1.Clinical Investigation of Burns from Caramelized Sugar Candy (Dalgona)
Journal of Korean Burn Society 2021;24(2):30-33
Purpose:
Dalgona, a kind of candy made of caramelized sugar, is a popular snack for children. Given the popularity of preparing dalgona, increasingly many patients are treated for burns sustained while preparing dalgona. We report the clinical features and dangers of burns from dalgona.
Methods:
We retrospectively reviewed the clinical records of 11 inpatients and outpatients who had been treated for burns they received while preparing dalgona from March 2020 to December 2020. The data reviewed were age, sex, the severity of the burn, the size and location of the burn, the type of treatment, and the place where the injury occurred.
Results:
The age of the patients ranged from 3 to 19 years, and the average age was 10.2 years (2 male, 9 female). Three patients had superficial second-degree burns, while eight had deep second-degree or third-degree burns. Most of the cases were treated with a local skin flap or skin graft. All the burned lesions were on the hands and feet. In all cases, the burns occurred at home due to accidental spillage.
Conclusion
Most of the patients were children and teenagers, and they had serious burns. Therefore, we report these findings to emphasize the need for public awareness of the potential for burn injuries to occur during dalgona preparation.
2.Effect of reminders on cervical cancer screening.
Heon Joo BOO ; Kyeong Soo KIM ; Whan Seok CHOI ; Ho Cheol SHIN ; Eun Sook PARK
Journal of the Korean Academy of Family Medicine 1992;13(6):552-558
No abstract available.
Mass Screening*
;
Uterine Cervical Neoplasms*
3.Meningeal Melanocytoma Associated with Ota's Nevus: Report of a case.
Woo Sung MOON ; Joo Heon KIM ; Dong Geun LEE ; Ho Yeul CHOI ; Sang Ho KIM
Korean Journal of Pathology 1992;26(6):605-609
Primary meningeal melanocytoma of the central nervous system is extremely rare. We report a case of meningeal melanocytoma associated with Ota's nevus as a recurrent form in a 53-year old male. The meningeal melanocytoma was removed from right parietooccipital lobe 4 years ago and recurred in right parietal, occipital and left frontal lobes. Ultrastructurally, the tumor cells were characterized by the presence of numerous melanosomes and premelanosomes in their cytoplasm. Moreover, the tumor was lacking in histologic and ultrastructural features of pigmented meningioma, melanotic schwannoma and prolonged clinical course was different from primary meningeal melanoma or metastatic malignant melanoma.
Neoplasm Metastasis
4.Expression Patterns of S100A6 Gene in Human Thyroid Diseases.
Joo Heon KIM ; Jae Wha KIM ; Seon Young YOON ; Jong Hyuck JOO ; In Seong CHOI ; Mee Ja PARK
Korean Journal of Pathology 2000;34(11):934-940
S100A6 (calcyclin) is a member of the S100 family and has been originally isolated from the cDNA library of Syrian baby hamster kidney cells. The S100A6 gene expression is reported to remain high throughout the cell cycle following induction by serum or growth factors, suggesting that the gene may be required for cell cycle progression. Nevertheless, the role that S100A6 may play in tumor progression remains unknown. In this study, we have explored the expression patterns of S100A6 gene in human thyroid tissues by northern blot analysis. Using the S100A6 monoclonal antibody, we carried out the immunohistochemical staining to determine the distribution/localization of S100A6 protein within tumor or non-tumorous cells of the thyroid. To modulate the regulation of endogenously expressed S100A6 protein in the intracellular level, overexpressed or anti-sense treated transfectant was constructed by using the eukaryotic expression vector. As a result, immunohistochemistry for S100A6 showed a strong positivity in the malignant tumors of thyroid and a high expression level of S100A6 protein affected cell proliferation in the overexpressed transfectant. These findings suggest that S100A6 may be involved in the tumor pathogenesis and provides another parameter for the differentiation of malignant and benign lesions. A well defined monoclonal antibody against S100A6 protein is now available for the immunohistochemical studies of the various thyroid tissues.
Animals
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Blotting, Northern
;
Cell Cycle
;
Cell Proliferation
;
Cricetinae
;
Gene Expression
;
Gene Library
;
Humans*
;
Immunohistochemistry
;
Intercellular Signaling Peptides and Proteins
;
Kidney
;
Thyroid Diseases*
;
Thyroid Gland*
5.Combination Gene Therapy Using IL-2 and GM-CSF Genes Transferred by a Defective Infectious Single Cycle Herpes Virus (DISC Virus) in Head and Neck Squamous Cell Cancer Model.
Se Heon KIM ; Won Pyo HONG ; Eun Chang CHOI ; Joo Heon YOON ; Jae Jin CHOI ; Hyun Chul YOON
Korean Journal of Otolaryngology - Head and Neck Surgery 2001;44(1):71-79
BACKGROUND AND OBJECTIVES: The Herpes Simplex type 2 Defective Infectious Single Cycle virus (DISC virus) is an attenuated virus originally produced as a viral vaccine, but it also serves as an efficient gene transfer vehicle. The main goals of this study were to examine determinants of gene transfer using DISC vectors for squamous cell carcinoma and to evaluate the efficacy of vaccination with the DISC virus carrying a combination of immunomodulatory genes (IL-2, GM-CSF) as cancer therapy in a model of squamous cell cancer in the C3H/HeJ mice. MATERIALS AND METHODS: We determinated the gene and protein expression of DISC-IL-2 and DISC-GM-CSF transfected SCCVII cells by RT-PCR and ELISA method. Also, we evaluated the ex vivo vaccination effects of DISC-IL-2 and DISC-GMCSF on preventing the development of SCCVII tumor. RESULTS: SCCVII cells transduced by the DISC virus vector (MOI=10) carrying the IL-2, or the GM-CSF gene, produced nanogram quantities of IL-2 or GM-CSF per 10(6) cells. Of particular interest was the observation that cells irradiated at different doses (5,000 cGy, 10,000 cGy) secreted levels of GM-CSF or IL-2 that were comparable to non-irradiated cells. In vivo vaccination using tumor cells transduced ex vivo with DISC-IL-2 or DISC-GMCSF resulted in protection against subsequent tumor challenge (p<0.01). Among the multiple immunomodulatory transgenes vaccination groups, the DISC-GMCSF transfected vaccine showed the greatest suppression of tumor development and growth (p<0.001). CONCLUSION: These data demonstrate that: 1) The DISC virus vector is capable of efficient gene transfer to SCCVII cells, 2) The GM-CSF secreting, genetically modified tumor vaccine (SCCVII/GMCSF) efficiently protected against tumor cell challenge and suppressed tumor growth in our tumor model. The DISC virus-mediated, cytokine gene transfer may prove to be useful in clinical therapy for head and neck cancers.
Animals
;
Carcinoma, Squamous Cell
;
Enzyme-Linked Immunosorbent Assay
;
Genetic Therapy*
;
Granulocyte-Macrophage Colony-Stimulating Factor*
;
Growth and Development
;
Head*
;
Herpes Simplex
;
Interleukin-2*
;
Mice
;
Neck*
;
Neoplasms, Squamous Cell*
;
Transgenes
;
Vaccination
6.Two Cases of Emphysematous Cystitis.
Joo Ik PARK ; Joo Myeong SHIM ; Seong Yoon JUNG ; Young Hoo SEO ; Jae Il JUNG ; Ho Cheol CHOI ; Sung Hyup CHOI ; Heon Sung LEE
Korean Journal of Urology 2000;41(8):1033-1095
No abstract available.
Cystitis*
7.Pleomorphic Xanthoastrocytoma in a 58-year-old Woman: A case report.
Joo Heon KIM ; Myoung Jae KANG ; Dong Geun LEE ; Ho Yeul CHOI ; Sang Ho KIM ; Min Cheol LEE
Korean Journal of Pathology 1995;29(1):122-125
A case of left parietal pleomorphic xanthoastrocytoma that occurred in a 58-year-old woman is reported clinicopathologically. Histopathologic diagnosis of pleomorphic xanthoastrocytoma was made because of the unique pleomorphic histologic features, positive glial fibrillary acidic protein in immunohistochemical staining. The flow cytometric analysis reveals DNA aneuploidy and relatively high S-phase fraction. The pleomorphic xanthoastrocytoma is considered as a special subgroup of glioma on the basis of superficial cortical location, GFAP expression, marked cellular atypia, xanthomatous cells, and relatively favorable prognosis.
Female
;
Humans
8.Goblet Cell Carcinoid of the Appendix: A case report.
Joo Heon KIM ; Ho LEE ; So Young OH ; Myoung Jae KANG ; Ho Yeul CHOI ; Dong Geun LEE
Korean Journal of Pathology 1996;30(9):839-842
Carcinoid tumors of the appendix are common incidental findings, but appendiceal tumors with histologic features of both carcinoids and adenocarcinomas are rare, and their biologic behavior and histogenesis are still unclear. We report a case of goblet cell carcinoid of the appendix in a 54-year-old male, who exhibited pain in the right lower abdomen. Microscopically, the tumor contained smooth-bordered, widely separated nests composed of tumor cells with abundant mucin. The principal tumor cell type had a close resemblance to the normal goblet cell. Histochemically, the tumor cells revealed positive reaction for PAS and alcian blue stain. Immunohistochemically, the tumor showed strong reactivity for carcinoembryonic antigen, chromogranin and, neuron specific enolase but none for cytokeratin and epithelial membrane antigen.
Adenocarcinoma
9.A Case of Intracardiac Migration of Distal Ventriculo-Peritonal(V-P) Shunt Catheter.
Byung Joo KIM ; Seung Heon CHA ; Dong June PARK ; Geun Sung SONG ; Chang Hwa CHOI ; Young Woo LEE
Journal of Korean Neurosurgical Society 2000;29(2):270-273
No abstract available.
Catheters*
10.A Case of Williams Elfin Facies Syndrome.
Kyung Jin SHIN ; Heon Seob SONG ; Byung Sook PARK ; In Soo CHOI ; Chan Uhng JOO ; Jung Ku JO
Journal of the Korean Pediatric Society 1987;30(6):684-690
No abstract available.
Facies*