1.Extraskeletal osteogenic sarcoma of the mediastinum: 1 case report.
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(5):413-416
No abstract available.
Mediastinum*
;
Osteosarcoma*
2.Benign Fibrous Histiocytoma of Spinal Cord.
Hae Joo NAM ; Won Hee CHOI ; Tae Sook LEE
Korean Journal of Pathology 1988;22(4):510-514
Fibrous histiocytoma composed of fibroblasts and histiocytes is quite variable in histologic pattern. The biologic behavior is unpredictable by histologic ground. This tumor is well-known in subcutaneous tissue and deep soft tissue, but quite rare in central nervous system. We experienced a case of the fibrous histiocytoma involving the dura mater of spinal cord in a 26 year old female patient. In gross findings, the mass was a well demarcated, ovoid mass attached to the dura matter, and measured 2.5x1.5 cm in diameter. The cut surface was rubbery, solid, gray-white or yellow. Microscopically, the lesion consisted of polyhedral cells with round or oval nuclei and faintly eosinophilic or vaculoated cytoplasm, and multinucleated giant cells. Some giant cells were Touton-type. Composing cells were bland-looking. Mitotic figures were average 3 per 10 high power fields.
Female
;
Humans
3.Malignant Mixed Mullerian Tumor of the Ovary: A case report.
Hae Joo NAM ; Won Hee CHOI ; Tae Sook LEE
Korean Journal of Pathology 1987;21(4):303-307
The clinical and pathological features of a case Malignant mixed mullerian tumor of the ovary in 45 year-old female patient with a brief review of the literature are presented. She had both ovarian tumors. The masses are multilocular cystic tumor with interspersed solid component. The cystic component is filled with serous fluid. Microscopically the tumor is composed of epithelial element & intimately related mesenchymal element. The epithelial element shows the findings of adenocarcinoma of solid, glandular and papillary growth. The mesenchymal element is composed of malignant-looking stroma with cartilage formation.
Female
;
Humans
;
Adenocarcinoma
4.Introduction of Relative Survival Analysis Program: Using Sample of Cancer Registry Data with Stata Software.
Kyu Won JUNG ; Hyun Joo KONG ; Seon Hee YIM ; Young Joo WON ; Joohon SUNG ; Hai Rim SHIN
Korean Journal of Epidemiology 2007;29(2):222-229
Patient survival is one of the most important measures for the evaluation of progress in cancer patient care across the wide spectrum from diagnosis to treatment. The optimal monitoring method for cancer patient survival is to estimate survival based on representative data from cancer patients in the population, which is only achievable through using population-based cancer registration data. Relative survival is used to compare the survival experience in a study cohort that expected to result from background population mortality rates. This technique is useful when the cause of death is not accurate or not available, since it provides a measure of excess mortality in a group of patients with a certain disease. The purpose of this article is to demonstrate the procedures for estimating relative survival using the statistical software Stata. For this survival analysis to show the procedure, the example data set was randomly selected from the National Cancer Incidence Database, which was used in a recent article reporting the overall relative survival of cancer patients diagnosed during 1993-2002 in Korea.
Cause of Death
;
Cohort Studies
;
Dataset
;
Diagnosis
;
Humans
;
Incidence
;
Korea
;
Mortality
;
Patient Care
;
Survival Analysis*
5.Clinical significance of cellular immunity in the renal interstitium of IgA nephropathy.
Tae See CHUNG ; Young Joo KWON ; Won Yong CHO ; Hyoung Kyu KIM ; Nam Hee WON
Korean Journal of Nephrology 1991;10(2):157-165
No abstract available.
Glomerulonephritis, IGA*
;
Immunity, Cellular*
;
Immunoglobulin A*
6.Clinical significance of cellular immunity in the renal interstitium of IgA nephropathy.
Tae See CHUNG ; Young Joo KWON ; Won Yong CHO ; Hyoung Kyu KIM ; Nam Hee WON
Korean Journal of Nephrology 1991;10(2):157-165
No abstract available.
Glomerulonephritis, IGA*
;
Immunity, Cellular*
;
Immunoglobulin A*
7.PAX2 Expression in Renal Dysplasia.
Yoon Hee LEE ; Woo Hee JUNG ; Soon Won HONG ; Hyeon Joo JEONG
Korean Journal of Pathology 2007;41(2):69-78
BACKGROUND: Renal dysplasia is the abnormal development of the kidney. The condition is usually detected in childhood along with other urinary tract anomalies, but can remain unnoticed until adulthood. It was recently reported that a PAX2 gene mutation plays a major role in the development of renal dysplasia. The aim of this study was to examine the expression of PAX2 in dysplastic kidneys of children and adults. METHODS: A total of 30 cases diagnosed with renal dysplasia after a nephrectomy were examined. PAX2 expression was evaluated using immunohistochemistry. Apoptosis was detected using an Apop Tag detection kit. RESULTS: In the dysplastic kidneys, there was strong PAX2 expression in the epithelia of the primitive ducts in both children and adults, but the degree was significantly lower in adults (p=0.007). However, the mesenchyme surrounding the primitive ducts of children showed stronger staining for the smooth muscle actin antibody and trichrome than the adults. The apoptosis index was significantly higher in the primitive duct epithelia than in the surrounding normal collecting duct epithelia (p=0.000). CONCLUSIONS: PAX2 is overexpressed in the primitive ducts of renal dysplasia, which is sustained until adulthood and is associated with increased apoptosis. However, a decrease in PAX2 expression in the dysplastic epithelia and mesenchymal cuff of adults suggest a gradual regression of the dysplastic elements with time.
Actins
;
Adult
;
Apoptosis
;
Child
;
Humans
;
Immunohistochemistry
;
Kidney
;
Mesoderm
;
Muscle, Smooth
;
Nephrectomy
;
Urinary Tract
8.A Case Combined Germ Cell Tumor in Testis.
Hae Joo NAM ; Won Hee CHOI ; Tae Sook LEE ; Jun Gyu SUH ; Kyung Chul LEE
Yeungnam University Journal of Medicine 1985;2(1):293-297
Primary germ cell tumor of the testis is rare, which occupies 1 to 2% of all reported malignant male neoplasms. Combined primary germ cell tumor of the testis composed of embryonal carcinoma and seminoma is more rare tumor. The authors experienced a case of 50-year old male who presented with painless enlargement of right testicle. He has had radical orchiectomy and diagnosed by pathologically as combined germ cell tumor of testis. The testicle is measuring 180 gm in weight and 9×6×5 cm in dimension, and almostly replaced by tumor mass. Grossly the tumor is rubbery solid smooth tumor mass, with variegated cut surface with geographically outlined diffuse necrotic area. Histologically the tumor is composed of two components of tumor, which are solid growth pattern of large round to polyhedral cells with clear or granular cytoplasm and distinct cell border, and anastomosing glandular and papillary arrangement of anaplastic epithelial cells. The former corresponds to seminoma, and the latter to embryonal carcinoma. Each tumor lobule is separated by abundant fibrous stroma.
Carcinoma, Embryonal
;
Cytoplasm
;
Epithelial Cells
;
Germ Cells*
;
Humans
;
Male
;
Neoplasms, Germ Cell and Embryonal*
;
Orchiectomy
;
Seminoma
;
Testis*
9.Effects of carbon tetrachloride on structures in hepatocytes following DMN induced hepatotoxicity.
Young Chun KANG ; Hae Joo NAM ; Dong Suk KIM ; Won Hee CHOI ; Tae Sook LEE
Yeungnam University Journal of Medicine 1991;8(2):84-94
The purpose of this study was to evaluate the influence of high dose carbon tetrachloride (CCI4) on the hepatotoxic effect of dimethylnitrosamine (DMN) which induces acute hemorrhagic necrosis in liver. Rats were injected intraperitoneally DMN dissolved in physiologic saline by a dose of 40 mg/kg. For changes related to CCI⁴ pretreatment, rats were injected intraperitoneally CCI⁴ dissolved in olive oil by a dose of 0.4 mg/kg, and then injected DMN. The livers were extracted from the rats 3, 6, 12, 24, 48, 72, and 120 hours after CCI⁴ and/ or DMN injection. Liver tissues were examined with light and electron microscopes. The results were summarized as follows; Light microscopic findings: Severe centrilobular hemorrhagic necrosis developed from 12 hours after injection of DMN and continued to 120 hours. On injection of DMN after CCI4 pretreatment, Massive necrosis occurred early. But active regenerative changes were produced in 24 hours. In 120 hours, the liver recovered in almost normal appearance. The degree of necrosis in pretreated group was similar to that in DMN injection only, and the time of recovery was faster in pretreated group. Electron microscopic findings: The early change was mainly disorganization of RER in DMN injection, and clumping and vesicular dilatation of ER in injection of CCI4. In pretreatment group, the early change was similar in appearance with CCI4 group, but severer in degree. According to the results, it was revealed that acute toxic effect of DMN was recovered more rapidly in pretreatment group. Thus it was suggested that CCI4 had protective effect in DMN hepatotoxicity.
Animals
;
Carbon Tetrachloride*
;
Carbon*
;
Dilatation
;
Dimethylnitrosamine
;
Hepatocytes*
;
Liver
;
Necrosis
;
Olive Oil
;
Rats
10.Histopathological study of gastric adenoma.
Dong Sug KIM ; Hae Joo NAM ; Won Hee CHOI ; Tae Sook LEE ; Moon Kwan CHUNG
Yeungnam University Journal of Medicine 1991;8(2):76-83
A total of 53 gastric adenomas from endoscopically biopsied gastric mucosa were examined histopathologically. The average age at the time of endoscopic biopsy was 59 years, and gastric adenomas were found to be more frequent in the aged, particularly above the age of 50. The majority of adenomas occurred at the antrum. Concerning the shape of the adenomas, Yamada type II was more frequent (55%). All adenomas were accompanied by varying degree of intestinal metaplasia, and this findings suggest that gastric adenoma develops from intestinal metaplasia. In adenomas with severe atypia (grade III), endocrine cells (argyrophil and argentaffin cells) were markedly decreased or absent. Gastric adenocarcinomas coexistent with adenoma were seen in 5 (9.4%) out of 53 cases, and were more frequent in male than female patients (sex ratio, 4:1) and the average age was 61.4 years. It is suggested that there is a necessity of thorough follow-up study for definitive correlation between gastric adenoma and adenocarcinoma.
Adenocarcinoma
;
Adenoma*
;
Biopsy
;
Endocrine Cells
;
Female
;
Follow-Up Studies
;
Gastric Mucosa
;
Humans
;
Male
;
Metaplasia
;
Stomach