vaccine against hemorrhagic fever with renal syndrome in humans.
Chang Hong LEE ; Kwan Soo BYUN ; Woo Joo KIM ; Young Dae WOO ; Ho Wang LEE
Journal of the Korean Society of Virology 1992;22(2):239-243
No abstract available.
Antibodies*
;
Hemorrhagic Fever with Renal Syndrome*
;
Humans*
;
Immunization*
5.The surgical correction for pectus excavatum.
Woo Chul SONG ; Ho Seung SHIN ; Byung Joo KIM ; Hee Chul PARK ; Ki Woo HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(7):712-718
No abstract available.
Funnel Chest*
6.Median sternotomy for bilateral resection or plication of bullae.
Hee Chul PARK ; Suck Jun KONG ; Ho Seung SHIN ; Bung Joo KIM ; Ki Woo HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(2):182-189
No abstract available.
Sternotomy*
7.Mediastinal lipoma: one case report.
Chang Lyul MYUNG ; Ho Seung SHIN ; Byung Joo KIM ; Hee Chul PARK ; Ki Woo HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(8):795-799
No abstract available.
Lipoma*
8.Clinical evaluation of 111 cases of open heart surgery.
Hyeon In PYO ; Ho Seong SHIN ; Byeong Joo KIM ; Hee Chul PARK ; Ki Woo HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(9):870-880
No abstract available.
Heart*
;
Thoracic Surgery*
9.Three Cases of Hemolytic Diseases of Newborns due to Anti - E Antibody.
Hee Joo HONG ; Jee Hyun KIM ; Sun Hee CHOI ; Chong Woo BAE ; Yong Mook CHOI
Korean Journal of Perinatology 2001;12(2):163-167
No abstract available.
Humans
;
Infant, Newborn*
10.Expression Pattern of Tumor Progression and Metastasis-related Gene Proteins - CD44H, CD44v6, erbB-2, and p53 -in Gastric Carcinoma.
Sung Woo JOO ; Young Jhoon CHIN ; Dae Cheol KIM ; Gi Yeoung HUH ; Sook Hee HONG
Korean Journal of Pathology 1996;30(9):751-763
Immunohistochemical studies of the molecules associated with gastric tumor progression and metastasis were done to evaluate their relationship with known prognostic factors and their usefulness in assessment of the progression of gastric carcinoma in 127 gastric carcinoma tissues. The 4 antibodies used in this study were CD44H, CD44v6, erbB-2, and p53. The CD44H expression was detected in 76 (59.8%), CD44v6 in 63 (49.6%), erbB-2 in 18 (14.2%), and mutant p53 in 98 (77.2%) out of 127 cases of gastric carcinomas. There was no significant correlation between the expression rates of each four proteins. The expression rates of all 4 proteins were not significantly correlated with age and sex of the patients and lymph node metastasis, but the correlation between CD44v6 expression and the depth of tumor invasion and tumor stage was significant (p<0.05). These results suggest that CD44v6 is closely associated with tumor invasion, and high levels of CD44H, erbB-2 and p53 are associated with tumorigenesis of the stomach as they are highly expressed in early as well as in advanced gastric carcinomas. The findings also support the conclusion that the loss of control of alternative CD44 mRNA splicing resulted in production of CD44v6 splicing variant in tumor cell facilitates tissue invasion by increased adherence of the tumor cell to an extracellular matrix or by tumor cell migration. It can be expected that CD44v6 overexpression in tumor cells appears to be an important prognostic indicator for gastric tumor progression.
Neoplasm Metastasis
;
Cell Transformation, Neoplastic
;
Stomach Neoplasms
Result Analysis
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