1.A Case of Sotos Syndrome.
In Seok KIM ; Joon Hee KIM ; Young Youn CHOI ; Jae Sook MA ; Tai Joo HWANG
Journal of the Korean Pediatric Society 1995;38(5):725-729
No abstract available.
Sotos Syndrome*
2.10-Prism-Diopter Fixation Test for Amblyopia.
Journal of the Korean Ophthalmological Society 2009;50(2):269-274
PURPOSE: To evaluate the clinical usefulness of the 10-prism-diopter (PD) fixation test in the diagnosis of amblyopia. METHODS: The study comprised 132 children (42 normal, 90 amblyopes) who underwent the 10-PD fixation test and stereoacuity test. The sensitivity, specificity, false-positive and false-negative rates of the 10-PD fixation test were analyzed according to the clinical diagnosis. RESULTS: The 10-PD fixation test sensitivity was 86%, the specificity was 61%, the false-positive rate was 17% and the false-negative rate was 24%. Data showed agreement between the 10-PD fixation test and the stereoacuity test (gamma=0.737, p=0.000). The results in the 10-PD base-down test and base-out test also showed agreement (gamma=0.779, p=0.000). CONCLUSIONS: The 10-PD fixation test is a simple and useful method in detecting amblyopia.
Amblyopia
;
Child
;
Humans
;
Sensitivity and Specificity
3.Intra-abdominal Angiosarcomatosis Induced by Irradiation.
Hee Jin CHANG ; Youn Joo KIM ; Sung Eun YANG ; Sung Sook PAENG ; Jung Il SUH
Korean Journal of Pathology 1997;31(3):269-274
Therapeutic irradiation can induce angiosarcoma. Radiation-induced angiosarcoma constitutes 20% of all angiosarcomas. Although its common site of origin is the skin and subcutaneous tissue, it rarely arises in small or large bowels with a presentation as multifocal abdominal angiosarcomatosis. We report a case of intra-abdominal angiosarcomatosis involving the jejunum, ileum, transverse colon, mesentery and right ovary in a 63-year-old female. It developed 10 years after therapeutic irradiation for squamous cell carcinoma of uterine cervix. She developed panperitonitis due to intestinal perforation. She died from sepsis 3 days after segmental resection of the small bowel and right oophorectomy. We reviewed the previously reported cases and describe the clinicopathologic features of this tumor.
Carcinoma, Squamous Cell
;
Cervix Uteri
;
Colon, Transverse
;
Female
;
Hemangiosarcoma
;
Humans
;
Ileum
;
Intestinal Perforation
;
Jejunum
;
Mesentery
;
Middle Aged
;
Ovariectomy
;
Ovary
;
Sepsis
;
Skin
;
Subcutaneous Tissue
4.The Effect of a Proton-pump Inhibitor in Unexplained Chronic Cough Patients.
Joo Youn YANG ; Ho Youn LEE ; Nam Hee KIM ; Youn Seup KIM
Tuberculosis and Respiratory Diseases 2006;61(2):137-142
BACKGROUND: Recent studies have suggested an association between chronic cough and gastroesophageal reflux. Our study aimed to assess the utility of a proton-pump inhibitor in unexplained chronic cough patients. METHODS: Patients with chronic cough of unknown etiology were evaluated using a chest x-ray, methacholine challenge test, and an empirical trial of postnasal drip therapy. After excluding other potential causes of the cough, forty patients were included in the study and treated for 8 weeks with a proton-pump inhibitor. RESULTS: Eleven and three patients in the first and second 4 weeks were lost to follow-up, leaving twenty-six patients finally included in the study. Of these patients, two were unimproved, eight partially responded to the proton-pump inhibitor and sixteen responded completely after the 8 week treatment. CONCLUSION: We suggest that empirical treatment with a proton pump inhibitor in all patients with persistent cough, which is not secondary to asthma or postnasal drip syndrome, represents a practical and simple approach to this ailment.
Asthma
;
Cough*
;
Gastroesophageal Reflux
;
Humans
;
Lost to Follow-Up
;
Methacholine Chloride
;
Proton Pumps
;
Thorax
5.Ameliorative Effects of NXP031 on MPTP-Induced Neurotoxicity
Joo Hee LEE ; Min Kyung SONG ; Youn-Jung KIM
Journal of Korean Biological Nursing Science 2021;23(3):199-207
Purpose:
The purpose of this study was to investigate effects of NXP031, an inhibitor of oxidation by specifically binding to the complex of DNA aptamer/vitamin C, on dopaminergic neurons loss and the reaction of microglia in an animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced subchronic Parkinson’s disease (PD).
Methods:
A subchronic PD mouse model was induced via an intraperitoneal (IP) injection of MPTP 30 mg/kg per day for five days. NXP031 (vitamin C/aptamer at 200 mg/4 mg/kg) and vitamin C at 200 mg/kg were administered via IP injections at one hour after performing MPTP injection. This process was performed for five days. Motor function was then evaluated with pole and rotarod tests, after which an immunohistochemical analysis was performed.
Results:
NXP031 administration after MPTP injection significantly improved motor functions (via both pole and rotarod tests) compared to the control (MPTP injection only) (p < .001). NXP031 alleviated the loss of dopaminergic neurons in the substantia nigra (SN) and striatum caused by MPTP injection. It was found to have a neuroprotective effect by reducing microglia activity.
Conclusion
NXP031 can improve impaired motor function, showing neuroprotective effects on dopaminergic neurons in the SN and striatum of MPTP-induced subchronic Parkinson’s disease mouse model. Results of this study suggest that NXP031 has potential in future treatments for PD and interventions for nerve recovery.
6.Ameliorative Effects of NXP031 on MPTP-Induced Neurotoxicity
Joo Hee LEE ; Min Kyung SONG ; Youn-Jung KIM
Journal of Korean Biological Nursing Science 2021;23(3):199-207
Purpose:
The purpose of this study was to investigate effects of NXP031, an inhibitor of oxidation by specifically binding to the complex of DNA aptamer/vitamin C, on dopaminergic neurons loss and the reaction of microglia in an animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced subchronic Parkinson’s disease (PD).
Methods:
A subchronic PD mouse model was induced via an intraperitoneal (IP) injection of MPTP 30 mg/kg per day for five days. NXP031 (vitamin C/aptamer at 200 mg/4 mg/kg) and vitamin C at 200 mg/kg were administered via IP injections at one hour after performing MPTP injection. This process was performed for five days. Motor function was then evaluated with pole and rotarod tests, after which an immunohistochemical analysis was performed.
Results:
NXP031 administration after MPTP injection significantly improved motor functions (via both pole and rotarod tests) compared to the control (MPTP injection only) (p < .001). NXP031 alleviated the loss of dopaminergic neurons in the substantia nigra (SN) and striatum caused by MPTP injection. It was found to have a neuroprotective effect by reducing microglia activity.
Conclusion
NXP031 can improve impaired motor function, showing neuroprotective effects on dopaminergic neurons in the SN and striatum of MPTP-induced subchronic Parkinson’s disease mouse model. Results of this study suggest that NXP031 has potential in future treatments for PD and interventions for nerve recovery.
7.Effects of Long- and Short-term Consumption of Energy Drinks on Anxiety-like, Depression-like, and Cognitive Behavior in Adolescent Rats
Joo Hee LEE ; Jong Hyeon LEE ; You Jeong CHOI ; Youn Jung KIM
Journal of Korean Biological Nursing Science 2020;22(2):111-118
Purpose:
The purpose of this study was to understand the impact of long- and short-term energy drinks on anxiety-like, depressionlike, and cognitive behavior in adolescent rats.
Methods:
Adolescent rats (age six weeks) were randomly classified into a control group (CON), a long-term administration group (LT), and a short-term administration group (ST). The LT group was orally administered 1.5 mL/100 g (body weight) of energy drink twice daily for 14 days, the ST group was orally administered for one day, and the control group applied the same amount of normal saline. Later, an open-field test, a forced swim test, novel object recognition test, and an 8-arm radial maze test was conducted to assess the rats’ anxiety, depression, and cognitive function.
Results:
There were different effects in the long- and short-term groups of energy drink administration. In the LT group, anxiety- and depressive-like behavior increased because of increased movement in the side corner and decrease of immobility time. Also, the time to explore novel objects decreased, and the number of correct responses was reduced, indicating a learning and memory function disorder. However, the ST group was not different from the control group.
Conclusion
These results indicate that long-term consumption of energy drinks can increase anxiety-like, depression-like behavior, and this can lead to decrease in learning and memory functions. Thus, nurse and health care providers should understand the impact of energy drink consumption in adolescence to provide appropriate practices and education.
8.Recurrent Thyroid Papillary Carcinoma in Children Under Ten Years Old: Report of Two Cases and Literature Review.
Byeong Joo NOH ; Ji Youn SUNG ; Youn Wha KIM ; Yong Koo PARK
Korean Journal of Pathology 2014;48(4):297-301
Papillary thyroid carcinoma (PTC) in children under ten years old is very rare. To date, 18 cases of PTC in children under ten years old (including our two cases) have been reported in Korea. Here, we describe two cases of recurrent PTC with follicular variant and conventional type in an 8-year-old boy and a 7-year-old boy, respectively, and discuss clinicopathologic and molecular characteristics that differ in pediatric patients from adults.
Adult
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Carcinoma, Papillary*
;
Child*
;
Humans
;
Korea
;
Male
;
Thyroid Gland*
;
Thyroid Neoplasms
9.Association between family structure and food group intake in children.
Youn Joo BAEK ; Hee Young PAIK ; Jae Eun SHIM
Nutrition Research and Practice 2014;8(4):463-468
BACKGROUNDS/OBJECTOVES: Family has an impact on dietary intake of children as a proximal food environment and family structures are changing and becoming more diverse. This study was performed to identify the association between family structure and food group intake of children aged 3-18 years in Korea. SUBJECTS/METHODS: A total of 3,217 children with complete data on variables for household information, dietary intake and sampling weights were obtained from 2010-2011 Korea National Health and Nutrition Examination Survey. Children's family structure was classified into 3 groups (Living with both parents, Living with one parent and Living without parents). To evaluate children's food group intake, scores of individual food groups ('Grains', 'Meat, Fish, Eggs and Beans', 'Vegetables', 'Fruits' and 'Milk and Dairy products') was calculated from percent adherence to the recommended servings of the Korean Food Guidance System (KFGS). 'Food group mean score' was obtained by calculating the average of five food group scores. RESULTS: After adjusting for age, sex, number of family members, and household income, children living with both parents had higher scores in 'Fruits' (P < 0.01), 'Milk and Dairy products' (P < 0.05), and mean score of individual food group score (P < 0.001) compared to children living with one parent. Individual food group scores and mean scores of individual food group scores were associated with different socio-demographic factors in study children. Family structure was associated with 'Fruits,' 'Milk and Dairy products' score and mean scores of food group scores. CONCLUSIONS: These results suggested that different approach might be required to solve nutrition problem in children depending on their family structure and other socio-demographic factors.
Child*
;
Eggs
;
Family Characteristics
;
Humans
;
Korea
;
Nutrition Surveys
;
Ovum
;
Parents
;
Weights and Measures
10.Clinical assessment of neonatal transient tricuspid insufficiency: Doppler echocardiographic study.
Se Geun PARK ; Dong Gun PARK ; Ji Hee PARK ; Chang Sung SON ; Joo Won LEE ; Youn Chang TOCKGO
Journal of the Korean Pediatric Society 1993;36(6):785-790
Eight neonates with transient tricuspid insufficiency are presented which was confirmed clinical and two dimensional echocardiographic assessment. We found that two dimensional Doppler echocardiography was very useful in the detection of transient tricuspid insufficiency during neonatal age as noninvasive method. Transient tricuspid insufficiency is a clinical disorder in the newborn period caused by myocardial dysfunction, secondary to asphyxia with or without hypoglycemia and associated with right ventricular overloading caused by pulmonary hypertention. The clinical diagnosis was based on a history of perinatal distress, distinctive murmur, ECG changes, biochemical abnormalities and myocardial imaging. 1) The sex ratio of TTI was 1:1. 2) The average gestational age was 34 weeks and mean body weight was 2.06 Kg, respectably. 3) Major symptoms were dyspnea, cyanosis, and tachypnea. 4) Tricuspid regurgitation was detected from the lst day to the 4th day of the life and was improved from the 7th day to the 30th day of the life. 5) The peak velocity through tricuspid valve ranged from the 2.7 m/sec to 4.0 m/sec and the estimated right ventricular pressure ranged from 39 mmHg to 74 mmHg. 6) Associated diseases were neonatal hyperbilirubinemia (100%), prematurity (87.5%), atrial right to left shunt (87.5%), patent ductus arteriosus (75%), hyaline membrane disease (25%), and transient tachypnea of newborn (12.5%).
Asphyxia
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Body Weight
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Cyanosis
;
Diagnosis
;
Ductus Arteriosus, Patent
;
Dyspnea
;
Echocardiography*
;
Echocardiography, Doppler
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Electrocardiography
;
Gestational Age
;
Humans
;
Hyaline Membrane Disease
;
Hyperbilirubinemia, Neonatal
;
Hypoglycemia
;
Infant, Newborn
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Sex Ratio
;
Tachypnea
;
Transient Tachypnea of the Newborn
;
Tricuspid Valve
;
Tricuspid Valve Insufficiency
;
Ventricular Pressure