BACKGROUND: Both atrophic gastritis and intestinal metaplasia may progress to gastric dysplasia. This study aimed to analyze the factors influencing progression of atrophic gastritis and intestinal metaplasia to dysplasia. METHODS: People diagnosed with atrophic gastritis and intestinal metaplasia for the first time received a follow-up endoscopy and were investigated for the cumulative incidence rate of gastric dysplasia by age, gender, smoking habit, alcohol intake, rice consumption and family history of stomach cancer. RESULTS: The cumulative incidence rate increased with age, consuming > or =3 bowls of rice per day and family history of stomach cancer. Multivariate analysis showed that the cumulative incidence rate of gastric dysplasia increased in subjects >61 years (RR=2.54, P=0.014), in those consuming > or =3 bowls of rice per day (RR=1.46, P=0.021) and in those with a family history of stomach cancer (RR=1.31, P=0.037). CONCLUSIONS: More active management, such as intensive endoscopic follow-up examinations, lifestyle change and education regarding gastric dysplasia, are required in those older than 61 years, having a higher intake of grain or with a family history of stomach cancer.
Edible Grain ; Endoscopy ; Follow-Up Studies ; Gastritis, Atrophic ; Humans ; Incidence ; Life Style ; Metaplasia ; Multivariate Analysis ; Risk Factors ; Smoke ; Smoking ; Stomach ; Stomach Neoplasms

No abstract available.
Humans ; Infant* ; Intussusception*

Gastric adenocarcinoma is the most common cancer of the gastrointestinal tract in Korea, and its prognosis is related to several factors, such as depth of invasion, lymph node metastasis, and differentiation. Heat-shock proteins (HSPs) are present constitutively in normal cells, where they play an important role in normal cell metabolism. In mammarian cells, they are induced by a variety of physical and chemical stimuli. Among them, HSP70 is found at a higher level in growing cells than in resting cells. The p53 gene is located on the short arm of the chromosome 17 and acts as a cancer suppressor gene. A mutant p53 gene induces a malignant transformation. The mutant p53 protein binds with HSP70 and the p53-HSP70 complex has functional significance in the transforming capacity of the mutant p53. We evaluated the correlation between the HSP70 scores and the p53 protein expression by immunohistochemical methods and compared it with well-known prognostic factors, such as depth of invasion, size, histologic type, and DNA ploidy pattern, in 37 gastric adenocarcinomas. The HSP70 expression was scored according to the staining intensity and extent. An immunoreactivity of over 1% in tumor cell nuclei was considered as positive for p53 protein. The results are summarized as follows: The p53 protein expression rate did not significantly differ based on depth of invasion, histologic type, lymph node metastasis, or DNA ploidy. The HSP70 scores was higher in group II (AGC with TNM stage III) than in group I (EGC & AGC with TNM stage II) and in p53-positive carcinomas than in p53- negative carcinomas(P<0.05). In conclusion, the p53 protein and HSP70 were closely correlated to each other in our immunohistochemical study for gastric adenocarcinomas and the HSP70 scores may play a role in the progression of a gastric adenocarcinoma. However, further studies are needed for determining their prognostic values in gastric adenocarcinomas. HSP70 and p53 expression are factors, just like depth of invasion. The question is their value.
Adenocarcinoma ; Arm ; Cell Nucleus ; Chromosomes, Human, Pair 17 ; DNA ; Gastrointestinal Neoplasms ; Genes, p53 ; Genes, Tumor Suppressor ; Heat-Shock Proteins* ; HSP70 Heat-Shock Proteins* ; Korea ; Lymph Nodes ; Metabolism ; Neoplasm Metastasis ; Ploidies ; Prognosis ; Stomach

Gastric adenocarcinoma is the most common cancer of the gastrointestinal tract in Korea, and its prognosis is related to several factors, such as depth of invasion, lymph node metastasis, and differentiation. Heat-shock proteins (HSPs) are present constitutively in normal cells, where they play an important role in normal cell metabolism. In mammarian cells, they are induced by a variety of physical and chemical stimuli. Among them, HSP70 is found at a higher level in growing cells than in resting cells. The p53 gene is located on the short arm of the chromosome 17 and acts as a cancer suppressor gene. A mutant p53 gene induces a malignant transformation. The mutant p53 protein binds with HSP70 and the p53-HSP70 complex has functional significance in the transforming capacity of the mutant p53. We evaluated the correlation between the HSP70 scores and the p53 protein expression by immunohistochemical methods and compared it with well-known prognostic factors, such as depth of invasion, size, histologic type, and DNA ploidy pattern, in 37 gastric adenocarcinomas. The HSP70 expression was scored according to the staining intensity and extent. An immunoreactivity of over 1% in tumor cell nuclei was considered as positive for p53 protein. The results are summarized as follows: The p53 protein expression rate did not significantly differ based on depth of invasion, histologic type, lymph node metastasis, or DNA ploidy. The HSP70 scores was higher in group II (AGC with TNM stage III) than in group I (EGC & AGC with TNM stage II) and in p53-positive carcinomas than in p53- negative carcinomas(P<0.05). In conclusion, the p53 protein and HSP70 were closely correlated to each other in our immunohistochemical study for gastric adenocarcinomas and the HSP70 scores may play a role in the progression of a gastric adenocarcinoma. However, further studies are needed for determining their prognostic values in gastric adenocarcinomas. HSP70 and p53 expression are factors, just like depth of invasion. The question is their value.
Adenocarcinoma ; Arm ; Cell Nucleus ; Chromosomes, Human, Pair 17 ; DNA ; Gastrointestinal Neoplasms ; Genes, p53 ; Genes, Tumor Suppressor ; Heat-Shock Proteins* ; HSP70 Heat-Shock Proteins* ; Korea ; Lymph Nodes ; Metabolism ; Neoplasm Metastasis ; Ploidies ; Prognosis ; Stomach

No abstract available.
Rickettsia typhi* ; Rickettsia*

Chronic sclerosing sialadenitis, Mikulicz disease or Kuttner tumor has been recently recognized as a spectrum of IgG4-related sclerosing disease. IgG4-related disease is characterized by a high serum IgG4 level and tissue infiltration of IgG4-positive plasmacytes. We report three cases of chronic sclerosing sialadenitis with variably associated systemic involvement. All patients presented with a submandibular mass or swelling, and all the resected submandibular glands showed diffuse lymphocytic infiltration, lymphoid follicles, and septal fibrosis. Two of the specimens revealed numerous IgG-positive plasma cells, most of which were IgG4-positive on immunohistochemical staining. One of them was associated with dacryoadenitis and hypophysitis. The other patient had ureterorenal lesions. Immunohistochemical study was unavailable in remaining one case, but the histologic features along with elevated IgG level and associated pancreatitis supported the diagnosis. All patients received steroid therapy postoperatively and are doing well. Salivary gland involvement in IgG4-related fibrosclerosis should be recognized in systemic medical pathology.
Dacryocystitis ; Fibrosis ; Humans ; Immunoglobulin G ; Mikulicz' Disease ; Pancreatitis ; Plasma Cells ; Salivary Glands ; Sialadenitis ; Submandibular Gland

A total of 53 patients infected with Taenia solium were treated with praziquantel in two different dose levels. Twenty-six cases were treated with praziquantel in a single oral dose of 5 mg/kg body weight. All cases except one were completely cured. The cure rate was 96.2 per cent. The other 27 cases were treated with a single dose of 10 mg/kg body weight. All cases were completely cured and revealed a cure rate of 100 per cent. Side effects were mild and transient. About half of the cases complained of a mild abdominal pain. Soft stool or diarrhea and dizziness were observed in some cases. Tests on clinical hematology, serum biochemistry and urinalysis were performed immediately before and one day after treatment in all cases. There were no significant abnormalities detected in these tests.
parasitology-helminth-cestoda ; Taenia solium ; chemotherapy-praziquantel ; abdominal pain ; hematology ; serum ; biochemistry ; urinalysis

No abstract available.
Antibodies, Anticardiolipin* ; Female ; Pregnancy ; Pregnancy Outcome* ; Pregnancy*

No abstract available.
Chorionic Gonadotropin* ; Humans* ; Hypertension* ; Pregnancy*